Pneumonectomy After Induction Rx: Is it Safe?
|
|
- Camron Reeves
- 5 years ago
- Views:
Transcription
1 Pneumonectomy After Induction Rx: Is it Safe? David J. Sugarbaker, M.D. Director, Chief, Division of Thoracic Surgery The Olga Keith Weiss Chair of Surgery of Medicine at,
2 Pneumonectomy after induction Rx Optimal treatment strategies for operable advanced stage lung cancer is still uncertain In patients with locally advanced lung cancer, improved resectability has been seen after concurrent chemoradiotherapy at, Chest x-ray courtesy of David J. Sugarbaker, M.D.
3 Challenges with pneumonectomy after induction therapy Chemoradiation may reduce pulmonary function and can result in significant fibrosis around key hilar structures Induction therapy may increase patient susceptibility to pulmonary edema and impair ability of bronchial stumps to heal Known complications/morbidity associated with pneumonectomy after induction therapy include: ARDS, pulmonary edema, broncho-pleural fistula, arrhythmias, prolonged air leak, vocal cord paralysis, and empyema Krasna MJ, Gamliel Z, Burrows WM, Sonett JR, Kwong KF, Edelman MJ, et al. Pneumonectomy for lung cancer after preoperative concurrent chemotherapy and high-dose radiation. Ann Thorac Surg. 2010;89(1):200-6; discussion 6. at,
4 INT 0139, 2009 Phase III trial Induction chemort followed by either surgery or definitive RT Mortality of 26% after pneumonectomy after induction Albain KS, Swann RS, Rusch VW, Turrisi AT, 3rd, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374(9687): at
5 Overall survival not improved Improved OS for patients undergoing lobectomy when compared to no resection No survival benefit in patients undergoing pneumonectomy when compared to no resection Albain KS, Swann RS, Rusch VW, Turrisi AT, 3rd, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374(9687): at
6 Intergroup year survival for ypn0 41% Survival benefit for downstaging 5 year survival for ypn+ 24% No surgery after induction: 8% Albain KS, Swann RS, Rusch VW, Turrisi AT, 3rd, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374(9687): at
7 Caglar et al, pts received concurrent chemoradiation (CRT) 100 CRT only 44 deemed resectable and underwent surgical resection Caglar HB, Baldini EH, Othus M et al. Outcomes of patients with Stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer 2009;115: at
8 Caglar et al, /44 pts (73%) with LN downstaging 2 year survival in surgical resection group was 73% 2 year survival in CRT only was 37% Caglar HB, Baldini EH, Othus M et al. Outcomes of patients with Stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer 2009;115: at
9 Allen et al, 2008 Retrospective review, 73 pts Patients underwent pneumonectomy after induction chemort 6% 30 day mortality, 10% 100 day mortality Allen AM, Mentzer SJ, Yeap BY, Soto R, Baldini EH, Rabin MS, et al. Pneumonectomy after chemoradiation: the Dana-Farber Cancer Institute/Brigham and Women's Hospital experience. Cancer. 2008;112(5): at
10 Allen et al, Conclusions Lymph node downstaging after induction chemort leads to improved survival Not all pts had N2 nodes so lymph node downstage rate could not be assessed in their study Trimodality approach should be done at high volume centers at, Allen AM, Mentzer SJ, Yeap BY, Soto R, Baldini EH, Rabin MS, et al. Pneumonectomy after chemoradiation: the Dana-Farber Cancer Institute/Brigham and Women's Hospital experience. Cancer. 2008;112(5):
11 Does pneumonectomy after induction therapy improve survival? Daly et al, 2006 Retrospective review 30 patients undergoing pneumonectomy after chemort at, Daly BD, Fernando HC, Ketchedjian A, Dipetrillo TA, Kachnic LA, Morelli DM, et al. Pneumonectomy after high-dose radiation and concurrent chemotherapy for nonsmall cell lung cancer. Ann Thorac Surg. 2006;82(1):
12 Daly et al, 2006 Death in 4 pts, 13.3% Median survival 22 months, 5 year 33% 3yr survival after high-dose RT and concurrent chemotherapy without surgery as definitive tx for stage IIIA-N2 disease in INT % 55% with N2 nodal downstaging but no correlation with survival at, Daly BD, Fernando HC, Ketchedjian A, Dipetrillo TA, Kachnic LA, Morelli DM, et al. Pneumonectomy after high-dose radiation and concurrent chemotherapy for nonsmall cell lung cancer. Ann Thorac Surg. 2006;82(1):
13 Bueno et al, 2000 Determine predictive value of nodal status at resection for stage IIIA N2+ All patients staged surgically Mediastinoscopy/anterior mediastinotomy 103 pts, restaged radiographically Bueno R, Richards WG, Swanson SJ, Jaklitsch MT, Lukanich JM, Mentzer SJ, et al. Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann Thorac Surg. 2000;70: at
14 29/103 pts (28%) downstaged to N0, 5 year survival of 35.8% 74/103 pts (72%) pts with persistent disease with N1/N2 status, 5 year survival of 9% Recommend restaging with thoracoscopy, PET, lymph node biopsy via EUS at Bueno R, Richards WG, Swanson SJ, Jaklitsch MT, Lukanich JM, Mentzer SJ, et al. Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann Thorac Surg. 2000;70:
15 Restaging the mediastinum after induction therapy will allow the surgeon to prevent resection in patients with less survival benefit Methods to restage mediastinum include: VATS Redo mediastinoscopy PET EBUS at
16 Jaklitsch et al, 2013 Can VATS be used to restage ipsilateral mediastinal LN after neoadjuvant therapy? Prospective multi-institutional trial, 68 pts Jaklitsch MT, Gu L, Demmy T, Harpole DH, D Amico TA, McKenna RJ et al. Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol J Thorac Cardiovasc Surg 2013; 146:9 16. at
17 Jaklitsch et al, pts underwent VATS: 3 negative stations confirmed in 7 pts Persistent N2 in 16 pts 4 pts with pleural carcinomatosis 20 pts with obliterated nodal stations Recommend PET/EBUS as adjuncts in restaging Jaklitsch MT, Gu L, Demmy T, Harpole DH, D Amico TA, McKenna RJ et al. Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol J Thorac Cardiovasc Surg 2013; 146:9 16. at
18 De Waele, pts underwent redo mediastinoscopy after induction therapy 79 with chemotherapy, 25 with chemort Redo mediastinoscopy feasible in all pts except 1, died of hemorrhage Sensitivity 71%, specificity 100%, accuracy 84% De Waele M, Serra-Mitjans M, Hendriks J, et al. Accuracy and survival of repeat mediastinoscopy after induction therapy for non-small cell lung cancer in a combined series of 104 patients. Eur J Cardiothorac Surg 2008;33: at
19 Nasir et al, pts underwent induction chemotherapy,rt or both after staging with PET/CT EBUS then utilized for restaging Pts found to be N2 negative underwent thoracotomy and lymphadenectomy Nasir BS, Bryant AS, Minnich DJ, et al. The efficacy of restaging endobronchial ultrasound in patients with non-small cell lung cancer after preoperative therapy. Ann Thorac Surg. 2014;98: at
20 Nasir et al, pts with negative EBUS, 3 underwent mediastinoscopy and 2 with persistent nodal disease 22 patients underwent thoracotomy and 1 pt was found to have N2 disease Negative predictive value of 88% Nasir BS, Bryant AS, Minnich DJ, et al. The efficacy of restaging endobronchial ultrasound in patients with non-small cell lung cancer after preoperative therapy. Ann Thorac Surg. 2014;98: at
21 Conclusions Pneumonectomy after induction therapy is feasible and safe Careful patient selection, N2 disease status Restage patients after neoadjuvant therapy Should be performed by experienced surgeons at high volume centers at,
22 Thank you at,
VATS after induction therapy: Effective and Beneficial Tips on Strategy
VATS after induction therapy: Effective and Beneficial Tips on Strategy AATS Focus on Thoracic Surgery Mastering Surgical Innovation Las Vegas Nevada Oct. 27-28 2017 Scott J. Swanson, M.D. Professor of
More informationTristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease
Tristate Lung Meeting 2014 Pro-Con Debate: Surgery has no role in the management of certain subsets of N2 disease Jennifer E. Tseng, MD UFHealth Cancer Center-Orlando Health Sep 12, 2014 Background Approximately
More informationMEDIASTINAL STAGING surgical pro
MEDIASTINAL STAGING surgical pro Paul E. Van Schil, MD, PhD Department of Thoracic and Vascular Surgery University of Antwerp, Belgium Mediastinal staging Invasive techniques lymph node mapping cervical
More informationLung cancer Surgery. 17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY March, 2017 Berlin, Germany
17 TH ESO-ESMO MASTERCLASS IN CLINICAL ONCOLOGY 24-29 March, 2017 Berlin, Germany Lung cancer Surgery Sven Hillinger MD, Thoracic Surgery, University Hospital Zurich Case 1 59 y, female, 40 py, incidental
More informationGENERAL THORACIC SURGERY
GENERAL THORACIC SURGERY Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non small cell lung cancer: Results of CALGB Protocol 39803
More informationVAMLA/TEMLA. Todd L. Demmy
VAMLA/TEMLA Todd L. Demmy Disclosures/ Questions Objectives - Staging Learn new lymphadenectomy (LA) results: Video-Assisted Mediastinal (VAMLA) Transcervical Extended Mediastinal (TEMLA) Compare with
More informationComplex Thoracoscopic Resections for Locally Advanced Lung Cancer
Complex Thoracoscopic Resections for Locally Advanced Lung Cancer Duke Thoracoscopic Lobectomy Workshop March 21, 2018 Thomas A. D Amico MD Gary Hock Professor of Surgery Section Chief, Thoracic Surgery,
More informationVideo-Mediastinoscopy Thoracoscopy (VATS)
Surgical techniques Video-Mediastinoscopy Thoracoscopy (VATS) Gunda Leschber Department of Thoracic Surgery ELK Berlin Chest Hospital, Berlin, Germany Teaching Hospital of Charité Universitätsmedizin Berlin
More informationExperience has proven that pneumonectomy is a safe
Pneumonectomy After Chemoradiation Therapy for Non-Small Cell Lung Cancer: Does Side Really Matter? Anthony W. Kim, MD, L. Penfield Faber, MD, William H. Warren, MD, Sanjib Basu, PhD, Sean C. Wightman,
More informationTreatment of Clinical Stage I Lung Cancer: Thoracoscopic Lobectomy is the Standard
Treatment of Clinical Stage I Lung Cancer: Thoracoscopic Lobectomy is the Standard AATS General Thoracic Surgery Symposium May 5, 2010 Thomas A. D Amico MD Professor of Surgery, Duke University Medical
More informationPost-Induction PET Does Not Correlate with Persistent Nodal Disease or Overall Survival in Surgically Treated Stage IIIA Non-Small Cell Lung Cancer
Post-Induction PET Does Not Correlate with Persistent Nodal Disease or Overall Survival in Surgically Treated Stage IIIA Non-Small Cell Lung Cancer R. Taylor Ripley, Kei Suzuki, Kay See Tan, Manjit Bains,
More informationT3 NSCLC: Chest Wall, Diaphragm, Mediastinum
for T3 NSCLC: Chest Wall, Diaphragm, Mediastinum AATS Postgraduate Course April 29, 2012 Thomas A. D Amico MD Professor of Surgery, Chief of Thoracic Surgery Duke University Health System Disclosure No
More informationDoes Pneumonectomy Have a Role in the Treatment of Stage IIIA Non-Small Cell Lung Cancer?
Does Pneumonectomy Have a Role in the Treatment of Stage IIIA Non-Small Cell Lung Cancer? Asad A. Shah, MD, Mathias Worni, MD, MHS, Christopher R. Kelsey, MD, Mark W. Onaitis, MD, Thomas A. D Amico, MD,
More informationThe surgeon: new surgical aproaches
The surgeon: new surgical aproaches Paul Van Schil, MD Department of Thoracic and Vascular Surgery Antwerp University, Belgium no disclosures, no conflict of interest Malignant pleural mesothelioma: clinical,
More informationTrimodally treatment for stage IIIa NSCLC patients increases survival while not effecting surgical mortality or complexity
Aravot et al. Journal of Cardiothoracic Surgery (2019) 14:7 https://doi.org/10.1186/s13019-018-0829-z RESEARCH ARTICLE Trimodally treatment for stage IIIa NSCLC patients increases survival while not effecting
More informationNon-small-cell lung cancer restaging with transcervical extended mediastinal lymphadenectomy
European Journal of Cardio-thoracic Surgery 37 (2010) 776 781 www.elsevier.com/locate/ejcts Non-small-cell lung cancer restaging with transcervical extended mediastinal lymphadenectomy Marcin Zieliński
More informationMediastinal Staging. Samer Kanaan, M.D.
Mediastinal Staging Samer Kanaan, M.D. Overview Importance of accurate nodal staging Accuracy of radiographic staging Mediastinoscopy EUS EBUS Staging TNM Definitions T Stage Size of the Primary Tumor
More informationInduction chemotherapy followed by surgical resection
Surgical Resection for Residual N 2 Disease After Induction Chemotherapy Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Matthew A. Levin, BS, David E. Becker, MA, Roger Keresztes, MD, and Nasser
More informationLung Cancer Epidemiology. AJCC Staging 6 th edition
Surgery for stage IIIA NSCLC? Sometimes! Anne S. Tsao, M.D. Associate Professor Director, Mesothelioma Program Director, Thoracic Chemo-Radiation Program May 7, 2011 The University of Texas MD ANDERSON
More informationThoracoscopic Lobectomy: Technical Aspects in Years of Progress
Thoracoscopic Lobectomy: Technical Aspects in 2015 16 Years of Progress 8 th Masters of Minimally Invasive Thoracic Surgery Orlando September 25, 2015 Thomas A. D Amico MD Gary Hock Professor of Surgery
More informationThe Itracacies of Staging Patients with Suspected Lung Cancer
The Itracacies of Staging Patients with Suspected Lung Cancer Gerard A. Silvestri, MD,MS, FCCP Professor of Medicine Medical University of South Carolina Charleston, SC silvestri@musc.edu Staging Lung
More informationThe right middle lobe is the smallest lobe in the lung, and
ORIGINAL ARTICLE The Impact of Superior Mediastinal Lymph Node Metastases on Prognosis in Non-small Cell Lung Cancer Located in the Right Middle Lobe Yukinori Sakao, MD, PhD,* Sakae Okumura, MD,* Mun Mingyon,
More informationNeoadjuvant Chemoradiation for Clinically Advanced Non-Small Cell Lung Cancer: An Analysis of 233 Patients
Neoadjuvant Chemoradiation for Clinically Advanced Non-Small Cell Lung Cancer: An Analysis of 233 Patients Anthony W. Kim, MD, Michael J. Liptay, MD, Philip Bonomi, MD, William H. Warren, MD, Sanjib Basu,
More informationHistory of Surgery for Lung Cancer
Welcome to Master Class for Oncologists Session 1: 7:30 AM - 8:15 AM San Francisco, CA October 23, 2009 Innovations in The Surgical Treatment of Lung Cancer Speaker: Scott J. Swanson, MD 2 Presenter Disclosure
More informationCase presentation. Paul De Leyn, MD, PhD Thoracic Surgery University Hospitals Leuven Belgium
Case presentation Paul De Leyn, MD, PhD Thoracic Surgery University Hospitals Leuven Belgium Perspectives in Lung Cancer Brussels 6-7 march 2009 LEUVEN LUNG CANCER GROUP Department of Thoracic Surgery
More informationSurgery for early stage NSCLC
1-3 March 2017, Manchester, UK Surgery for early stage NSCLC Dominique H. Grunenwald, MD, PhD Professor Emeritus in Thoracic and Cardiovascular surgery Pierre & Marie Curie University. Paris. France what
More informationThree-arm robot-assisted thoracoscopic surgery for locally advanced N2 non-small cell lung cancer
Surgical Technique Three-arm robot-assisted thoracoscopic surgery for locally advanced N2 non-small cell lung cancer Xinghua Cheng, Chongwu Li, Jia Huang, Peiji Lu, Qingquan Luo Shanghai Chest Hospital,
More informationHeterogeneity of N2 disease
Locally Advanced NSCLC Surgery? No. Ramaswamy Govindan M.D Co-Director, Section of Medical Oncology Alvin J Siteman Cancer Center at Washington University School of Medicine St. Louis, Missouri Heterogeneity
More informationDisclosures. Preoperative Treatment: Chemotherapy or ChemoRT? Adjuvant chemotherapy helps. so what about chemo first?
Disclosures Preoperative Treatment: Chemotherapy or ChemoRT? Advisory boards Genentech (travel only), Pfizer Salary support for clinical trials Celgene, Merck, Merrimack Matthew Gubens, MD, MS Assistant
More informationSafety and Utility of Mediastinoscopy in Non-Small Cell Lung Cancer in a Complex Mediastinum
Safety and Utility of Mediastinoscopy in Non-Small Cell Lung Cancer in a Complex Mediastinum Brian E. Louie, MD, Seema Kapur, MD, Alexander S. Farivar, MD, Samuel J. Youssef, MD, Jed Gorden, MD, Ralph
More informationThe Management of Patients With Stage IIIA Non Small Cell Lung Cancer With N2 Mediastinal Node Involvement
Original Article 599 The Management of Patients With Stage IIIA Non Small Cell Lung Cancer With N2 Mediastinal Node Involvement Renato G. Martins, MD, MPH a ; Thomas A. D Amico, MD b ; Billy W. Loo Jr,
More informationThoracoscopic Lobectomy for Locally Advanced Lung Cancer. Masters of Minimally Invasive Thoracic Surgery Orlando September 19, 2014
for Locally Advanced Lung Cancer Masters of Minimally Invasive Thoracic Surgery Orlando September 19, 2014 Thomas A. D Amico MD Gary Hock Endowed Professor and Vice Chair of Surgery Chief Thoracic Surgery
More informationAdam J. Hansen, MD UHC Thoracic Surgery
Adam J. Hansen, MD UHC Thoracic Surgery Sometimes seen on Chest X-ray (CXR) Common incidental findings on computed tomography (CT) chest and abdomen done for other reasons Most lung cancers discovered
More informationsurgical approach for resectable NSCLC
surgical approach for resectable NSCLC Dominique H. Grunenwald, MD, PhD Professor Emeritus in Thoracic and Cardiovascular surgery Pierre & Marie Curie University. Paris. France 1933 Graham EA, Singer JJ.
More informationPathologic staging of the mediastinal lymph nodes is
Mediastinoscopy: Still the Gold Standard Joseph B. Shrager, MD Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, and Veterans Administration
More informationSurgical management of lung cancer
Surgical management of lung cancer Nick Roubos FRACS Cardiothoracic Surgeon Box Hill Hospital, Epworth Eastern Thoracic Oncology Non Small Cell Lung Cancer (NSCLC) Small Cell Lung Cancer Mesothelioma Pulmonary
More informationThe Journal of Thoracic and Cardiovascular Surgery
Accepted Manuscript Mesothelioma: Live to Fight Another Day Andrea S. Wolf, MD, Raja M. Flores, MD PII: S0022-5223(17)32747-2 DOI: 10.1016/j.jtcvs.2017.11.060 Reference: YMTC 12301 To appear in: The Journal
More informationTratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón
Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Santiago Ponce Aix Servicio Oncología Médica Hospital Universitario 12 de Octubre Madrid Stage III: heterogenous disease
More informationPatients with stage IIIa non-small cell lung cancer
GENERAL THORACIC When is it Best to Repeat a 2-Fluoro-2-Deoxy-D- Glucose Positron Emission Tomography/Computed Tomography Scan on Patients with Non-Small Cell Lung Cancer Who Have Received Neoadjuvant
More informationThe tumor, node, metastasis (TNM) staging system of lung
ORIGINAL ARTICLE Peripheral Direct Adjacent Lobe Invasion Non-small Cell Lung Cancer Has a Similar Survival to That of Parietal Pleural Invasion T3 Disease Hao-Xian Yang, MD, PhD,* Xue Hou, MD, Peng Lin,
More informationLung cancer is the leading cause of cancer-related
Advanced Non-Small Cell Lung Cancer: Induction Chemotherapy and Chemoradiation Before Operation Arnold Cyjon, MD, Moshe Nili, MD, Gershon Fink, MD, Mordechai R. Kramer, MD, Eyal Fenig, MD, Judith Sandbank,
More informationPerioperative outcomes and lymph node assessment after induction therapy in patients with clinical N1 or N2 non-small cell lung cancer
Original Article Perioperative outcomes and lymph node assessment after induction therapy in patients with clinical N1 or N2 non-small cell lung cancer Jessica Glover 1, Frank O. Velez-Cubian 2, Kavian
More informationPOINT: Operative risk of pneumonectomy Influence of preoperative induction therapy
Gaissert et al Point/Counterpoint POINT: Operative risk of pneumonectomy Influence of preoperative induction therapy Henning A. Gaissert, MD, Dong Yoon Keum, MD, Cameron D. Wright, MD, Marek Ancukiewicz,
More informationCorrelation of pretreatment surgical staging and PET SUV(max) with outcomes in NSCLC. Giancarlo Moscol, MD PGY-5 Hematology-Oncology UTSW
Correlation of pretreatment surgical staging and PET SUV(max) with outcomes in NSCLC Giancarlo Moscol, MD PGY-5 Hematology-Oncology UTSW BACKGROUND AJCC staging 1 gives valuable prognostic information,
More informationControversies in management of squamous esophageal cancer
2015.06.12 12.47.48 Page 4(1) IS-1 Controversies in management of squamous esophageal cancer C S Pramesh Thoracic Surgery, Department of Surgical Oncology, Tata Memorial Centre, India In Asia, squamous
More informationTumors of the superior sulcus and central T4 tumors are an
ORIGINAL ARTICLE Survival after Trimodality Treatment for Superior Sulcus and Central T4 Non-small Cell Lung Cancer Paul De Leyn, MD, PhD,* Johan Vansteenkiste, MD, PhD, Yolande Lievens, MD, PhD, Dirk
More informationThe Role of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in the Diagnosis of Recurrent Non-small Cell Lung Cancer after Surgery
ORIGINAL ARTICLE The Role of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in the Diagnosis of Recurrent Non-small Cell Lung Cancer after Surgery Seo Goo Han 1, Hongseok Yoo 1, Byung
More informationSalvage Lung Resection After Definitive Radiation (>59 Gy) for Non-Small Cell Lung Cancer: Surgical and Oncologic Outcomes
Salvage Lung Resection After Definitive Radiation (>59 Gy) for Non-Small Cell Lung Cancer: Surgical and Oncologic Outcomes Julie E. Bauman, MD, Michael S. Mulligan, MD, Renato G. Martins, MD, Brenda F.
More informationRobotic assisted VATS lobectomy for loco-regionally advanced non-small cell lung cancer
Surgical Technique Page 1 of 5 Robotic assisted VATS lobectomy for loco-regionally advanced non-small cell lung cancer Simon R. Turner, M. Jawad Latif, Bernard J. Park Thoracic Surgery Service, Memorial
More informationNon small cell Lung Cancer
Non small cell Lung Cancer The 13th refresher course for residents in radiation oncology Jiraporn Setakornnukul, M.D. Radiation oncology division, Radiology department Siriraj Hospital, Mahidol University
More informationIs N2 Disease a Contraindication for Surgical Resection for Superior Sulcus Tumors? No
2. Goldstraw P, Crowley J, Chansky K, et al ; International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions. The IASLC Lung Cancer Staging Project:
More informationMalignant pleural mesothelioma: Role of MDCT in early diagnosis and prediction of resectability for radical surgery
Malignant pleural mesothelioma: Role of MDCT in early diagnosis and prediction of resectability for radical surgery Poster No.: C-0890 Congress: ECR 2010 Type: Educational Exhibit Topic: Chest Authors:
More informationRTOG Lung Cancer Committee 2012 Clinical Trial Update. Wally Curran RTOG Group Chairman
RTOG Lung Cancer Committee 2012 Clinical Trial Update Wally Curran RTOG Group Chairman 1 RTOG Lung Committee: Active Trials Small Cell Lung Cancer Limited Stage (Intergroup Trial) Extensive Stage (RTOG
More informationPatients with pathologically diagnosed involved mediastinal
MINI-SYMPOSIUM ON EMERGING TECHNIQUES FOR LUNG CANCER STAGING European Trends in Preoperative and Intraoperative Nodal Staging: ESTS Guidelines P. De Leyn, MF, PhD,* D. Lardinois, MD, P. Van Schil, MD,
More informationIs uniportal thoracoscopic surgery a feasible approach for advanced stages of non-small cell lung cancer?
Original rticle Is uniportal thoracoscopic surgery a feasible approach for advanced stages of non-small cell lung cancer? Diego Gonzalez-Rivas 1,2, Eva Fieira 1, Maria Delgado 1, Lucía Mendez 1, Ricardo
More informationVariability in Defining T1N0 Non-Small Cell Lung Cancer Impacts Locoregional Failure and Survival
Variability in Defining T1N0 Non-Small Cell Lung Cancer Impacts Locoregional Failure and Survival Mert Saynak, MD, Jessica Hubbs, MS, Jiho Nam, MD, Lawrence B. Marks, MD, Richard H. Feins, MD, Benjamin
More information11/21/ M with LUL Mass Case Presentation / Round Table Discussion. Multiple-choice question What stage is this tumor?
MS 62M with LUL Mass Case Presentation / Round Table Discussion Dr. Jasleen Kukreja and Johannes Kratz Department of Thoracic Surgery University of California, San Francisco 62M, presented to clinic 6/2009
More informationInduction Chemoradiation Is Not Superior to Induction Chemotherapy Alone in Stage IIIA Lung Cancer
Induction Chemoradiation Is Not Superior to Induction Chemotherapy Alone in Stage IIIA Lung Cancer Asad A. Shah, MD, Mark F. Berry, MD, Ching Tzao, MD, PhD, Mihir Gandhi, MS, Mathias Worni, MD, Ricardo
More informationRole of Surgery in Management of Non Small Cell Lung Cancer. Dr. Ahmed Bamousa Consultant thoracic surgery Prince Sultan Military Medical City
Role of Surgery in Management of Non Small Cell Lung Cancer Dr. Ahmed Bamousa Consultant thoracic surgery Prince Sultan Military Medical City Introduction Surgical approach Principle and type of surgery
More informationFacing Surgery for Lung Cancer? Learn about minimally invasive da Vinci Surgery
Facing Surgery for Lung Cancer? Learn about minimally invasive da Vinci Surgery Treatments & Surgery Options: The treatment and surgical options for the most common lung cancer, non-small cell lung cancer,
More informationACOSOG (NCCTG, CALGB) Alliance Thoracic Committee Kemp H. Kernstine, MD PhD
ACOSOG (NCCTG, CALGB) Alliance Thoracic Committee Kemp H. Kernstine, MD PhD 7-12-12 ACOSOG Thoracic Committee Chair: Bryan Meyers, M.D., MPH Vice Chairs: Malcolm Brock, MD Tom DiPetrillo, M.D. Ramaswamy
More informationShort-Course Induction Chemoradiotherapy With Paclitaxel for Stage III Non-Small-Cell Lung Cancer
Short-Course Induction Chemoradiotherapy With Paclitaxel for Stage III Non-Small-Cell Lung Cancer Thomas W. Rice, MD, David J. Adelstein, MD, Jay P. Ciezki, MD, Mark E. Becker, MD, Lisa A. Rybicki, MS,
More informationLONG-TERM SURGICAL OUTCOMES OF 1018 PATIENTS WITH EARLY STAGE NSCLC IN ACOSOG Z0030 (ALLIANCE) TRIAL
LONG-TERM SURGICAL OUTCOMES OF 1018 PATIENTS WITH EARLY STAGE NSCLC IN ACOSOG Z0030 (ALLIANCE) TRIAL Stacey Su, MD; Walter J. Scott, MD; Mark S. Allen, MD; Gail E. Darling, MD; Paul A. Decker, MS; Robert
More informationLong-Term Survival After Video-Assisted Thoracic Surgery Lobectomy for Primary Lung Cancer
Long-Term Survival After Video-Assisted Thoracic Surgery Lobectomy for Primary Lung Cancer Kazumichi Yamamoto, MD, Akihiro Ohsumi, MD, Fumitsugu Kojima, MD, Naoko Imanishi, MD, Katsunari Matsuoka, MD,
More informationThe eponym Pancoast tumor derives from the noted Philadelphia radiologist
General Thoracic Surgery Kwong et al High-dose radiotherapy in trimodality treatment of Pancoast tumors results in high pathologic complete response rates and excellent long-term survival King F. Kwong,
More informationSurgical Approaches to Locally Advanced NSCLC. Kemp H. Kernstine, MD, PhD Professor and Chairman UT Southwestern Medical Center Dallas, TX
Surgical Approaches to Locally Advanced NSCLC Kemp H. Kernstine, MD, PhD Professor and Chairman UT Southwestern Medical Center Dallas, TX Keep it real simple. Do one thing and do it the best you can. -Harry
More informationSmall cell lung cancer (SCLC), which represents 20%
ORIGINAL ARTICLES: GENERAL THORACIC Surgical Results for Small Cell Lung Cancer Based on the New TNM Staging System Masayoshi Inoue, MD, Shinichiro Miyoshi, MD, Tsutomu Yasumitsu, MD, Takashi Mori, MD,
More informationACOSOG Thoracic Committee. Kemp H. Kernstine, MD PhD
ACOSOG Thoracic Committee Kemp H. Kernstine, MD PhD ACOSOG Thoracic Committee Chair: Bryan Meyers, M.D., MPH Vice Chairs: Malcolm Brock, MD Tom DiPetrillo, M.D. Ramaswamy Govindan, M.D. Carolyn Reed, MD
More informationBronchogenic Carcinoma
A 55-year-old construction worker has smoked 2 packs of ciggarettes daily for the past 25 years. He notes swelling in his upper extremity & face, along with dilated veins in this region. What is the most
More informationVideo-assisted thoracoscopic surgery in lung cancer staging
Review Article on Thoracic Surgery Page 1 of 7 Video-assisted thoracoscopic surgery in lung cancer staging Frederico Krieger Martins, Guilherme Augusto Oliveira, Juliano Cé Coelho, Márcio Chmelnitsky Kruter,
More informationEVIDENCE BASED MANAGEMENT OF STAGE III NSCLC MILIND BALDI
EVIDENCE BASED MANAGEMENT OF STAGE III NSCLC MILIND BALDI Overview Introduction Diagnostic work up Treatment Group 1 Group 2 Group 3 Stage III lung cancer Historically was defined as locoregionally advanced
More informationRole of CT imaging to evaluate solitary pulmonary nodule with extrapulmonary neoplasms
Original Research Article Role of CT imaging to evaluate solitary pulmonary nodule with extrapulmonary neoplasms Anand Vachhani 1, Shashvat Modia 1*, Varun Garasia 1, Deepak Bhimani 1, C. Raychaudhuri
More informationThe Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy
The Role of Consolidation Therapy for Stage III Non-Small Cell Lung Cancer With Persistent N2 Disease After Induction Chemotherapy Arya Amini, BA, Arlene M. Correa, PhD, Ritsuko Komaki, MD, Joe Y. Chang,
More informationLung Cancer staging Role of ENDOBRONCHIAL ULTRASOUND(Ebus) EBUS
Lung Cancer staging Role of ENDOBRONCHIAL ULTRASOUND(Ebus) Arvind Perathur Winter Retreat Feb 13 th 2011 Mason City IA 50401 EBUS Tiger now offers a very economical and environmentally friendly all electric
More informationPostoperative Mortality in Lung Cancer Patients
Review Postoperative Mortality in Lung Cancer Patients Kanji Nagai, MD, Junji Yoshida, MD, and Mitsuyo Nishimura, MD Surgery for lung cancer frequently results in serious life-threatening complications,
More informationNewly Diagnosed Cases Cancer Related Death NCI 2006 Data
Multi-Disciplinary Management of Esophageal Cancer: Surgical and Medical Steps Forward Alarming Thoracic Twin Towers 200000 150000 UCSF UCD Thoracic Oncology Conference November 21, 2009 100000 50000 0
More informationNon-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist
Non-small Cell Lung Cancer: Multidisciplinary Role: Role of Medical Oncologist Vichien Srimuninnimit, MD. Medical Oncology Division Faculty of Medicine, Siriraj Hospital Outline Resectable NSCLC stage
More informationA Phase II Single-Institution Study of Neoadjuvant Stage III A/B Chemotherapy and Radiochemotherapy in Non-Small Cell Lung Cancer
A Phase II Single-Institution Study of Neoadjuvant Stage III A/B Chemotherapy and Radiochemotherapy in Non-Small Cell Lung Cancer Andreas Granetzny, MD, Eberhard Striehn, MD, Ulrich Bosse, MD, Wolfgang
More informationES-SCLC Joint Case Conference. Anthony Paravati Adam Yock
ES-SCLC Joint Case Conference Anthony Paravati Adam Yock Case 57 yo woman with 35 pack year smoking history presented with persistent cough and rash Chest x-ray showed a large left upper lobe/left hilar
More informationRecommendations 1 For mediastinal nodal staging in patients with suspected or proven non-small-cell lung cancer
Guideline 545 Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the
More informationINTERACTIVE SESSION 2
INTERACTIVE SESSION 2 2 patients with lung metastases, with complete response after oncologic treatment - Clinical Case Presentation: Dr. Esther Casado Dr. Sergi Call - Expert Opinion: Dr. Raúl Embún Dr.
More informationPreoperative Workup for Pulmonary Resection. Kristen Bridges, M.D. Richmond University Medical Center January 21, 2016
Preoperative Workup for Pulmonary Resection Kristen Bridges, M.D. Richmond University Medical Center January 21, 2016 Patient Presentation 50 yo male with 70 pack year smoking history Large R hilar lung
More informationExtrapleural Pneumonectomy: A Blessing or a Curse in the Management of Pleural Malignant Mesothelioma?
Original Research Extrapleural Pneumonectomy: A Blessing or a Curse in the Management of Pleural Malignant Mesothelioma? PLEURA January-December 2015: 1-7 ª The Author(s) 2015 DOI: 10.1177/2373997515595219
More informationLes techniques invasives et minimalement invasives dans le staging du cancer bronchopulmonaire. V. Ninane, Hôpital Saint-Pierre, Bruxelles, Belgique
Les techniques invasives et minimalement invasives dans le staging du cancer bronchopulmonaire V. Ninane, Hôpital Saint-Pierre, Bruxelles, Belgique 1 Invasive Mediastinal Staging Purpose : to exclude Involvement
More informationEndobronchial Ultrasound in the Diagnosis & Staging of Lung Cancer
Endobronchial Ultrasound in the Diagnosis & Staging of Lung Cancer Dr Richard Booton PhD FRCP Lead Lung Cancer Clinician, Consultant Respiratory Physician & Speciality Director Manchester University NHS
More informationRole of EBUS in mediastinal staging of lung cancer. -Dr. Nandakishore Baikunje
Role of EBUS in mediastinal staging of lung cancer -Dr. Nandakishore Baikunje Overview of the seminar Introduction Endosonography to stage the mediastinum Technical aspects of EBUS-TBNA for mediastinal
More informationPrevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma
Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma Abdel Rahman M. Abdel Rahman, MD, Rabab M. Gaafar, MD, Hoda A. Baki, MD, Hesham M. El Hosieny, MD, Fatma Aboulkasem, MD,
More informationLung Cancer. Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD
Lung Cancer Current Therapy JEREMIAH MARTIN MBBCh FRCSI MSCRD Objectives Describe risk factors, early detection & work-up of lung cancer. Define the role of modern treatment options, minimally invasive
More informationSuperior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis
ORIGINAL ARTICLES: Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis Shun-ichi Watanabe, MD, Kenji Suzuki, MD, and Hisao Asamura, MD
More informationGUIDELINE RECOMMENDATIONS
European Journal of Cardio-Thoracic Surgery 48 (2015) 1 15 doi:10.1093/ejcts/ezv194 Cite this article as: Vilmann P, Frost Clementsen P, Colella S, Siemsen M, De Leyn P, Dumonceau J-M et al. Combined endobronchial
More informationCombined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer
TASK FORCE REPORT ESGE/ERS/ESTS GUIDELINES Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer European Society of Gastrointestinal Endoscopy (ESGE) Guideline,
More informationPredictive risk factors for lymph node metastasis in patients with resected nonsmall cell lung cancer: a case control study
Moulla et al. Journal of Cardiothoracic Surgery (2019) 14:11 https://doi.org/10.1186/s13019-019-0831-0 RESEARCH ARTICLE Open Access Predictive risk factors for lymph node metastasis in patients with resected
More informationAccepted Manuscript. Indications for Invasive Mediastinal Staging for Non-small Cell Lung Cancer. Jules Lin, MD, Felix Fernandez, MD
Accepted Manuscript Indications for Invasive Mediastinal Staging for Non-small Cell Lung Cancer Jules Lin, MD, Felix Fernandez, MD PII: S0022-5223(18)31872-5 DOI: 10.1016/j.jtcvs.2018.07.027 Reference:
More informationUniportal video assisted thoracoscopy major lung resections after neoadjuvant chemotherapy
Original Article Uniportal video assisted thoracoscopy major lung resections after neoadjuvant chemotherapy Mahmoud Ismail 1, Dania Nachira 2, Marc Swierzy 1, Gian Maria Ferretti 2, Julianna Paulina Englisch
More informationSleeve Lobectomy Compared with Pneumonectomy after Induction Therapy for Non Small-Cell Lung Cancer
Original Article Sleeve Lobectomy Compared with Pneumonectomy after Induction Therapy for Non Small-Cell Lung Cancer Giulio Maurizi, MD,* Antonio D Andrilli, MD,* Marco Anile, MD, Anna Maria Ciccone, MD,*
More informationVideo-assisted thoracic surgery pneumonectomy: the first case report in Poland
Case report Videosurgery Video-assisted thoracic surgery pneumonectomy: the first case report in Poland Cezary Piwkowski, Piotr Gabryel, Mariusz Kasprzyk, Wojciech Dyszkiewicz Thoracic Surgery Department,
More informationRobotic lobectomy: revolution or evolution?
Editorial Robotic lobectomy: revolution or evolution? Jules Lin Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA Correspondence to: Jules
More informationLarry Tan, MD Thoracic Surgery, HSC. Community Cancer Care Educational Conference October 27, 2017
Larry Tan, MD Thoracic Surgery, HSC Community Cancer Care Educational Conference October 27, 2017 To describe patient referral & triage for the patient with suspected lung cancer To describe the initial
More informationEarly and locally advanced non-small-cell lung cancer (NSCLC)
Early and locally advanced non-small-cell lung cancer (NSCLC) ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up P. E. Postmus, K. M. Kerr, M. Oudkerk, S. Senan, D. A. Waller, J.
More informationImproving the Inaccuracies of Clinical Staging of Patients with NSCLC: A Prospective Trial
Improving the Inaccuracies of Clinical Staging of Patients with NSCLC: A Prospective Trial Robert James Cerfolio, MD, FACS, Ayesha S. Bryant, MD, MSPH, Buddhiwardhan Ojha, MD, MPH, and Mohammad Eloubeidi,
More information