CancerBase R E S E A R C H

Transcription

1 CancerBase R E S E A R C H

2 CancerBase 1 WEB PRESENCE 4 ATOM HP 2 NCCN GUIDELINES 5 BIOINFORMATICS 3 CHOOSING DRUGS 6 MEDMIND

3 Web Presence R E S E A R C H

4 What is CancerBase trying to communicate?

5 cancerbase.org

6 Why build a website for cancer? 60 % 82% with of patients prefer learning online than from their doctor. of clinical appointments are improved prior knowledge from internet. Source: Surveys conducted Data for each year based on a pooled analysis of all surveys conducted during that year. PEW RESEARCH CENTER

7 Internet Use by Age % of U.S. adults who use the internet, by age % 65 & Older 457% growth 64% Over half of all diagnosed cancer patients are 70 yrs of age or older Source: Surveys conducted Data for each year based on a pooled analysis of all surveys conducted during that year. PEW RESEARCH CENTER

8 Stakeholder patient caregiver research scientist foundations Need community knowledge data mission

9 github.com

10 github.com

11 patientslikeme.com

12 patientslikeme.com

13 cancerbase.org

14 Patient Registeries An organized collection of clinical data used to evaluate populations with specific diseases, conditions, or exposures. Patient registeries help develop behavioral patterns to improve healthcare.

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16 Research-Powered Data Registry of P.R. s Patientslikeme ParentProject MD Liferaft concerns: lack of data standardization, ease of use, patient rights

17 Elements of a successful registry Ease of use Recruitment, encouragement, gratitude Collaborative relationships with researches Partnerships with a broad range of stakeholders patientslikeme.com

18 Next Steps How might we effectively build a community? How might we accommodate users with differing needs? How might we increase clarity?

19 NCCN Guidelines R E S E A R C H

20 NCCN Evidence Blocks Decision tree for Invasive Breast Cancer NCCN stands for the National Comprehensive Cancer Network.

21 Complicated decision-making 283 points on this tree visible rest of tree { {

22 E = Efficacy S = Safety Q = Quality C = Consistency A = Affordability E S Q C A E S Q C A E S Q C A E S Q C A

23 Monthy cost of treatments Treatment cost per drug perscription Non HER-2 is more affordable to treat herceptin kadclya perjeta tykerb pacitaxel doxorubicine capetacibine gemcitabine vinorelbine erubilin HER-2 treatments non HER-2 treatments

24 Choosing Drugs R E S E A R C H

25 Choosing the right drug is complex. What stage and type of cancer does the patient have? What previous therapy has the patient received? What is the patients level of comfort with treatment?? And more...

26 Novartis drugs Norvatis manufactures two main drugs: TYVERB ZYKADIA Used to treat cancer caused by large amounts of the HER2 protein. Treats genes that fused with others to create an abnormal protein fusion.

27 Stages of approval The 4 stages until FDA approval for drugs Phase 1 1 year Phase 2 2 years Phase 3 Phase 4 4 years? years Year 1 Year 2 Year 3 Year 4 Year 5 Year 6 Year 7 Year? Once it s submitted for FDA approval around 7 yrs, the wait time varies widely.

28 Patients Like Me Product: DigitalMe Be able to test medicine on digital versions of patients using RNA, DNA, and proteins before testing on them in real life.

29 Watson Product: Watson for Oncology Help doctors find the best medical solutions. AI-driven; updates with new findings to boost patient confidence in recommendations.

30 Alphabet Product: Gritstone Uses machine learning to develop new cancer drugs. Develops immunotherapies for specific patient types.

31 Atom HP R E S E A R C H

32 The current landscape of data harvesting. In-clinic testing Surveys and questionnaires Wearable technology

33 Cedars-Sinai Fitbit Trials Why and how they re doing it. WHY More reliable patient data Eliminate physician bias Predict best treatment & patient response. HOW Track resting heart rate Daily activity & sleep

34 Sloan-Kettering Heller Wearable Why and how they re doing it. WHY Predict cancer in patients Eliminate the need for intrusive biopsies. HOW Biomarkers inside patient Nanotube sensors Band emits and reads infrared.

35 itbra - Cyrcadia Health Why and how they re doing it. WHY Predict breast cancer Alert at-risk patients to visit doc More accurately diagnose women with DBT. HOW Heat analysis Use AI to determine cancer risk

36 Bioinformatics R E S E A R C H

37 What do you mean by bioinformatics? It s the science of collecting and analyzing complex biological data such as genetic codes....but how does this relate to cancer?

38 Data collection How data is being accumulated, currently WEB SCRAPING MED. DATABASES

39 Data analysis How data is being made sense of, currently. TRADITIONAL MACHINE LEARNING

40 Use cases How bioinformatics can be used for cancer. Growth/metastasis prediction Treatment precision Life expectancy Stage identification

41 Medmind R E S E A R C H

42 What is Medmind? It s a personalized medical history timeline that uses computer vision to empower patients with the knowledge of the FDA drug database.

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44 Inspecting the application The good and the bad of MedMind. PROBLEMS Overwhelming content Is it better than what s already out there? SOLUTIONS Landing page for mobile app Simpler, navigable interface Detailed research on other apps

45 medmind.co

46 CancerBase 1 WEB PRESENCE 4 ATOM HP 2 NCCN GUIDELINES 5 BIOINFORMATICS 3 CHOOSING DRUGS 6 MEDMIND