Membrane heterogeneity
|
|
- Alfred Stone
- 5 years ago
- Views:
Transcription
1 Membrane heterogeneity From lipid domains to curvature effects PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P. F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op donderdag 29 oktober 2009 klokke uur door Stefan Semrau geboren te Solingen, Duitsland in 1979 i
2 Promotiecommissie Promotor: Prof. dr. T. Schmidt Copromotor: Dr. C. Storm (TU Eindhoven) Referent: Prof. dr. O.G. Mouritsen (University of Southern Denmark, Odense) Overige leden: Prof. dr. F. MacKintosh (Vrije Universiteit Amsterdam) Prof. dr. J. van Ruitenbeek Prof. dr. M. Orrit Prof. dr. T.J. Aartsma Dr. J. van Noort Dr. M. Overhand Casimir PhD Series, Delft-Leiden, ISBN An electronic version of this thesis can be found at Het onderzoek beschreven in dit proefschrift is onderdeel van het wetenschappelijke programma van de Stichting voor Fundamenteel Onderzoek der Materie (FOM), die financieel wordt gesteund door de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO). ii
3 There is never any end. There are always new sounds to imagine; new feelings to get at. And always, there is the need to keep purifying these feelings and sounds so that we can really see what we ve discovered in its pure state. So that we can see more and more clearly what we are. In that way, we can give to those who listen the essence, the best of what we are. But to do that at each stage, we have to keep on cleaning the mirror. John Coltrane ( ), Jazz saxophonist Für meine Familie iii
4 iv
5 Contents 1 Introduction Membrane heterogeneity Artificial membranes Formation and observation Selected results Living cells Single molecule tracking Selected results Future directions Elastic parameters of multi-component membranes Introduction Model Experiment Results Discussion Membrane mediated interactions Introduction Materials and Methods GUV formation Image analysis Evidence for interactions Radial distribution function Size distribution Domain budding Measuring the interactions Domain position tracking
6 vi CONTENTS Domain distance statistics Conclusion Membrane mediated sorting Introduction Materials and Methods Analytical model Simulations Experimental verification Conclusion Particle image correlation spectroscopy (PICS) Introduction Theory Algorithm Relation to diffusion dynamics Figure of merit and achievable accuracy Diffusion modes Materials and Methods Monte Carlo simulations Single-molecule microscopy Results Monte Carlo simulations Diffusional behavior of H-Ras mutants Discussion A Beyond the ideal situation B Correction for positional correlations due to diffraction Adenosine A 1 receptor signaling unraveled by PICS Introduction Materials and Methods Single-molecule microscopy Particle Image Correlation Spectroscopy (PICS) Analysis of MSDs (Mean square displacements) Cell culture Agonist stimulation assay Decoupling of G-protein with Pertussis toxin Results The activated receptor translocates to microdomains 111
7 CONTENTS vii The observed microdomains are related to the cytoskeleton The receptor is partially precoupled to its G-protein Discussion Counting autofluorescent proteins in vivo Introduction Materials and Methods DNA constructs Cell culture Single-molecule microscopy Image analysis Results and Discussion Blinking and bleaching of fluorescent proteins Robust intensity distributions Detection probability Experimental validation Clustering due to membrane heterogeneity Limitations and errors Conclusion Acknowledgement A Image processing and analysis A.1 Definitions A.2 Autofluorescent background subtraction B Detection probability C Intensity distribution C.1 Mandel theory C.2 2-state model C.3 3-state model C.4 Robust intensity distributions C.5 Complete intensity distribution D Overlapping single-molecule signals Bibliography 150 Samenvatting 173 Publications 177 Curriculum Vitae 180
8 viii CONTENTS
Force generation at microtubule ends: An in vitro approach to cortical interactions. Liedewij Laan
Force generation at microtubule ends: An in vitro approach to cortical interactions Liedewij Laan Force generation at microtubule ends: An in vitro approach to cortical interactions PROEFSCHRIFT TER VERKRIJGING
More informationMolecular understanding of tamoxifen resistance in breast cancer. Renée de Leeuw
Molecular understanding of tamoxifen resistance in breast cancer Renée de Leeuw Omslag ontworpen door: Theophile Suijkerbuijk (www.theophile.nl) Molecular understanding of tamoxifen resistance in breast
More informationTravel Medicine: Knowledge, Attitude, Practice and Immunisation
Travel Medicine: Knowledge, Attitude, Practice and Immunisation The work represented in this thesis was carried out at the Depatment of Infectious Diseases of the Leiden University Medical Centre Printing
More informationData Mining Scenarios. for the Discoveryof Subtypes and the Comparison of Algorithms
Data Mining Scenarios for the Discoveryof Subtypes and the Comparison of Algorithms Data Mining Scenarios for the Discoveryof Subtypes and the Comparison of Algorithms PROEFSCHRIFT ter verkrijging van
More informationMultimodality Imaging of Anatomy and Function in Coronary Artery Disease. Joanne D. Schuijf
Multimodality Imaging of Anatomy and Function in Coronary Artery Disease Joanne D. Schuijf The research described in this thesis was performed at the departments of Cardiology and Radiology of the Leiden
More informationMembrane heterogeneity
Membrane heterogeneity From lipid domains to curvature effects PROEFSCHRIFT ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P. F. van der Heijden,
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/23056 holds various files of this Leiden University dissertation Author: Velders, Matthijs A. Title: Optimization of care for ST-elevation myocardial infarction
More informationMultimodality imaging in chronic coronary artery disease Maureen M. Henneman
Multimodality imaging in chronic coronary artery disease Maureen M. Henneman 080237 Henneman boek.indb 1 03-11-2008 10:56:25 The studies described in this thesis were performed at the Department of Cardiology
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/22544 holds various files of this Leiden University dissertation Author: Speksnijder, Niels Title: Determinants of psychosis vulnerability : focus on MEF2
More informationHuntington s Disease Hypothalamic, endocrine and metabolic aspects
Huntington s Disease Hypothalamic, endocrine and metabolic aspects N. Ahmad Aziz i ISBN: 978-94-6108023-3 Design & layout: N. Ahmad Aziz Cover design: Jorien M.M. van der Burg Printed by: GildePrint, Enschede
More informationTesticular microlithiasis and undescended testis. Joery Goede
Testicular microlithiasis and undescended testis Joery Goede ISBN : 978-94-91082-02-3 Author : Joery Goede Lay-out : Ruth Visser, VisserVisuals, Amsterdam, the Netherlands Printing : Ridderprint, the Netherlands
More informationCardiac Bone Marrow Cell Injection for Chronic Ischemic Heart Disease
Cardiac Bone Marrow Cell Injection for Chronic Ischemic Heart Disease Monique R.M. Jongbloed 070303 Beeres Boek.indb 1 06-09-2007 17:13:27 The studies described in this thesis were performed at the Department
More informationComputer-Aided Detection of Wall Motion Abnormalities in Cardiac MRI. Avan Suinesiaputra
Computer-Aided Detection of Wall Motion Abnormalities in Cardiac MRI Avan Suinesiaputra Colophon About the cover: The cover is an Arabic calligraphy made by an 11-year old M. Zulkhairi Rhiza Tala, which
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/38506 holds various files of this Leiden University dissertation. Author: Nies, Jessica Annemarie Bernadette van Title: Early identification of rheumatoid
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20959 holds various files of this Leiden University dissertation. Author: Diepstraten, Jeroen Title: The influence of morbid obesity on the pharmacokinetics
More informationINTER- AND INTRA INDIVIDUAL VARIATION IN EARPRINTS LYNN M EIJERM AN
INTER- AND INTRA INDIVIDUAL VARIATION IN EARPRINTS LYNN M EIJERM AN Inter- and intra-individual variation in earprints Meijerman, Lynn Thesis University Leiden With Ref. ISBN-10: 90-806456-9-9 ISBN-13:
More informationEchocardiographic evaluation of left ventricular function in ischemic heart disease. Sjoerd A. Mollema
Echocardiographic evaluation of left ventricular function in ischemic heart disease Sjoerd A. Mollema The studies described in this thesis were performed at the Department of Cardiology of the Leiden University
More informationThe role of the general practitioner in the care for patients with colorectal cancer Brandenbarg, Daan
University of Groningen The role of the general practitioner in the care for patients with colorectal cancer Brandenbarg, Daan IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationUniversity of Groningen. Diabetes mellitus and rhegmatogenous retinal detachment Fokkens, Bernardina Teunisje
University of Groningen Diabetes mellitus and rhegmatogenous retinal detachment Fokkens, Bernardina Teunisje IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/23937 holds various files of this Leiden University dissertation. Author: Liu, Zhen Title: Exploring the interplay between TGF-β and VEGF signalling in
More informationCitation for published version (APA): Zeddies, S. (2015). Novel regulators of megakaryopoiesis: The road less traveled by
UvA-DARE (Digital Academic Repository) Novel regulators of megakaryopoiesis: The road less traveled by Zeddies, S. Link to publication Citation for published version (APA): Zeddies, S. (2015). Novel regulators
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/38594 holds various files of this Leiden University dissertation Author: Haan, Melina C. den Title: Cell therapy in ischemic heart disease models : role
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/42781 holds various files of this Leiden University dissertation. Author: Elbaz M.S.M.M. Title: Three-dimensional in-vivo intra-cardiac vortex flow from
More informationEnzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M.
UvA-DARE (Digital Academic Repository) Enzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M. Link to publication Citation for published version (APA): Arends, M. (2017).
More informationUvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication
UvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication Citation for published version (APA): van der Bom, T. (2014). The systemic right ventricle. General
More informationBuilding blocks for return to work after sick leave due to depression de Vries, Gabe
UvA-DARE (Digital Academic Repository) Building blocks for return to work after sick leave due to depression de Vries, Gabe Link to publication Citation for published version (APA): de Vries, G. (2016).
More informationUniversity of Groningen. Understanding negative symptoms Klaasen, Nicky Gabriëlle
University of Groningen Understanding negative symptoms Klaasen, Nicky Gabriëlle IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please
More informationUniversity of Groningen. Alcohol septal ablation Liebregts, Max
University of Groningen Alcohol septal ablation Liebregts, Max IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document
More informationDiagnostic strategies in children with chronic gastrointestinal symptoms in primary care Holtman, Geeske
University of Groningen Diagnostic strategies in children with chronic gastrointestinal symptoms in primary care Holtman, Geeske IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationTumor control and normal tissue toxicity: The two faces of radiotherapy van Oorschot, B.
UvA-DARE (Digital Academic Repository) Tumor control and normal tissue toxicity: The two faces of radiotherapy van Oorschot, B. Link to publication Citation for published version (APA): van Oorschot, B.
More informationCitation for published version (APA): Tjon-Kon-Fat, R. I. (2017). Unexplained subfertility: Illuminating the path to treatment.
UvA-DARE (Digital Academic Repository) Unexplained subfertility Tjon-Kon-Fat, R.I. Link to publication Citation for published version (APA): Tjon-Kon-Fat, R. I. (2017). Unexplained subfertility: Illuminating
More informationUniversity of Groningen. ADHD and atopic diseases van der Schans, Jurjen
University of Groningen ADHD and atopic diseases van der Schans, Jurjen IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the
More informationThe role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C.
UvA-DARE (Digital Academic Repository) The role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C. Link to publication Citation for published
More informationDissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Coumou, J.
UvA-DARE (Digital Academic Repository) Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Coumou, J. Link to publication Citation for published version (APA): Coumou, J. (2016).
More informationCitation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats
UvA-DARE (Digital Academic Repository) Randomized controlled trials in reproductive medicine Braakhekke, M.W.M. Link to publication Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized
More informationUvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication
UvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication Citation for published version (APA): Ebbing, E. A. (2018). What tumor cells cannot resist: Mechanisms
More informationUvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication
UvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication Citation for published version (APA): Kuizenga-Wessel, S. (2017). Functional defecation
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/41537 holds various files of this Leiden University dissertation Author: Mombo-Ngoma, Ghyslain Title: Parasitic infections during pregnancy : birth outcomes
More informationUvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie. Link to publication
UvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie Link to publication Citation for published version (APA): Jansen, S. (2015). Falling: should one blame the heart?
More informationUvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication
UvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication Citation for published version (APA): ter Horst, K. W. (2017). Obesity, ectopic
More informationUniversity of Groningen. Stormy clouds in seventh heaven Meijer, Judith
University of Groningen Stormy clouds in seventh heaven Meijer, Judith IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the
More informationUniversity of Groningen. Physical activity and cognition in children van der Niet, Anneke Gerarda
University of Groningen Physical activity and cognition in children van der Niet, Anneke Gerarda IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationMolecular and mechanical functions of the intermediate filament protein GFAP Stassen, O.M.J.A.
UvA-DARE (Digital Academic Repository) Molecular and mechanical functions of the intermediate filament protein GFAP Stassen, O.M.J.A. Link to publication Citation for published version (APA): Stassen,
More informationFunctional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M.
UvA-DARE (Digital Academic Repository) Functional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M. Link to publication Citation for published version
More informationUvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication
UvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication Citation for published version (APA): Witvliet, M. J. (2017). Anorectal malformations
More informationUvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication
UvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication Citation for published version (APA): Berkhemer, O. A. (2016). Intraarterial
More informationStudies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R.
UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version
More informationCitation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions
UvA-DARE (Digital Academic Repository) Malaria, HIV and sickle cell disease in Ghana Owusu, E.D.A. Link to publication Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle
More informationCover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/20570 holds various files of this Leiden University dissertation. Author: Zwaal, Peer van der Title: On rotator cuff tears : studies on evaluation, clinical
More informationCitation for published version (APA): van der Paardt, M. P. (2015). Advances in MRI for colorectal cancer and bowel motility
UvA-DARE (Digital Academic Repository) Advances in MRI for colorectal cancer and bowel motility van der Paardt, M.P. Link to publication Citation for published version (APA): van der Paardt, M. P. (2015).
More informationUniversity of Groningen. Adaptation after mild traumatic brain injury van der Horn, Harm J.
University of Groningen Adaptation after mild traumatic brain injury van der Horn, Harm J. IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationCitation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease: Monitoring, nutrition and surgery.
UvA-DARE (Digital Academic Repository) Pediatric inflammatory bowel disease Diederen, K. Link to publication Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease:
More informationUniversity of Groningen. Cost and outcome of liver transplantation van der Hilst, Christian
University of Groningen Cost and outcome of liver transplantation van der Hilst, Christian IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationThe role of the general practitioner during treatment and follow-up of patients with breast cancer Roorda-Lukkien, Carriene
University of Groningen The role of the general practitioner during treatment and follow-up of patients with breast cancer Roorda-Lukkien, Carriene IMPORTANT NOTE: You are advised to consult the publisher's
More informationUvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication
UvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication Citation for published version (APA): d'hooghe, J. N. S. (2018). Bronchial Thermoplasty
More informationCitation for published version (APA): Kruizinga, R. (2017). Out of the blue: Experiences of contingency in advanced cancer patients
UvA-DARE (Digital Academic Repository) Out of the blue Kruizinga, R. Link to publication Citation for published version (APA): Kruizinga, R. (2017). Out of the blue: Experiences of contingency in advanced
More informationPercutaneous coronary intervention in acute myocardial infarction: from procedural considerations to long term outcomes Delewi, R.
UvA-DARE (Digital Academic Repository) Percutaneous coronary intervention in acute myocardial infarction: from procedural considerations to long term outcomes Delewi, R. Link to publication Citation for
More informationPathophysiology and management of hemostatic alterations in cirrhosis and liver transplantation Arshad, Freeha
University of Groningen Pathophysiology and management of hemostatic alterations in cirrhosis and liver transplantation Arshad, Freeha IMPORTANT NOTE: You are advised to consult the publisher's version
More informationTowards strengthening memory immunity in the ageing population van der Heiden, Marieke
University of Groningen Towards strengthening memory immunity in the ageing population van der Heiden, Marieke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationUniversity of Groningen. ADHD & Addiction van Emmerik-van Oortmerssen, Katelijne
University of Groningen ADHD & Addiction van Emmerik-van Oortmerssen, Katelijne IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please
More informationIn search of light therapy to optimize the internal clock, performance and sleep Geerdink, Moniek
University of Groningen In search of light therapy to optimize the internal clock, performance and sleep Geerdink, Moniek IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationUniversity of Groningen. Pelvic Organ Prolapse Panman, Chantal; Wiegersma, Marian
University of Groningen Pelvic Organ Prolapse Panman, Chantal; Wiegersma, Marian IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please
More informationTobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R.
UvA-DARE (Digital Academic Repository) Tobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R. Link to publication Citation for published version (APA): Bosdriesz,
More informationInsulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis Grefhorst, Aldo
University of Groningen Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis Grefhorst, Aldo IMPORTANT NOTE: You are advised to consult the publisher's version
More informationUniversity of Groningen. Improving outcomes of patients with Alzheimer's disease Droogsma, Hinderika
University of Groningen Improving outcomes of patients with Alzheimer's disease Droogsma, Hinderika IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationAntimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T.
UvA-DARE (Digital Academic Repository) Antimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T. Link to publication Citation for published version (APA): Nguyen, V. T. (2017).
More informationUniversity of Groningen. Functional outcome after a spinal fracture Post, Richard Bernardus
University of Groningen Functional outcome after a spinal fracture Post, Richard Bernardus IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationUse of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L.
UvA-DARE (Digital Academic Repository) Use of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L. Link to publication Citation for published
More informationCitation for published version (APA): van de Vijver, S. J. M. (2015). Cardiovascular disease prevention in the slums of Kenya
UvA-DARE (Digital Academic Repository) Cardiovascular disease prevention in the slums of Kenya van de Vijver, Steven Link to publication Citation for published version (APA): van de Vijver, S. J. M. (2015).
More informationUvA-DARE (Digital Academic Repository) Gastrointestinal consequences of bariatric surgery Boerlage, T.C.C. Link to publication
UvA-DARE (Digital Academic Repository) Gastrointestinal consequences of bariatric surgery Boerlage, T.C.C. Link to publication Citation for published version (APA): Boerlage, T. C. C. (2018). Gastrointestinal
More informationUniversity of Groningen. Communication abilities of children with ASD and ADHD Kuijper, Sanne
University of Groningen Communication abilities of children with ASD and ADHD Kuijper, Sanne IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationUniversity of Groningen. Correlative microscopy reveals abnormalities in type 1 diabetes de Boer, Pascal
University of Groningen Correlative microscopy reveals abnormalities in type 1 diabetes de Boer, Pascal IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish
More informationUniversity of Groningen. Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up Verberne, Charlotte
University of Groningen Carcinoembryonic Antigen (CEA) in colorectal cancer follow-up Verberne, Charlotte IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish
More informationUniversity of Groningen. Covered stents in aortoiliac occlusive disease Grimme, Frederike. DOI: /j.ejvs /j.jvir
University of Groningen Covered stents in aortoiliac occlusive disease Grimme, Frederike DOI: 10.1016/j.ejvs.2014.08.009 10.1016/j.jvir.2015.04.007 IMPORTANT NOTE: You are advised to consult the publisher's
More informationCitation for published version (APA): Wolff, D. (2016). The Enigma of the Fontan circulation [Groningen]: Rijksuniversiteit Groningen
University of Groningen The Enigma of the Fontan circulation Wolff, Djoeke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check
More informationCitation for published version (APA): Sinkeler, S. J. (2016). A tubulo-centric view on cardiorenal disease [Groningen]
University of Groningen A tubulo-centric view on cardiorenal disease Sinkeler, Steef Jasper IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationUniversity of Groningen. A geriatric perspective on chronic kidney disease Bos, Harmke Anthonia
University of Groningen A geriatric perspective on chronic kidney disease Bos, Harmke Anthonia IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More information3D workflows in orthodontics, maxillofacial surgery and prosthodontics van der Meer, Wicher
University of Groningen 3D workflows in orthodontics, maxillofacial surgery and prosthodontics van der Meer, Wicher IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF)
More informationFinding the balance between overtreatment and undertreatment of ductal carcinoma in situ Elshof, L.E.
UvA-DARE (Digital Academic Repository) Finding the balance between overtreatment and undertreatment of ductal carcinoma in situ Elshof, L.E. Link to publication Citation for published version (APA): Elshof,
More informationDeveloping an exergame for unsupervised home-based balance training in older adults van Diest, Mike
University of Groningen Developing an exergame for unsupervised home-based balance training in older adults van Diest, Mike IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationPatient reported outcomes in chronic skin diseases: ehealth applications for clinical practice van Cranenburgh, O.D.
UvA-DARE (Digital Academic Repository) Patient reported outcomes in chronic skin diseases: ehealth applications for clinical practice van Cranenburgh, O.D. Link to publication Citation for published version
More informationNovel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements van de Hoef, T.P.
UvA-DARE (Digital Academic Repository) Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements van de Hoef, T.P. Link to publication
More informationUvA-DARE (Digital Academic Repository) On the innovative genius of Andreas Vesalius Brinkman, R.J.C. Link to publication
UvA-DARE (Digital Academic Repository) On the innovative genius of Andreas Vesalius Brinkman, R.J.C. Link to publication Citation for published version (APA): Brinkman, R. J. C. (2017). On the innovative
More informationUvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication
UvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication Citation for published version (APA): Rosema, N. A. M. (2015). Toothbrushing efficacy. General rights It
More informationUniversity of Groningen. Rhegmatogenous retinal detachment van de Put, Mathijs
University of Groningen Rhegmatogenous retinal detachment van de Put, Mathijs IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check
More informationAtherosclerosis, cognitive impairment, and depression in old age
Atherosclerosis, cognitive impairment, and depression in old age David Vinkers Atherosclerosis, cognitive impairment, and depression in old age Proefschrift ter verkrijgingvande graadvandoctor aande Universiteit
More informationUniversity of Groningen. Prediction and monitoring of chronic kidney disease Schutte, Elise
University of Groningen Prediction and monitoring of chronic kidney disease Schutte, Elise IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
More informationCitation for published version (APA): van Es, N. (2017). Cancer and thrombosis: Improvements in strategies for prediction, diagnosis, and treatment
UvA-DARE (Digital Academic Repository) Cancer and thrombosis van Es, N. Link to publication Citation for published version (APA): van Es, N. (2017). Cancer and thrombosis: Improvements in strategies for
More informationCitation for published version (APA): Bijl, M. (2001). Apoptosis and autoantibodies in systemic lupus erythematosus Groningen: s.n.
University of Groningen Apoptosis and autoantibodies in systemic lupus erythematosus Bijl, Marc IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationUniversity of Groningen. Diagnosis and imaging of essential and other tremors van der Stouwe, Anna
University of Groningen Diagnosis and imaging of essential and other tremors van der Stouwe, Anna IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationGut microbiota and nuclear receptors in bile acid and lipid metabolism Out, Carolien
University of Groningen Gut microbiota and nuclear receptors in bile acid and lipid metabolism Out, Carolien IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationCitation for published version (APA): Donker, M. (2014). Improvements in locoregional treatment of breast cancer
UvA-DARE (Digital Academic Repository) Improvements in locoregional treatment of breast cancer Donker, Mila Link to publication Citation for published version (APA): Donker, M. (2014). Improvements in
More informationUniversity of Groningen. The role of human serum carnosinase-1 in diabetic nephropathy Zhang, Shiqi
University of Groningen The role of human serum carnosinase-1 in diabetic nephropathy Zhang, Shiqi IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite
More informationApoptosis in (pre-) malignant lesions in the gastro-intestinal tract Woude, Christien Janneke van der
University of Groningen Apoptosis in (pre-) malignant lesions in the gastro-intestinal tract Woude, Christien Janneke van der IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationRetrobiosynthetic study of salicylic acid in Catharanthus roseus cell suspension cultures
Retrobiosynthetic study of salicylic acid in Catharanthus roseus cell suspension cultures Natali Rianika Mustafa Retrobiosynthetic study of salicylic acid in Catharanthus roseus cell suspension cultures.
More informationUniversity of Groningen. Ablation of atrial fibrillation de Maat, Gijs
University of Groningen Ablation of atrial fibrillation de Maat, Gijs IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the
More informationPrevention and care of chemotherapy-induced gastrointestinal mucositis Kuiken, Nicoline
University of Groningen Prevention and care of chemotherapy-induced gastrointestinal mucositis Kuiken, Nicoline IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationUvA-DARE (Digital Academic Repository) Hip and groin pain in athletes Tak, I.J.R. Link to publication
UvA-DARE (Digital Academic Repository) Hip and groin pain in athletes Tak, I.J.R. Link to publication Citation for published version (APA): Tak, I. J. R. (2017). Hip and groin pain in athletes: Morphology,
More informationCitation for published version (APA): de Groof, E. J. (2017). Surgery and medical therapy in Crohn s disease: Improving treatment strategies
UvA-DARE (Digital Academic Repository) Surgery and medical therapy in Crohn s disease de Groof, E.J. Link to publication Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical
More information