Nerium oleander Oleandrin

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Britton Briggs
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1 66 55 (4 (008 ( Apocynacea ( 55

2 Study of the Effect of Collecting Time of Nerium Oleander Leaves on theire Concentration in Damascus and Lattakia Regions M Abdullatif ( ABSTRACT from the Apocynacea family is considered an ornamental and perennial green plant which grows wildly in the Mediterranean sea area only, and is planted all over the world This plant is very poisonous, where several leaves suffice to kill a man Recently, this plant has been classified as a medicinal plant which can be used to cure some types of cancer diseases since it contains Glycosides substance (more than 30 Glycosides with the most poisonous one being The results show that the concentration of in the leaves vary according to season and region of planting The higher concentration was found in the Damascus region in May (08 g 00 g dried leaves, whereas the lowest concentration was in the Lattakia region in February (0097 g 00 g dried leaves Key words,, Glycosides ( Associate professor, Department of Horticulture, Faculty of Agronomy, Tishreen University, Lattakia, Syria 56

3 66 55 (4 (008 Apocynaceae (Hardin and Arena, (Pankhurst, ( Chopra, et al, (Shumaik, et al, 988 (Lampe and McCann, 985 ( (Hardin and Arena, 974 (987 (Chiej, 984 (Chopra, et al, 986 (989 Bufalin 30 Neriine (Neuwinger, 000 Digitoxin (Goetz, 998; Newman, et al, 006 % (Lamm, et al, 999 ANVIRZEL Ozelle Pharmaceuticals (Ozel, 99 (Wang, et al,

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6 Official method of 00 (analysis, 990 (Wagner and Bladt, %90 6 % Watman 00 (TLC HPLC TLC [(8 UV 0 0 ( ( ] 54 RF 60

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12 REFERENCES Chiej, R (984 Encyclopaedia of Medicinal Plants MacDonald Press Chopra, R N, Nayar S L and Chopra I C (986 Glossary of Indian Medicinal Plants (Including the Supplement Council of Scientific and Industrial Research, New Delhi Goetz, R J (998 Oleander Indiana Plants Poisonous to Livestock and Pets, Purdue University, 998 Hardin, JW and Arena, JM (974 Human poisoning from native and cultivated plants, nd ed Kingsport, Tennessee, Duke University Press Lamm D, Kamat, A, DeHaven, J (999 Cytotoxic effect of Nerium Oleander extract (ANVIRZEL on bladder cancer cell, ASCO Annual Meeting, Lampe, KF and McCann, MA (985 AMA handbook of poisonous and injurious plants, Chicago, Illinois, American Medical Association Masri, A (99 Range Rehabilitation, Consultancy report FAOGCP SYR003ITA Merck Index (000 CDROM Windows, Version 3 (CDROM, Chapman & HallCRC Neuwinger, HD (000 African Traditional Medicine A Dictionary of Plant Use and Applications Medpharm Scientific Publishers, Stuttgart Newman, R A, Yang, P, Hittelman, WN, Lu, T, Ho, D H, Ni, D, Chan, D, Vijjeswarapu, M, Cartwright, C, Dixon, S, Felix, E, Addington, C (006 mediated oxidative stress in human melanoma cells, JExp Ther Oncol, 5 ( Official Methods of Analysis (990 5th Ed, Methods 9608, 9509, Assoc of Off Analytical Chemists, Arlington, VA Ozel HZ, inventor (99 Extracts of Nerium species, methods of preparation, and use therefore US patent 5,35,745 Aug 4 Pankhurst, R (ed (005 L Flora Europaea Royal Botanic Garden Edinburgh Schvartsman, S (979 Plantas venenosas Sarvier Sao Paulo Shaw, D and Pearn, J (979 Oleander poisoning Med J Aust, 6769 Shumaik, JM, Wu, AW and Ping, AC (988 Oleander poisoning treatment with digoxinspecific Fab antibody fragments Ann Emerg Med, 7( Wagner, H, Bladt, S (995 Plant drug analysis, nd ed, Berlin Springer, 995 Wang, X, Plomley, JB, Newman, R, Cisneros, A (000 LCMSMS Analysis of an oleander extract for cancer treatment Anal Chem, Received Accepted for Publ

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