Clinical Research Institute HUCH Sponsored, fully signed Clinical Trial Agreements (except grants)

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1 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the January x x January x NightstaRx Ltd A Randomised, Open Label, Outcomes-Assessor Masked, Prospective, Parallel Controlled Group, Phase 3 Clinical Trial Of Retinal Gene Therapy For Choroideremia Using An Adeno- Head and Neck Center Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1) January x Novartis Finland Oy An open-label, multi center, Phase IIIb study to assess the safety and efficacy of midostaurin (PKC412) in patients 18 years of age or older with newly-diagnosed FLT3-mutated Acute Myeloid Leukemia who are eligible for 7+3 or 5+2 chemotherapy January x Orion Pharmaceuticals Safety and Pharmacokinetics of ODM-208 in Patients with Metastatic Castration-resistance Prostate Cancer January x Insel Gruppe AG Solitaire with the intention for thrombectomy plus intravenous t-pa versus direct Solitaire stent-retriever thrombectomy in acute anterior circulation stroke (SWIFT DIRECT) Head and Neck Center February x Kyowa Kirin International X-Linked Hypophosphatemia Registry Children and Adolescents February x Essential Medical Inc. Post-Market Clinical Registry to Evaluate the Safety and Performance of MANTA Vascular Closure Device Under Real World Conditions in the European Union Heart and Lung Center February x x February x Dr. Falk Pharma GmbH Double-blind, randomized, placebo-controlled, phase III study comparing norursodeoxycholic acid capsules with placebo in the treatment of primary sclerosing cholangitis Abdominal Center

2 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the March x x March x Chordate Medical AB A clinical investigation of Kinetic Oscillation Stimulation by the Chordate System S101 in the treatment of Non Allergic Rhinitis (KOSNAR) Head and Neck Center March X Santen Ciclosporin 1 mg/ml eye drop emulsion (Ikervis ) for the treatment of severe keratitis in adult patients with dry eye disease, which has not improved despite treatment with tear substitutes: Clinical effectivness, tolerability and safety in a real world setting. Head and Neck Center March x x March x Alnylam Pharmaceuticals Inc. ALN-ASI-003 A Phase 3 Randomized, Double-blind, Placebocontrolled Multicenter with an Open-label Extension to Evaluate the Efficacy and Safety of Givosiran in Patients with Acute Hepatic Porphyrias Internal Medicine and Rehabilitation March x Insel Gruppe AG March x COMPASS Pathways Ltd. Early versus late initiation of direct oral anticoagulants in post-ischaemic stroke patients with atrial fibrillation (ELAN): an international, multicentre, randomised-conrolled, twoarm, assessor-blinded trial The safety and efficacy of Psilocybin in participants with treatment-resistant depression (P-TRD) Head and Neck Center Psychiatry Center

3 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the March x Incyte Corporation March x Boehringer-Ingelheim A randomized, double-blind, placebo-controlled phase 3 study of Itacitinib or placebo in combination with corticosteroids for the treatment of first-line acute graft versus-host disease (GRAVITAS-301) Safety, tolerability, and pharmacokinetics of multiple rising oral doses of BI in patients with idiopathic pulmonary fibrosis (IPF) on no background anti-fibrotic (Part 1) and safety and tolerability of BI on top of Nintedanib and Pirfenidone (Part 2)., Hematology HUCH Heart and lung Center April x x April x Celgene Corporation A PHASE 1 MULTICENTER, OPEN-LABEL STUDY TO ASSESS THE SAFETY, PHARMACOKINETICS AND PRELIMINARY EFFICACY OF CC IN COMBINATION WITH DEXAMETHASONE IN SUBJECTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA April x x May x Oulu Univeristy Assessment of brain dysfunction in intensive care patients by analyzing propofol-induced EEG changes Perioperative, Intensive Care an Pain Medicine May x x

4 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the May x Aarhus University Hospital/Institute of Clinical Medicine Aarhus University Hospital NOR-GRASPALL Single-Arm PK/PD and safety study of GRASPA for patients with hypersensitivity to PEG-Asparaginase, diagnosed with Ph(-) Acute Lymphoblastic Leukemia Children and Adolescents May x Bristol-Myers Squibb A Randomized, Double-Blind Phase 2/3 of Relatlimab Combined with Nivolumab versus Nivolumab in Participants with Previously Untreated Metastatic or Unresectable Melanoma May x Deciphera Pharmaceuticals, LLC A Phase 3, InterVentional, Double-Blind, Placebo Controlled to Assess the Safety and Efficacy of DCC-2618 In Patients with Advanced Gastrointestinal Stromal Tumors who have Received Treatment with Prior Anticancer Therapies May x Novo Nordisk Farma Oy Effect and safety of semaglutide 2.4 mg once-weekly in subjects with overweight or obesity Abdominal Center June x F Hoffmann-La Roche Limited A phase II, randomized, active-controlled, multi-center study comparing the efficacy and safety of targeted therapy or cancer Immunotherapy guided by genomic profiling versus platinum-based chemotherapy in patients with cancer of unknown primary site who have received three cycles of platinum doublet chemotherapy

5 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the June x F Hoffmann-La Roche Limited A phase III, randomized, double-blind, placebo-controlled, multicentre study of the efficacy and safety of atezolzumab plus chemotherapy for patients with early relapsing recurrent (inoperable locally advanced or metastatic) triple-negative breast cancer August x Celgene Corporation August x Sanofi A phase 2, single-arm, multi,cohort, multi-center trial to determine the efficacy and safety of JCAR017 in adult subjects with aggressive b-cell non-hodgkin lymphoma A Randomized, Double-blind, Placebo-controlled, Parallelgroup, Multicenter to Evaluate the Effects of SOtagLiflozin on Clinical Outcomes in HemOdynamIcally STable Patients with Type 2 Diabetes POST Worsening Heart Failure Emergency Care / Heart and Lung Center

6 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the

7 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the

8 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the

9 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the

10 , fully signed Clinical Trial Agreements (except grants) Sponsor Full name of the Hospital clinic where the is details of the