Tracheobronchopulmonary Carcinoid Tumors: Analysis of 40 Patients
|
|
- Shannon Jenkins
- 5 years ago
- Views:
Transcription
1 Ann Thorac Cardiovasc Surg 2011; 17: 7 12 Original Article Tracheobronchopulmonary Carcinoid Tumors: Analysis of 40 Patients Reza Bagheri, MD, 1 Mohammad taghi Rajabi Mashhadi, MD, 1 S.Ziaallah Haghi, MD, 1 Ali Sadrizadh, MD, 1 and Fariba Rezaeetalab, MD 2 Introduction: Carcinoid tumors are a type of neuroendocrine tumors which usually involve the upper airways and the patients most often complain of cough and hemoptysis. Materials and Methods: This study was performed from 1990 through 2007 on 40 patients with carcinoid tumor who had been followed up for at least 3 years. The statistical analysis were based on tumor epidemiology, treatment and the 3- year survival. The factors influencing the survival were analyzed using SPSS and exact fisher test. Results: M/F was 16/24 with mean age 34 years. Their most common symptoms were coughing (90%). The left main bronchus was the most common site of involvement (25%). 95% of all the cases underwent surgery and 5% of the patients underwent chemoradiotherapy due to distant metastasis. The most common surgical procedure was lobectomy or biloectomy (57.8%). Bronchial sleeve resection was performed on 10.4% of the patients. The most common pathology was the typical form (90%) and 5% of the madiastinal lymph nodes were involvd all of the atypical type. Carcinoid syndrome was seen in one patient (2.5%) and post operative adjuvant treatment was done in 5% of the patients after surgery because of mediastinal lymph node involvement. Post operative recurrence occurred in one patient (2.6%) of the atypical form with mediastinal lymph nodes involvement. The most common complication of surgery was a long- term air leakage (10.4%) and the surgical death rate was 0%. 3- Year survival was 92.5%. The factors influencing the survival included the pathological type, distant metastasis and mediastinal lymph node involvement. Conclusion: Carcinoid tumors have mostly been responsive to surgical intervention, resulting in a long term survival. Copyright ERS 2009 of the abstract in Eur Respir J 2009, 34, Suppl. 53: P167. Key words: carcinoid tumor, surgical resection, adjuvant therapy 1 Thoracic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran 2 Pulmonary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran (current affiliation) 1 Endoscopic and Minimal Invasive Research Center, 2 Lung Diseases and Tuberculosis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Received: February 27, 2008; Accepted: January 31, 2010 Corresponding author: Reza Bagheri, MD. (current affiliation) Endoscopic and Minimal Invasive Research Center, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran Bagherir@mums.ac.ir 2011 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery. All rights reserved. Introduction Pulmonary carcinoid tumors are neuroendocrine malignant tumors that represent 1% to 2% of all lung tumors. According to histopathologic criteria, carcinoids could be divided into typical (TC) and atypical (AC) carcinoids. Carcinoids are in a spectrum of neuroendocrine tumors, ranging from low-grade malignant TC, intermediate AC, high- grade large cell neuroendocrine carcinoma to small cell lung carcinoma. Familial pulmonary carcinoids are rare. The most common symptoms are hemoptysis, cough, recurrent pulmonary infection, 7
2 Bagheri R et al. Table 1 Prevalence of clinical findings in carcinoid tumor patients (40 patients). fever, chest discomfort and chest pain, unilateral wheezing, and shortness of breath. Paraneoplastic syndromes are rare and include carcinoid syndrome, Cushing s syndrome, and ectopic growth hormone secretion. The diagnosis is usually established by flexible bronchoscopy and biopsy, although occasionally this can result in severe hemorrhage. Immunoscintigraphy by somatostatin analogues can also help in the diagnosis. The treatment of choice is surgical resection, and prognosis is relatively good for TC, though it is not usually favorable for AC. The role of radiotherapy and chemotherapy as a part of multimodality treatment or palliation is still debated. 1) This study was aimed to assess the result of treatment and 3-year survival rate of patients with carcinoid tumors. Materials and Methods This is a descriptive study which was performed on 40 patients admitted to Qhaem and Omid hospitals of Mashhad University of Medical Sciences from 1990 to They were evaluated after appropriate treatment (38 patients had undergone surgery and 2 patients underwent chemoradiotherapy without surgery because of distant metastasis at the time of admission). They were followed up for at least 3 years. Average time of follow up was 9.5 ± 0.6 years (3 17 years). The following factors were statically analyzed: age, sex, clinical symptoms, tumor location, diagnostic procedures before treatment, therapeutic method and its complications and 3-year survival. The factors influenced 3-year survival rate were also studied by Statistical Package for the Social Sciences (SPSS) version 11.5 and Fisher s exact test. Results Percent Number Clinical finding 95% 38 Cough 75% 30 Hemoptysis 55% 22 Dyspnea 27.5% 11 Wheezing Table 2 Prevalence of involved airways in carcinoid tumor (40 patients). percent Num Location 5% 2 Trachea 25% 10 Left main bronchus 20% 8 Right main bronchus 12.5% 5 Left upper lobe bronchus 5% 2 Right upper lobe bronchus 12.5% 5 Left lower lobe bronchus 10% 4 Right lower lobe bronchus 5% 2 Right middle lobe bronchus 2.5% 1 Lingual 2.5% 1 Miliary pattern 40 patients were enrolled in the study, including 16 males and 24 females (M/F = 0.66). their age ranged from 12 to 88 years with a mean age of 34 years. The most common symptoms were cough (40%) and hemoptysis (25%). The prevalence of the clinical findings in carcinoid tumor patients is shown in Table 1. Chest X-ray and CT scan were used as diagnostic tools in all patients. Flexible bronchoscopy was performed in all patients as a standard diagnostic procedure before treatment. A biopsy sample with a definitive pathological report was taken from 32 patients (80%); however, because of the risk of severe hemorrhage, a biopsy was not performed, and surgery was performed without biopsy on the other 8 (20%) patients. The most common location of the tumor was in the left main bronchus (25%). Table 2 shows the prevalence of involved airways in carcinoid tumor. Generally the tumor most commonly involved the proximal airway on the left side. Bilateral form was not observed in our study. Thirty-eight patients (95%) underwent surgical operation. Only 2 cases (5%) showed distant metastasis on admission and did not undergo surgery. In one patient a miliary pattern of lung involvement was seen, in addition to the distant metastasis. The most common surgical technique was lobectomy, which was performed in 14 cases (37%). Table 3 shows the prevalence of the technical procedures used in the 38 surgical cases. We performed bronchial sleeve resection in four patients in whom three underwent bronchial sleeve upper lobectomy and one, bronchial sleeve lower lobectomy. On pathological examination, 36 patients had the typical carcinoid form (90%) and 4 had the atypical carcinoid form (10%). Classical mediastinal lymphadenectomy was performed on 4 patients during operation, because of 8
3 Table 3 Prevalence of technical procedures (38 patients). Percent Num Technique 37% 14 Lobectomy 20.8% 8 Bilobectomy 20.8% 8 Pneumonectomy 10.4% 4 Bronchial sleeve resection 5.2% 2 Segmentectomy 5.2% 2 Tracheal resection Tracheobronchopulmonary Carcinoid Tumors mediastinal lymphatic involvement; however, in 2 patients (5%), metastatic lymphatic involvement was seen after the pathological report both of whom had the atypical carcinoid form. Only one of the cases showed the clinical symptoms of carcinoid syndrome in which hepatic metastasis occurred. Postoperative adjuvant therapy was required in 2 patients (5%) with atypical carcinoid form and mediastinal lymphatic involvement, (chemoradiotherapy); however, in 2 patients (5%) who had distant metastasis on admission, chemoradiotherapy was performed without an operation. Chemotrapeutic regimens were cisplatin with etopside which was given in 6 courses with 3 weeks interval and in each course cisplaten was given with the dose of 80 mg/m 2 and etopside with the dose of 100 mg/m 2. The dosage of radiotherapy was 5000 rad which was given in 5 weeks (5 times each week). Also in cases with unresectable tumor and in patients who could not tolerate surgery, the dosage of radiotherapy was enhanced, but only if the tumor has an acceptable response to it. Postoperative recurrence was seen in form of distant metastasis in one case (2.5%) in atypical carcinoid form with mediastinal lymphatic involvement. 37 (92.5%) patients had no recurrence after surgery. In the 3-year evaluation for survival, 37 patients (92.5%) were still alive while 3 (7.5%) patients died, in whom 2 cases had distant metastasis at the time of admission and one patient went to the US, 1.5 years after the initial surgery with distant metastasis. All the patients who underwent sleeve resection were still alive with no sign of recurrence on follow up. Regarding factors affecting the survival, patients were placed into two groups (more and less than 3 years survival), and were evaluated for parameters such as age, sex, side of involvement, type of pathology, mediastinal lymph node involvement and distant metastasis (early and late). All patients with typical carcinoid were alive after 3 years and only one patient with atypical carcinoid was alive after 3 years which shows that type of pathology affects survival (P <0.05). Other factors such as mediastinal lymph node involvement (P = 0.001) and early distant metastasis (P = 0.004) were also effective on survival, but other factors were not meaningful statistically. Table 4 shows the role of various factors in the survival of 40 patients with carcinoid tumors. We also determined 3 years survival according to Kaplan Meier method for the patients whom underwent appropriate treatment (Fig. 1). Postoperative complications were seen in 6 (15.6%) out of 38 patients and the most common were: prolonged air leakage in 4 patients (10.5%) which was controlled with conservative treatments (use of low suction), and wound infection in 2 patients (5.2%) which responded to usual treatments (opening the wound, washing and secondary repair). In one patient who had been discharged, empyema occurred after 3 months because of persistent space formation (from the prolonged air leakage group), and it was controlled by operation and using decortications and muscular flap. No surgical mortality occurred. Discussion Carcinoid tumors are malignant neuroendocrine tumors, first described in 1888 in the ileum. When neuroendocrine cells were first discovered, they were called clear cells and, later, amine precursor uptake and decarboxylation (APUD) system cells. The term neuroendocrine was introduced because of capability to synthesizing hormonal products and numbers of these 9
4 Bagheri R et al. Table 4 Studying the role of effective factors in the survival of pulmonary carcinoid patients (40 patients). Variables More than 3-years survey Less than 3-years survey Fisher exact test (37 patients) (3 patients) (P-value) Age Less than 60 y 30 (81%) 2 (66.6% ) More than 60 y 7 (19%) 1 (33.3%) Sex M 15 (40.5%) 1 (33.3%) F 22 (59.5%) 2 (66.6%) Tumor location Left side 20 (54%) 1 (33.3%) Right side 15 (40.5%) 1 (33.3%) Tracheal 2 (5.5%) 0 (0%) Miliary 0 (0%) 1 (33.3%) P >0.05 P >0.05 P >0.05 Mediastinal lymph node involvement 0 (0%) 3 (100%) P = Metastasis Early 0 (0%) 2 (66.6%) P = Delay 0 (0%) 1 (33.3% ) P = Metastasis 0 (0%) 3 (100%) P = Tumor pathology Typical 36 (97.3%) 0 Atypical 1 (2.7%) 3 (100%) P <0.05 Fig. 1 3 years survival of 40 patients with tracheobronchopulmonary Carcinoid Tumor cases according to Kaplan Meier method. products are identical to the nervous system. 2) Carcinoid tumors can be placed in the spectrum of neuroendocrine tumors, from low grade malignant typical carcinoids to intermediate atypical carcinoid to high grade small cell lung cancer (SCLC). 3) Bronchial carcinoids occur in any age but usually in the middle of 5th- decade of life equally in both sexes. 4) In our study the median age was 34 years and male to female ration was In a study performed by Modlin et al, 25% of patient s were asymptomatic but in the symptomatic cases cough and hemoptysis were the most common symptoms. 5) In our study all the patients were symptomatic and cough 10
5 Tracheobronchopulmonary Carcinoid Tumors and hemoptysis were the most common symptoms. Bronchial carcinoids mostly occur in major airways (central airways). These tumors are highly vascular and originate submucusally. The carcinoid syndrome is rare, presents at diagnosis (1% 2% incidence) and is severe in patients with large primary tumors or extensive hepatic metastases. 6) Diagnosis is usually established by fibreoptic bronchoscopy and biopsy, although it can occasionally result in severe hemorrhage. 7) In our study the most common location of tumor was in the left main bronchus, and only one case (2.5%) showed the clinical symptoms of carcinoid syndrome with hepatic metastasis. All patients underwent flexible bronchoscopy but the biopsy was taken in 80% of patients before surgery. But because of the occurrence of severe hemorrhage, biopsy was not performed, and surgery performed without biopsy in (20%) patients. Biological behavior and prognosis of bronchial cacinoid tumors are better than other lung cancers. 8) The best method in treatment of carcinoid tumors is surgical resection with lymph node sampling. Surgery and long terms outcome are significantly related to histological type, node involvement and pathological status. 9) Because of the central localization of these tumors, for saving the pulmonary parenchyma, sleeve resection was performed in these tumors. Sleeve resection achieves local tumor control and is associated with a low mortality and bronchial anostomatic complication rate as well as excellent long term survival. 10) In our study, 38 patients (95%) underwent surgical operation, and lobectomy was the most common surgical technique (37%). Sleeve resection was performed in (10.4%) of patient with excellent long term results with no mortality or recurrence. All patients in whom sleeve resection was performed had typical carcinoid tumor. A study comparing typical and atypical carcinoid tumors showed that typical carcinoid tumors had more significant endobronchial polypoid growth and better survival than atypical carcinoid tumors, but mediastinal lymph node involvement had been more significant in atypical carcinoid tumors. 11) Patients with atypical carcinoid tumors and regional lymph node metastasis have a high likelihood of developing recurrent disease, if treated with surgical resection alone, and have a significantly worse outcome. 12) In our study, 90% of patients had typical carcinoid form but mediastinal lymph node involvement was seen in 2 patients with atypical carcinoid tumor with worse prognosis than the typical carcinoid tumor. Although surgery remains the standard of treatment for operable disease, histology is the most important factor in determining the role of adjuvant therapy. Completely resected typical or atypical carcinoid tumors without mediastinal lymph node involvement do not require adjuvant therapy but resected atypical carcinoid with mediastinal lymph node involvement or unresectable cases requires adjuvant therapy. 13) In our study, post operative adjuvant therapy was performed in atypical carcinoid tumors with positive mediastinal lymph node involvement in 2 patients (5%) and in those with metastatic lesions on admission in 2 patients (5%) In a Spanish multicentric study (2007) histology and node involvements appeared as the most important factors influencing the prognosis. 14) In another studies histological type, pathological stage and lymph node 8, 15) involvement affected the prognosis. In our study, histology, lymph node involvement and early distant metastasis appeared as the most important factors affecting the prognosis. Conclusion Based on good postoperative results in carcinoid tumor patients, surgical resection has been the treatment of choice in these tumors. Factors which appear to influence the prognosis are the pathological form, mediastinal lymph node involvement and distant metastasis in carcinoid tumor patients. Acknowledgement The authors wish to thank Vice Chancellery of Research of Mashhad University of Medical Sciences, Dr Amir Asnaashari, Dr. Mozhgan Bahadorinia, Dr. Reza Shojaeyan, Dr. Seyed Reza Hosseini, and Toktam Moghiman for their support and cooperation in accomplishing the study. The authors also appreciate Dr. Nurshafiee for composing and edition of this article. References 1) Hage R, de la Rivière AB, Seldenrijk CA, van den Bosch JM. Update in pulmonary carcinoid tumors: a reviw article. Ann Surg Oncol 2003; 10: ) Kulke MH, Mayer RJ. Carcinoid tumors. N Engl J Med 1999; 340: ) Rena O, Filosso PL, Ruffini E, Oliaro A. Bronchopulmonary carcinoid tumors. Minerva Chir : 11
6 Bagheri R et al ) Paladugu RR, Benfield JR, Pak HY, Ross RK, Teplitz RL. Bronchopulmonary Kulchitzky cell carcinomas. A new classification scheme for typical and atypical carcinoids. Cancer 1985; 55: ) Modlin IM, Sandor A. An Analysis of 835 cases of carcinoid tumors. Cancer 1997; 79: ) Harpole DH Jr, Feldman JM, Buchanan S, Young WG, Wolfe WG. Bronchial carcinoid tumors: a retrospective analysis of 126 patients. Ann Thorac Surg 1992; 54: ) van Boxem TJ, Venmans BJ, van Mourik JC, Postmus PE, Sutedja TG. Bronchoscopic treatment of intraluminal typical carcinoid: a pilot study. J Thorac Cardiovasc Surg 1998; 116: ) Ferguson MK, Landreneau RJ, Hazelrigg SR, Altorki NK, Naunheim KS, et al. Long-term outcome after resection for bronchial carcinoid tumors. Eur J Cardiothorac Surg 2000; 18: ) Martini N, Zaman M B, Bains M, A Manjti S, Bains M, et al. Treatment and prognosis in bronchial carcinoids involving regional lymph nodes. J Thorac Cardiovasc Surg 1994; 107: ) Fadel E, Yildizeli B, Chapelier AR, D Centa I, Mussot S, et al. Sleeve lobectomy for brochogenic cancers factor affecting survival. Ann Thorac Surg 2002; 74: ) Akiba T, Naruke T, Kondo H, Goya T, Tsuchiya R, et al. Carcinoid tumor of the lung: clinicopathological study of 32 cases. J Clin Oncol 1992; 22: ) Thomas CF Jr, Tazelaar HD, Jett JR. Typical and atypical pulmonary carcinoids : outcome in patients presenting with regional lymph node involvement. Chest 2001; 119: ) Mackley HB, Videtic GM. Primary carcinoid tumors of the lung: a role for radiotherapy. Oncology 2006; 20: ) García-Yuste M, Matilla JM, Cueto A, Paniagua JM, Ramos G, et al. Typical and atypical carcinoid tumours: analysis of the experience of the Spanish Multi-centric Study of Neuroendocrine Tumours of the Lung. Eur J Cardiothorac Surg 2007; 31: ) Chughtai TS, Morin JE, Sheiner NM, Wilson JA, Mulder DS. Bronchial carcinoid--twenty years experience defines a selective surgical approach. Surgery 1997; 122:
Bronchoscopic Treatment with Argon Plasma Coagulation for Recurrent Typical Carcinoids: Report of a Case
NTINER RESERH 24: 4073-4078 (2004) ronchoscopic Treatment with rgon Plasma oagulation for Recurrent Typical arcinoids: Report of a ase KIMITO ORINO 1, HIDEKI KWI 1,2 and JUNIHI OGW 2 1 Department of Thoracic
More informationBronchogenic Carcinoma
A 55-year-old construction worker has smoked 2 packs of ciggarettes daily for the past 25 years. He notes swelling in his upper extremity & face, along with dilated veins in this region. What is the most
More informationClinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung Zhi Yang, Zitong Wang, Yong Duan & Shaofa Xu Department
More informationPeng Song, Ruochuan Zang, Lei Liu, Xiayimaier Dan, Shugeng Gao. Introduction
Original Article Long-term outcomes and prognostic factors of patients with surgically treated pulmonary atypical carcinoid tumors: our institutional experience with 68 patients Peng Song, Ruochuan Zang,
More informationCarcinoid Tumor with Localized Bronchiectasis
Case Report 2013 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran ISSN: 1735-0344 TANAFFOS Carcinoid Tumor with Localized Bronchiectasis Hassan Ghobadi, Esmaeil Farzaneh, Hossein
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More informationOutcomes after surgical resection of pulmonary carcinoid tumors
Okereke et al. Journal of Cardiothoracic Surgery (2016) 11:35 DOI 10.1186/s13019-016-0424-0 RESEARCH ARTICLE Outcomes after surgical resection of pulmonary carcinoid tumors Ikenna C. Okereke 1*, Angela
More informationResults of Systematic Nodal Dissection in Typical and Atypical Carcinoid Tumors of the Lung
ORIGINAL ARTICLE Results of Systematic Nodal Dissection in Typical and Atypical Carcinoid Tumors of the Lung Alain Wurtz, MD,* Lotfi Benhamed, MD,* Massimo Conti, MD,* Brigitte Bouchindhomme, MD, and Henri
More informationThe right middle lobe is the smallest lobe in the lung, and
ORIGINAL ARTICLE The Impact of Superior Mediastinal Lymph Node Metastases on Prognosis in Non-small Cell Lung Cancer Located in the Right Middle Lobe Yukinori Sakao, MD, PhD,* Sakae Okumura, MD,* Mun Mingyon,
More informationSuperior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis
ORIGINAL ARTICLES: Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis Shun-ichi Watanabe, MD, Kenji Suzuki, MD, and Hisao Asamura, MD
More informationThe roles of adjuvant chemotherapy and thoracic irradiation
Factors Predicting Patterns of Recurrence After Resection of N1 Non-Small Cell Lung Carcinoma Timothy E. Sawyer, MD, James A. Bonner, MD, Perry M. Gould, MD, Robert L. Foote, MD, Claude Deschamps, MD,
More informationTHORACIC MALIGNANCIES
THORACIC MALIGNANCIES Summary for Malignant Malignancies. Lung Ca 1 Lung Cancer Non-Small Cell Lung Cancer Diagnostic Evaluation for Non-Small Lung Cancer 1. History and Physical examination. 2. CBCDE,
More informationAnalysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors
DOI:http://dx.doi.org/10.7314/APJCP.2014.15.5.2205 Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors RESEARCH ARTICLE Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/23566
More informationBronchial Carcinoid as a Cause of Hemoptysis Deepa Bhanot, M.D. 1, Samuel Akidiva, M.D. 1, Stephen F. Hagan, M.D. 1,2 1 University of Kansas
as a Cause of Hemoptysis Deepa Bhanot, M.D. 1, Samuel Akidiva, M.D. 1, Stephen F. Hagan, M.D. 1,2 1 University of Kansas School of Medicine-Wichita Department of Internal Medicine 2 Private Practice, Wichita,
More informationMarcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans R. J. Elbers, MD, PhD; and Jules M. M. van den Bosch, MD, PhD, FCCP
Prognostic Assessment of 2,361 Patients Who Underwent Pulmonary Resection for Non-small Cell Lung Cancer, Stage I, II, and IIIA* Marcel Th. M. van Rens, MD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans
More informationPredictors of Disease-free Survival and Recurrence in Patients with Resected Bronchial Carcinoid Tumors
Original Thoracic 159 Predictors of Disease-free Survival and Recurrence in Patients with Resected Bronchial Carcinoid Tumors Paul C. Lee 1 Nonso C. Osakwe 1 Navnett Narula 2 Jeffrey L. Port 1 Subroto
More informationDespite their reputation of benignity, carcinoid tumors
Operative Risk and Prognostic Factors of Typical Bronchial Carcinoid Tumors Xavier Ducrocq, MD, Pascal Thomas, MD, Gilbert Massard, MD, Pierre Barsotti, MD, Roger Giudicelli, MD, Pierre Fuentes, MD, and
More informationNon-Small Cell Lung Cancer: Disease Spectrum and Management in a Tertiary Care Hospital
Non-Small Cell Lung Cancer: Disease Spectrum and Management in a Tertiary Care Hospital Muhammad Rizwan Khan,Sulaiman B. Hasan,Shahid A. Sami ( Department of Surgery, The Aga Khan University Hospital,
More informationObjective: We sought to determine the variables influencing long-term survival of patients treated for bronchial carcinoid tumors.
Bronchial carcinoid tumors: Surgical management and long-term outcome Pier Luigi Filosso, MD Ottavio Rena, MD Giovanni Donati, MD Caterina Casadio, MD Enrico Ruffini, MD Esther Papalia, MD Alberto Oliaro,
More informationThe role of adjuvant chemotherapy following resection of early stage thymoma
Perspective The role of adjuvant chemotherapy following resection of early stage thymoma Masatsugu Hamaji Department of Thoracic Surgery, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto,
More informationTreatment Strategy for Patients With Surgically Discovered N2 Stage IIIA Non-Small Cell Lung Cancer
Treatment Strategy for Patients With Surgically Discovered N2 Stage IIIA Non-Small Cell Lung Cancer Ryoichi Nakanishi, MD, Toshihiro Osaki, MD, Kozo Nakanishi, MD, Ichiro Yoshino, MD, Takashi Yoshimatsu,
More informationThe Role of Radiation Therapy
The Role of Radiation Therapy and Surgery in the Treatment of Bronchogenic Carcinoma R Adams Cowley, M.D., Morris J. Wizenberg, M.D., and Eugene J. Linberg, M.D. A study of the combined use of preoperative
More informationLYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG
LYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG Tsuneyo Takizawa, MD a Masanori Terashima, MD a Teruaki Koike, MD a Takehiro Watanabe, MD a Yuzo Kurita, MD b Akira Yokoyama, MD b Keiichi
More informationStandard treatment for pulmonary metastasis of non-small
ORIGINAL ARTICLE Resection of Pulmonary Metastasis of Non-small Cell Lung Cancer Kenichi Okubo, MD,* Toru Bando, MD,* Ryo Miyahara, MD,* Hiroaki Sakai, MD,* Tsuyoshi Shoji, MD,* Makoto Sonobe, MD,* Takuji
More informationSurgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better?
Case Report Page 1 of 5 Surgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better? Jury Brandolini, Luca Bertolaccini, Alessandro Pardolesi, Piergiorgio
More informationThe Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC)
The Impact of Adjuvant Chemotherapy in Pulmonary Large Cell Neuroendocrine Carcinoma (LCNC) Disclosure None Background Torino, Italy LCNC Rare tumor (2% to 3% all resected primary lung cancers) Preoperative
More informationCarcinoid Tumors of the Lung: Do Atypical Features Require Aggressive Management?
Carcinoid Tumors of the Lung: Do Atypical Features Require Aggressive Management? Charles-Henri Marty-An6, MD, Val6rie Costes, MD, Jean-Louis Pujol, MD, Michel Alauzen, MD, Pierre Baldet, MD, and Henri
More informationRelevance of Lymph Node Micrometastases in Radically Resected Endobronchial Carcinoid Tumors
Relevance of Lymph Node Micrometastases in Radically Resected Endobronchial Carcinoid Tumors Tommaso Claudio Mineo, MD, Gianluca Guggino, MD, Davide Mineo, MD, Gianluca Vanni, MD, and Vincenzo Ambrogi,
More informationCarcinoid tumors compose a small proportion of nonsmall. Is Sublobar Resection Sufficient for Carcinoid Tumors?
ORIGINAL ARTICLES: SURGERY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org. To take the CME activity related to this article, you must have either an STS
More informationPulmonary Resection for Metastases from Colorectal Cancer
ORIGINAL ARTICLE Pulmonary Resection for Metastases from Colorectal Cancer Paul M. van Schaik, MD,* Ewout A. Kouwenhoven, MD, PhD,* Robert J. Bolhuis, MD,* Bonne Biesma, MD, PhD, and Koop Bosscha, MD,
More informationTracheal Adenocarcinoma Treated with Adjuvant Radiation: A Case Report and Literature Review
Published online: May 23, 2013 1662 6575/13/0062 0280$38.00/0 This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial-NoDerivs 3.0 License (www.karger.com/oa-license),
More informationPrognostic value of visceral pleura invasion in non-small cell lung cancer q
European Journal of Cardio-thoracic Surgery 23 (2003) 865 869 www.elsevier.com/locate/ejcts Prognostic value of visceral pleura invasion in non-small cell lung cancer q Jeong-Han Kang, Kil Dong Kim, Kyung
More informationThe prognostic relevance of classifying neuroendocrine
Large Cell Neuroendocrine Carcinoma and Large Cell Carcinomas With Neuroendocrine Morphology of the Lung: Prognosis After Complete Resection and Systematic Nodal Dissection Joseph Zacharias, FRCS (CTh),
More informationRevisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis
Jpn J Clin Oncol 1997;27(5)305 309 Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis -, -, - - 1 Chest Department and 2 Section of Thoracic Surgery,
More informationAlthough ipsilateral intrapulmonary metastasis (PM), Evaluation of TMN Classification for Lung Carcinoma With Ipsilateral Intrapulmonary Metastasis
Evaluation of TMN Classification for Lung Carcinoma With Ipsilateral Intrapulmonary Metastasis Morihito Okada, MD, Noriaki Tsubota, MD, Masahiro Yoshimura, MD, Yoshifumi Miyamoto, MD, and Reiko Nakai,
More informationMolly Boyd, MD Glenn Mills, MD Syed Jafri, MD 1/1/2010
LSU HEALTH SCIENCES CENTER NSCLC Guidelines Feist-Weiller Cancer Center Molly Boyd, MD Glenn Mills, MD Syed Jafri, MD 1/1/2010 Initial Evaluation/Intervention: 1. Pathology Review 2. History and Physical
More informationCase report. Malignant melanoma of the lung: a case report. Open Access
Case report Open Access Malignant melanoma of the lung: a case report Aziz Ouarssani 1, Fouad Atoini 1, Rafik Reda 1, Fatima Ait Lhou 1, Mustapha Idrissi Rguibi 1 1 Military Hospital Moulay Ismail, Meknes,
More informationPulmonary resection remains the most effective. Survival in Synchronous vs Single Lung Cancer. Upstaging Better Reflects Prognosis
Survival in Synchronous vs Single Lung Cancer Upstaging Better Reflects Prognosis Marcel Th. M. van Rens, MD; Pieter Zanen, MD, PhD; Aart Brutel de la Rivière, MD, PhD, FCCP; Hans R. J. Elbers, MD, PhD;
More informationAdam J. Hansen, MD UHC Thoracic Surgery
Adam J. Hansen, MD UHC Thoracic Surgery Sometimes seen on Chest X-ray (CXR) Common incidental findings on computed tomography (CT) chest and abdomen done for other reasons Most lung cancers discovered
More informationSleeve lobectomy for lung adenocarcinoma treated with neoadjuvant afatinib
Case Report Sleeve lobectomy for lung adenocarcinoma treated with neoadjuvant afatinib Ichiro Sakanoue 1, Hiroshi Hamakawa 1, Reiko Kaji 2, Yukihiro Imai 3, Nobuyuki Katakami 2, Yutaka Takahashi 1 1 Department
More informationQuality of Life (QOL) versus Curability for Lung Cancer Surgery
Quality of Life (QOL) versus Curability for Lung Cancer Surgery Hirokuni Yoshimura, MD Standard operations for lung cancer patients are generally accepted as performing lobectomy or pneumonectomy on the
More informationAre the 18 F-FDG positron emission tomography/computed tomography findings in bronchopulmonary carcinoid tumors different than expected?
Are the 18 F-FDG positron emission tomography/computed tomography findings in bronchopulmonary carcinoid tumors different than expected? Levent Alpay MD, Tunc Lacin MD, Serda Kanbur MD, Hakan Kiral MD,
More informationMEDIASTINAL LYMPH NODE METASTASIS IN PATIENTS WITH CLINICAL STAGE I PERIPHERAL NON-SMALL-CELL LUNG CANCER
MEDIASTINAL LYMPH NODE METASTASIS IN PATIENTS WITH CLINICAL STAGE I PERIPHERAL NON-SMALL-CELL LUNG CANCER Tsuneyo Takizawa, MD a Masanori Terashima, MD a Teruaki Koike, MD a Hideki Akamatsu, MD a Yuzo
More informationShort- and Long-Term Outcomes after Pneumonectomy for Primary Lung Cancer
Original Article Short- and Long-Term Outcomes after Pneumonectomy for Primary Lung Cancer Takeshi Kawaguchi, MD, Takashi Tojo, MD, Keiji Kushibe, MD, Michitaka Kimura, MD, Yoko Nagata, MD, and Shigeki
More informationTristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease
Tristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease Jennifer E. Tseng, MD UFHealth Cancer Center-Orlando Health Sep 12, 2014 Background Approximately
More informationVisceral pleural involvement (VPI) of lung cancer has
Visceral Pleural Involvement in Nonsmall Cell Lung Cancer: Prognostic Significance Toshihiro Osaki, MD, PhD, Akira Nagashima, MD, PhD, Takashi Yoshimatsu, MD, PhD, Sosuke Yamada, MD, and Kosei Yasumoto,
More informationCarcinoma of the Lung
THE ANNALS OF THORACIC SURGERY Journal of The Society of Thoracic Surgeons and the Southern Thoracic Surgical Association VOLUME 1 I - NUMBER 3 0 MARCH 1971 Carcinoma of the Lung M. L. Dillon, M.D., and
More informationTreatment of oligometastatic NSCLC
Treatment of oligometastatic NSCLC Jarosław Kużdżał Department of Thoracic Surgery Jagiellonian University Collegium Medicum, John Paul II Hospital, Cracow New idea? 14 NSCLC patients with solitary extrathoracic
More informationLymph node dissection for lung cancer is both an old
LOBE-SPECIFIC EXTENT OF SYSTEMATIC LYMPH NODE DISSECTION FOR NON SMALL CELL LUNG CARCINOMAS ACCORDING TO A RETROSPECTIVE STUDY OF METASTASIS AND PROGNOSIS Hisao Asamura, MD Haruhiko Nakayama, MD Haruhiko
More informationRoutine reinforcement of bronchial stump after lobectomy or pneumonectomy with pedicled pericardial flap (PPF)
Routine reinforcement of bronchial stump after lobectomy or pneumonectomy with pedicled pericardial flap (PPF) Abstract The results of 25 cases underwent a pedicled pericardial flap coverage for the bronchial
More informationA Case of Bronchial Carcinoid Presenting With Collapse of Lung, Initially Treated For Wheeze
CASE REPORT A Case of Bronchial Carcinoid Presenting With Collapse of Lung, Initially Treated For Wheeze Avradip Santra ABSTRACT: A 60 year male patient, smoker since last 30 years, who had been unsuccessfully
More informationIn 1989, Deslauriers et al. 1 described intrapulmonary metastasis
ORIGINAL ARTICLE Prognosis of Resected Non-Small Cell Lung Cancer Patients with Intrapulmonary Metastases Kanji Nagai, MD,* Yasunori Sohara, MD, Ryosuke Tsuchiya, MD, Tomoyuki Goya, MD, and Etsuo Miyaoka,
More informationDoppler ultrasound of the abdomen and pelvis, and color Doppler
- - - - - - - - - - - - - Testicular tumors are rare in children. They account for only 1% of all pediatric solid tumors and 3% of all testicular tumors [1,2]. The annual incidence of testicular tumors
More informationPrognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China
www.springerlink.com Chin J Cancer Res 23(4):265 270, 2011 265 Original Article Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai,
More informationLung Cancer-a primer. Sai Yendamuri, MD Professor and Chair, Dept of Thoracic Surgery,RPCI,Buffalo
Lung Cancer-a primer Sai Yendamuri, MD Professor and Chair, Dept of Thoracic Surgery,RPCI,Buffalo CLINICAL CATEGORIES THE SOLITARY PULMONARY NODULE MULTIPLE PULMONARY NODULES Differential Diagnosis Malignant
More informationP sumed to have early lung disease with a favorable
Survival After Resection of Stage I1 Non-Small Cell Lung Cancer Nael Martini, MD, Michael E. Burt, MD, PhD, Manjit S. Bains, MD, Patricia M. McCormack, MD, Valerie W. Rusch, MD, and Robert J. Ginsberg,
More informationTitle: What has changed in the surgical treatment strategies of non-small cell lung cancer in
1 Manuscript type: Original Article DOI: Title: What has changed in the surgical treatment strategies of non-small cell lung cancer in twenty years? A single centre experience Short title: Changes in the
More informationand Strength of Recommendations
ASTRO with ASCO Qualifying Statements in Bold Italics s patients with T1-2, N0 non-small cell lung cancer who are medically operable? 1A: Patients with stage I NSCLC should be evaluated by a thoracic surgeon,
More informationThe tumor, node, metastasis (TNM) staging system of lung
ORIGINAL ARTICLE Peripheral Direct Adjacent Lobe Invasion Non-small Cell Lung Cancer Has a Similar Survival to That of Parietal Pleural Invasion T3 Disease Hao-Xian Yang, MD, PhD,* Xue Hou, MD, Peng Lin,
More informationLung cancer pleural invasion was recognized as a poor prognostic
Visceral pleural invasion classification in non small cell lung cancer: A proposal on the basis of outcome assessment Kimihiro Shimizu, MD a Junji Yoshida, MD a Kanji Nagai, MD a Mitsuyo Nishimura, MD
More informationLung Cancer. Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD
Lung Cancer Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD Objectives Describe risk factors, early detection & work-up of lung cancer. Define the role of modern treatment options, minimally invasive
More informationBronchial Carcinoma and the Lymphatic Sump: The Importance of Bronchoscopic Findings
Bronchial Carcinoma and the Lymphatic Sump: The Importance of Bronchoscopic Findings Gordon F. Murray, M.D., Ormond C. Mendes, M.D., and Benson R. Wilcox, M.D. ABSTRACT The lymphatic sump of Borrie is
More informationOutcome and Prognostic Factors in Bronchial Carcinoids. A Single-Center Experience
original article A Single-Center Experience Pier Luigi Filosso, MD, FETCS, FCCP,* Alberto Oliaro, MD, FETCS,* Enrico Ruffini, MD, FETCS,* Giulia Bora, MD,* Paraskevas Lyberis, MD,* Sofia Asioli, MD, Luisa
More informationMediastinal Staging. Samer Kanaan, M.D.
Mediastinal Staging Samer Kanaan, M.D. Overview Importance of accurate nodal staging Accuracy of radiographic staging Mediastinoscopy EUS EBUS Staging TNM Definitions T Stage Size of the Primary Tumor
More informationIn the mid 1970s, visceral pleural invasion (VPI) was included
ORIGINAL ARTICLE Tumor Invasion of Extralobar Soft Tissue Beyond the Hilar Region Does Not Affect the Prognosis of Surgically Resected Lung Cancer Patients Hajime Otsuka, MD,* Genichiro Ishii, MD, PhD,*
More informationPulmonary Metastasectomy for Pulmonary Metastases of Head and Neck Squamous Cell Carcinomas
ORIGINAL ARTICLES: SURGERY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org. To take the CME activity related to this article, you must have either an STS
More informationISPUB.COM. Rare Cases: Tracheal/bronchial Obstruction. O Wenker, L Moehn, C Portera, G Walsh HISTORY ADMISSION
ISPUB.COM The Internet Journal of Radiology Volume 1 Number 1 O Wenker, L Moehn, C Portera, G Walsh Citation O Wenker, L Moehn, C Portera, G Walsh.. The Internet Journal of Radiology. 1999 Volume 1 Number
More informationDiagnosis and Staging of Non-Small Cell Lung Cancer Carlos Eduardo Oliveira Baleeiro, MD. November 18, 2017
Diagnosis and Staging of Non-Small Cell Lung Cancer Carlos Eduardo Oliveira Baleeiro, MD November 18, 2017 Disclosures I do not have a financial interest/arrangement or affiliation with one or more organizations
More informationChirurgie beim oligo-metastatischen NSCLC
24. Ärzte-Fortbildungskurs in Klinischer Onkologie 20.-22. Februar 2014, Kantonsspital St. Gallen Chirurgie beim oligo-metastatischen NSCLC Prof. Dr. med. Walter Weder Klinikdirektor Thoraxchirurgie, UniversitätsSpital
More informationHISTORY SURGERY FOR TUMORS WITH INVASION OF THE APEX 15/11/2018
30 EACTS Annual Meeting Barcelona, Spain 1-5 October 2016 SURGERY FOR TUMORS WITH INVASION OF THE APEX lung cancer of the apex of the chest involving any structure of the apical chest wall irrespective
More informationSurgical treatment in non-small cell lung cancer with pulmonary oligometastasis
He et al. World Journal of Surgical Oncology (2017) 15:36 DOI 10.1186/s12957-017-1105-8 RESEARCH Open Access Surgical treatment in non-small cell lung cancer with pulmonary oligometastasis Jinyuan He,
More informationImpact of Radical Systematic Mediastinal Lymphadenectomy on Tumor Staging in Lung Cancer
Impact of Radical Systematic Mediastinal Lymphadenectomy on Tumor Staging in Lung Cancer Jakob R. Izbicki, MD, Bernward Passlick, MD, Ortrud Karg, MD, Christian Bloechle, MD, Klaus Pantel, MD, Wolfram
More informationOutcome after emergency surgery in patients with a free perforation caused by gastric cancer
experimental and therapeutic medicine 1: 199-203, 2010 199 Outcome after emergency surgery in patients with a free perforation caused by gastric cancer Hironori Tsujimoto 1, Shuichi Hiraki 1, Naoko Sakamoto
More informationLung cancer Surgery. 17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY March, 2017 Berlin, Germany
17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY 24-29 March, 2017 Berlin, Germany Lung cancer Surgery Sven Hillinger MD, Thoracic Surgery, University Hospital Zurich Case 1 59 y, female, 40 py, incidental
More informationTwo cases of the bronchial carcinoid tumors successfully treated with the parenchymal-sparing bronchoplastic resections
Case Report Two cases of the bronchial carcinoid tumors successfully treated with the parenchymal-sparing bronchoplastic resections Katarzyna Drożdż 1,2, Mariusz Chabowski 3,4, Angelika Chachaj 1,2, Paweł
More informationA Case of Locally Advanced Well-Differentiated Fetal Adenocarcinoma of the Lung Treated with Concurrent Chemoradiation Therapy
http://dx.doi.org/10.4046/trd.2013.74.5.226 ISSN: 1738-3536(Print)/2005-6184(Online) Tuberc Respir Dis 2013;74:226-230 CopyrightC2013. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights
More informationSlide 1. Slide 2. Slide 3. Investigation and management of lung cancer Robert Rintoul. Epidemiology. Risk factors/aetiology
Slide 1 Investigation and management of lung cancer Robert Rintoul Department of Thoracic Oncology Papworth Hospital Slide 2 Epidemiology Second most common cancer in the UK (after breast). 38 000 new
More informationcame from a carcinoma and in 12 from a sarcoma. Ninety lesions were intrapulmonary and the as the chest wall and pleura. Details of the primary
Thorax 1982;37:366-370 Thoracic metastases MARY P SHEPHERD From the Thoracic Surgical Unit, Harefield Hospital, Harefield ABSTRACI One hundred and four patients are reviewed who were found to have thoracic
More informationPrognostic factors of postrecurrence survival in completely resected stage I non-small cell lung cancer with distant metastasis
< A supplementary figure and table are published online only at http://thx.bmj.com/content/ vol65/issue3. 1 Institute of Clinical Medicine, National Yang-Ming University, 2 Department of Surgery, Cathay
More informationEXTENDED SLEEVE LOBECTOMY FOR LUNG CANCER: THE AVOIDANCE OF PNEUMONECTOMY
EXTENDED SLEEVE LOBECTOMY FOR LUNG CANCER: THE AVOIDANCE OF PNEUMONECTOMY Morihito Okada, MD Noriaki Tsubota, MD Masahiro Yoshimura, MD Yoshifumi Miyamoto, MD Hidehito Matsuoka, MD, Shinsuke Satake, MD
More informationThe International Association for the Study of Lung Cancer (IASLC) Lung Cancer Staging Project, Data Elements
Page 1 Contents 1.1. Registration... 2 1.2. Patient Characteristics... 3 1.3. Laboratory Values at Diagnosis... 5 1.4. Lung Cancers with Multiple Lesions... 6 1.5. Primary Tumour Description... 10 1.6.
More informationMashhad Iran, Home: Work: Cell:
Mashhad Iran, 9187 8831 63 Home: 0098-511-8012840 Work: 0098-511-8436199 Cell: 0098-912-346-3752 Email: Bagherir@mums.ac.ir THORACIC SURGEON Associate Professor of Mashhad University of Medical Sciences
More informationPrimary Endobronchial Carcinoid Tumour: Case Report and Review of Literature
Clinical Medicine Journal Vol. 1, No. 2, 2015, pp. 43-47 http://www.aiscience.org/journal/cmj Primary Endobronchial Carcinoid Tumour: Case Report and Review of Literature Archana Kumari 1, *, Pankaj Sharma
More informationBronchial sleeve lobectomy is a lung parenchyma saving
ORIGINAL ARTICLE Quality of Life after Lung Cancer Surgery: A Prospective Pilot Study comparing Bronchial Sleeve Lobectomy with Pneumonectomy Bram Balduyck, MD, Jeroen Hendriks, MD, PhD, Patrick Lauwers,
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationRelevance of an Intensive Postoperative Follow-up After Surgery for Non Small Cell Lung Cancer
Relevance of an Intensive Postoperative Follow-up After Surgery for Non Small Cell Lung Cancer Virginie Westeel, MD, Didier Choma, MD, François Clément, MD, Marie-Christine Woronoff-Lemsi, PhD, Jean-François
More informationComplex Thoracoscopic Resections for Locally Advanced Lung Cancer
Complex Thoracoscopic Resections for Locally Advanced Lung Cancer Duke Thoracoscopic Lobectomy Workshop March 21, 2018 Thomas A. D Amico MD Gary Hock Professor of Surgery Section Chief, Thoracic Surgery,
More informationVideo-Mediastinoscopy Thoracoscopy (VATS)
Surgical techniques Video-Mediastinoscopy Thoracoscopy (VATS) Gunda Leschber Department of Thoracic Surgery ELK Berlin Chest Hospital, Berlin, Germany Teaching Hospital of Charité Universitätsmedizin Berlin
More informationTumour size as a prognostic factor after resection of lung carcinoma
Tumour size as a prognostic factor after resection of lung carcinoma A. S. SOORAE AND R. ABBEY SMITH Thorax, 1977, 32, 19-25 From the Cardio-Thoracic Unit, Walsgrave Hospital, Clifford Bridge Road, Coventry
More informationPneumonectomy After Induction Rx: Is it Safe?
Pneumonectomy After Induction Rx: Is it Safe? David J. Sugarbaker, M.D. Director, Chief, Division of Thoracic Surgery The Olga Keith Weiss Chair of Surgery of Medicine at, Pneumonectomy after induction
More informationA Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome
World J Surg (2017) 41:780 784 DOI 10.1007/s00268-016-3777-6 ORIGINAL SCIENTIFIC REPORT A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome Jian Li 1,2 Chengwu
More informationLung cancer is a major cause of cancer deaths worldwide.
ORIGINAL ARTICLE Prognostic Factors in 3315 Completely Resected Cases of Clinical Stage I Non-small Cell Lung Cancer in Japan Teruaki Koike, MD,* Ryosuke Tsuchiya, MD, Tomoyuki Goya, MD, Yasunori Sohara,
More informationThe Itracacies of Staging Patients with Suspected Lung Cancer
The Itracacies of Staging Patients with Suspected Lung Cancer Gerard A. Silvestri, MD,MS, FCCP Professor of Medicine Medical University of South Carolina Charleston, SC silvestri@musc.edu Staging Lung
More informationImplications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers
日大医誌 75 (1): 10 15 (2016) 10 Original Article Implications of Progesterone Receptor Status for the Biology and Prognosis of Breast Cancers Naotaka Uchida 1), Yasuki Matsui 1), Takeshi Notsu 1) and Manabu
More informationMucoepidermoid Carcinoma of the Trachea ORIGINAL ARTICLES
ORIGINAL ARTICLES Mucoepidermoid Carcinoma of the Trachea and Bronchus: The Case for Conservative Resection Robert H. Breyer, M.D., John R. Dainauskas, M.D., Robert J. Jensik, M.D., and L. Penfield Faber,
More informationClinical Outcome of Reconstruction With Tissue Expanders for Patients With Breast Cancer and Mastectomy
Clinical Outcome of Reconstruction With Tissue Expanders for Patients With Breast Cancer and Mastectomy Mitsui Memorial Hospital Department of Breast and Endocine surgery Daisuke Ota No financial support
More informationThoracoscopic Lobectomy for Locally Advanced Lung Cancer. Masters of Minimally Invasive Thoracic Surgery Orlando September 19, 2014
for Locally Advanced Lung Cancer Masters of Minimally Invasive Thoracic Surgery Orlando September 19, 2014 Thomas A. D Amico MD Gary Hock Endowed Professor and Vice Chair of Surgery Chief Thoracic Surgery
More informationVisceral pleura invasion (VPI) was adopted as a specific
ORIGINAL ARTICLE Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database Junji Yoshida,
More informationRelevance of an extensive follow-up after surgery for nonsmall cell lung cancer
ORIGINAL ARTICLE LUNG CANCER Relevance of an extensive follow-up after surgery for nonsmall cell lung cancer Delphine Gourcerol 1,2, Arnaud Scherpereel 1,2, Stephane Debeugny 3, Henri Porte 2,4, Alexis
More information