Because every decision matters

Transcription

1 Because every decision matters Diagnostic Solutions Breast & Skeletal Health Solutions GYN Surgical Solutions

2 Be Sure. In healthcare, nothing is more important than being sure. Especially when making critical diagnostic decisions that affect the lives and health of patients. At Hologic, we re committed to creating innovations designed to address the evolving challenges of an increasingly complex global healthcare environment. We deliver world-class diagnostic, detection and surgical advances rooted in science, driven by technology, and inspired by our relentless desire to help healthcare professionals discover, diagnose and treat their patients with growing certainty. A History of Innovation Our Genius 3D Mammography exams help find invasive breast cancers earlier and reduce unnecessary recalls. 1,2.3 Our molecular diagnostic tests identify diseases like HPV, chlamydia, gonorrhea, trichomonas, and HIV often within days of infection. The NovaSure minimally invasive gynecological procedure offers women a lifetime of freedom from heavy menstrual bleeding via a simple five-minute procedure. And our Horizon bone densitometer is the only DXA system that reveals the smallest fractures at the earliest stage helping to keep patients strong and healthy. Today, Hologic is a multi-billion dollar global healthcare company with over 5,000 employees. Our three divisions, Diagnostic, Breast and Skeletal Health, and GYN Surgical Solutions, form the foundation for an organization focused on delivering breakthrough products considered the gold standard in markets around the world. Fueled by passion, we push the boundaries of science to develop life-changing technologies and solutions designed to drive clinical performance and help patients live longer, stronger and healthier lives. We are relentless, determined, and focused on delivering what s next to make a difference in the lives of people everywhere First FDA-cleared nucleic acid test First dual-energy X-ray absorptiometry system for evaluating osteoporosis First FDA-cleared molecular diagnostic test kit for sexually transmitted infections (STIs) FDA approval of Fetal Fibronectin Enzyme Immunoassay (ffn) for predicting the risk of pre-term birth FDA-approved ThinPrep Pap test, liquid-based cytology for cervical cancer screening NovaSure endometrial ablation treatment for abnormal uterine bleeding FDA approval of Selenia digital mammography system the beginning of a new era in breast cancer screening First FDA-approved nucleic acid test for screening donated blood prior to transfusion Tigris molecular testing system for automated screening of STIs FDA approval of Procleix Ultrio triplex blood screening assay for HIV-1, hepatitis B and C FDA approval of breakthrough Selenia Dimensions 3D breast cancer screening system with Genius 3D Mammography exam Panther automated, integrated molecular testing system CE-IVD certification for the first HIV viral load assay for diagnosis and treatment monitoring Horizon bone densitometer for assessing three critical health problems, including osteoporosis 2 3

3 In the lab 79% of the U.S. blood supply is tested with Hologic technologies. 4 The science of early detection. When it comes to detecting cervical cancer and infectious diseases, the earlier the better. Hologic s innovative assays and automation systems work seamlessly together to promote early detection, treatment, and better clinical and financial outcomes. Accelerating the speed of discovery and diagnosis. Laboratories around the world are challenged to improve efficiency and reduce costs without compromising the integrity of patient samples. Hologic Panther and Tigris DTS molecular testing systems and Tomcat sample preparation instrument bring the power of automation to molecular testing. We continually invest in developing new technologies designed to elevate the speed, accuracy and precision of our systems, giving laboratories greater freedom and more control over workflow. Protecting women from cancer and STIs. We introduced the first FDA-cleared diagnostic test kit for sexually transmitted infections (STIs) nearly 30 years ago. And we revolutionized Pap testing for cervical cancer in 1996 with our ThinPrep Pap test, now the most widely used cervical specimen collection product in the world. Today, our state-of-the-art Aptima assays quickly identify diseases like chlamydia, gonorrhea and trichomonas vaginalis at early stages. And ThinPrep is the only FDA-approved test that boosts lab productivity by allowing for integrated screening for cervical cell abnormalities and HPV from a single sample using our Aptima HPV assays. Co-testing, or the concurrent use of HPV and Pap, is the preferred method for cervical cancer screening for women between the ages of 30 and In additional to screening for HPV and STIs, we offer the fetal Fibronectin (ffn) test a safe, reliable way to predict the risk of pre-term birth with 99.2% accuracy. 6 Transforming the way the world fights viral disease. Procleix assays, developed in partnership with Grifols and manufactured by Hologic, increase the safety of the world s donated blood supply by accurately detecting the genetic presence of viruses, including HIV, hepatitis C, hepatitis B and the West Nile Virus. They ve helped reduce the risk of contracting dangerous diseases from blood transfusions in the U.S. to less than one in one million. 7 Hologic assays go beyond screening for disease. They re also used to monitor patients who have already been diagnosed to make sure they have control over their disease. The Aptima HIV-1 Quant Dx assay is the first HIV viral load assay for both diagnosis and treatment monitoring.* We are committed to developing additional assays that accurately measure how well anti-viral therapy for diseases like hepatitis B and hepatitis C is working. * CE-IVD certified; not available for sale in the U.S. 4 5

4 In breast health { Reveal More. These 3D slices reveal an area of distortion proven to be cancer that was missed with a conventional 2D mammogram. With Hologic technology, doctors can scroll through images of the breast like pages of a book and see fine individual details more clearly, no longer hidden by overlapping tissue See what others miss. Genius 3D Mammograms have revolutionized breast cancer detection. No mammography system is proven more accurate. Our technology is helping find breast cancers earlier, while reducing recall rates and false positives. 1,2,3 Available only on the Hologic Selenia Dimensions system, our 3D Mammography exam is proven clinically superior to conventional mammography. More than 8 million women in the U.S. have benefited from this breakthrough exam. 8 3D Mammograms deliver countless advantages not only for the women who benefit from early detection, but also for the physicians who care for them and the facilities that offer this lifesaving technology. Compassionate care when she needs it most. When a woman faces the possibility of breast cancer, her life takes a detour. But with world-class screening, diagnostic and treatment technologies, Hologic is there at every major touch point to guide the way. We offer advanced biopsy devices and guidance systems for every imaging technology. And our Trident system enables physicians to evaluate tissue samples on the spot, right in the biopsy suite, for quick, accurate diagnoses. If a woman is diagnosed with breast cancer and her cancer is caught early and is localized she can take advantage of our powerful five-day MammoSite targeted radiation treatment to get back to her life sooner. 41% Hologic Genius 3D Mammograms detect 41% more invasive breast cancers, while simultaneously reducing unnecessary recalls by 15%, according to a study published in the Journal of the American Medical Association

5 In GYN surgery 2 million NovaSure procedures have been performed worldwide. 8 In skeletal health Reveal small details before they become big health problems. Bone health is a major issue for both men and women. That s why Hologic is committed to supporting the diagnosis and management of osteoporosis at the earliest stage possible. We understand how important it is to keep bones strong and healthy, so you can continue to stay physically active and live life to its fullest. With the Horizon DXA system, a 10-second spine and femur scan can help clinicians assess the patient s risk of a fracture. Can you change a life in just minutes? Heavy menstrual bleeding is a major health problem that interrupts life for millions of women. In fact, one in every five women suffers from what is known as abnormal uterine bleeding (AUB) by the time she reaches menopause. Hologic offers women two frontline options to treat this challenging health problem. While AUB can negatively affect a woman s comfort, confidence and quality of life, she can take back control by choosing the simple, five-minute, minimally invasive NovaSure procedure. There are no incisions with this one-time, customized treatment. It can be quickly performed in the office or operating room. And over 90% of women return to normal, light or no periods at all, which may reduce the number of unnecessary hysterectomies. Hologic also offers a minimally invasive way for gynecologists to remove often painful polyps and fibroids that may be the root cause of uterine bleeding. The Hologic MyoSure procedure enables fast, safe removal of intrauterine pathology in less than 15 minutes without having to make a single incision. With up to 10 years of clinical data to support the effectiveness of our minimally invasive gynecological solutions, Hologic is the recognized leader in treating AUB. We were the first company to introduce a dual-energy X-ray absorptiometry system, setting the standard for bone densitometry. Now we ve taken it to the next level with our Horizon DXA platform. This state-of-the-art solution is designed to create exceptional images and detailed diagnostic information that reveal what s going on inside a person s body, regardless of his or her size or shape. It s the only DXA system to offer a single-energy femur exam capability that allows physicians to visualize atypical femur fractures 1 in 3 women a debilitating condition that can result from longterm use of common osteoporosis therapies. In addition to accurately screening for osteoporosis, the Horizon DXA system combines a wealth of advanced, proprietary technologies to assess obesity and identify aortic calcifications, a significant predictor of cardiovascular disease. Our high quality clinical images enable doctors to see more so they can make informed diagnoses and treatment decisions in time to have a positive impact on every patient s health and well-being. 1 in 5 men over 50 will experience an osteoporosis-related fracture. People over the age of 50 are at greater risk of having an osteoporosis-related fracture at some point in life according to the International Osteoporosis Foundation. 8 9

6 A 35-year-old woman is trusting you to figure out why she suffers from heavy menstrual bleeding. Because in healthcare you need to be sure. A young mother is worried about a breast lump she discovers while taking a shower. At Hologic, we understand how important it is to deliver advanced testing, imaging and treatment solutions that bring greater certainty to clinicians and make a real difference in the lives of patients looking for answers. That s why we stand behind our breakthrough solutions with comprehensive services you can count on. Service to keep Hologic systems performing at their peak. Hologic delivers everything from clinical applications and technical product support to rapid, onsite service dispatch. Healthcare professionals can choose from a range of fixedcost service plans to help avoid downtime and protect their investment in Hologic products. Plus, our customers can reach out to our highly trained technical specialists by phone or online to get expert, real-time support, when and where they need it. Education to help improve clinical performance. We offer a comprehensive curriculum of clinical educational programs covering a broad range of cutting-edge healthcare topics from breast and cervical cancer screening to the latest advances in minimally invasive gynecologic surgery. Courses are accessible online or delivered live at several global learning centers for your convenience. In addition, we support continuing education programs with unrestricted educational grants. Support to drive financial value. Hologic provides resources that will help you navigate the complex reimbursement landscape, attract patients, and build the success of your business. A team of professional managed care experts is available at no additional cost to answer your billing, coding, coverage, claims and reimbursement questions. We ve also developed a library of standard and customizable marketing materials to help you reach your most important audiences. A busy college professor has an irregular Pap test and wonders if she could have cervical cancer. More certainty for all. A retired business owner has chronic back pain and can t pick up his first grandchild. The Science of Sure signals our commitment to continuously deliver advanced products and services that provide greater certainty for everyone. Healthcare professionals can be sure they re delivering the right diagnoses. Patients can feel confident that they re receiving the most accurate diagnosis and best treatment. Administrators can rest assure that will be there for the long run. And investors can be certain they re backing a company with a clear vision for the future

7 Hologic is a global company using The Science of Sure to improve lives by innovating and bringing to market the best diagnostic, detection and surgical technology in the world. We integrate The Science of Sure into everything we do to help healthcare professionals discover, diagnose and treat their patients with progressive certainty to deliver ever-greater peace of mind. hologic.com info@hologic.com Diagnostic Solutions Breast & Skeletal Health Solutions GYN Surgical Solutions References: 1. Friedewald S, Rafferty E, Rose S, et al. Breast Cancer Screening using Tomosynthesis in Combination with Digital Mammography. Journal of the American Medical Association July;311(24): Epub 2014 June Skaane P, Bandos A, Gullien R, et al. Comparison of Digital Mammography Alone and Digital Mammography Plus Tomosynthesis in a Population-based Screening Program. Radiology Apr; 267(1): Epub 2013 Jan Rose S, Tidwell A, Bujnock L, et al. Implementation of Breast Tomosynthesis in a Routine Screening Practice: An Observational Study. American Journal of Roentengenology Jun; 200(6): Epub 2013 May Grifols Investors and Analysts meeting 2015 June Saslow D, Solomon D, Lawson HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. J Low Genit Tract Dis. 2012;16(3): Peaceman AM, Andrews WW, Thorp JM, et al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: A multicenter trial. Am J Obstet Gynecol. 1997;177: Zou S., Stramer S., Dodd R., Donor Testing and Risk: Current Prevalence, Incidence, and Residual Risk of Transfusion-Transmissible Agents in US Allogeneic Donations. Tranfusion Medicine Reviews, Vol. 26, No. 2, 2012 April. 8. Market data on file at Hologic. PB Rev Hologic, Inc. U.S./Intl. All rights reserved. Printed in the United States. Hologic, 3D Mammography, Aptima, Dimensions, Genius, Horizon, MammoSite, MyoSure, NovaSure, Panther, Selenia, The Science of Sure, ThinPrep, Tigris, Tomcat, and Trident are trademarks and/or registered trademarks of Hologic, Inc. and/or its subsidiaries in the United States and/ or other countries. Procleix and Ultrio are registered trademarks of Grifols, SA. This information is not intended as a product solicitation or promotion where such activities are prohibited. Because Hologic materials are distributed through websites, ebroadcasts and tradeshows, it is not always possible to control where such materials appear.