Monday 25 June 2007 Morning Time: 20 minutes. Multiple Choice Answer Sheet HB pencil, eraser and calculator

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1 Surname Initial(s) Signature Paper Reference(s) 5006 Edexcel GSE Science iology 1b Topic 3: Electrical and hemical Signals Topic 4: Use, Misuse and buse Foundation and Higher Tiers Monday 25 June 2007 Morning Time: 20 minutes Materials required for examination Multiple hoice nswer Sheet H pencil, eraser and calculator Items included with question papers Nil Instructions to andidates Use an H pencil. o not open this booklet until you are told to do so. Mark your answers on the separate answer sheet. Foundation tier candidates: answer questions Higher tier candidates: answer questions ll candidates are to answer questions efore the test begins: heck that the answer sheet is for the correct test and that it contains your candidate details. How to answer the test: For each question, choose the right answer,,, or and mark it in H pencil on the answer sheet. For example, the answer would be marked as shown. Mark only one answer for each question. If you change your mind about an answer, rub out the first mark thoroughly, then mark your new answer. o any necessary calculations and rough work in this booklet. You may use a calculator if you wish. You must not take this booklet or the answer sheet out of the examination room. Printer s Log. No. N29510 W850/R1535/ /5/3/3/46,500 *N29510* Turn over This publication may be reproduced only in accordance with Edexcel Limited copyright policy Edexcel Limited.

2 Questions 1 to 16 must be answered by Foundation tier candidates only. Higher tier candidates start at question 17. oiled egg The picture shows Jane removing her hand quickly after she touched an egg that had just been boiled. 1. Jane s behaviour is called a voluntary response an involuntary response a stimulus an impulse 2. Jane s movement involved neurones passing impulses. Which was the first neurone to be used? relay sensory motor effector 3. Jane wants to find out if cold hands react differently from warm hands when touching a hot egg. The best way to do this would be to measure how long it took for a cold hand from one person to be removed from the egg a cold and a warm hand from one person to be removed from the egg the cold hands from several people to be removed from the egg the cold and the warm hands from several people to be removed from the egg N

3 4. Which should Jane use to measure the reaction time? ice clock thermometer egg The most popular drug in the world The most popular drug in the world is one you probably have every day. This is caffeine. affeine is found in tea, coffee and cola. 5. affeine is a painkiller sedative stimulant antibiotic 6. The main organ affected by caffeine is the brain lungs liver stomach 7. If you drink a lot of coffee with caffeine you are likely to have a slower heart rate take longer to react be more alert feel sleepy N Turn over

4 8. These are the ingredients in 250 ml of a popular fizzy drink. TURINE GLUURONOLTONE FFEINE NIIN VITMIN 6 PNTOTHENI I VITMIN 12 SUROSE GLUOSE 1000 mg 600 mg 80 mg 20 mg 5 mg 5 mg mg 21.5 g 5.25 g How many mg of caffeine would there be in 500 ml of the same drink? 80 mg 160 mg 250 mg 500 mg Peter s illness Peter was worried because he began to lose weight and became very tired. He went to see his doctor. His doctor took a blood sample from Peter. The pie chart shows the four main parts of Peter s blood. key plasma platelets red blood cells white blood cells 9. Most of Peter s blood is made up of plasma platelets red blood cells white blood cells 10. The doctor tested Peter s blood for glucose. Glucose is mostly found dissolved in the plasma platelets red blood cells white blood cells N

5 The doctor showed Peter a graph showing normal blood glucose concentration and the blood glucose concentration found in Peter s blood. blood glucose concentration in mmol per litre 28 ± 24 ± 20 ± 16 ± 12 ± 8± 4± normal blood Peter's blood 11. The concentration in Peter s blood was Peter s blood glucose concentration was much higher than normal. His doctor told him he had diabetes fatigue inflammation an addiction 13. The doctor said that Peter had the illness because an organ in his body was not making enough enzymes insulin red blood cells stimulants N Turn over

6 14. Which organ in Peter s body was not working properly? intestine brain liver pancreas 15. Peter wanted a second sample of his blood to be tested. This was so the result could be more reliable averaged safer more ethical 16. The doctor told Peter he would feel better if he had a hormone injection. Which row of the table is correct for hormones? type of message carried by hormones hormones transported by chemical nerves electrical blood chemical blood electrical nerves N

7 Higher tier candidates start at question 17 and answer questions 17 to 40. Questions 17 to 24 must be answered by all candidates: Foundation tier and Higher tier. Salmonella poisoning Salmonella bacteria can cause disease in humans and animals. 17. What is the name given to disease-causing organisms? foreign bodies microbes pathogens viruses 18. acteria such as Salmonella can be destroyed in the body by red blood cells plasma platelets white blood cells 19. Salmonella bacteria can be found in raw chicken. They grow very quickly in the correct conditions. What are the best conditions to store raw chicken to reduce the growth of Salmonella bacteria? below 4 and dry below 4 and damp above 15 and dry above 15 and damp 20. Salmonella bacteria can affect the body when eaten in infected food. What is this type of transmission called? vector borne vehicle borne vertical contact horizontal contact N Turn over

8 Paracetamol Paracetamol is a drug for pain relief that can be bought in supermarkets. It is the most used painkiller in ritain. 21. Which part of the body may be seriously damaged by taking an overdose of paracetamol? heart kidney liver lungs 22. How does paracetamol relieve the pain of a headache? Transmission across the synapse is slowed down Transmission across the synapse is speeded up Electrical impulses are stopped from travelling along neurones Electrical impulses travel the opposite way along neurones 23. Which is not a reason for paracetamol being the most used painkiller in ritain? There are no side effects if used in small amounts Paracetamol is easily available Paracetamol is cheap to buy Large doses can be taken 24. Heroin can be prescribed by doctors for more severe pain. The problem with prescribing heroin in this way is that heroin is a recreational drug patients may develop a tolerance for heroin heroin use increases the risk of infection patients may suffer liver damage TOTL FOR FOUNTION TIER PPER: 24 MRKS Foundation tier candidates do not answer any more questions after question 24. N

9 Questions 25 to 40 must be answered by Higher tier candidates only. Foundation tier candidates do not answer questions 25 to 40. Tuberculosis patient was suffering from T. Samples from their breath, saliva and fingers were taken and cultured in Petri dishes in the laboratory. The Petri dishes were covered, sealed and incubated. The results are shown below. colony of T bacteria colony of T bacteria breath fingerprint saliva 25. ased on the results of the experiment, what would you conclude was the most likely way for T to be spread? by animal vector by hand to hand contact through droplets in the air in drinking water 26. efore the experiment the Petri dishes were irradiated to sterilise them. Why was this important? to ensure the cultures would grow as a control for the experiment to kill all other microorganisms before the experiment to protect the scientists doing the experiment 27. Why were the Petri dishes covered and sealed? to stop contamination from airborne microorganisms to increase the numbers of microorganisms growing to keep the Petri dishes warm in the incubator to minimise the growth of T microorganisms N Turn over

10 28. What type of microorganism causes T? bacterium antigen fungus virus Use the graph to answer questions 29 and 30. The graph shows the number of deaths from T in ritain since number of deaths per million year 29. The graph shows that most people died between 1820 and 1840 the number of deaths halved between 1840 and 1880 immunisation changed the number of deaths there have been no deaths from T since In 1940 ritain had a population of 12 million people. How many people died from T during this year? N

11 31. What would be the effect in ritain of the emergence of drug resistant T? The number of cases of T would increase and they would be easier to treat The number of cases of T would increase and they would be more difficult to treat The number of cases of T would be unaffected but they would be easier to treat The number of cases of T would be unaffected but the drugs would have the same effect 32. These two statements are about conditions and the spread of T. 1 The community all live close to one another. 2 Very few people go into or out of the community. Which are likely to increase the spread of T? 1 only 2 only both 1 and 2 neither ontraception Julie wanted to avoid getting pregnant. She read the passage below in a newspaper. The female sex hormones, oestrogen and progesterone, are found in one type of contraceptive pill. If used correctly, there is only a 0.25% chance of pregnancy in the first year of use. n unfortunate side effect is an increased risk of a stroke. 33. Julie calculated that if one million women used the pill, the number who could get pregnant in the first year of use would be N Turn over

12 34. Oestrogen helps as a contraceptive because it thins the uterus lining promotes FSH release thickens the uterus lining inhibits FSH release 35. Progesterone helps as a contraceptive because it maintains the uterus lining prevents ovulation promotes LH release thickens the uterus lining 36. The organ that can be damaged by a stroke is the uterus brain liver lung N

13 evelopment of drugs to fight cancer ccording to research in merica the number of deaths from most types of cancer is falling due to the development of new and improved drugs. The graph shows the number of drugs in development for cancer as of pril 30, bladder cancer brain cancer breast cancer cervical cancer colon cancer head/neck cancer kidney cancer leukemia liver cancer lung cancer lymphoma multiple myeloma neuroblastoma ovarian cancer pancreatic cancer prostate cancer sarcoma skin cancer solid tumors stomach cancer cancer-related conditions other cancers unspecified cancers Source: In 1999 according to the graph which two types of cancer had the most drugs in development? breast cancer and colon cancer colon cancer and skin cancer skin cancer and lung cancer lung cancer and breast cancer 38. The highest number of cancer deaths in merica is due to lung cancer but more drugs are being developed for breast cancer. The most likely reason for this is that the marketing and funding for lung cancer is very successful the marketing and funding for breast cancer is very successful drugs for breast cancer are more expensive to manufacture it is possible to cure lung cancer N Turn over

14 39. One cause of lung cancer is known to be smoking tobacco. What is the effect of tar and nicotine on the body? Nicotine causes mutations of cells in the lungs and tar can clog up the cilia Nicotine is addictive and tar binds to red blood cells instead of oxygen hemicals in tar cause cell mutations and nicotine is addictive hemicals in tar block goblet cells and nicotine damages alveoli 40. These three statements are about the use of opiates in the treatment of terminally ill patients. Which are true? 1 Opiates are addictive and are not prescribed to terminally ill patients. 2 Opiates offer very strong pain relief. 3 Opiates can prolong the life of terminally ill patients. 2 only 1 and 2 only 2 and 3 only 1, 2 and 3 TOTL FOR HIGHER TIER PPER: 24 MRKS EN N

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