M.Sc., Industrial Biotechnology, Department of Biotechnology, Bharathiar University, Coimbatore, India

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1 SATISH KUMAR RAMRAJ University of Oklahoma Health Sciences Center, Department of Obstetrics and Gynecology Section of Gynecologic Oncology 975 N.E. 10 th St. Rm BRC1270 Oklahoma City, OK, 73104, USA Phone: Education Ph.D., Biotechnology, Department of Biotechnology, Pondicherry University, Pondicherry, India (Advisor- Prof. Arul Venkatesan) M.Sc., Industrial Biotechnology, Department of Biotechnology, Bharathiar University, Coimbatore, India B.Sc., Microbiology, Department of Microbiology, RVS College, Bharathiar University, Coimbatore, India Professional Experience Postdoctoral Fellow, June 2015-present Department of Gynecologic Oncology, Stephenson Cancer Center, Oklahoma City, OK, 73104, USA Associate Research Fellow, August June 2015 Department of Radiation Oncology, Stephenson Cancer Center, Oklahoma City, OK, 73104, USA Junior Research Fellow, June 2006 May 2007 BU-DRDO Center for Life Sciences, Bharathiar University Campus, Coimbatore, India Lecturer, October 2005 May 2006 Department of Biotechnology, RVS College, Coimbatore, India Summer- Internship, PSG Institute of Medical Sciences & Research, Coimbatore, India Honors/Awards March 2018, Ovarinnovate: Ovarcome Research Excellence Award from Foundation for Women s Cancer Sept. 2014, Scholar-in training award, 60th Annual meeting of the Radiation Research Society, Las Vegas, NV Sept. 2013, Scholar-in training award, 59th Annual meeting of the Radiation Research Society, New Orleans, LA

2 July. 2007, Junior/Senior Research Fellowship, Indian Council of Medical Research, awarded for Ph.D., Dec. 2005, CSIR-UGC - National Eligibility Test (NET) award, Lectureship eligibility in life science April. 2001, Proficient student award, Department of Microbiology, RVS College, Coimbatore Peer-Reviewed Publications (Selected) Ramraj, S., Smith, K.M., Janakiram, N.B., Toal, C., Raman, A., Benbrook, D.M. (2018). Correlation of Clinical Data with Fallopian Tube Specimen Immune Cells and Tissue Culture Capacity. Tissue and Cell, 52, Aravindan, S., Ramraj, S., Kandasamy, K., Thirugnanasambandan, S. S., Somasundaram, D. B., Herman, T. S., & Aravindan, N. (2017). Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells. Oncotarget, 8(4), PMCID: PMC Ramraj, S., Aravindan, S., Somasundaram, D. B., Herman, T. S., Natarajan, M., & Aravindan, N. (2016). Serum-circulating mirnas predict neuroblastoma progression in mouse model of high-risk metastatic disease. Oncotarget, 7(14), PMCID: PMC Pandian, V., Ramraj, S., Khan, F. H., Azim, T., & Aravindan, N. (2015). Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. Stem Cell Research & Therapy, 6(1), 2. PMCID: PMC Aravindan, S., Ramraj, S, Somasundaram, S. T., Herman, T. S., & Aravindan, N. (2015). Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemnessmaintenance in residual pancreatic cancer. Stem Cell Research & Therapy, 6(1), 182. PMCID: PMC *Khan, F. H., *Pandian, V., *Ramraj, S., Aravindan, S., Natarajan, M., Azadi, S., et al. (2015). RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes. Oncotarget, 6(34), PMCID: PMC * Contributed Equally Khan, F. H., Pandian, V., Ramraj, S., Natarajan, M., Aravindan, S., Herman, T. S., & Aravindan, N. (2015). Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes. BMC Cancer, 15, 514. PMCID: PMC Khan, F. H., Pandian, V., Ramraj, S., Aravindan, S., Herman, T. S., & Aravindan, N. (2015). Reorganization of metastamirs in the evolution of metastatic aggressive neuroblastoma cells. BMC Genomics, 16(1), 501. PMCID: PMC

3 Aravindan, S., Ramraj, S., Somasundaram, S. T., & Aravindan, N. (2015). Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer. Journal of Biomedical Science, 22(1), 28. PMCID: PMC Aravindan, N., Aravindan, S., Pandian, V., Khan, F. H., Ramraj, S., Natt, P., & Natarajan, M. (2014). Acquired Tumor Cell Radiation Resistance at the Treatment Site Is Mediated Through Radiation-Orchestrated Intercellular Communication. International Journal of Radiation Oncology, Biology, Physics, 88(3), PMCID: PMC Ramraj, S., Kanmani, P., Yuvaraj, N., Paari, K.A., Pattukumar, V., & Arul, V. (2013) Traditional Indian fermented foods: a rich source of lactic acid bacteria. International Journal of Food Science & Nutrition. 64(4): PMID: Ramraj, S., Kanmani, P., Yuvaraj, N., Paari, K.A., Pattukumar, V., Thirunavukkarasu, C., & Arul, V. (2012) Lactobacillus plantarum AS1 isolated from south Indian fermented food Kallappam suppress 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in male Wistar rats. Applied Biochemistry & Biotechnology. 166(3): PMID: Ramraj, S., Kanmani, P., Yuvaraj, N., Paari, K.A., Pattukumar, V., & Arul, V. (2011) Lactobacillus plantarum AS1 binds to cultured human intestinal cell line HT-29 and inhibits cell attachment by enterovirulent bacterium Vibrio parahaemolyticus. Letters in Applied Microbiology. 53(4): PMID: Ramraj, S., Raghu Varman, D., Kanmani, P., Yuvaraj, N., Paari, K.A., Pattukumar, V., & Arul, V. (2010) Isolation, characterization and identification of a potential probiont from South Indian fermented foods (Kallappam, Koozh and Mor Kuzhambu) and its use as biopreservative. Probiotics and Antimicrobial Proteins. 2 (3): PMID: Complete List of Published Work in My Bibliography: 732/public Published Book Chapters Ramraj, S., Venkatesan, A., Health Benefits of Human Probiont Lactobacillus plantarum. Nutraceuticals and Functional Foods in Human Health and Disease Prevention, Edited by Debasis Bagchi, Harry G. Preuss, and Anand Swaroop, 10/2015: chapter 35: pages ; CRC Press., Taylor and Francis Groups ISBN:

4 Abstracts and Meeting Presentations Ramraj S, Pelikan R, Chandra V, Benbrook D. Synergistic combination of mortalintargeting and p53 reactivator drugs for ovarian cancer [Abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium 2018; 2018 Sept 13-15; Seattle, WA. Ramraj S, Pelikan P, Chandra V, Benbrook D. SHetA2 targets mortalin-p53 interaction in differential induction of apoptosis in ovarian cancer over normal cells. AACR Annual Meeting 2017, April 1-5, Washington DC. Ramraj S, Thavathiru E, Toal C, Smith C, Crouse E, Benbrook D. Targeting Mortalin-P53 Interaction In Differential Induction Of Apoptosis In Cancer Over Normal Cells. GREAT Symposium 2016, OUHSC. March, Ramraj S, Khan FH, Azim T and Aravindan N Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. 106th Annual Meeting of the American Association for Cancer Research; April 18-22, 2015, Philadelphia, PA. Khan FH, Pandian V, Ramraj S, Aravindan S, Herman TS, Natarajan M, Aravindan N Reorganization of metastamirs in the evolution of metastatic aggressive high-risk neuroblastoma. 106th Annual Meeting of the American Association for Cancer Research; April 18-22, 2015, Philadelphia, PA Aravindan N, Ramraj S, Khan FK, Aravindan S, Herman TS and Natarajan M Radiotherapy induction of MUC16 in -dependent self-maintenance of NFkB and repressed by tumor targeted delivery of EF24. 15th International Congress of Radiation Research, May 15-29, 2015, Kyoto, Japan. Khan FH, Ramraj S, Pandian V, Aravindan S, Herman TS, Natarajan M, Aravindan N Non-random genetic rearrangements driven highly malignant tumor-cell population dictates the development of high-risk neuroblastoma. 105th Annual Meeting of the American Association for Cancer Research; San Diego, CA. Ramraj S, Pandian V, Khan FH, Aravindan S, Herman TS, Natarajan M, Aravindan N. Profiling of circulating mirnas is a critical prognostic biomarker tool for high-risk neuroblastoma. 105th Annual Meeting of the American Association for Cancer Research; San Diego, CA. Pandian V, Khan FH, Ramraj S, Aravindan S, Natarajan M, Herman TS and Aravindan N. Molecular reprogramming in high-risk progressive neuroblastoma. 105th Annual Meeting of the American Association for Cancer Research; San Diego, CA Ramraj S, Natarajan M, Aravindan S, Herman TS, Aravindan N. EF24 targets radiationinduced NFkB dependent stemness in triple negative breast cancer cells. 36th Annual San Antonio Breast cancer symposium, 2013, San Antonio, Texas, USA.

5 Ramraj S, Aravindan N, Natarajan M, Pandian V, Khan F, Herman TS, Aravindan S: High polarity polyphenol fractions from brown algae target radiation-induced tumor invasion and metastasis in therapy-resistant residual pancreatic cancer. 60th Annual Meeting of Radiation Research Society., Las Vegas; 09/2014 Durbas M, Aravindan S, Natarajan M, Ramraj S, Pandian V, Khan F, Herman T, Aravindan N: Synthetic mono-ketone, EF24 affects autophagy in radio-resistant neuroblastoma cells. 60th Annual Meeting of the Radiation Research Society., Las Vegas, NV, USA; 09/2014 Natarajan M, Aravindan S, Khan F, Ramraj S, Herman T, Aravindan N: Nitric oxide mediated inhibition of NFkB arbitrates EF24-induced radio-sensitization in neuroblastoma tumor model. 60th Annual Meeting of the Radiation Research Society., Las Vegas, NV, USA; 09/2014 Khan F, Masilamani R, Ramraj S, Pandian V, Aravindan S, Natarajan M, Herman T, Aravindan N: Raspberry polyphenol targets cancer stem cells in residual pancreatic cancer after radiotherapy: A comprehensive In-vivo / Ex-vivo approach. 60th Annual Meeting of the Radiation Research Society, Las Vegas, NV`; 09/2014 Ramraj S, Caroline D, Aravindan S, Aravindan N. Anti-metastatic potential of sulfated polysaccharides from Turbinaria conoides in pancreatic cancer [Abstract]. SCC Cancer Research Symposium; 2013, Mar 29; Stephenson Cancer Center, Oklahoma city, OK Pandian V, Major R, Khan FH, Ramraj S, Natt P, and Aravindan N. Radiation-induced MMP9 maintains Rel signaling through second-signaling feedback via both Erk and IKK activation and endorses delayed invasion and metastasis of Neuroblastoma. Stephenson Cancer Center 2nd Annual Research Symposium. March 29, Oklahoma City, OK. Ramraj S, Pandian V, Khan FH, Natt P, Aravindan N. Diet derived polyphenol targets EMT and pluripotency maintenance transcriptome in pancreatic cancer stem cells. Stephenson Cancer Center 2nd Annual Research Symposium. March 29, Oklahoma City, OK. Khan FH, Ramraj S, Natt P, Pandian V, Aravindan N. Radiation induced TNF-α dependent second signaling Feedback associated post-translational nuclear-import of NFκB regulates tumor invasion/metastasis in human Neuroblastoma. Stephenson Cancer Center 2nd Annual Research Symposium. March 29, Oklahoma City, OK. Natt P, Khan FH, Pandian V, Ramraj S, and Aravindan N. Irreversible EGFR tyrosine kinase inhibitior, EKB-569 potentiates radiotherapy in tumor cell killing. Stephenson Cancer Center 2nd Annual Research Symposium. March 29, Oklahoma City, OK. Research Support Completed Indian Council of Medical Research (Ramraj-PI, Venkatesan-Mentor) 01/03/ /31/2012

6 Purification, Characterization and Large scale production of Novel bacteriocin from bacterial probiont isolated from the gut of the shrimp, fish and fermented food to use as human probiotic Ongoing Foundation for Women s Cancer (Ramraj-PI, Benbrook-Mentor) 04/01/ /31/2019 Synergistic combination of mortalin targeting and p53 reactivator drugs as a highly potent and safe treatment option for ovarian cancer Presbyterian Health Foundation (Gunderson-PI, Ramraj-Postdoc, Benbrook-Co-I) 07/01/ /30/2020 Mebendazole Therapy for Ovarian Cancer Treatment Independent Reviewer of Journals BMC Cancer PLOS One Oncotargets and therapy Journal of Translational Medicine Journal of Cancer Therapy Biomarkers in Cancer Japanese Clinical Medicine Cancer Science & Research: Open Access Journal of Cell Death International Journal of Cancer Scientific Organization Membership American Association of Cancer Research (AACR) : Associate member Radiation Research Society (RRS): Senior SIT member