EORTC LUNG CANCER GROUP GROUP MEETING
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2 Sunday 7 th October 2018 Time slot Topic / Title of presentation Chair Board meeting Arrivals & Welcome coffee Welcome & Introduction New Board,, Membership status, Calendar and publications/abstracts, Finances B. Besse, N.Reguart, J.Remon, B. Besse,, A-M Dingemans, T. Berghmans Protocols in SCLC and Thymic Malignancies: 1417 (REACTION): A phase II study of etoposide and cis/carboplatin with or without pembrolizumab in untreated extensive small cell lung cancer B. Besse (NivoThym): Single-arm, multicenter, phase II study of immunotherapy in patients with type B3 thymoma and thymic carcinoma previously treated with chemotherapy N. Girard B. Besse, Jessica Menis Oligometastatic disease consensus: update Protocols in early stage, locally advanced and brain metastases NSCLC: A-M Dingemans (HALT): Targeted therapy beyond progression with or without dose-intensified radiotherapy in oligoprogressive disease (OPD) in oncogene Addicted Lung Tumours M. Guckenberger, N. Andratschke J. Edwards, A. Levy, Cécile Le Pechoux 1416 (PEARLS): A Randomized, Phase 3 Trial With Anti- PD-1 Monoclonal Antibody Pembrolizumab (MK-3475) Versus Placebo for Patients With Early Stage NSCLC After Resection and Completion of Standard Adjuvant Therapy (PEARLS) M. O Brien
3 1807: Randomized phase II trials of early radiosurgery versus delayed radiosurgery or other salvage treatment (EVER) with either checkpoint inhibition (EVER-IO) or tyrosine kinase inhibitors (EVER-TKI) for the treatment of patients with brain metastases from non-small cell lung cancer (NSCLC) M. Guckenberger, N. Andratschke Concept: PRIMALung Lunch 14:40 15:10 Young Investigators Projects I L. Hendriks, M. Giaj Levra Protocols in advanced NSCLC: 1613 (APPLE): Feasibility and activity of AZD9291 (osimertinib) treatment on Positive PLasma T790M in EGFR mutant NSCLC patients - R. Dziadziuszko, J. Remon 1643 (SOLUTION): Randomized phase II study of durvalumab and tremelimumab combination versus standard of care plus durvalumab following first-line platinum based chemotherapy plus durvalumab in two cohorts of patients with non-squamous and squamous NSCLC L. Hendriks (SPLENDOUR): A randomised, open-label phase III trial evaluating the addition of denosumab to standard first-line anticancer treatment in advanced NSCLC Final analysis results B. Hasan B. Besse, J. Corral, E. Smit Concepts: 1825 (ALKALINE): Activity of Lorlatinib based on ALK resistance mutations on blood in 2nd or subsequent lines in ALK positive NSCLC patients - A-M Dingemans, L. Mezquita A phase II randomized, open label, study of nivolumab plus ipilimumab in combination with platinum-based chemotherapy compared with platinum-based chemotherapy, compared with nivolumab plus ipilimumab for the treatment of elderly patients with advanced, metastatic non-small cell lung cancer (NSCLC). - S. Novello, M. Giaj Levra
4 16:10 18:10 KEY Lectures 16:10-16:30 The role of the Spanish Medical Oncology Society (SEOM) in the European Oncology Community Ruth Vera 16:30-16:50 How do I foresee lung cancer treatment in the five years to come Luis Paz-Ares :10 Coffee break 17:10-17:30 Is it possible to improve patients outcomes in oligometastatic NSCLC with local therapy? Ramon Rami-Porta 17:30-17:50 PDL-1 vs TMB: do we have a winner? Fernando López-Ríos 17:50-18:10 Clinical applications of liquid biopsy: screening, molecular residual disease and new designs of clinical trials Rafael López López Joint session with Pharma Sponsor 18:10-18:25 Bls early portfolio: focus on NSCLC Dejan Radonjic 18:25-18:40 Tumor DNA Digital NGS in Thoracic malignancies Noemí Reguart 19:00 20:30 Free Time 20:30 Dinner at EL VIVERO Paseo Balmins, s/n
5 Monday 8 th October 2018 Time slot Topic / Title of presentation Chair Breakfast for young investigators TR protocols and projects: SPECTA: Screening Patients with thoracic tumors for Efficient Clinical Trial Access B. Besse Concept: IMMUcan project: Integrated IMMUnoprofiling of large adaptive CANcer patients cohorts B. Besse S. Novello, F. Fachinetti 1824-LCG EuroBioradon : European observational study of the indoor radon in non-small cell lung cancer (NSCLC) patients harboring driver molecular alterations L. Mezquita 10:00 10:30 Young Investigators Projects II L. Hendriks, A. Levy
6 Protocols in mesothelioma 1205: EORTC randomized phase II study of pleurectomy/ decortication (P/D) preceded or followed by chemotherapy in patients with early stage malignant pleural mesothelioma J. Raskin 10:30-11: (NEMO): Nintedanib as maintenance treatment of malignant pleural mesothelioma: a double-blind randomized phase II study of the EORTC Lung Cancer Group - A. Pochesci L. Greillier, G. Pasello Concepts: 1752 (MESAVEL): Phase II trial in pretreated Malignant pleural MESothelioma with AVELumab in combination with Nintedanib or Chemotherapy - N. Reguart, F. Fachinetti 11:00-11:30 Coffee break New proposals PECATI phase II study: PEmbrolizumab, CArboplatin, paclitaxel in thymic carcinoma J. Remon CTLA4 Intratumoral and PDL1 inhibitor Combination in CBNPC B. Duchemann 11:30 12:30 A phase II study of Nivolumab in Large Cell Neuro-Endocrine Lung Cancer (LCNEC) with PROFICIENT LKB1 C. Lindsay Treatment of early-stage NSCLC; current clinical practice in Europe and unrevealing factors influencing decision making; SABR or resection K. Hartemink B. Besse, A-M. Dingemans, S. Novello PIE-trial: PD1/PD-L1 Inhibitor-combinations in EGFR mutant NSCLC patients progressing after EGFR TKI G. Pasello A randomized phase III trial comparing doublet platinum chemotherapy with or without atezolizumb and bevacizumab in EGFR mutated patients after failure to effective tyrosin-kinase inhibitors A. Ortega Wrap-up & Conclusions B. Besse
7 End of the meeting B. Besse Lunch
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