Breast Cancer Clinical Pathway Committee Development Meeting
|
|
- Martha Houston
- 6 years ago
- Views:
Transcription
1
2 Breast Cancer Clinical Pathway Committee Development Meeting
3 Agenda Start Time Topic 8:0 am 8:0 am Welcome, Introductions, and Objectives for the Session 8:0 am 8: am Value-based Care in Breast Cancer Treatment 8: am 8: am Welcome, Introductions, and Objectives for the Panelists 8: am 9:00 am Background and Experience of Panelists 9:00 am 9: am Current State of Breast Cancer 9: am 9: am Review of Current Treatments for Metastatic Breast Cancer 9: am 0:0 am Break 0:0 am 0: am Q&A Session 0: am 0:0 am Considerations During Pathway Development 0:0 am :0 am Pathway Development for First-line Metastatic Breast Cancer :0 am :0 am Pathway Development for Second-line Metastatic Breast Cancer :0 am :0 pm Wrapup: Breast Cancer Treatment Pathway and Q&A
4 Objectives Observe the development of a clinical pathway for breast cancer Gain an understanding of the steps involved in developing a clinical pathway Understand the variables factored into clinical pathway development Witness the dialogue and discussion involved in creating a clinical pathway
5 Simulation The exercise you are about to observe is a simulation of a pathway development process in breast cancer Clinical pathways are intended to streamline physician prescribing patterns to improve patient outcomes while also reducing the overall cost of care The steering committee for pathway generation involves clinicians with both breadth and depth of knowledge and experience with the particular cancer type, in this case, breast cancer This program is typically double-blinded, meaning the sponsor does not know the panel and the panel does not know the sponsor to ensure candid and honest feedback and discussion
6 Mock Pathway The mock pathway simulation was developed to increase transparency of the clinical pathway development process for interested stakeholders To remove any bias from the mock pathways steering committee clinical decision making, the programs have historically been double-blinded in which the steering committee members are blinded to the interested stakeholder and the stakeholder is blinded to the specifics of the participants This program is being recorded for the purposes of producing a final report, after which the recording will be destroyed It is the intent of this design to generate candid feedback regarding your opinions and experience
7 Value-based Care in Breast Cancer Treatment
8 Switch from Volume-based to Value-based Care: Improving Patient Health Outcomes while Reducing Cost Volume-based Value-based Fee-for-service reimbursement High quality not rewarded No shared financial risk Acute inpatient hospital focus IT investment incentives not seen by hospital Standalone care systems can thrive Regulatory actions impede hospital-physician collaboration Value = outcomes/cost Payment rewards population value: quality and efficiency Quality impacts reimbursement Partnerships with shared risk Increased patient severity IT utilization essential for population health management Scale increases in importance Realigned incentives, encouraged coordination Adapted from: American Hospital Association. Accessed August, 07.
9 Value-based Care Reimbursement APM = alternative payment model; MIPS = merit-based incentive payment system; QP = quality payment. The Society for Post-Acute and Long-Term Care Medicine Accessed August, 07.
10 Oncology Care Model (OCM) Improve health outcomes and produce higher quality and lower cost of oncology care through improvements in patient-centered comprehensive care Comprehensive coordinated cancer care Enhanced payments Quality improvement driven by data /7 access to care Patient navigation Improve care coordination Care management payment Episode based Performance based Application of meaningful and timely data
11 OCM Payment Model Medicare Fee-for- Service Payments Episodebased Payment Performancebased Payment Total Payment $60 per month per beneficiary for the 6-month period beginning with chemotherapy initiation Intended to finance care transformation requirements Based on the difference between the expected costs and the actual costs of an individual practice Practices must report on quality, communication, coordination, experience, and outcomes Must exceed minimum quality threshold to be eligible for payment
12 Welcome Panelists
13 Objectives Discuss current treatment guidelines for breast cancer Characterize how breast cancer pathways are adopted into clinical practices Identify the critical pieces of information that are used to develop the pathway and any gaps in information Determine the likelihood of pathway implementation Discuss the impact of cost on pathway Achieve consensus on a metastatic breast cancer systemic treatment pathway
14 Agenda Start Time Topic 8: am 8: am Welcome, Introductions, and Objectives for the Panelists 8: am 9:00 am Background and Experience of Panelists 9:00 am 9: am Current State of Breast Cancer 9: am 9: am Review of Current Treatments for Metastatic Breast Cancer 9: am 0:0 am Break 0:0 am 0: am Q&A Session 0: am 0:0 am Considerations During Pathway Development 0:0 am :0 am Pathway Development for First-line Metastatic Breast Cancer :0 am :0 am Pathway Development for Second-line Metastatic Breast Cancer :0 am :0 pm Wrapup: Breast Cancer Treatment Pathway and Q&A
15 Simulation The purpose of this exercise is to simulate a national payersponsored pathway development process in breast cancer Based on your experience, you have been selected as a network member to serve on the steering committee to create the pathway The sponsoring payer s intent is for this to be a cooperative pathway development process that takes into account efficacy, toxicity, cost, and quality The audience is interested in not only observing the academic process of pathway development, but also your insight regarding barriers and incentives for network provider pathway adoption
16 Mock Pathway The mock pathway simulation was developed to increase transparency of the clinical pathway development process for interested stakeholders To remove any bias from the mock pathways steering committee clinical decision making, the programs have historically been double-blinded, in which the steering committee members are blinded to the interested stakeholder and the stakeholder is blinded to the specifics of the participants This program is being recorded for the purposes of producing a final report, after which the recording will be destroyed It is the intent of this design to generate candid feedback regarding your opinions and experience
17 Introductions To be in accord with this design, please refrain from using personal or practice identifiers. Identify with first name, practice region, and practice category. What size is your practice? Solo practice, small practice (- physicians), medium practice (6-0 physicians), large practice (>0 physicians) In what region is your practice located? Northeast, Mid-Atlantic, Southeast, Southwest, Mountain, West What best describes your practice? Privately held group practice, IPA in partnership with a hospital, fully owned by a hospital, academic practice How many years have you been in practice?, 6-0, -, 6-0, How many unique patients with breast cancer do you actively manage in a typical week? Briefly, what has been your experience in developing clinical pathways in your practice and/or with payers?
18 Current State of Breast Cancer
19 Disease Overview % of women will be diagnosed with invasive breast cancer Only % of women with breast cancer have a family history of the disease and only %-0% are linked to known familial inherited gene mutations BRCA mutations are frequently associated with triple-negative breast cancers Breast cancer classifications: Subtype HR status HER status Prognosis Luminal A HR+ HER- Good Luminal B HR+ HER+ or HER- Intermediate/Poor HER type HR- HER+ or HER- Poor Basal-like/Triple-negative HR- HER- Poor HR = hormone receptor (estrogen-receptor and/or progesterone receptor). Accessed Sept., Accessed Sept., 07.
20 Breast Cancer: Incidence by Subtype 0% % % 7% HR+/HER- HR-/HER- HR+/HER+ HR-/HER+ Kohler BA, et al. J Natl Cancer Inst. 0;07(6):djv08. N = 78,
21 Treatment of Stage IV Breast Cancer HR+/HER+ Systemic disease or de novo stage IV Bone disease present Add bonemodifying agent Bone disease not present Molecular profiling HR+/HER- HR-/HER+ HR-/HER- NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks Accessed Sept., 07.
22 Breast Cancer: Survival by Subtype Gong Y, et al. Sci Rep. 07;7:. doi: 0.08/srep.
23 Part : Focus on Triple-negative Breast Cancer (TNBC)
24 NCCN Guidelines: Adjuvant Therapy for HER- Disease Preferred Regimens Dose Dense AC (doxorubicin/cyclophosphamide) followed by weekly paclitaxel Dose Dense AC (doxorubicin/cyclophosphamide) followed by paclitaxel every weeks TC (docetaxel and cyclophosphamide) Other Regimens Dose Dense AC (doxorubicin/cyclophosphamide) AC (doxorubicin/cyclophosphamide) CMF (cyclophosphamide/methotrexate/fluorouracil) AC followed by docetaxel every weeks AC followed by weekly paclitaxel EC (epirubicin/cyclophosphamide) TAC (docetaxel/doxorubicin/cyclophosphamide) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks.07.
25 GeparSixto Trial: Addition of Carboplatin to Neoadjuvant Therapy for Early TNBC Stage II-III triplenegative breast cancer Previously untreated Non-metastatic N=9 Randomize : carboplatin AUC min/ml weekly + paclitaxel 80 mg/m once per week non-pegylated liposomal doxorubicin 0 mg/m once per week bevacizumab mg/kg IV every weeks paclitaxel 80 mg/m once per week non-pegylated liposomal doxorubicin 0 mg/m once per week bevacizumab mg/kg IV every weeks Von Minckwitz G, et al, Lancet Oncol. 0;(7):77-76.
26 GeparSixto Trial: Secondary Analysis of BRCA Germline Mutation Cohort Plus Carboplatin (n=6) Noncarboplatin (n=) pcr 7% % BRCA / mutation cohort BRCA / mutation (n=0) 8% 7% pcr 66% 67% No BRCA / mutation cohort pcr % 6% Hahnen E, et al, JAMA Oncol. 07 Jul. doi: 0.00/jamaoncol [Epub ahead of print]
27 NCCN Guidelines: Treatment of mtnbc ER-, PR- and HER- (mtnbc) Chemotherapy NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks.07.
28 Recently-approved Breast Cancer Therapies Therapy Approval Date Kisqali (ribociclib) /07 Ibrance (palbociclib) /0 Kadcyla (ado-trastuzumab emtansine) /0 Afinitor (everolimus) 7/0 Perjeta (pertuzumab injection) 6/0 (None approved for TNBC)
29 NCCN Guidelines: Recurrent or Metastatic Breast Cancer for HER- Disease Preferred Single Agents Doxorubicin Pegylated liposomal doxorubicin Paclitaxel Capecitabine Gemcitabine Vinorelbine Eribulin Other Single Agents Cyclophosphamide Carboplatin Docetaxel Albumin-bound paclitaxel Cisplatin Epirubicin Ixabepilone Combinations CAF/FAC (cyclophosphamide/doxorubicin/fluorouracil) FEC (fluorouracil/epirubicin/cyclophosphamide) AC (doxorubicin/cyclophosphamide) EC (epirubicin/cyclophosphamide) CMF (cyclophosphamide/methotrexate/fluorouracil) Docetaxel/capecitabine GT (gemcitabine/paclitaxel) Gemcitabine/carboplatin Paclitaxel/bevacizumab NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks.07.
30 NCCN Evidence Blocks Value Measures Visual representation of value based on key measures: (E) Efficacy of Regimen/Agent o Highly effective to palliative (S) Safety of Regimen/Agent o No meaningful toxicity to highly toxic (Q) Quality of Evidence o High-quality evidence to poor-quality/no evidence (C) Consistency of Evidence o Highly consistent (multiple trials) to anecdotal evidence only (A) Affordability of Regimen/Agent (includes drug cost, supportive care, infusions, toxicity monitoring, management of toxicity) o Very inexpensive to very expensive Score of - for each category with being the least favorable and the most favorable, determined by NCCN panel members based on their knowledge and clinical experience Accessed August, 07.
31 NCCN Evidence Blocks (Categories & Definitions) Efficacy of Regimen/Agent Highly effective: Cure likely and often provides long-term survival advantage Very effective: Cure unlikely but sometimes provides long-term survival advantage Moderately effective: Modest impact on survival, but often provides control of disease Minimally effective: No, or unknown impact on survival, but sometimes provides control of disease Palliative: Provides symptomatic benefit only Safety of Regimen/Agent Usually no meaningful toxicity: Uncommon or minimal toxicities; no interference with activities of daily living (ADLs) Occasionally toxic: Rare significant toxicities or low-grade toxicities only; little interference with ADLs Mildly toxic: Mild toxicity that interferes with ADLs E = Efficacy of Regimen/Agent S = Safety of Regimen/Agent Q = Quality of Evidence C = Consistency of Evidence A = Affordability of Regimen/Agent Moderately toxic: Significant toxicities often occur but life threatening/fatal toxicity is uncommon; interference with ADLs is frequent Highly toxic: Significant toxicities or life threatening/fatal toxicity occurs often; interference with ADLs is usual and severe Quality of Evidence High quality: Multiple well-designed randomized trials and/or meta-analyses Good quality: One or more well-designed randomized trials Average quality: Low quality randomized trial(s) or well-designed nonrandomized trial(s) Low quality: Case reports or extensive clinical experience Poor quality: Little or no evidence Consistency of Evidence Highly consistent: Multiple trials with similar outcomes Mainly consistent: Multiple trials with some variability in outcome May be consistent: Few trials or only trials with few patients, whether randomized or not, with some variability in outcome Inconsistent: Meaningful differences in direction of outcome between quality trials Anecdotal evidence only: Evidence in humans based upon anecdotal experience Affordability of Regimen/Agent (includes drug cost, supportive care, infusions, toxicity monitoring, management of toxicity) Very inexpensive Inexpensive Moderately expensive Expensive Very expensive Example Evidence Block E = S = Q = C = A =. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks.07.
32 NCCN Guidelines: Recurrent or Metastatic Breast Cancer for HER- Disease Preferred Single Agents Doxorubicin Pegylated Liposomal Doxorubicin Paclitaxel Capecitabine Gemcitabine Vinorelbine Eribulin A = Affordability of Regimen/Agent; C = Consistency of Evidence; E = Efficacy of Regimen/Agent; Q = Quality of Evidence, S = Safety of Regimen/Agent.
33 NCCN Guidelines: Recurrent or Metastatic Breast Cancer for HER- Disease Cyclophosphamide Carboplatin Docetaxel Other Single Agents Cisplatin Epirubicin Ixabepilone A = Affordability of Regimen/Agent; C = Consistency of Evidence; E = Efficacy of Regimen/Agent; Q = Quality of Evidence, S = Safety of Regimen/Agent. Albumin-bound paclitaxel
34 NCCN Guidelines: Recurrent or Metastatic Breast Cancer for HER- Disease CAF/FAC (cyclophosphamide/ doxorubicin/ fluorouracil) Docetaxel/ Capecitabine FEC (fluorouracil/ epirubicin/ cyclophosphamide) Combinations AC (doxorubicin/ cyclophosphamide) GT (gemcitabine/ paclitaxel) EC (epirubicin/ cyclophosphamide) Gemcitabine/ Carboplatin A = Affordability of Regimen/Agent; C = Consistency of Evidence; E = Efficacy of Regimen/Agent; Q = Quality of Evidence, S = Safety of Regimen/Agent. CMF (cyclophosphamide/ methotrexate/ fluorouracil) Paclitaxel/ Bevacizumab
35 Break
36 Q&A Session
37 Welcome Back Panelists
38 Considerations During Pathway Development
39 Pathway Development Collaboration between payer and provider: Develop pathway based on currently available treatments Discuss what factors are associated with treatment preferences and inclusion/exclusion (eg, efficacy, safety, practice economics, patient burden, MOA, disease characteristics, etc) Facilitate participating physician consensus using the highest level of evidence Intent to define minimum regimens to cover 80% of eligible patients
40 Pathway Development (Cont d) Collaboration between payer and provider: Allow room for individualized medicine and physician discretion for best clinical practice Provide an efficient means of measuring and communicating compliance Identify potential issues with pathway adoption/compliance overall and with specific therapies Provide incentive for compliance, creating a win-win-win scenario for patients, physicians, and the payer All pathways validated by external sources such as ASCO, NCCN, etc ASCO = American Society of Clinical Oncology.
41 The Golden Rules Choice of treatment should always be guided by efficacy if clinically relevant If efficacy between therapeutic alternatives is equal, then toxicity might drive choice When efficacy and toxicity are similar among regimens, economics should drive utilization
42 General Rules of Pathways A clinical trial is always compliant and the preferred therapy when available Palliative care and hospice are reasonable at any time for the appropriate patient It is expected and is good clinical medicine for up to 0% of patients to be treated off pathways The treatment provided should be consistent with the intent of the pathway
43 Pathway Development for Metastatic Triple-negative Breast Cancer
44 Pathway Creation First-line mtnbc What are the most important parameters that you consider for patients with mtnbc? Overall survival PFS Response rate Time to response Duration of response Depth of response Toxicity Symptom relief Sites of metastases Other mtnbc = metastatic triple-negative breast cancer; PFS = progression-free survival.
45 Pathway Creation First-line mtnbc (Cont d) What is the role of sequential single-agent versus combination chemotherapy? What is the impact of adjuvant therapy selection on choice for metastatic treatment? What is the impact of adjuvant therapy response on choice for metastatic treatment? mtnbc = metastatic triple-negative breast cancer.
46 NCCN Guidelines: Recurrent or Metastatic Breast Cancer for HER- Disease Preferred Single Agents Doxorubicin Pegylated liposomal doxorubicin Paclitaxel Capecitabine Gemcitabine Vinorelbine Eribulin Other Single Agents Cyclophosphamide Carboplatin Docetaxel Albumin-bound paclitaxel Cisplatin Epirubicin Ixabepilone Combinations CAF/FAC (cyclophosphamide/doxorubicin/fluorouracil) FEC (fluorouracil/epirubicin/cyclophosphamide) AC (doxorubicin/cyclophosphamide) EC (epirubicin/cyclophosphamide) CMF (cyclophosphamide/methotrexate/fluorouracil) Docetaxel/capecitabine GT (gemcitabine/paclitaxel) Gemcitabine/carboplatin Paclitaxel/bevacizumab NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ). Breast Cancer NCCN Evidence Blocks.07.
47 Pathway Creation Second-line mtnbc What is the impact of response to first-line therapy? What is the impact of tolerance to first-line therapy? What is the impact of sites of metastases? What is the impact of performance status? What is the role of sequential single-agent vs combination chemotherapy?
48 Wrapup: Breast Cancer Treatment Pathway
49 Questions?
COME HOME Innovative Oncology Business Solutions, Inc.
Innovative Oncology Business Solutions, Inc. Breast Cancer Diagnostic/Therapeutic Pathway V11, April 2015 Required Structured Data Fields: ICD9 Code Stage Staging Components Performance Status Treatment
More informationTriple Negative Breast Cancer: Part 2 A Medical Update
Triple Negative Breast Cancer: Part 2 A Medical Update April 29, 2015 Tiffany A. Traina, MD Breast Medicine Service Memorial Sloan Kettering Cancer Center Weill Cornell Medical College Overview What is
More informationAppendix 2. Adjuvant Regimens. AC doxorubin 60 mg/m 2 every 3 weeks x 4 cycles Cyclophosphamide 600 mg/m 2
Appendix 2 Adjuvant Regimens AC doxorubin 60 mg/m 2 every 3 weeks x 4 cycles Cyclophosphamide 600 mg/m 2 CMF IV cyclophosphamide 600 mg/m 2 days 1 & 8 every 4 weeks methotrexate 40 mg/m 2 for 6 cycles
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Herceptin) Reference Number: ERX.SPA.42 Effective Date: 07.01.16 Last Review Date: 05/17 Line of Business: Commercial [Prescription Drug Plan] Revision Log See Important Reminder at the
More informationSYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
SYSTEMIC TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Sunil Shrestha 1*, Ji Yuan Yang, Li Shuang and Deepika Dhakal Clinical School of Medicine, Yangtze University, Jingzhou, Hubei Province, PR. China Department
More informationClinical Research on PARP Inhibitors and Triple-Negative Breast Cancer (TNBC)
Clinical Research on PARP Inhibitors and Triple-Negative Breast Cancer (TNBC) Eric P Winer, MD Disclosures for Eric P Winer, MD No real or apparent conflicts of interest to disclose Key Topics: PARP and
More informationRegimens highlighted in red contain an expensive drug that is not currently publicly funded for the regimen and treatment intent.
Palliative Breast Cancer Regimens The following table lists the evidence-informed regimens (both IV and non-iv) for breast cancer used in the palliative setting. It is expected that the prescribing oncologist
More informationDisease Update: Metastatic Breast Cancer
Disease Update: Metastatic Breast Cancer Aimee Faso, PharmD, BCOP, CPP Oncology Clinical Specialist, GI/Breast UNC Hospitals and Clinics August 2015 Objectives Identify treatment choices of metastatic
More informationPerjeta (pertuzumab)
Perjeta (pertuzumab) Line(s) of Business: HMO; PPO; QUEST Integration Medicare Advantage Original Effective Date: 10/01/2015 Current Effective Date: 01/01/201809/16/2018 POLICY A. INDICATIONS The indications
More information亞東紀念醫院 Breast Cancer 化學治療處方集
亞東紀念醫院 Breast Cancer 化學治療處方集 2008-08 制定 最近修改日期 :2015-01 CMF Breast cancer 化學治療處方參考集 Adjuvant Classic CMF Cyclophosphamide 100mg/m2 PO qd; D1-D14 Methotrexate 40mg/m 2 in N/S 100 ml IV drip 30 mins; D1,
More informationAdjuvant Systemic Therapy in Early Stage Breast Cancer
Adjuvant Systemic Therapy in Early Stage Breast Cancer Julie R. Gralow, M.D. Director, Breast Medical Oncology Jill Bennett Endowed Professor of Breast Cancer Professor, Global Health University of Washington
More informationSupplementary appendix
Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Cortazar P, Zhang L, Untch M, et al. Pathological
More informationNeoadjuvantTreatment In BC When, How, Who?
NeoadjuvantTreatment In BC When, How, Who? Clifford Hudis, M.D. Chief, Breast Cancer Medicine Service, MSKCC Professor of Medicine, Weill Cornell Medical College President, ASCO 15 Potential Benefits Of
More informationTriple Negative Breast cancer New treatment options arenowhere?
Triple Negative Breast cancer New treatment options arenowhere? Ofer Rotem, M.D., B.Sc. Breast Unit, Davidoff center Rabin Medical center October 2017 Case 6/2013 - M.D., 38 years old woman, healthy, no
More informationAdvances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings. Eve Rodler, MD University of California at Davis October 2016
Advances in Breast Cancer Therapeutics in the Adjuvant and Metastatic Settings Eve Rodler, MD University of California at Davis October 2016 17th Annual Advances in Oncology September 30-October 1, 2016
More informationClinical Pathways in the Oncology Care Model
Clinical Pathways in the Oncology Care Model Centers for Medicare & Medicaid Services Innovation Center (CMMI) Andrew York, PharmD, JD Faculty Andrew York, PharmD, JD Social Science Research Analyst Patient
More informationChapter. Contents Breast Cancer Adjuvant Epirubicin weekly. Docetaxel Copy No:
Chapter 2: Breast Cancer Contents Chapter 2: Breast Cancer... 1 Breast Cancer... 2 Adjuvant...... 2 Epi-CMF... 2 FEC / docetaxel... 3 FEC100... 4 AC/EC/TC... 4 (neo) adjuvant... 5... 5 HER2 positive: TCarboH...
More informationOUTLINE PAST PRESENTFUTURE BREAST CANCER INCIDENCE AND MORTALITY CURRENT STATE OF MEDICAL ONCOLOGY SECOND ANNUAL BREAST CANCER SYMPOSIUM
OUTLINE CURRENT STATE OF MEDICAL ONCOLOGY SECOND ANNUAL BREAST CANCER SYMPOSIUM October 11, 2014 SARA M GARRIDO, M.D., F.A.C.P Chief Medical Officer at AMS Miami, October 11, 2014 PAST PRESENTFUTURE -BRIEF
More informationNational Horizon Scanning Centre. Bevacizumab (Avastin) in combination with non-taxanes for metastatic breast cancer - first line therapy
Bevacizumab (Avastin) in combination with non-taxanes for metastatic breast cancer - first line therapy December 2007 This technology summary is based on information available at the time of research and
More informationEvolving Insights into Adjuvant Chemotherapy. Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology
Evolving Insights into Adjuvant Chemotherapy Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology 80 70 60 50 40 30 20 10 0 EBCTCG 2005/6 Overview Control Arms with No Systemic
More informationTNBC: Current Challenge and Perspectives. Henry L Gomez MD, PhD
TNBC: Current Challenge and Perspectives Henry L Gomez MD, PhD What Is a Triple-Negative Breast Cancer (TNBC)? Triple negative : ER negative, PgR negative, HER2 negative Depending on thresholds used
More informationConsiderations in Adjuvant Chemotherapy. Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology
Considerations in Adjuvant Chemotherapy Joyce O Shaughnessy, MD Baylor Sammons Cancer Center Texas Oncology US Oncology 80 70 60 50 40 30 20 10 0 EBCTCG 2005/6 Overview Control Arms with No Systemic Treatment
More informationNadia Harbeck Breast Center University of Cologne, Germany
Evidence in Favor of Taxane Based Combinations and No Anthracycline in Adjuvant and Metastatic Settings Nadia Harbeck Breast Center University of Cologne, Germany Evidence in Favor of Taxane Based Combinations
More informationChemotherapy With or Without Targeted Drugs* in Metastatic Breast Cancer
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Chemotherapy With or Without Targeted Drugs* in Metastatic Breast Cancer * Substances without published evidence based on at
More informationMetastatic Breast Cancer What is new? Subtypes and variation?
Metastatic Breast Cancer What is new? Subtypes and variation? Anne Blaes, MD, MS University of Minnesota, Division of Hematology/Oncology Director, Adult Cancer Survivor Program Current estimates for metastatic
More informationFirst draft submitted: 12 April 2017; Accepted for publication: 1 September 2017; Published online: 5 January 2018
For reprint orders, please contact: reprints@futuremedicine.com Outcomes research examining treatments, quality of life and costs in HER2-negative and triple-negative metastatic breast cancer: a systematic
More informationDR LUIS MANSO UNIDAD TUMORES DE MAMA Y GINECOLÓGICOS HOSPITAL 12 DE OCTUBRE MADRID
DR LUIS MANSO UNIDAD TUMORES DE MAMA Y GINECOLÓGICOS HOSPITAL 12 DE OCTUBRE MADRID RESUMEN DE ARTICULOS THERESA BOLERO 3 NOAH UP-DATE GEPAR SIXTO RADIOTHERAPY EBCTCG CTCs MISCELANEAS Lancet Oncol 2014;
More informationPRO: Pathologic Complete Response Does Predict Outcome for Early Stage Breast Cancer Patients
PRO: Pathologic Complete Response Does Predict Outcome for Early Stage Breast Cancer Patients Amelia B. Zelnak, M.D., M.Sc. Assistant Professor of Hematology and Medical Oncology Winship Cancer Institute
More informationSystemic Therapy Considerations in Inflammatory Breast Cancer
Systemic Therapy Considerations in Inflammatory Breast Cancer Shani Paluch-Shimon, MBBS, MSc Director, Breast Oncology Unit Shaare Zedek Medical Centre, Jerusalem Israel Disclosures Roche: Speakers bureau,
More informationSystemic Therapy for Locally Advanced Breast Cancer
Systemic Therapy for Locally Advanced Breast Cancer Soo-Chin Lee Head & Senior Consultant Department of Haematology-Oncology National University Cancer Institute, Singapore Clinical Care Senior Principal
More informationAdvances in the Management. of Breast Cancer
reviews therapy Advances in the Management of Breast Cancer by Rowan T. Chlebowski, MD, PhD, Professor of Medicine, University of California, Los Angeles School of Medicine; Chief, Division of Medical
More informationDieta Brandsma, Department of Neuro-oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
What is hot in breast cancer brain metastases? Dieta Brandsma, Department of Neuro-oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands 8th Annual Brain Metastases Research and Emerging Therapy
More informationBreast Cancer Breast Managed Clinical Network
Initial Evaluation Clinical Stage Pre-Treatment Evaluation Treatment and pathological stage Less than 4 positive lymph nodes Adjuvant Treatment ER Positive HER2 Negative (see page 2 & 3 ) HER2 Positive
More informationReview of adjuvant and neo-adjuvant abstracts from SABCS 2011 January 7 th 2012
Review of adjuvant and neo-adjuvant abstracts from SABCS 2011 January 7 th 2012 Ruth M. O Regan, MD Professor and Vice-Chair for Educational Affairs, Department of Hematology and Medical Oncology, Emory
More informationInterviews are based on data presented at the 2012 American Society of Clinical Oncology Annual Meeting, June 1-5, 2012, Chicago, Illinois* *PeerVoice is an independent publisher of conference news and
More informationBREAST CANCER (RECURRENT OR METASTATIC) TREATMENT REGIMENS (Part 1 of 5)
BREAST CANCER (RECURRENT METASTATIC) TREATMENT S (Part 1 of 5) Clinical Trials: The NCCN recommends cancer patient participation in clinical trials as the gold standard for treatment. Cancer therapy selection,
More information新竹馬偕紀念醫院癌症中心 乳癌化學治療藥物處方
新竹馬偕紀念醫院癌症中心 乳癌化學治療藥物處方 文件修訂記錄 修正次數 修正日期 修正版別 修 改 內 容 1 2011.04.07 1.0 初次訂定 2 2013.05.08 2.0 修訂 3 2013.04.30 3.0 修訂 :Triple-Negative Breast Cancer 處方 新增 :Neoadjuvant-p7~8 4 2014.04.29 4.0 修訂 :FEC + Trastuzumab
More informationthat the best available evidence has not demonstrated that pcr can predict long-term outcomes in the neoadjuvant setting.
pcr in one arm of a randomized clinical trial comparing two neoadjuvant chemotherapies predicts for improved event-free or overall survival in that arm of the clinical trial. perc noted that the NeoALTTO
More informationThe Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now?
1 The Role of Pathologic Complete Response (pcr) as a Surrogate Marker for Outcomes in Breast Cancer: Where Are We Now? Terry Mamounas, M.D., M.P.H., F.A.C.S. Medical Director, Comprehensive Breast Program
More informationTreatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic Therapy
Women s Empowerment Cancer Advocacy Network (WE CAN) Conference Bucharest, Romania October 2015 Treatment Options for Breast Cancer in Low- and Middle-Income Countries: Adjuvant and Metastatic Systemic
More informationWELLPOINT RESPONDS TO ANCO s COMMENTS
WELLPOINT RESPONDS TO ANCO s COMMENTS Thank you again for taking the time to meet with us to learn about Anthem s Cancer Care Quality Program and the Wellpoint Cancer Treatment Pathways as well as your
More informationRole of chemotherapy in BRCA and Triple negative breast cancer. Fernando Moreno Servicio de Oncología Médica Hospital Clinico San Carlos
Role of chemotherapy in BRCA and Triple negative breast cancer Fernando Moreno Servicio de Oncología Médica Hospital Clinico San Carlos Association between TNBC & germline mutations in BRCA 1/2 TNBC is
More informationBreast : ASCO Abstracts for Review
Breast : ASCO 2011 Susana Campos, MD, MPH Dana Farber Cancer Institute Abstracts for Review Prevention Neoadjuvant Metastatic Brain mets LBA 504: Exemestane for primary prevention of breast cancer in postmenopausal
More informationRecent Progress in Metastatic Breast Cancer:
Recent Progress in Metastatic Breast Cancer: Focus on Cytotoxic Therapy A CME-CERTIFIED ACTIVITY Medical Experts: Mohammad Jahanzeb, MD Medical Oncologist Professor of Clinical Medicine, Hematology-Oncology
More informationTRANSPARENCY COMMITTEE OPINION. 15 February 2006
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 15 February 2006 Taxotere 20 mg, concentrate and solvent for solution for infusion B/1 vial of Taxotere and 1 vial
More informationCorporate Medical Policy
Corporate Medical Policy Ado-Trastuzumab Emtansine (Trastuzumab-DM1) for Treatment of File Name: Origination: Last CAP Review: Next CAP Review: Last Review: ado_trastuzumab_emtansine_(trastuzumab-dm1)_for_treatment_of_her-2_positivemalignancies
More informationClinical Management Guideline for Breast Cancer
Initial Evaluation Clinical Stage Pre-Treatment Evaluation Treatment and pathological stage Adjuvant Treatment Less than 4 positive lymph nodes ER Positive HER2 Negative (see page 2 & 3 ) Primary Diagnosis:
More informationTRANSPARENCY COMMITTEE OPINION. 29 April 2009
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 29 April 2009 NAVELBINE 20 mg, soft capsules B/1 (CIP: 365 948-4) NAVELBINE 30 mg, soft capsules B/1 (CIP: 365 949-0)
More informationNational Horizon Scanning Centre. Sunitinib (Sutent) for advanced and/or metastatic breast cancer. December 2007
Sunitinib (Sutent) for advanced and/or metastatic breast cancer December 2007 This technology summary is based on information available at the time of research and a limited literature search. It is not
More informationHorizon Scanning Centre November Vinflunine (Javlor) monotherapy for advanced breast cancer SUMMARY NIHR HSC ID: 7887
Horizon Scanning Centre November 2012 Vinflunine (Javlor) monotherapy for advanced breast cancer SUMMARY NIHR HSC ID: 7887 This briefing is based on information available at the time of research and a
More information10/15/2012. Inflammatory Breast Cancer vs. LABC: Different Biology yet Subtypes Exist
Triple-Negative Breast Cancer: Optimizing Treatment for Locally Advanced Breast Cancer Beth Overmoyer MD Director, Inflammatory Breast Cancer Program Dana Farber Cancer Institute Overview Inflammatory
More informationMedical Therapies in Ovarian Cancer The Arabic Perspectives. Mezghani Bassem -Tunisia
Tunisian Health System: Social Welfare with a Public insurance for all citizens including Indigent persons. (± Additional private insurance) Choice: Public Hospital/Private Clinics (Indigents Public H)
More informationSeptember 2017 A LOOK AT PARP INHIBITORS FOR OVARIAN CANCER. Drugs Under Review. ICER Evidence Ratings. Other Benefits. Value-Based Price Benchmarks
September 2017 Drugs Under Review ICER s report reviewed the clinical effectiveness and value of olaparib (Lynparza, AstraZeneca), rucaparib (Rubraca, Clovis Oncology), and niraparib (Zejula, Tesaro),as
More informationAGO e. V. in der DGGG e.v. sowie in der DKG e.v.
AGO e. V. in der DGGG e.v. sowie in der DKG e.v. Guidelines Breast Version 2015.1 www.ago-online.de Disease-Free and Overall Survival in Metastatic Breast Cancer AGO e. V. in der DGGG e.v. sowie in der
More informationCancer du sein métastatique et amélioration de la survie Pr. X. Pivot
Cancer du sein métastatique et amélioration de la survie Pr. X. Pivot Date of preparation: November 2015. EU0250i TTP/PFS Comparaisons First line metastatic breast cancer Monotherapy Docetaxel Chan 1999
More informationLocally Advanced Breast Cancer: Systemic and Local Therapy
Locally Advanced Breast Cancer: Systemic and Local Therapy Joseph A. Sparano, MD Professor of Medicine & Women s Health Albert Einstein College of Medicine Associate Chairman, Department of Oncology Montefiore
More informationDR. BOMAN N. DHABHAR Consulting Oncologist Jaslok Hospital, Fortis Hospital Mulund, Wockhardt Hospital Mumbai & BND Onco Centre INDIA
Recent Advances of Docetaxel in Management of Breast Cancer DR. BOMAN N. DHABHAR Consulting Oncologist Jaslok Hospital, Fortis Hospital Mulund, Wockhardt Hospital Mumbai & BND Onco Centre INDIA 1 ADJUVANT
More informationEvolving Practices in Breast Cancer Management
Evolving Practices in Breast Cancer Management The Georgia Tumor Registrars Association 2016 Priscilla R. Strom, MD, FACS Objectives 1. understand newer indications for neoadjuvant treatment 2. understand
More informationTerapia sistemica neoadiuvante: in quali tumori? Quali risultati? Dott. Giacomo Pelizzari
Terapia sistemica neoadiuvante: in quali tumori? Quali risultati? Dott. Giacomo Pelizzari Neoadjuvant Treatment A window of opportunity Rational: Historically proposed to enable breast-conserving surgery
More informationWhen is Chemotherapy indicated in Advanced Luminal Breast Cancer?
When is Chemotherapy indicated in Advanced Luminal Breast Cancer? Soo-Chin Lee Head & Senior Consultant Department of Haematology-Oncology Clinical Care National University Cancer Institute, Singapore
More informationTreatment of Early-Stage HER2+ Breast Cancer
Treatment of Early-Stage HER2+ Breast Cancer Chau T. Dang, MD Chief, MSK Westchester Medical Oncology Service Breast Medicine Service Memorial Sloan Kettering Cancer Center Disclosures I have research
More informationNEOADJUVANT THERAPY FOR BREAST CANCER: LOCAL EXPERT OPINION AND RECENT EVIDENCE
NEOADJUVANT THERAPY FOR BREAST CANCER: LOCAL EXPERT OPINION AND RECENT EVIDENCE Dr. Joanne Chiu Medical Oncology Queen Mary Hospital The University of Hong Kong HONG KONG SURVEY FOR NEOADJUVANT THERAPY
More informationImmunotherapy for Breast Cancer. Aurelio B. Castrellon Medical Oncology Memorial Healthcare System
Immunotherapy for Breast Cancer Aurelio B. Castrellon Medical Oncology Memorial Healthcare System Conflicts Research support : Cascadian therapeutics, Puma biotechnology, Odonate therapeutics, Pfizer,
More informationNon-Anthracycline Adjuvant Therapy: When to Use?
Northwestern University Feinberg School of Medicine Non-Anthracycline Adjuvant Therapy: When to Use? William J. Gradishar MD Betsy Bramsen Professor of Breast Oncology Director, Maggie Daley Center for
More informationTriple Negative Breast Cancer
GASCO 2016 San Antonio Breast Cancer Symposium Review Triple Negative Breast Cancer Amelia Zelnak, MD, MSc Atlanta Cancer Care Northside Hospital Cancer Institute Disclosures: consultant for Novartis,
More informationAdjuvant Chemotherapy + Trastuzumab
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer Adjuvant Chemotherapy + Trastuzumab (Optimal Drugs / Dosage / Trastuzumab) Adjuvant Chemotherapy (Optimal Drugs / Optimal Dosage
More informationAdvances in chemotherapy for HER2-negative metastatic breast cancer
Review Article Page 1 of 5 Advances in chemotherapy for HER2-negative metastatic breast cancer Hirofumi Mukai, Mayuko Ito Department of Breast and Medical Oncology, National Cancer Center Hospital East,
More informationPostoperative Adjuvant Chemotherapies. Stefan Aebi Luzerner Kantonsspital
Postoperative Adjuvant Chemotherapies Stefan Aebi Luzerner Kantonsspital stefan.aebi@onkologie.ch Does Chemotherapy Work in Older Patients? ER : Chemotherapy vs nil Age
More informationClinical Policy: Pertuzumab (Perjeta) Reference Number: ERX.SPMN.94
Clinical Policy: (Perjeta) Reference Number: ERX.SPMN.94 Effective Date: 07/16 Last Review Date: 06/16 Coding Implications Revision Log See Important Reminder at the end of this policy for important regulatory
More informationNational Horizon Scanning Centre. Aflibercept (VEGF Trap) for advanced chemo-refractory epithelial ovarian cancer. December 2007
Aflibercept (VEGF Trap) for advanced chemo-refractory epithelial ovarian cancer December 2007 This technology summary is based on information available at the time of research and a limited literature
More informationCorporate Medical Policy
Corporate Medical Policy Pertuzumab for Treatment of Malignancies File Name: Origination: Last CAP Review: Next CAP Review: Last Review: pertuzumab_for_treatment_of_malignancies 2/2013 4/2017 4/2018 6/2017
More informationContemporary Chemotherapy-Based Strategies for First-Line Metastatic Breast Cancer
Contemporary Chemotherapy-Based Strategies for First-Line Metastatic Breast Cancer Hope S. Rugo, MD Professor of Medicine Director, Breast Oncology and Clinical Trials Education University of California
More informationIt is a malignancy originating from breast tissue
59 Breast cancer 1 It is a malignancy originating from breast tissue including both early stages which are potentially curable, and metastatic breast cancer (MBC) which is usually incurable. Most breast
More informationUpdate on New Perspectives in Endocrine-Sensitive Breast Cancer. James R. Waisman, MD
Update on New Perspectives in Endocrine-Sensitive Breast Cancer James R. Waisman, MD Nothing to disclose DISCLOSURE TAILORx Oncotype Recurrence Score TAILORx Study Design Sparano, J Clin Oncol 2008;26:721-728
More informationBREAST CANCER RISK REDUCTION (PREVENTION)
BREAST CANCER RISK REDUCTION (PREVENTION) Articles Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled
More informationExiste-t-il un sous groupe à risque qui pourrait bénéficier d une modification de la durée de traitement par trastuzumab? X. Pivot CHRU De Besançon
Existe-t-il un sous groupe à risque qui pourrait bénéficier d une modification de la durée de traitement par trastuzumab? X. Pivot CHRU De Besançon In 25 results of 4 Adjuvant Herceptin trials have definitively
More informationNeo-adjuvant and adjuvant treatment for HER-2+ breast cancer
Neo-adjuvant and adjuvant treatment for HER-2+ breast cancer Angelo Di Leo «Sandro Pitigliani» Medical Oncology Unit Hospital of Prato Istituto Toscano Tumori Prato, Italy NOAH: Phase III, Open-Label Trial
More informationDisclosures. Objectives. Novel Agents in the Systemic Management of Breast Cancer (Breast Cancer Update 2012) Peter Kabos, MD
Mountain States Cancer Conference 2012 Novel Agents in the Systemic Management of Breast Cancer (Breast Cancer Update 2012) Peter Kabos, MD University of Colorado Denver Disclosures No relevant disclosures
More informationSYSTEMIC THERAPY OPTIONS FOR BREAST CANCER IN 2014
SYSTEMIC THERAPY OPTIONS FOR BREAST Oncology Day 2014 CANCER IN 2014 Dr. Katherine Enright, M.D., M.P.H., F.R.C.P.(C) Katherine.enright@Trilliumhealthpartners.ca OBJECTIVES 1. Outline an approach to the
More informationTriple-Negative Breast Cancer
June 2017 Triple-Negative Breast Cancer Amir Sonnenblick, MD, PhD Sharett institute of oncology Hadassah-Hebrew university medical center, Jerusalem, Israel This presentation is the intellectual property
More informationAdjuvant Chemotherapy TNBC & HER2 Subtype
Adjuvant Chemotherapy TNBC & HER2 Subtype 2015.08.15 Gun Min Kim Yonsei Cancer Center Division of Medical Oncology Department of Internal Medicine Yonsei University College of Medicine gmkim77@yuhs.ac
More informationBreast Cancer Earlier Disease. Stefan Aebi Luzerner Kantonsspital
Breast Cancer Earlier Disease Stefan Aebi Luzerner Kantonsspital stefan.aebi@onkologie.ch Switzerland Breast Cancer Earlier Disease Diagnosis and Prognosis Local Therapy Surgery Radiation therapy Adjuvant
More informationEARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY. Dr. Carlos Garbino
EARLY STAGE BREAST CANCER ADJUVANT CHEMOTHERAPY Dr. Carlos Garbino EARLY BREAST CANCER ADJUVANT CHEMOTHERAPY SUSTANTIVE DIFFICULTIES FOR A WORLDWIDE APPLICABILITY DUE TO IMPORTANT INEQUALITIES + IN DIFFERENT
More informationNow Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting
A service of the U.S. National Institutes of Health Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting Trial record 1 of 1 for: Keynote 355 Previous Study Return to List
More informationImmunoconjugates in Both the Adjuvant and Metastatic Setting
Immunoconjugates in Both the Adjuvant and Metastatic Setting Mark Pegram, M.D. Director, Stanford Breast Oncology Program Co-Director, Molecular Therapeutics Program Trastuzumab Treatment of Breast Tumor
More information非臨床試験 臨床の立場から 京都大学医学部附属病院戸井雅和
資料 2 2 非臨床試験 臨床の立場から 京都大学医学部附属病院戸井雅和 1 Preclinical studies Therapeutic Window: Efficacy/Toxicity Disease Specificity Subtype Specificity Combination: Concurrent/Sequential Therapeutic situation: Response/
More informationMdi Medical Management of Breast Cancer Morbidity and Mortality Aug 13, 2009 Irina Kovatch, PGY3 Introduction Metastatic disease is the principal cause of death from breast cancer Metastatic events often
More informationSystemic chemotherapy for metastatic breast cancer
Oncology and Translational Medicine October 2015, Vol. 1, No. 5, P226 232 DOI 10.1007/s10330-014-0048-6 REVIEW ARTICLE Systemic chemotherapy for metastatic breast cancer Yannan Zhao, Biyun Wang ( ) Department
More informationSystemic chemotherapy regimens in early breast cancer patients: updated recommendations from the BSMO breast cancer task force
375 Systemic chemotherapy regimens in early breast cancer patients: updated recommendations from the BSMO breast cancer task force H. Wildiers, MD, PhD 1, FP. Duhoux, MD, PhD 2, A. Awada, MD, PhD 3, E.
More informationHER2-Negative Breast Cancer - 5EU Drug Forecast and Market Analysis to 2023
HER2-Negative Breast Cancer - 5EU Drug Forecast and Market Analysis to 2023 HER2-Negative Breast Cancer - 5EU Drug Forecast and Market Analysis to 2023 BioPortfolio has been marketing business and market
More informationNovel Chemotherapy Agents for Metastatic Breast Cancer. Joanne L. Blum, MD, PhD Baylor-Sammons Cancer Center Dallas, TX
Novel Chemotherapy Agents for Metastatic Breast Cancer Joanne L. Blum, MD, PhD Baylor-Sammons Cancer Center Dallas, TX New Chemotherapy Agents in Breast Cancer New classes of drugs Epothilones Halichondrin
More informationNCCN TRENDS DEMOGRAPHICS. Results: December Distribution of Respondent Types (n = 1,833) Page 1
NCCN TRENDS Results: December 2011 NCCN Trends is an analytics tool from the National Comprehensive Cancer Network (NCCN ) that surveys how clinicians across the U.S. and around the globe are delivering
More informationWas gynäkologische OnkologInnen über Erblichkeit wissen sollten. 9. Brustkrebskongress Köln und Niederrhein 2016
Was gynäkologische OnkologInnen über Erblichkeit wissen sollten Rita K. Schmutzler, Universitätsklinik Köln Koordinatorin des Konsortiums Familiärer Brust- und Eierstockkrebs 9. Brustkrebskongress Köln
More informationTriple negative breast cancer -neoadjuvant and adjuvant systemic therapy
Triple negative breast cancer -neoadjuvant and adjuvant systemic therapy Sung-Bae Kim, MD, PhD Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul, Korea DISCLOSURE
More informationDocetaxel. Class: Antineoplastic agent, Antimicrotubular, Taxane derivative.
Docetaxel Class: Antineoplastic agent, Antimicrotubular, Taxane derivative. Indications: -Breast cancer: -Non small cell lung cancer -Prostate cancer -Gastric adenocarcinoma _Head and neck cancer Unlabeled
More informationNew chemotherapy drugs in metastatic breast cancer. Guy Jerusalem, MD, PhD
New chemotherapy drugs in metastatic breast cancer Guy Jerusalem, MD, PhD MBC Patients survival over time Median survival increases over time, but is still measured in months This is not yet a chronic
More informationTREATMENT. Systemic Therapy: Chemotherapy for Breast Cancer. Knowledge Summary
TREATMENT Systemic Therapy: Chemotherapy for Breast Cancer Knowledge Summary TREATMENT Systemic Therapy: Chemotherapy for Breast Cancer INTRODUCTION Chemotherapy plays a central role in the treatment of
More informationEribulin for locally advanced or metastatic breast cancer third line; monotherapy
Eribulin for locally advanced or metastatic breast cancer third line; monotherapy April 2009 This technology summary is based on information available at the time of research and a limited literature search.
More informationNovel Preoperative Therapies for HER2-Positive Breast Cancer. Debu Tripathy, MD University of Southern California Norris Comprehensive Cancer Center
Novel Preoperative Therapies for HER2-Positive Breast Cancer Debu Tripathy, MD University of Southern California Norris Comprehensive Cancer Center Key Findings to Date in the Neoadjuvant Therapy of HER2+
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: Trastuzumab (Herceptin), Trastuzumab-dkst (Ogivri) Reference Number: CP.PHAR.228 Effective Date: 07.01.18 Last Review Date: 05.18 Line of Business: Oregon Health Plan Coding Implications
More information