William Conan Mustain, MD

Transcription

1 William Conan Mustain, MD Address Education University of Arkansas for Medical Sciences Division of Colon and Rectal Surgery 4301 W. Markham St., Slot 520 Little Rock, AR Office: (501) xxx-xxxx Fax: (501) xxx-xxxx B.S. Biology Magna Cum Laude Florida State University Tallahassee, FL Doctor of Medicine, M.D. University of Mississippi School of Medicine Jackson, MS Categorical Intern, General Surgery Resident, General Surgery Surgical Research Fellow Department of Surgery and Markey Cancer Center Resident, General Surgery Administrative Chief Resident, General Surgery Resident, Colon and Rectal Surgery University Hospitals-Case Medical Center Cleveland, OH Medical License Kentucky (Training License) Ohio (Training License) Arkansas; License #: E-9260, 2015-present 1

2 Academic Appointments 2015-Present Assistant Professor of Surgery Colon and Rectal Surgery University of Arkansas for Medical Sciences Little Rock, AR Professional Organizations 2007-present 2012-present 2014-present American College of Surgeons Resident and Associate Society American College of Surgeons Professional Association Political Action Committee, Senatorial Circle American Society of Colon & Rectal Surgeons Honors & Awards 2003 Phi Beta Kappa; Alpha Chapter of Florida; Florida State University 2008 Bobby C. Powell Intern of the Year Award; Department of Surgery; 2010 Clinical Teaching Award in Surgery; University of Kentucky College of Medicine Class of First Place, Postdoctoral Basic Science; Poster Competition; Markey Cancer Center Research Day An orthotopic murine model of colon cancer using colonoscopic submucosal injection Alpha Omega Alpha; Beta Chapter of Kentucky; University of Kentucky College of Medicine Peer Reviewed Publications Lineaweaver WC, Lei MP, Mustain W, Oswald TM, Cui D, Zhang F. Vascular endothelium growth factor, surgical delay, and skin flap survival. Ann Surg 2004 Jun; 239(6): Zhang F, Brooks D, Chen W, Mustain W, Chen MB, Lineaweaver WC. Improvement of venous flap survival by application of vascular endothelial growth factor in a rat model. Ann Plast Surg 2006 Jun; 56(6): Song C, Zhang F, Zhang J, Mustain WC, Chen MB, Chen T, Lineaweaver WC. Neuroma-incontinuity model in rabbits. Ann Plast Surg 2006 Sep; 57(3): Chen WJ, Zhang F, Mustain WC, Tucci M, Hu EC, Lineaweaver WC. Prefabrication of vascularized bone flap by demineralized bone matrix. J Craniofac Surg 2007 Jan; 18(1): 43-8 Mustain WC, Rychahou PG, Evers BM. The role of neurotensin in physiologic and pathologic processes. Curr Opin Endocrinol Diabetes Obes 2011 Feb; 18(1):

3 Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res 2012 Mar 15; 72(6): Mustain WC, Davenport DL, Hourigan JS, Vargas HD. Obesity and laparoscopic colectomy: outcomes from the ACS-NSQIP database. Dis Colon Rectum 2012 Apr; 55(4): Valentino JD, Elliott VA, Zaytseva YY, Rychahou PG, Mustain WC, Wang C, Gao T, Evers BM. Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer. Surgery 2012 Aug; 152(2): Mustain WC, Davenport DL, Parcells JP, Vargas HD, Hourigan JS. Abdominal vs. perineal approach for treatment of rectal prolapse: comparable safety in a propensity-matched cohort. Am Surg 2013 Jul; 79(7): Valentino JD, Rychahou PG, Mustain WC, Elliott VA, Evers BM. Murine portal vein catheterization to analyze liver-directed therapies. J Surg Res 2013 Dec; 185(2):690-6 Mustain WC, Starr ME, Valentino JD, Cohen DA, Okamura D, Wang C, Evers BM, Saito H. Inflammatory cytokine gene expression in mesenteric adipose tissue during acute experimental colitis. PLoS One 2013 Dec; 8(12):e83693 Valentino JD, Li J, Mustain WC, Elliott VA, Campbell K, Weiss HL, Wang C, Song J, Anthony L, Townsend CM, Evers BM. Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors. Clin Cancer Res 2014 Mar;20(5): Zaytseva YY, Elliott VA, Rychahou PG, Mustain WC, Kim JT, Valentino JD, Gao T, O Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis 2014 Jun;35(6): Rychahou P, Haque F, Shu Y, Zaytseva Y, Weiss HL, Lee E, Mustain W, Valentino J, Guo P, Evers B. Delivery of RNA nanoparticles into colorectal cancer metastases following systemic administration. ACS Nano 2015 Feb:24;9(2): Crawshaw B., Delaney C.P., Mustain W.C., Russ A.J., Shanmugan S., Champagne B.J., Steele S.R., Lee D. Failing to prepare is preparing to fail: a single blinded randomized controlled trial to determine the impact of a preoperative instructional video on resident s ability to perform laparoscopic colectomy. Accepted for publication in Diseases of the Colon & Rectum Presentations 2004 Use of vein graft arteriovenous fistulae in microsurgical flap reconstruction: immediate versus delayed flap transfer. Stover SA, Gerzenshtein J, Mustain WC, Lei MP, Zhang F, Angel MF, Lineaweaver WC. Oral presentation: 2004 Plastic Surgery Senior Residents Conference Educational Program. March 2004; Milwaukee, WI 2010 Obesity and laparoscopic colectomy: postoperative outcomes using the ACS-NSQIP dataset. Mustain WC, Davenport DL, Hourigan JS, Vargas HD. Poster presentation: The American Society of Colon and Rectal Surgeons Annual Scientific Meeting. May 2010; Minneapolis, MN 3

4 2010 Outcomes of Hand-Assisted Laparoscopic Colectomy in Obese vs. Non-obese patients. Mustain WC, Davenport DL, Lackey JH, Hourigan JS, Vargas HD. Poster presentation: American College of Surgeons 96 th Annual Clinical Congress. October 2010; Washington, DC 2011 Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O Connor KL, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM. Poster presentation: Metabolism and Cancer. October 2011; Baltimore, MD 2012 Inflammatory responses in mesenteric adipose tissue during experimental colitis. Mustain WC. Oral presentation: The Hanging with Zwisch Research Colloquium, University of Kentucky Department of Surgery. March 2012; 2012 An orthotopic murine model of colon cancer using colonoscopic submucosal injection. Mustain WC, Rychahou PG, Zaytseva YY, Valentino JD, Evers BM. Poster presentation: Markey Cancer Center Research Day. May 2012; 2012 Fatty acid synthase promotes metastasis of colorectal cancer via induction of directed migration of cancer cells and alteration of tumor microenvironment. Zaytseva YY, Elliott VA, Valentino JD, Mustain WC, Stevens PD, Gao T, Rychahou PG, Weiss HL, Lee EY, Evers BM. Oral presentation: Markey Cancer Center Research Day. May 2012; 2012 Intra-abdominal adipose tissue as a major source of IL-6 during acute experimental colitis. Mustain WC, Starr ME, Okamura D, Evers B, Saito H. Poster presentation: 53 rd Annual Meeting of the Society for Surgery of the Alimentary Tract, at Digestive Disease Week May 2012; San Diego, CA 2012 Development of a novel murine model of portal vein catheterization as a strategy to analyze liver-directed therapies for colorectal cancer metastasis. Valentino JD, Rychahou PG, Mustain WC, Evers BM. Poster presentation: 53 rd Annual Meeting of the Society for Surgery of the Alimentary Tract, at Digestive Disease Week May 2012; San Diego, CA 2012 Inhibition of fatty acid synthase reduces metastasis in colorectal cancer via altered expression of CD44 and disruption of the signaling network downstream of the CD44/c-MET complex. Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O Connor KL, Morris AJ, Sunkara M, Weiss HL, Lee EY, Evers BM. Oral presentation: American Gastroenterological Association, at Digestive Disease Week May 2012; San Diego, CA 4

5 2013 Abdominal vs. perineal approach for treatment of rectal prolapse: comparable safety in a propensity-matched cohort. Mustain WC, Davenport DL, Parcells JP, Vargas HD, Hourigan JS. Oral presentation: Southeastern Surgical Congress Annual Scientific Meeting. January 2013; Jacksonville, FL 2013 Surgical pathology of colorectal cancer. Mustain WC. Oral presentation: University of Kentucky Department of Surgery Grand Rounds. March 2013; 2013 Abdominal vs. perineal approach for treatment of rectal prolapse. Mustain WC, Davenport DL, Parcells JP, Vargas HD, Hourigan JS. Oral presentation: Spring Meeting of the Piedmont Society of Colon & Rectal Surgeons. March 2013; Longboat Key, FL 2013 Targeting colorectal cancer liver metastases with folateconjugated ultrastable RNA nanoparticles. Rychahou P, Shu Y, Simonelli F, Zaytseva Y, Elliott V, Lee E, Weiss H, Mustain W, Valentino J, Guo P, Evers B. Poster presentation: American Gastroenterological Association, at Digestive Disease Week May 2013; Orlando, FL 2013 Tumor-specific expression of fatty acid synthase promotes metastasis and angiogenesis in colorectal cancer. Zaytseva YY, Elliott VA, Rychahou PG, Mustain WC, Kim JT, Valentino JD, Gao T, O Connor KL, Neltner JM, Weiss HL, Evers BM. Poster presentation: Target Cancer Metabolism. May 2013; Boston, MA 2015 Failing to prepare is preparing to fail: a single blinded randomized controlled trial to determine the impact of a preoperative instructional video on resident s ability to perform laparoscopic colectomy. Crawshaw B., Delaney C.P., Mustain W.C., Russ A.J., Shanmugan S., Champagne B.J., Steele S.R., Lee D. The American Society of Colon and Rectal Surgeons Annual Scientific Meeting. June 2015, Boston, MA 5