Challenges in systemic treatment for metastatic bladder cancer. Phichai Chansriwong, MD Ramathibodi Hospital, Mahidol University
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1 Challenges in systemic treatment for metastatic bladder cancer Phichai Chansriwong, MD Ramathibodi Hospital, Mahidol University
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4 OS PCG 15.8 vs GC 12.7 NS
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8 Cisplatin ineligible
9 Second-line chemotherapy for muscle invasive bladder cancer: There are no definitive recommendations for second-line therapy Chemotherapy options may include drugs such as cisplatin, gemcitabine, pemetrexed, carboplatin, vinblastine, and bleomycin.
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11 OS 6.9 vs 4.6 months vinflunine
12 Unmet need: Chemotherapy For Advanced Stage stills has limit efficacy Median OS for untreated stage IV: 3-4 months Bladder cancer is a chemo-sensitive tumor ; However, Chemotherapy intervention results in prolongation of median OS to mo 3-year survival: 15-20%
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16 Large Immunotherapy Published Bladder Cancer Clinical Trials Presented By Andrea Apolo at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
17 Slide 4 Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
18 1 st line
19 2 nd line
20 New Treatment Options for Patients With <br />Advanced Metastatic Urothelial Carcinoma Presented By Andrea Apolo at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
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25 1 st line in cisplatin ineligible Atezolizumab as 1L Therapy in Cisplatin-Ineligible Locally Advanced/Metastatic Urothelial Carcinoma: IMvigor210 Cohort 1 Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
26 IMvigor210 Cohort 2: Study Design<br />Basis for Accelerated Approval Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
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28 Frontline Therapy for UC: Cis-Ineligible Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
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30 KEYNOTE-045 Study Design (NCT ) Presented By Joaquim Bellmunt at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
31 Assessments Presented By Joaquim Bellmunt at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
32 Overall Survival: Total Presented By Joaquim Bellmunt at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
33 Updated Efficacy From IMvigor210: <br />Atezolizumab in Platinum-Treated Locally Advanced/Metastatic Urothelial Carcinoma (muc) Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
34 IMvigor210 Cohort 2: Study Design<br />Basis for Accelerated Approval Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
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36 IMvigor 210 Safety<br />Summary Presented By Matthew Milowsky at 2017 Genitourinary Cancers Symposium
37 Keynote 045 Treatment-Related AEs Occurring in 10% of Patientsa Presented By Joaquim Bellmunt at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
38 AEs of Interest Occurring in 1 Patienta,b Presented By Joaquim Bellmunt at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
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40 Phase 3 IMvigor211 Study Design Presented By Andrea Apolo at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
41 Atezolizumab PD-L1 Assay:<br /> Presented By Andrea Apolo at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
42 IMvigor211: OS Analysis: IC2/3 Population Presented By Andrea Apolo at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
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44 Comparison of key parameters in the randomised phase III studies. Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
45 10.3
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48 OS by TMB Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
49 OS by TMB and PD-L1 Status Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
50 2 nd line
51 Take home massage Consensus statement for platinum refractory disease. Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
52 Consensus statement: front line therapy. Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
53 Summary: single agent immune therapy in platinum refractory disease. Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
54 Summary: single agent immune therapy in chemotherapy naïve patients. Presented By Thomas Powles at 2018 Genitourinary Cancers Symposium: Translating Evidence to Multidisciplinary Care
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Optimal sequencing in treatment muscle invasive bladder cancer : oncologists. Phichai Chansriwong, MD Ramathibodi Hospital, Mahidol University
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