Radiofrequency Ablation (RFA) For Lung Tumors: Seven Years Experience.

Transcription

1 Radiofrequency Ablation (RFA) For Lung Tumors: Seven Years Experience. Poster No.: C-1619 Congress: ECR 2011 Type: Scientific Exhibit Authors: G. DE VENUTO 1, G. XHEPA 1, M. DE CHIARA 1, M. Mangini 2, Keywords: DOI: A. Leonardi 3, N. Lucchina 2, A. M. IERARDI 1, G. Carrafiello 1, C. Fugazzola 2 ; 1 VARESE/IT, 2 Varese/IT, 3 Varese (VA)/IT Interventional non-vascular, Lung, Thorax, CT-Angiography, Fluoroscopy, Ablation procedures, Neoplasia /ecr2011/C-1619 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 9

2 Purpose To review recurrence patterns in patients with lung cancer (primary or secondary) treated with percutaneous image-guided radiofrequency (RF) ablation. Methods and Materials From January 2003 to August 2010, thirty-two patients (24 with primary non-small-celllung-cancer (NSCLC) and 8 with metastases) with single tumors were treated. Posttreatment imaging results were available for each patient. Follow up was performed using CT scan at 1, 3, 6, 12, 18, 24 months after the procedure, than annually. Patterns of recurrence were classified as local, intra-pulmonary, nodal, mixed and distant. We evaluated the overall survival after RFA and factors associated with recurrences. Images for this section: Page 2 of 9

3 Fig. 1: CT scan performed before a peripheric lung lesion (A); RF electrode is positioned perfectly within the tumor (B); CT scan performed after one month revealed a complete necrosis (C); CT scan performed after six months revealed the absence of local recurrence and a further reduction in volume of the lesion (D. Fig. 2: Patients and lesions characteristics Page 3 of 9

4 Results Seventeen (53.1%) patients demonstrated no evidence of recurrence at follow-up imaging (range, months; mean, 32.5 months). Recurrence was seen in 15 (46.9 %) patients (range, 6-36 months; mean, 14.8 months). Local recurrence (40%) after RFA was the most frequent. Median disease free survival was 20 months. Sex, tumor location, tumor size and tumor stage were not associated with risk of recurrence. Patient age ( P >0.10) was related to risk of recurrence. Images for this section: Fig. 1: Patients subdivided in two groups (recurrence and no-recurrence) on the basis of tumor stage. Page 4 of 9

5 Fig. 2: Progression-free survival (PFS) after RFA. Page 5 of 9

6 Fig. 3: Box-plots show the significative influence (p>0.10) of age on the risk of recurrence. Page 6 of 9

7 Conclusion Local recurrence as most common pattern suggests that more aggressive initial RFA may offer improvement in outcomes. Images for this section: Fig. 1: Lesions recurrence after RF ablation (*Recurrence patterns: local, intrapulmonary, nodal, mixed, and distant) Page 7 of 9

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