NIHR HTA General Board Minutes of the July 2018 Meeting

Transcription

1 Date 17 July 2018 (Day 1) NIHR HTA General Board Minutes of the July 2018 Meeting Place Present members Danubius, London Professor Andrew Farmer Professor John Norrie Professor Hywel Williams Mr Alan Chant Mrs Amanda Roberts Professor Julie Brittenden Professor Mike Clarke Professor Matt Costa Dr Peter Coventry Professor Fay Crawford Professor Rumona Dickson Dr Jennifer Hirst Professor Kerenza Hood Professor Nick James Professor Steff Lewis Professor Danny McAuley Dr Rumana Omar Professor Rupert Pearse Professor Mark Peters Professor Craig Ramsay Professor Christine Roffe Dr Sarah Stock Professor Andrew Sutton Dr Sara Twaddle Professor Olivia Wu Chair Deputy Chair Programme Director PPI representative PPI representative NETSCC, HTA Secretariat Apologies Observers Quoracy Information Dr Simon Fraser (Clinical Advisor, NETSCC) Mrs Steph Garfield-Birkbeck (Head of the HTA Programme) Mrs Karen Williams (Senior Research Manager) Miss Louise Maclachlan (Research Manager) Miss Rachel Corbett (Assistant Research Manager) Professor Mike Crawford Professor Julia Lawton Dr Matthew Ridd Dr Marc Serfaty Michael Bowdery, Head of Programmes, Social Care and Health Research Division, Welsh Government Voting members: 28 Quorum = 19 Voting members present on Day 1: 24 (86%)

2 Researcher-led Stage 2 Proposals 17/94/36: Individually randomised controlled multi-centre trial to determine the clinical and cost effectiveness of an adapted yoga programme for older adults with multimorbidity, including an embedded process evaluation (Tew, Northumbria University) Declared a conflict and left the room: Mrs Amanda Roberts, Professor Julie Brittenden, Dr Peter Coventry 17/94/28: FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a master protocol of two randomised trials to evaluate the non-inferiority of high flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care (Ramnarayan, Great Ormond Street Hospital for Children NHS Foundation Trust) Declared a conflict and left the room: Professor Kerenza Hood, Professor Mark Peters 17/94/13: Multimodal Intervention Of Nutrition And Activity Versus Usual Care For Patients With Oesophago-Gastric Cancer (MONACO 1) (Bowrey, University Hospitals of Leicester NHS Trust) Declared a conflict and left the room: Professor Hywel Williams, Professor John Norrie Commissioned Stage 2 Proposals 17/117: Therapeutic interventions for self-harm in adolescents - an individual patient data metaanalysis Panel: Mental Health Declared a conflict and left the room: Professor Andrew Farmer, Dr Peter Coventry, Dr Andrew Sutton 17/117/01: Therapeutic interventions for self-harm in children and adolescents: an individual patient data (IPD) meta-analysis (Panagioti, The University of Manchester) 17/117/11: ReducIng Self-Harm in Adolescents: Individual Patient meta-analysis (RISA-IPD) (Cottrell, University of Leeds) [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 2 of 12

3 Mental Health Themed Call Stage 2 Evidence Synthesis Proposals 17/152/01: Physical activity for the prevention and management of mental illness: an umbrella review of the evidence to guide patient care (Stubbs, Institute of Psychiatry, Psychology & Neuroscience, King's College London) Declared a conflict and left the room: Dr Peter Coventry 17/152/02: Personalising effective preventive interventions for individuals at clinical high risk of psychosis: individual participant data network meta-analysis with development and validation of an individualised Preventive Treatment of Psychosis (iptop) predictive model (Fusar-Poli, South London and Maudsley NHS Foundation Trust) Declared a conflict and left the room: Professor Andrew Farmer Researcher-led Stage 2 Evidence Synthesis Proposals 17/148/03: The immunogenicity and efficacy of pneumococcal vaccines: a systematic review and network meta-analysis of individual participant data. (Voysey, University of Oxford) Declared a conflict and left the room: Dr Jennifer Hirst, Professor Andrew Farmer 17/148/05: Determining optimal strategies for primary prevention of cardiovascular disease: systematic review, network meta-analysis and cost-effectiveness review (Uthman, University of Warwick) Declared a conflict and left the room: no conflicts 17/148/07: Prediction of Fetal Growth Restriction: Individual Participant Data (IPD) Meta-Analysis With Decision Curve Analysis International Prediction of Complications in Pregnancy: Fetal Growth restriction (IPPIC-FGR) (Thangaratinam, Queen Mary University of London) Chair: Professor Hywel Williams Declared a conflict and left the room: Dr Fay Crawford, Dr Sarah Stock, Professor Andrew Farmer, Professor John Norrie, Professor Michael Clarke, Professor Rupert Pearse 3 of 12 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018]

4 17/148/08: The clinical and cost-effectiveness of virtual reality training interventions for the rehabilitation of upper limb function for people following stroke: a systematic review and economic evaluation (Stockley, University of Central Lancashire) Declared a conflict and left the room: Professor Christine Roffe 17/148/10: Autologous chondrocyte implantation in ankle and hip: a rapid review. (Waugh, University of Warwick) Declared a conflict and left the room: Professor Rumona Dickson 17/148/11: Compliant flooring for fall-related injury prevention: a systematic review of clinical and cost-effectiveness studies (Drahota, University of Portsmouth) Declared a conflict and left the room: Dr Simon Fraser Commissioned Stage 2 Evidence Synthesis Proposals 17/138: Surgery for early osteoarthritis Panel: Interventional Procedures Declared a conflict and left the room: Mr Alan Chant, Professor Andrew Farmer, Professor Christine Roffe, Professor Craig Ramsay, Professor Michael Clarke, Dr Peter Coventry 17/138/02: The role of surgery in the management of early osteoarthritis of the hip and knee: Evidence synthesis and decision analysis modelling (Kunutsor, University of Bristol) 17/138/06: The role of surgery in the management of Early Osteoarthritis of the hip and knee: a systematic review and economic analysis (Rice, Newcastle University) 17/138/08: Systematic review and decision analytic modelling of the clinical and costeffectiveness of surgery for early osteoarthritis (Simpson, The University of Sheffield) [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 4 of 12

5 NIHR127398: The clinical effectiveness and cost effectiveness of surgery for early osteoarthritis of the hip and knee joint (Price, University of Oxford) NIHR127487: The clinical and cost-effectiveness of timely vs. delayed surgery for early osteoarthritis: a systematic review and decision modelling (Mujica-Mota, University of Exeter Medical School) 5 of 12 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018]

6 Date 18 July 2018 (Day 2) Place Present members NETSCC, HTA Secretariat Apologies Observers Quoracy Information Danubius, London Professor Andrew Farmer Professor John Norrie Professor Hywel Williams Mr Alan Chant Mrs Amanda Roberts Professor Julie Brittenden Professor Mike Clarke Professor Matt Costa Dr Peter Coventry Professor Fay Crawford Professor Rumona Dickson Dr Jennifer Hirst Professor Kerenza Hood Professor Nick James Professor Steff Lewis Professor Danny McAuley Dr Rumana Omar Professor Rupert Pearse Professor Mark Peters Professor Craig Ramsay Dr Matthew Ridd Professor Christine Roffe Dr Sarah Stock Professor Andrew Sutton Dr Sara Twaddle Professor Olivia Wu Dr Simon Fraser (Clinical Advisor, NETSCC) Mrs Karen Williams (Senior Research Manager) Miss Louise Maclachlan (Research Manager) Miss Rachel Corbett (Assistant Research Manager) Professor Mike Crawford Professor Julia Lawton Dr Marc Serfaty Chair Deputy Chair Programme Director PPI representative PPI representative Michael Bowdery, Head of Programmes, Social Care and Health Research Division, Welsh Government Nicola McArdle (Assistant Research Manager, NETSCC) Voting members: 28 Quorum = 19 Voting members present on Day 2: 25 (89%) [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 6 of 12

7 Day 2 Researcher-Led Stage 1 Proposals 17/147/33: The VITDALIZE UK Study: Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: UK arm of an international multi-centre, placebo-controlled double-blind trial (Parekh, University of Birmingham) Declared a conflict and left the room: Dr Andrew Sutton, Professor Danny McAuley Arrived: Christine Roffe 17/147/44: A comprehensive model and economic evaluation of HCV elimination amongst people who inject drugs in England to guide case-finding intervention policy and implementation (Vickerman, University of Bristol) Declared a conflict and left the room: Dr Matthew Ridd 17/147/47: CHAPS: Compression Hosiery to Avoid Post-Thrombotic Syndrome (Davies, Imperial College London) Declared a conflict and left the room: Dr Sarah Stock, Professor Craig Ramsay, Professor Julie Brittenden, Professor Steff Lewis, Professor John Norrie 17/147/13: Glaucoma Risk Prediction in Ocular Hypertension (GRIP): a cohort study using electronic medical records to determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma. (Azuara-Blanco, Queen's University Belfast) Declared a conflict and left the room: Professor Craig Ramsay, Professor Danny McAuley, Professor Hywel Williams, Professor John Norrie, Professor Kerenza Hood 17/147/32: Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency Pre-Hospital hip fracture care Delivery (RAPID 2) (Snooks, Swansea University) Declared a conflict and left the room: Professor Kerenza Hood Arrived: Professor Mike Clarke 7 of 12 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018]

8 18/19: The clinical and cost effectiveness of venous thromboembolism (VTE) risk assessment tools Panel: National Stakeholder Advisory Group Chair: Professor Hywel Williams Declared a conflict and left the room: Dr Sarah Stock, Professor Andrew Farmer, Professor Craig Ramsay, Professor John Norrie, Professor Julie Brittenden, Professor Steff Lewis NIHR127376: VTE-CERAT study: Clinical and Cost Effectiveness of Risk Assessment Tools (Davies, Imperial College London) NIHR127394: Study for thrombosis risk assessment in hospitalized medical patients (STAMP) (Chandra, University Hospitals of North Midlands NHS Trust) NIHR127454: The cost-effectiveness of venous thromboembolism risk assessment tools for hospital inpatients (Goodacre, The University of Sheffield) Commissioned Broad Brief Stage 1 Proposal 17/136: Sepsis Panel: Emergency and Hospital Care 17/136/02: Sepsis Trials In Critical Care (SepTIC) (Gordon, Imperial College London) Chair: Professor Hywel Williams Declared a conflict and left the room: Professor Andrew Farmer, Professor Danny McAuley, Professor John Norrie, Professor Kerenza Hood, Professor Mark Peters, Professor Michael Clarke, Professor Rumana Omar, Professor Steff Lewis Commissioned Stage 1 Proposal 18/18: Active case finding of coeliac disease Panel: Primary Care Declared a conflict and left the room: Dr Andrew Sutton, Dr Matthew Ridd, Professor Andrew Farmer Left the meeting: Professor Hywel Williams NIHR127354: Active case finding of coeliac disease: systematic review, current NHS approach and cost-effectiveness assessment (Kurien, The University of Sheffield) [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 8 of 12

9 , Return to PG Commissioned Broad Brief Stage 1 Proposals (Continued) 17/136: Sepsis Panel: Emergency and Hospital Care 17/136/19: Evaluating the clinical and cost effectiveness of probiotics in survivors from a critical illness for sepsis (Probiotics Post Sepsis: ProPS) (Mouncey, Intensive Care National Audit & Research Centre) Declared a conflict and left the room: Professor Danny McAuley, Professor Mark Peters 17/136: Sepsis Panel: Emergency and Hospital Care 17/136/04: Evaluation of a "sepsis calculator", a tool to direct antibiotic treatment in newborn babies who have risk factors for early-onset sepsis but are clinically well (Uthaya, Imperial College London) Declared a conflict and left the room: Professor Kerenza Hood 17/136: Sepsis Panel: Emergency and Hospital Care 17/136/08: 5% Albumin compared with Balance Crystalloid, Plasma-Lyte, intravenous fluid resuscitation in adult Sepsis patients presenting to Scottish hospitals: the ABC Sepsis trial (Gray, Lothian Health Board) Declared a conflict and left the room: Dr Sarah Stock, Professor Craig Ramsay, Professor Danny McAuley, Professor John Norrie, Professor Olivia Wu, Professor Steff Lewis Left the meeting: Professor Nicholas James 17/136: Sepsis (competing applications) Panel: Emergency and Hospital Care Declared a conflict and left the room: Dr Simon Fraser, Dr Fay Crawford, Professor Andrew Farmer, Professor Kerenza Hood, Professor Rumana Omar, Professor Rumona Dickson, Professor Danny McAuley Left the meeting: Dr Sara Twaddle 9 of 12 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018]

10 17/136/01: Sepsis screening: utility of the national early warning score (NEWS) and exploration of prediction modelling to enhance risk stratification of the patient journey. (Hodgson, Western Sussex Hospitals NHS Trust) 17/136/05: Identifying the most effective and cost-efficient risk stratification tools for infection and sepsis (Schmidt, Portsmouth Hospitals NHS Trust) 17/136/10: Accuracy, effectiveness and cost-effectiveness of prehospital clinical early warning scores for adults with suspected sepsis (Goodacre, The University of Sheffield) 17/136/13: PROcalcitonin and NEWS evaluation for Timely identification of sepsis and Optimal use of antibiotics in the Emergency Department (PRONTO) (French, University of Liverpool) Mental Health Themed Call Stage 1 Proposals 17/111/07: Evaluation of a community based peer support intervention for those living with recurrent depression. (Recovery Model for Depression: ReMoDe) (Maxwell, University of Stirling) Declared a conflict and left the room: Dr Sarah Stock, Professor Craig Ramsay, Professor John Norrie, Professor Olivia Wu, Professor Steff Lewis Arrived: Professor Nicholas James Board recommendation: Request resubmission 17/113/13: The BASIL Trial: Behavioural Activation for Social Isolation or Loneliness (Gilbody, University of York) Declared a conflict and left the room: Dr Andrew Sutton, Professor Christine Roffe, Dr Peter Coventry 17/113/04: The Self Harm, Assessment, Follow-up and Engagement Treatment Trial (The SAFE Treatment Trial) (Guthrie, University of Leeds) Declared a conflict and left the room: Dr Andrew Sutton, Dr Matthew Ridd, Dr Peter Coventry [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 10 of 12

11 Commissioned Stage 1 Proposals (Continued) 18/22: Foot orthoses for children with symptomatic flat feet Panel: Women and Children's Health Declared a conflict and left the room: Dr Andrew Sutton, Dr Fay Crawford, Mrs Amanda Roberts, Professor Andrew Farmer, Professor Kerenza Hood, Professor Matthew Costa, Professor Olivia Wu, Dr Peter Coventry Left the meeting: Rumana Omar 18/22/01: Flatfoot Orthopaedic Appliances Trial - FLOAT An adaptive multi-centre randomised controlled trial to determine the comparative clinical and cost effectiveness of three treatment options in the management of idiopathic flatfeet in children aged 7 to 16 years (Theologis, Oxford University Hospitals NHS Trust) NIHR127510: Orthotics for Treatment of Symptomatic Flat Feet in Children (OSTRICH) (Torgerson, University of York) NIHR127334: OrThoses for children with SympTomatic flexible flat feet (THISTLE): A doubleblind randomised control study comparing the clinical and cost effectiveness between prefabricated off-the-shelf and custom foot orthoses (Santos, Queen Margaret University) 18/08: The effectiveness of early treatment with amitriptyline for the prevention of post-herpetic neuralgia Panel: Primary Care Declared a conflict and left the room: no conflicts NIHR127247: Prevention of Shingles Pain Trial (PROSPECT) (Gill, University of Warwick) NIHR127332: Amitriptyline for the prevention of postherpetic neuralgia (Valderas, Institute of Health Services Research, University of Exeter) 18/20: Bronchodilators and corticosteroids in bronchiectasis Panel: Emergency and Hospital Care 11 of 12 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018]

12 Declared a conflict and left the room: Professor Craig Ramsay, Professor Danny McAuley, Professor John Norrie, Professor Michael Clarke, Professor Steff Lewis Left the meeting: Mr Michael Bowdery NIHR127460: Bronchodilator In Bronchiectasis (BIBS) (De-Soyza, University of Newcastle upon Tyne) 18/21: Strategies for testing and treating TB infection Panel: National Stakeholder Advisory Group Declared a conflict and left the room: Professor Rumana Omar Left the meeting: Professor Mike Clarke NIHR127450: An evaluation of the clinical and cost effectiveness of alternative strategies for TB testing and treatment in the UK for i) new entrants and ii) recent contacts of patients with active TB (Madan, University of Warwick) NIHR127459: Cost-effectiveness of testing and treating latent TB infection (LTBI) and active TB disease in the UK using different strategies of patient targeting and different test technologies: a multidisciplinary transmission-dynamic health-economic analysis of powerful new data sets (White, Imperial College London) Close of day 2 [HTA GENERAL BOARD PUBLIC MINUTES - JULY 2018] 12 of 12