Prevention of Antineoplastic Medication induced Nausea and Vomiting in Pediatric Cancer Patients
|
|
- Joseph Gallagher
- 6 years ago
- Views:
Transcription
1 Prevention of Antineoplastic Medication induced Nausea and Vomiting in Pediatric Cancer Patients Done by :Meznah Zaid Al-Mutairi Pharm.D Candidate PNU University College of Pharmacy
2 Introduction Nausea and vomiting are common side effects for patients treated with systemic chemotherapy (70-80 %). Prevention and control of nausea and vomiting (N&V) are critical in the treatment of cancer patients.
3 Important definition
4 Pathogenesis of Chemotherapy-Induced Nausea and Vomiting Chemotherapy directly affects the higher neurologic centers in the central nervous system, the vomiting center located in the medulla oblongata, and peripheral neurologic receptors in the small intestine, inducing the release of neurotransmitters such as substance P and serotonin, which in turn signal the vomiting center, with the resultant CINV.
5 Dopamine VC Substance P Emetic Reflex Cannabinoids Small Intestine Serotonin
6 Importance of control of nausea and vomiting It effects patients quality of life. The compliance of treatment was decreased. It causes metabolic changes. It effects functional and intelligence capacity of patients. It causes anorexia and nutritional deficiency. Aspiration pneumonia and oesophagus damage might be seen. Effective chemotherapy treatments were discontinued because of this side effect.
7 Grade of nausea and vomiting National Cancer Institute Classification of Nausea and Vomiting 2013
8 Types of AINV Acute antineoplastic-induced nausea and vomiting: nausea, vomiting, and/or retching that occurs within 24 hours following the administration of an antineoplastic therapy. Delayed antineoplastic-induced nausea and vomiting: nausea, vomiting, and/or retching that occur more than 24 hours after and usually within 7 days of administration of an antineoplastic therapy. Anticipatory antineoplastic-induced nausea and vomiting: nausea, vomiting, and/or retching that occurs within 24 hours prior to administration of antineoplastic therapy (After a negative past experience with chemotherapy). The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
9 Types of AINV Breakthrough antineoplastic-induced nausea and vomiting: Occurs despite patient being treated with preventive therapy. Refractory antineoplastic-induced nausea and vomiting: Occur during subsequent cycles of chemotherapy when antiemetic prophylaxis has failed in earlier cycles. The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
10 Antiemetic Agents in Pediatric Cancer Patients 1- Serotonin (5-HT3) receptor antagonists. 2- Corticosteroids. 3- Neurokinin-1 receptor antagonists. 4- Benzamide analogs. 5- Phenothiazines. 6-Cannabinoids
11 Mechanism of action Neurokinin-1 receptor antagonists Aprepitant fosaprepitant Dopamine VC Benzamide analogs Metoclopramide Phenothiazines Prochlorperazine chlorpromazine Substance P Emetic Reflex Cannabinoids Small Intestine serotonin (5-HT3) receptor antagonists Granisetron ondansetron Serotonin Cannabinoids Dronabinol Nabilone
12 1-serotonin (5-HT3) receptor antagonists Granisetron and ondansetron : (5-HT 3 ) serotonin receptor antagonists have equivalent efficacy and safety. Combination with corticosteroids increased their efficacy. (5-HT 3 ) serotonin receptor antagonists are not effective for preventing delayed emesis.
13 1-serotonin (5-HT3) receptor antagonists Side effects : -Mild headache. -Transient elevation serum aminotreansferases -Constipation. -QT prolongation. Drug-drug interaction: Tramadol.
14 2-Corticosteroids Dexamethasone MOA: Unkown,thought to act by inhibiting prostaglandin synthesis in the cortex. Adverse effect : associated with single doses and short courses of steroids are infrequent, they may include euphoria, anxiety,insomnia, increased appetite and mild fluid retention. Drug-drug interaction: Doxorubicin. Ifosfamide.
15 3- Neurokinin-1 receptor antagonists Aprepitant or fosaprepitant: Aprepitant is approved for use in comination with other antiemetic drugs for preventing acute and delayed nausea and vomiting associated with initial and repeat courses of chemotherapy known to cause these problems,including high-dose cisplatin. Aprepitant improved the overall complete response (defined as no emetic episodes and no use of rescue therapy )by about 20% when added to a serotonin (5- HT3) receptor antagonists and dexamethasone.
16 3- Neurokinin-1 receptor antagonists Fosaprepitant vs. Aprepitant : Intravenous single-day fosaprepitant is now regarded as equivalent to 3 days of aprepitant for HEC. aprepitant (125 mg PO on day 1 then 80 mg on days 2-3) or fosaprepitant (150 mg IV on day 1). Fosaprepitant was not inferior to aprepitant for CR in the overall (71.9% vs. 72.3%).
17 3- Neurokinin-1 receptor antagonists Adverse effect : Asthenia,dizziness and hiccups. Drug-drug interaction: Dexamethasone. Imatinib.
18 4- Benzamide analogs Metoclopramide Adverse effect : Mild sedation, diarrhea and extrapyramidal reactions (eg. Dystonia, akathisia ). Given with benztropine ( mg/kg/dose 1-2 times daily) or Diphenhydramine (0.5-1 mg/kg/dose IV) to avoid extrapyramidal reactions.
19 5- phenothiazines Prochlorperazine,chlorpromazine and promethazine Chlorpromazine is often preferred in children because it is associated with fewer extrapyramidal reactions than prochlorperazine. Adverse events : Drowsiness,hypotension, akathisia and dystonia.
20 6-Cannabinoids Dronabinol and Nabilone Adverse events : Drowsiness, Dizziness, Euphoria, orthostatic hypotension, ataxia and appetite stimulation.
21 Non-Pharmacologic Treatment Eat the foods smaller and more frequent. Drink the liquids one hour before or after meals. Eat the cracker, toast, salty biscuit if the emesis occur in the morning. Walking short distance outdoors and inhale air deeply and slowly. Keep away from odors of foods, perfüme and fume. Do not sleep immediately after dinner. Begin eating light foods (soup, yoghurt) after control nause and vomitting.
22 POGO,2013
23 Emetogenic Potential of Antineoplastic agents Emetogenicity : the propensity of an agent to cause nausea, vomiting or retching. Current model includes four level for intravenous chemotherapy and two level for oral chemotherapy. Level for intravenous chemotherapy (minimal, low, moderate and high emetogenic risk ) and for oral chemotherapy (prophylaxis recommended and as needed). The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
24 high emetogenic Antineoplastic agents
25 Classification of Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patient This is a purely synthetic administered via SC injection, once daily. It has predictable anticoagulant activity and does not require monitoring. NO significant drug interactions were reported. Mechanism of action: it is indirect inhibitors of Xa. Unlike heparin and LMWHs, it has no effect on thrombin. The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
26 high emetogenic treatment algorithm The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
27 Antiemetic Dosage Recommendations for children receiving HIGHLY Emetogenic Antineoplastic Therapy The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
28 Duration of Antiemetic agents for children receiving HIGHLY Emetogenic Antineoplastic Therapy NK1 receptor antagonist (Aprepitant day 1-3) and 5-HT3 receptor antagonist PO/IV on day 1 only and dexamethasone PO/IV on days 1-3 or 1-4. The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013 Medscape,2014
29 Moderate emetogenic Antineoplastic agents
30 Classification of Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patient The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
31 Moderate emetogenic treatment algorithm The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
32 Antiemetic Dosage Recommendations for children receiving Moderately Emetogenic Antineoplastic Therapy The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
33 Duration of Antiemetic agents for children receiving Moderately Emetogenic Antineoplastic Therapy 5-HT3 receptor antagonist PO/IV on day 1 only and dexamethasone PO/IV on days 1-3 or 1-4. The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013 Medscape,2014
34 Low emetogenic Antineoplastic agents
35 Classification of Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patient The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
36 Low emetogenic treatment algorithm The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
37 Antiemetic Dosage Recommendations for children receiving LOW Emetogenic Antineoplastic Therapy The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
38 Minimal emetogenic Antineoplastic agents
39 Classification of Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patient The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
40 Minimal emetogenic treatment algorithm For multiple agent and multi-day antineoplastic therapy refer to recommendations in Low emetic risk table. The POGO Antineoplastic induced Nausea and Vomiting Guideline 2013
41 Lexicomp,2014
42 Thank You
Management of Nausea and Vomiting
June 01, 2015 By Rudolph M. Navari, MD, PhD, FACP [1] Although marked progress in controlling chemotherapy-induced emesis has occurred over the past 25 years, nausea and vomiting remain among the most
More informationConflicts of Interest. Review of Antiemetic Guidelines. Learning Objectives. What is Emesis Anyways? Pharmacy Technician Learning Objectives
Conflicts of Interest No financial relationships to disclose Review of Antiemetic Guidelines Matthew Fox, PharmD, BCPS, BCOP Clinical Oncology Pharmacist Baptist MD Anderson Jacksonville, Florida October
More informationManaging Adverse Events in the Cancer Patient. Learning Objectives. Chemotherapy-Induced Nausea/Vomiting
Managing Adverse Events in the Cancer Patient Lisa A Thompson, PharmD, BCOP Assistant Professor University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences Learning Objectives Describe
More informationGI Pharmacology -4 Irritable Bowel Syndrome and Antiemetics. Dr. Alia Shatanawi
GI Pharmacology -4 Irritable Bowel Syndrome and Antiemetics Dr. Alia Shatanawi 11-04-2018 Drugs used in Irritable Bowel Syndrome Idiopathic, chronic, relapsing disorder characterized by abdominal discomfort
More informationATTUALITÀ NEL CONTROLLO DELL EMESI
ATTUALITÀ NEL CONTROLLO DELL EMESI Dr Claudio Lotesoriere Dipartimento di Oncoematologia S.C. di Oncologia Medica P.O. San G. Moscati TARANTO email oncologia.taranto@gmail.com Types of CINV: Definitions
More informationChemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Nausea and Vomiting Aminah Jatoi, M.D. Professor of Oncology Mayo Clinic Rochester, Minnesota April 27, 2017 clinical and biologic fundamentals of chemotherapy induced nausea and vomiting
More informationUpdates in Chemotherapy-Induced Nausea and Vomiting (CINV) 2017
Updates in Chemotherapy-Induced Nausea and Vomiting (CINV) 2017 MELISSA C. MACKEY, PHARMD, BCPS, BCOP ONCOLOGY CLINICAL PHARMACIST DUKE UNIVERSITY HOSPITAL AUGUST 5, 2017 Objectives Review risk factors
More informationWhy Patients Experience Nausea and Vomiting and What to Do About It
Why Patients Experience Nausea and Vomiting and What to Do About It Rebecca Clark-Snow, RN, BSN, OCN The University of Kansas Cancer Center Westwood, Kansas Multiple Roles for Supportive Care in Cancer
More informationManagement of Chemotherapy Induced Nausea/Vomiting(CINV) in Adult Cancer Patients
Management of Chemotherapy Induced Nausea/Vomiting(CINV) in Adult Cancer Patients By Zahra Shaghaghi, Pharm-D, BCOP, PhC Prepared for 2018 NMSHP Balloon Fiesta Symposium Goals and Objectives: Describe
More informationManagement of Chemotherapy Induced Nausea/Vomiting(CINV) in Adult Cancer Patients
Management of Chemotherapy Induced Nausea/Vomiting(CINV) in Adult Cancer Patients By Zahra Shaghaghi, Pharm-D, BCOP, PhC Prepared for 2018 NMSHP Balloon Fiesta Symposium 1 Goals and Objectives: Describe
More informationSupportive care session 1:
Board review in oncology pharmacy 2013 Managing Disease or Treatment Related Complication Supportive care session 1: Chemotherapy induced-nausea and vomiting Suthan Chanthawong, B. Pharm, RPh. Objectives
More informationClinical Policy: Nabilone (Cesamet) Reference Number: ERX.NPA.35 Effective Date:
Clinical Policy: (Cesamet) Reference Number: ERX.NPA.35 Effective Date: 09.01.17 Last Review Date: 08.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationClinical Policy: Dolasetron (Anzemet) Reference Number: ERX.NPA.83 Effective Date:
Clinical Policy: (Anzemet) Reference Number: ERX.NPA.83 Effective Date: 09.01.18 Last Review Date: 08.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationGuideline Update on Antiemetics
Guideline Update on Antiemetics Clinical Practice Guideline Special Announcements Please check www.asco.org/guidelines/antiemetics for current FDA alert(s) and safety announcement(s) on antiemetics 2 Introduction
More informationAPPHON/ROPPHA Guideline for the Prevention and Management of Chemotherapy Induced Nausea and Vomiting in Children with Cancer
APPHON/ROPPHA Guideline for the Prevention and Management of Chemotherapy Induced Nausea and Vomiting in Children with Cancer 5850/5980 University Avenue, PO Box 9700, Halifax, N.S. B3K 6R8 PEDIATRIC HEMATOLOGY/ONCOLOGY
More informationGuidelines on Chemotherapy-induced Nausea and Vomiting in Pediatric Cancer Patients
Guidelines on Chemotherapy-induced Nausea Vomiting in Pediatric Cancer Patients COG Supportive Care Endorsed Guidelines Click here to see all the COG Supportive Care Endorsed Guidelines. DISCLAIMER For
More informationDECONTAMINATION AGENTS and ANTIEMETICS *** This material won t be covered in lecture, but you are responsible for it***
Decontamination and Antiemetics Med 5724 Page 1 of 8 DECONTAMINATION AGENTS and ANTIEMETICS *** This material won t be covered in lecture, but you are responsible for it*** REFERENCES: Katzung (9th ed.)
More informationNausea and Vomiting in Palliative Care
Nausea and Vomiting in Palliative Care Definitions Nausea - an unpleasant feeling of the need to vomit Vomiting - the expulsion of gastric contents through the mouth, caused by forceful and sustained contraction
More informationReview Article Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting
Hindawi Publishing Corporation BioMed Research International Volume 2015, Article ID 595894, 6 pages http://dx.doi.org/10.1155/2015/595894 Review Article Treatment of Breakthrough and Refractory Chemotherapy-Induced
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Cesamet) Reference Number: CP.PMN.160 Effective Date: 11.16.16 Last Review Date: 02.19 Line of Business: Commercial, Medicaid Revision Log See Important Reminder at the end of this policy
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Anzemet) Reference Number: CP.PMN.141 Effective Date: 09.01.06 Last Review Date: 08.18 Line of Business: Commercial, HIM, Medicaid Revision Log See Important Reminder at the end of this
More informationCigna Drug and Biologic Coverage Policy
Cigna Drug and Biologic Coverage Policy Subject Antiemetic Therapy Table of Contents Coverage Policy... 1 General Background... 6 Coding/Billing Information... 8 References... 8 Effective Date... 1/1/2018
More informationPREVENTION OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING IN ELDERLY CANCER PATIENTS JØRN HERRSTEDT, M.D. COPENHAGEN UNIVERSITY HOSPITAL HERLEV, DENMARK
PREVENTION OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING IN ELDERLY CANCER PATIENTS JØRN HERRSTEDT, M.D. COPENHAGEN UNIVERSITY HOSPITAL HERLEV, DENMARK HISTORY OF ANTIEMETICS 1979 A corticosteroid is superior
More informationA systemic review and meta analysis of Aprepitant Combination Regimens (ACR) for prevention of Chemotherapy induced Nausea
A systemic review and meta analysis of Aprepitant Combination Regimens (ACR) for prevention of Chemotherapy induced Nausea and Vomiting (CINV) in adults Fahad Zubair, PGY 3 UB CHS Internal Medicine Nausea
More informationGeneric (Brand) Strength & Dosage form Fml Limit Cost per Rx Notes 5-HT3 Antagonists
MEDICATION COVERAGE POLICY PHARMACY AND THERAPEUTICS ADVISORY COMMITTEE POLICY Nausea LAST REVIEW 9/11/2018 THERAPEUTIC CLASS Gastrointestinal Disorders REVIEW HISTORY 12/16, 11/15, 11/07 LOB AFFECTED
More information9/21/2016. Disclosures. Updates in the Management of Chemotherapy induced Nausea and Vomiting (CINV) Introduction. Objectives.
Updates in the Management of Chemotherapy induced Nausea and Vomiting (CINV) Diwura Owolabi, Pharm.D, BCOP Clinical Pharmacy Specialist, Blood and Marrow Transplantation Methodist University Hospital,
More informationEVALUATION OF ADEQUACY OF CONTROL OF CHEMOTHERAPY INDUCED VOMITING IN PAEDIATRIC PATIENTS WITH CANCER AT KENYATTA NATIONAL HOSPITAL
EVALUATION OF ADEQUACY OF CONTROL OF CHEMOTHERAPY INDUCED VOMITING IN PAEDIATRIC PATIENTS WITH CANCER AT KENYATTA NATIONAL HOSPITAL MANGHE ZEPHANIAH KIAMBI (U56/82680/2015) A research dissertation submitted
More informationCOMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT
European Medicines Agency Evaluation of Medicines for Human Use London, 17 February 2005 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT GUIDELINE ON NON-CLINICAL AND CLINICAL DEVELOPMENT OF
More informationClinical Policy: Ondansetron (Zuplenz) Reference Number: CP.PMN.45 Effective Date: Last Review Date: Line of Business: Medicaid
Clinical Policy: (Zuplenz) Reference Number: CP.PMN.45 Effective Date: 09.01.06 Last Review Date: 02.19 Line of Business: Medicaid Revision Log See Important Reminder at the end of this policy for important
More informationCHEMOTHERAPY-INDUCED NAUSEA AND VOMITING
CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING Jennifer Shamai MS, RN, AOCNS, BMTCN Professional Practice Leader Department of Clinical Practice And Professional Education Click How to the edit Experts Master
More informationTRANSPARENCY COMMITTEE OPINION. 31 January Date of marketing authorisation: 22 March 2005 (centralised marketing authorisation)
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 31 January 2007 ALOXI 250 µg solution for injection B/1 CIP 375,482-8 Applicant: THERABEL LUCIEN PHARMA palonosetron
More informationGUIDELINES FOR ANTIEMETIC USE IN ONCOLOGY SUMMARY CLASSIFICATION
GUIDELINES FOR ANTIEMETIC USE IN ONCOLOGY SUMMARY More than half of all cancer patients experience nausea or vomiting during the course of their treatment. If nausea or vomiting becomes severe enough,
More informationAntiemetics in chemotherapy
Antiemetics in chemotherapy Title of Guideline (must include the word Guideline (not protocol, policy, procedure etc) Contact Name and Job Title (author) Directorate & Speciality Date of submission Date
More informationSCI. SickKids-Caribbean Initiative Enhancing Capacity for Care in Paediatric Cancer and Blood Disorders
1.0 Introduction The (SCI) is a not-for-profit collaboration between the Hospital for Sick Children (SickKids), Toronto, Canada, and seven Caribbean health care institutions across six countries that strive
More informationESMO HIGHLIGHTS SUPPORTIVE AND PALLIATIVE CARE
ESMO 2016 - HIGHLIGHTS SUPPORTIVE AND PALLIATIVE CARE FLORIAN SCOTTE Cancer Department Supportive Care in Cancer Unit Georges Pompidou European Hospital Paris France esmo.org DISCLOSURE SLIDE Consultant
More informationGUIDELINE FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING.
Page 1 of 20 Guideline for the management of chemotherapy-induced nausea and vomiting, v2.1.1 GUIDELINE FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING. Version: 2.1.0 Ratified by: Date
More informationMASCC Guidelines for Antiemetic control: An update
MASCC / ISOO 17 th International Symposium Supportive Care in Cancer June 30 July 2, 2005 / Geneva, Switzerland MASCC Guidelines for Antiemetic control: An update Sussanne Börjeson, RN, PhD Linköping University,
More informationManagement of chemotherapyinduced nausea and vomiting
p h a r m a c o t h e r a p y Management of induced nausea and vomiting Authors Key words F. Van Ryckeghem and S. Van Belle Antiemetic therapy,, prevention Summary Chemotherapy-induced nausea and vomiting
More informationPediatric Trials 23/04/2018. Disclosures. Nausea and Vomiting Control in Adults and Children: Mind the Gap! Learning Objectives
Nausea and Vomiting Control in Adults and Children: Mind the Gap! Disclosures No relevant conflicts of interest Lee Dupuis, RPh, PhD May 5, 2018 2 Learning Objectives At the end of this presentation, attendees
More informationDavid G. Frame, PharmD. he etiology of nausea and vomiting is multifactorial,
r e v i e w Best Practice Management of CINV in Oncology Patients: I. Physiology and Treatment of CINV Multiple Neurotransmitters and Receptors and the Need for Combination Therapeutic Approaches David
More informationANTIEMETIC GUIDELINES: MASCC/ESMO
Open Issues for CINV Do we reliably measure that? Do we control nausea optimally? Are guidelines useful for oral therapies related nausea and vomiting? Breakthrough and refractory nausea and vomiting:
More informationSymptom Management. Thomas McKain, MD, ABFM, ABHPM Medical Director
Symptom Management Nausea & Vomiting Thomas McKain, MD, ABFM, ABHPM Medical Director Mr. Jones has nausea and vomiting. May I initiate Compazine from the Comfort Pak? Objectives 1. Delineate the Differential
More informationAn Old Dog with New Tricks? Olanzapine s Role in Chemotherapy Induced Nausea and Vomiting
An Old Dog with New Tricks? Olanzapine s Role in Chemotherapy Induced Nausea and Vomiting Pharmacotherapy Rounds John Malamakal Pharm.D., M.S. PGY1 Pharmacy Resident South Texas Veterans Health Care System,
More informationConsultations. Perspectives on Improving the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting (CINV)
Oncology Consultations Perspectives on Improving the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting (CINV) Developing Clinically and Economically Efficient Antiemetic Regimens A CME-Certified
More informationExplorations of the use of Olanzapine for Management of Chemotherapy-induced Nausea and Vomiting in Children
Explorations of the use of Olanzapine for Management of Chemotherapy-induced Nausea and Vomiting in Children by Jacqueline Flank A thesis submitted in conformity with the requirements for the degree of
More information9/3/2014. Conflict of Interest Disclosures. Learning Objectives. Definitions of Nausea/Vomiting. Definitions of Nausea/Vomiting
Conflict of Interest Disclosures LeAnn B. Norris Teva Pharmaceuticals Last Chance Webinar 2014 Oncology Supportive Care LeAnn B. Norris, PharmD, BCPS, BCOP Assistant Professor South Carolina College of
More informationEuropean Medicines Agency
European Medicines Agency SCIENTIFIC DISCUSSION 1. Introduction Emend is an oral substance P, aka human neurokinin 1 (NK-1)-receptor antagonist. Mammalian tachykinin substance P (SP) that binds to the
More informationStudent Project PRACTICE-BASED RESEARCH
Pharmacist-Driven Management of Chemotherapy Induced Nausea and Vomiting in Hospitalized Adult Oncology Patients. A Retrospective Comparative Study Ramy Elshaboury, PharmD 1 and Kathleen Green, PharmD,
More informationDrug Name: Aprepitant (Emend ) Manufacturer: Merck & Co., Inc.
Drug Name: Aprepitant (Emend ) Manufacturer: Merck & Co., Inc. Pharmacology: Aprepitant (previously known as MK-0839 and L-754030) is a new molecular entity that is the first in a new therapeutic class,
More informationSymptom Management of Gastrointestinal Alterations
Symptom Management of Gastrointestinal Alterations Parisa Tsutsumi RN, BSN, OCN, BMTCN University of Washington Medical Center Nausea and Vomiting Mucositis Taste Alterations Gastrointestinal Alterations
More informationJob title: Consultant Pharmacist/Advanced Practice Pharmacist
Title : Guidelines for the Use of Antiemetics Purpose: To provide trust-wide guidance on the safe and effective use of antiemetics for the prevention and treatment of chemotherapy and radiotherapy induced
More informationPrevention of chemotherapy induced nausea and vomiting in pediatric cancer patients
REVIEW ARTICLE Prevention of chemotherapy induced nausea and vomiting in pediatric cancer patients Shubham Roy 1, Rashi Kulshrestha 2, Abhishek Shankar 3, Goura Kishor Rath 4, Vipin Kharade 4 1 Department
More informationDrug: Aprepitant (Emend ) Date of Review: 4/01/10
CAMBRIDGESHIRE JOINT PRESCRIBING GROUP Business Case Evaluation and Recommendation Document Drug: Aprepitant (Emend ) Date of Review: 4/01/10 Business Case Decision and date: DOUBLE RED, 20 January 2010
More informationAntiemetic Prophylaxis with Ondansetron and Methylprednisolone vs Metoclopramide and Methylprednisolone in Mild and Moderately Emetogenic Chemotherapy
218 Journal of Pain and Symptom Management Vol. 18 No. 3 September 1999 Original Article Antiemetic Prophylaxis with Ondansetron and Methylprednisolone vs Metoclopramide and Methylprednisolone in Mild
More informationPrevention and Management of cancer disease and of chemo-and radiotherapyinduced nausea and vomiting
Prevention and Management of cancer disease and of chemo-and radiotherapyinduced nausea and vomiting Focusing on the updated MASCC/ESMO guidelines Karin Jordan Department of Hematology and Oncology, University
More informationGuidelines for the Use of Anti-Emetics with Chemotherapy
Guidelines for the Use of Anti-Emetics with The purpose of this document is to provide guidance on the rational use of anti-emetics for prevention and treatment of chemotherapy-induced nausea and vomiting
More informationAntiemesis. NCCN Clinical Practice Guidelines in Oncology. Antiemesis. Version Continue
Table of Contents Clinical in Oncology Version 2.2010 Continue www.nccn.org Version 2.2010, 04/07/2010 2010 National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration
More informationMOLECULAR AND CLINICAL ONCOLOGY 2: , 2014
MOLECULAR AND CLINICAL ONCOLOGY 2: 375-379, 2014 Palonosetron exhibits higher total control rate compared to first generation serotonin antagonists and improves appetite in delayed phase chemotherapy induced
More informationManagement of Postoperative Nausea and Vomiting in Ambulatory Surgery The Big Little Problem
Management of Postoperative Nausea and Vomiting in Ambulatory Surgery The Big Little Problem Mary Keyes, MD KEYWORDS Postoperative nausea and vomiting PONV prophylaxis PONV in ambulatory surgery KEY POINTS
More informationNausea and Vomiting Team. Outcome: Nausea and Vomiting. Scope of the Problem. Definition: Nausea
Nausea and Vomiting: The Continuing Battle to Improve Outcomes Jan Tipton, MSN, RN, AOCN Oncology CNS Medical University of Ohio Toledo, Ohio jtipton@meduohio.edu Nausea and Vomiting Team Jan Tipton, MSN,
More informationDrug Class Review on Newer Antiemetics
Drug Class Review on Newer Antiemetics Final Report January 2006 A literature scan of this topic is done periodically The purpose of this report is to make available information regarding the comparative
More informationDrug Therapy Guidelines
Drug Therapy Guidelines Applicable Medical Benefit Effective: 6/15/18 Pharmacy- Formulary 1 x Next Review: 6/19 Pharmacy- Formulary 2 x Date of Origin: 4/99 Antiemetic Agents: Zofran /ODT (ondansetron/ondansetron
More informationAntiemesis. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Version NCCN.org. Continue
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Version 1.2016 NCCN.org Continue Version 1.2016 03/15/16 National Comprehensive Cancer Network, Inc. 2016, All rights reserved. The NCCN
More informationOral Granisetron for the Prevention of Acute Late Onset Nausea and Vomiting in Patients Treated with Moderately Emetogenic Chemotherapy
Oral Granisetron for the Prevention of Acute Late Onset Nausea and Vomiting in Patients Treated with Moderately Emetogenic Chemotherapy CARL J. FRIEDMAN, a HOWARD A. BURRIS III, b KAREN YOCOM, a LINDA
More informationBy: Dawit Negusu (B.Pharm, MPharm candidate)
Prevalence of Chemo-induced Nausea and Vomiting, and Its impact on Patients Quality of Life at the Oncology Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia By: Dawit Negusu (B.Pharm,
More informationThalidomide for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy
Thalidomide for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy Geng Song, Qian He, Fanfan Li, and Nianfei Wang Department of Oncology, The Second Affiliated
More informationUsing a Simple Diary for Management of Nausea and Vomiting During Chemotherapy
Using a Simple Diary for Management of Nausea and Vomiting During Chemotherapy Problem identification Nausea and vomiting (N&V) are frequent complications following chemotherapy, even when taking 5-HT3
More informationDennis J. Cada, PharmD, FASHP, FASCP (Editor) * ; Ross Bindler, PharmD ; and Danial E. Baker, PharmD, FASHP, FASCP
Hosp Pharm 2016;51(2):165 175 2016 Thomas Land Publishers, Inc. www.hospital-pharmacy.com doi: 10.1310/hpj5102-165 Formulary Drug Reviews Rolapitant Dennis J. Cada, PharmD, FASHP, FASCP (Editor) * ; Ross
More informationCurrent and Emerging Therapeutic Options in the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) Objectives
Current and Emerging Therapeutic Options in the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) Susan Urba, M.D. University of Michigan Comprehensive Cancer Center Objectives Mechanisms of
More informationPrevention CINV (highly emetogenic) Prevention PONV
Reviews/Evaluations 5-Hydroxytryptamine3 (5-HT3) Receptor Antagonists Generic Name Brand Name Manufacturer Dolasetron Anzemet Aventis Granisetron Kytril Roche Ondansetron Zofran GlaxoSmithKline I. FDA
More informationNausea & Vomiting. Dr Eve Lyn TAN Liverpool Hospital NSW, AUSTRALIA
Nausea & Vomiting Dr Eve Lyn TAN Liverpool Hospital NSW, AUSTRALIA Prevalence prevalence varies *, systemic review 2007 : overall prevalence : nausea 30%, vomiting 20% in last 1-2 weeks of life : nausea
More information2018 Perioperative Management of PDNV
2018 Perioperative Management of PDNV Edward C. Adlesic, DMD Assistant Professor Oral and Maxillofacial Surgery Assistant Professor Dental Anesthesiology University of Pittsburgh School of Dental Medicine
More informationSubject: Fosnetupitant-Palonosetron (Akynzeo) IV
09-J3000-01 Original Effective Date: 06/15/18 Reviewed: 05/09/18 Revised: 01/01/19 Subject: Fosnetupitant-Palonosetron (Akynzeo) IV THIS MEDICAL COVERAGE GUIDELINE IS NOT AN AUTHORIZATION, CERTIFICATION,
More informationRolapitant (Varubi) A Substance P/Neurokinin-1 Receptor Antagonist for the Prevention of Chemotherapy-Induced Nausea and Vomiting
Rolapitant (Varubi) A Substance P/Neurokinin-1 Receptor Antagonist for the Prevention of Chemotherapy-Induced Nausea and Vomiting Tamara Goldberg, PharmD, BCPS; Brooke Fidler, PharmD; and Stephanie Cardinale,
More informationSue Faulkner, BSN RN OCN October 18, 2017 Updates from Congress 2017
Report: Occurrence and Implications of Chemotherapy-Induced nausea and Vomiting (CINV): Implications for the Oncology Nurse Practitioner to Optimize Patient Outcomes Sue Faulkner, BSN RN OCN October 18,
More informationClinical Review Report
CADTH COMMON DRUG REVIEW Clinical Review Report Netupitant/Palonosetron 300 mg/0.5 mg (Akynzeo) (Purdue Pharma) Indication: In combination with dexamethasone, onceper-cycle treatment for the prevention
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Kytril, Sancuso, Sustol) Reference Number: CP.PMN.74 Effective Date: 11.01.16 Last Review Date: 02.19 Line of Business: Commercial, Medicaid Coding Implications Revision Log See Important
More informationDepartment of Medical Oncology. Department of Biostatistics Cancer Institute (WIA), Chennai, India
Intravenous Fosaprepitant for the prevention of chemotherapy induced vomiting in children: a double blind placebo controlled, phase III randomized trial Venkatraman Radhakrishnan 1, Archit Joshi 1, Jaikumar
More informationChemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines
North of England Cancer Network Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines Adult Oncology & Haematology Quality and safety for every patient every time For more information
More informationNorthern Cancer Alliance
Northern Cancer Alliance Anti-emetic Guidelines for Chemotherapy Induced Nausea and Vomiting (CINV) Adult Oncology & Haematology Document Control Document Title: Antiemetic Guidelines for CINV NESCN v2.2
More informationPractical Management of Chemotherapy-Induced Nausea and Vomiting
Practical Management of Chemotherapy-Induced Nausea and Vomiting Review Article [1] April 15, 2005 By Wendy Wiser, DO [2] and Ann Berger, MSN, MD [3] Approximately 70% to 80% of all patients who receive
More informationDrug Use Criteria: Oral Serotonin 5-HT3 Receptor Antagonists for Nausea and Vomiting
Texas Vendor Drug Program Drug Use Criteria: Oral Serotonin 5-HT3 Receptor Antagonists for Nausea and Vomiting Publication History Developed September 1996. Revised July 2018; September 2016; June 2015;
More informationCompany Update. November 2015
Company Update November 2015 Legal Disclaimer This presentation contains "forward-looking statements" as defined by the Private Securities Litigation Reform Act of 1995. These forward-looking statements
More informationWest of Scotland Cancer Network Guideline for Managing Chemotherapy Induced Nausea and Vomiting
West of Scotland Cancer Network Guideline for Managing Chemotherapy Induced Nausea and Vomiting Definitions Acute nausea and vomiting Delayed nausea and vomiting Anticipatory nausea and vomiting Initial
More informationControlling nausea and vomiting: anti-emetic therapy advice
Controlling nausea and vomiting: anti-emetic therapy advice Chemotherapy A guide for patients and carers Contents Treatments that may cause nausea and vomiting... 2 Physical reasons that may cause nausea
More informationChemotherapy-induced nausea and vomiting
Comparison of antiemetic efficacy and safety of palonosetron vs ondansetron in the prevention of chemotherapy-induced nausea and vomiting in children Veerendra Patil, MD, FNB; Harsha Prasada, MD, DCH,
More informationChemotherapy-induced nausea and vomiting (CINV)
At a Glance Practical Implications e54 Author Information e57 Full text and PDF 5-HT3 Receptor Antagonist Effects in Cancer Patients With Multiple Risk Factors Original Research Claudio Faria, PharmD,
More informationGlobal Chemotherapy Induced Nausea & Vomiting (CINV) Market: Size, Trends & Forecasts ( ) September 2016
Global Chemotherapy Induced Nausea & Vomiting (CINV) Market: Size, Trends & Forecasts (2016-2020) September 2016 Global CINV Market Report Scope of the Report The report titled Global Chemotherapy Induced
More informationCLINICAL GUIDANCE FOR THE PREVENTION AND MANAGEMENT OF CHEMOTHERAPY AND RADIOTHERAPY INDUCED NAUSEA AND VOMITING IN ADULTS
CLINICAL GUIDANCE FOR THE PREVENTION AND MANAGEMENT OF CHEMOTHERAPY AND RADIOTHERAPY INDUCED NAUSEA AND VOMITING IN ADULTS Procedure reference: Document owner: 2196 Version: V2.1 Robert Duncombe, The Director
More informationNCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Antiemesis. Version NCCN.org. Continue
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Version 1.2011 NCCN.org Continue Note: All recommendations are category 2A unless otherwise indicated. Clinical Trials: NCCN believes that
More informationHMFP Comprehensive Headache Center Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center Instructor in
HMFP Comprehensive Headache Center Department of Anesthesia, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center Instructor in Anesthesia and Neurology Harvard Medical School Limited time
More informationCorporate Medical Policy
Antiemetic Injection Therapy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: antiemetic_injection_therapy 5/2015 3/2017 3/2018 3/2017 Description of Procedure
More informationSubject: NK-1 receptor antagonist injectable therapy (Emend, Cinvanti, Varubi )
09-J2000-60 Original Effective Date: 06/15/16 Reviewed: 04/11/18 Revised: 01/01/19 Subject: NK-1 receptor antagonist injectable therapy (Emend, Cinvanti, Varubi ) THIS MEDICAL COVERAGE GUIDELINE IS NOT
More informationPrevention and Management of Chemotherapy-Induced Nausea and Vomiting, Part 2
CONTINUING EDUCATION SERIES ONCOLOGY/IMMUNOLOGY Prevention and Management of Chemotherapy-Induced Nausea and Vomiting, Part 2 Shantel Mullin, PharmD* and M. Christina Beckwith, PharmD Outline Part 1 Introduction
More informationAntiemesis. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Version NCCN.org. Continue
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Version 1.2015 NCCN.org Continue Version 1.2015, 04/01/15 National Comprehensive Cancer Network, Inc. 2015, All rights reserved. The NCCN
More informationRegulatory Status FDA-approved indications: Emend is a substance P/neurokinin 1 (NK1) receptor antagonist, indicated: (1-2)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.50.05 Section: Prescription Drugs Effective Date: April 1, 2017 Subject: Emend Page: 1 of 6 Last Review
More informationSupportive Care for Patients with Cancer
3:15pm - 4:15pm: Breakout 4 - Oncology Option A: Supportive Care for Patients with Cancer ACPE UAN 0107-0000-10-021-L01-P 0.1 CEU/1.0 Hr. Activity Type: Application-Based Program Objectives for Pharmacists:
More informationAvailable online at ScienceDirect. journal homepage:
European Journal of Cancer 57 (2016) 23e30 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.ejcancer.com Original Research Efficacy and safety of rolapitant for prevention
More informationVomiting IAGH monthly meeting
Vomiting IAGH monthly meeting D A R V I S H M O G H A D A M K E R M A N M E D I C A L U N I V E R S I T Y 29 M E H R 1 3 8 9 Sources UpTodate 18.2 Yamada Principles of Clinical Gastroenterology 2008 Sleisenger
More information