OUR COMMUNITY: OUR WORLD: ONE HEALTH. Ebola : Geomedicine Conference

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1 OUR COMMUNITY: OUR WORLD: ONE HEALTH Ebola : Geomedicine Conference

2 Early Geomedicine

3 East Africa, El Nino 1997

4

5 RVF: A One Health Response Ecological prediction models Animal vaccination Human education

6 December 1, 2012

7 Ebola Virus Filovirus: Negative sense, enveloped RNA virus 5 subtypes: Zaire, Sudan, Tai Forest, Bundibugyo, Reston Incubation period: 2-21 days Transmission: NOT AIRBORNE - blood, urine, feces, saliva, semen (up to 90 days) - tears and sweat (possible) - only after symptoms and tracks with viral load - lives only hours on fomites - those at highest risk include o Healthcare workers o Family and friends of patients with Ebola Diagnosis: RT-PCR, Serology

8 Incubation Period

9 Symptoms

10 Transmissability DISEASE AVG. REPRODUCTIVE RATIO AVG. SERIAL INTERVAL AVG. FATALITY RATE Ebola % Smallpox % Measles % SARS % Diphtheria % Whooping cough % Flu % Rubella % Mumps % Chicken pox %

11 Ebola outbreaks Country Town Cases Deaths Species Year DRC Yambuku Zaire ebolavirus 1976 South Sudan Nzara Sudan ebolavirus 1976 DRC Tandala 1 1 Zaire ebolavirus 1977 South Sudan Nzara Sudan ebolavirus 1979 Gabon Mekouka Zaire ebolavirus 1994 Ivory Coast Tai Forest 1 0 Taï Forest ebolavirus 1994 DRC Kikwit Zaire ebolavirus 1995 Gabon Mayibout Zaire ebolavirus 1996 Gabon Booue Zaire ebolavirus 1996 South Africa Johannesburg 2 1 Zaire ebolavirus 1996 Uganda Gulu Zaire ebolavirus 2000 Gabon Libreville Zaire ebolavirus 2001 Republic of Congo Not specified Zaire ebolavirus 2001 Republic of Congo Mbomo Zaire ebolavirus 2002 Republic of Congo Mbomo Zaire ebolavirus 2003 South Sudan Yambio 17 7 Zaire ebolavirus 2004 DRC Luebo Zaire ebolavirus 2007 Uganda Bundibugyo Bundibugyo ebolavirus 2007 DRC Luebo Zaire ebolavirus 2008 Uganda Luwero District 1 1 Sudan ebolavirus 2011 Uganda Kibaale District 11* 4* Sudan ebolavirus 2012 DRC Isiro Health Zone 36* 13* Bundibugyo ebolavirus 2012 Uganda Luwero District 6* 3* Sudan ebolavirus 2012 *Numbers reflect laboratory confirmed cases only.

12 Ecological Drivers Initiators Habitat loss Extended drought Food insecurity Road infrastructure Amplifiers Urbanization Globalization Political instability Limited healthcare infrastructure

13 Ebola Outbreak Update-Oct 2, 2014 Countries with Widespread Transmission Country Total Cases Laboratory-Confirmed Cases Total Deaths Guinea Liberia Sierra Leone Total Countries with Travel-associated Cases Country Total Cases Laboratory-Confirmed Cases Total Deaths Senegal Spain United States Total Countries with Localized Transmission Country Total Cases Laboratory-Confirmed Cases Total Deaths Nigeria Total

14 Ebola Outbreak Update-Oct 2, 2014

15 Disease vs. Infrastructure

16 Genomic analysis supports single introduction Fig. 3 Molecular dating of the 2014 outbreak.(a) BEAST dating of the separation of the 2014 lineage from Middle African lineages (SL = Sierra Leone; GN = Guinea; DRC = Democratic Republic of Congo; tmrca: Sep 2004, 95% HPD: Oct May 2006). S K Gire et al. Science 2014;science Published by AAAS

17

18

19 Treatment and Prevention options

20 Opportunities to Prevent, Detect, and Respond to the Emergence and Transmission of Zoonotic Diseases Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases. IOM Forum on Microbial Threats Workshop Summary, 2009

21 Strategic Surveillance: Hot Spots and the Human Animal Interface 1 2 Strategic selection of locations for surveillance Strategic selection of species for surveillance USAID EMERGING PANDEMIC THREATS: PREDICT, RESPOND, IDENTIFY, PREVENT, PREPARE

22 VOA 2014

23 Reservoir: The Bat Connection

24 Geographical Information Systems: Potential Utility Tracking outbreak Targeting interventions Resource allocation Risk assessment

25 GIS support for MSF Ebola Response in Guinea S%20Support%20for%20the%20MSF%20Ebola%20Res ponse%20in%20guinea_case%20study.pdf

26 USAID Broad Agency Announcement for Fighting Ebola: A Grand Challenge for Development OppID=15479

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