The Occupational Cancer Research Program of the British Columbia Cancer Agency:

Transcription

1 The Occupational Cancer Research Program of the British Columbia Cancer Agency: UNIVERSITY OF ALBERTA, EDMONTON CLINICAL SCIENCES BUILDING 1

2 CARCINOEMBRYONIC ANTIGEN (CEA) Correlation suggested between CEA blood titers and degrees of sputum cytology abnormalities. 2

3 3

4 Occupational Cancer Research Program 1. Identify occupational cancer risk 2. Identify carcinogens in the workplace Occupational Cancer Research Program 1. Identify occupational cancer risk 2. Identify carcinogens in the workplace 4

5 CAUSE OF DEATH DEATH CERTIFICATE USUAL OCCUPATION ADDRESS AT DEATH CAUSE OF DEATH DEATH CERTIFICATE USUAL OCCUPATION ADDRESS AT DEATH 5

6 CAUSE OF DEATH DEATH CERTIFICATE USUAL OCCUPATION ADDRESS AT DEATH 6

7 BC CANCER REGISTRY PATHOLOGY REPORTS HOSPITAL PATIENT S NAME, SEX, AGE SITE, HISTOLOGY PHYSICIAN S NAME 7

8 8

9 FOLLOW UP POSTCARD REMINDER 2 nd week PHONE CALLS 4 th and 6 th week INCOMPLETE QUESTIONNAIRE Phone call QUESTIONNAIRES SENT AND RECEIVED REASONS FOR NOT RETURNING Number % Questionnaires Sent Received Not received Patient refusal Deceased or too ill Lost to follow up/other

10 PATIENTS CHARACTERISTICS Mean age SD Caucasian 96% Married 81% Education (mean years) Cigarette smoking 81.3% Alcohol consumption 86.9% TUMOR SITE DISTRIBUTION Colon, rectum, lung, nonmelanoma skin, prostate, bladder Stomach, melanoma skin, kidney, NHL Oral cavity/pharynx, brain larynx, testis, leukemia Esophagus, pancreas, soft tissue sarcoma, Hodgkin s, multiple myeloma 10

11 JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 11

12 12

13 Occupational Cancer Research Program 1. Identify occupational cancer risk factors 2. Identify carcinogens in the workplace JOB EXPOSURE MATRIX (JEM) Associates chemical and physical exposures to job titles in a given industry. Enables to pool in the analyses, all subjects with the same exposure. 13

14 JOB EXPOSURE MATRIX BC INDUSTRY BASED JEM HIERARCHICAL CODING SYSTEM 14

15 HIERARCHICAL CODING SYSTEM Chemicals coded according to structures and properties Substances grouped by chemical class and common constituents Allows analysis of individual, classes and broad groups of agents Increases statistical power by grouping chemicals with similar structural features Differentiates between compounds of similar structure, but different carcinogenic potential 15

16 CASE CONTROL STUDY OF PROSTATE CANCER Identify chemical substances associated with an increased prostate cancer risk. 16

17 CASE (prostate cancer) CONTROL (other cancer excluding lung and unknown primary) STUDY Cases Controls Total Studied* Farmers Linked to BC agricultural job exposure matrix *After excluding farmers who worked as farmers outside British Columbia. AGRICULTURE CHEMICALS SIGNIFICANTLY ASSOCIATED WITH A PROSTATE CANCER RISK Organophosphorus azinphos, diazinon, dimethoate, fenthion, malathion, parathion Organochlorine Aldrin, DDT, dicofol Carbamate: carbaryl Quinone: dichlone Triazine: simazine AGRICULTURE CHEMICALS SIGNIFICANTLY ASSOCIATED WITH A PROSTATE CANCER RISK Inorganic Thiazole Bipyridilium Other : copper sulphate, copper oxide : captan : paraquat : dichloropropane chinemethionat 17

18 The Occupational Cancer Research Program of the British Columbia Cancer Agency: PUBLICATIONS Book chapters 7 Peer reviewed publications 52 SUPPORT $ BC Worker s Compensation Board BC Health Research Foundation Health Canada (NHRDP) The Occupational Cancer Research Program of the British Columbia Cancer Agency: Director Band PR Statisticians Spinelli J, Coldman A, Le N Epidemiologists Gallagher R, Ward H, Deschamps, M Programmers Threlfall W, Ng V, Fang R Chemical engineers Grace J, Bert J, Anderson, J, Astrakianakis G, Keefe A Industrial hygienist Svirchev, L Research coordinators Moody J, Raynor D, Wong M, Kan D 18