Lecture 19 Evolution and human health
|
|
- Ellen Heath
- 5 years ago
- Views:
Transcription
1 Lecture 19 Evolution and human health
2 The evolution of flu viruses
3 The evolution of flu viruses Google Flu Trends data US data Check out:
4 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution.
5 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution. host-pathogen coevolution is also referred to as an evolutionary arms race.
6 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution. host-pathogen coevolution is also referred to as an evolutionary arms race. Adaptation Host Pathogen Counter Adaptation
7 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution. host-pathogen coevolution is also referred to as an evolutionary arms race. Example: the influenza A virus
8 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution. host-pathogen coevolution is also referred to as an evolutionary arms race. Example: the influenza A virus influenza A is a retrovirus with 11 genes (on 8 RNA strands).
9 The evolution of flu viruses the evolution of viruses and their hosts is a form of antagonistic coevolution. host-pathogen coevolution is also referred to as an evolutionary arms race. Example: the influenza A virus influenza A is a retrovirus with 11 genes (on 8 RNA strands). responsible for annual flu epidemics (killing about 30,000 to 35,000 Americans per year).
10 Influenza A virus also causes serious global pandemics:
11 Influenza A virus also causes serious global pandemics: Year Deaths in US Spanish flu ,000
12 Influenza A virus also causes serious global pandemics: Year Deaths in US Spanish flu ,000 Asian flu ,000
13 Influenza A virus also causes serious global pandemics: Year Deaths in US Spanish flu ,000 Asian flu ,000 Hong Kong flu ,000
14 The influenza A virus N H
15 The influenza A virus N H
16 The evolution of antigenic sites
17 The evolution of antigenic sites influenza A s major coat protein is hemagglutinin.
18 The evolution of antigenic sites influenza A s major coat protein is hemagglutinin. hemagglutinin is the main target of our immune system.
19 The evolution of antigenic sites influenza A s major coat protein is hemagglutinin. hemagglutinin is the main target of our immune system. amino acid sites in hemagglutinin that our immune system recognizes (and remembers) are called antigenic sites.
20 Locations of antigenic sites in hemagglutinin molecule
21 Phylogenetic analysis of influenza A
22 Phylogenetic analysis of influenza A Fitch et al. (1991) examined the phylogenetic relationships among flu strains over a 20-year period using hemagglutinin sequences.
23 Phylogenetic analysis of influenza A Fitch et al. (1991) examined the phylogenetic relationships among flu strains over a 20-year period using hemagglutinin sequences. this is equivalent to 20 million years of human evolution!
24 Hemagglutinin evolved at a constant rate!
25 Hemagglutinin evolved at a constant rate! Is this neutral evolution?
26 Hemagglutinin evolved at a constant rate! Is this neutral evolution? NOT LIKELY!
27 Annual flu epidemics arise from a single lineage!
28 Why did only a single flu strain persist?
29 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites?
30 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites? Surviving Extinct lineage lineages
31 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites? Surviving Extinct lineage lineages antigenic sites 33 31
32 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites? Surviving Extinct lineage lineages antigenic sites non-antigenic sites 10 35
33 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites? Surviving Extinct lineage lineages antigenic sites non-antigenic sites
34 Why did only a single flu strain persist? due to differences in mutations at antigenic vs. nonantigenic sites? Surviving Extinct lineage lineages antigenic sites non-antigenic sites Conclusion: The surviving lineage had significantly more mutations at antigenic sites
35 Positive selection in the hemagglutinin gene
36 Positive selection in the hemagglutinin gene positive selection occurs when the rate of replacement substitution exceeds the rate of silent substitution.
37 Positive selection in the hemagglutinin gene positive selection occurs when the rate of replacement substitution exceeds the rate of silent substitution. in influenza A, there are 18 codons exhibiting higher rates of replacement substitution!
38 Positive selection in the hemagglutinin gene positive selection occurs when the rate of replacement substitution exceeds the rate of silent substitution. in influenza A, there are 18 codons exhibiting higher rates of replacement substitution! why is this important?
39 Positive selection in the hemagglutinin gene positive selection occurs when the rate of replacement substitution exceeds the rate of silent substitution. in influenza A, there are 18 codons exhibiting higher rates of replacement substitution! why is this important? because this allows us to predict surviving strains and thus make flu vaccines!
40 Strains that persist have the most changes in hemagglutinin antigenic sites
41 * * * A phylogeny of influenza A based on the nucleoprotein gene * * * * * * * *
42 Influenza A can move between humans, birds, and pigs
43 Where did H3 come from?
44 H3 jumped into humans from birds
45 Influenza A can move between humans, birds and pigs
46 The origin of pandemic flu strains Human strain Bird strain Recombination in swine host Reinfect human host
47 H1N1 is a triple-reassortment virus
48 H1N1 is a triple-reassortment virus Segment Origin PB2 Avian North America PB1 Human circa 1993 PA Swine Eurasia HA Swine North America NP Swine Eurasia NA Swine Eurasia MP Swine Eurasia NS Swine Eurasia
49 The evolution of virulence
50 The evolution of virulence virulence is a term that describes the effect a pathogen has on its host.
51 The evolution of virulence virulence is a term that describes the effect a pathogen has on its host. high virulence major effect on host s fitness
52 The evolution of virulence virulence is a term that describes the effect a pathogen has on its host. high virulence major effect on host s fitness low virulence minor effect on its host s fitness
53 The evolution of virulence virulence is a term that describes the effect a pathogen has on its host. high virulence major effect on host s fitness low virulence minor effect on its host s fitness Example: rabbits and the myxoma virus in Australia
54 The evolution of virulence Example: rabbits and the myxoma virus in Australia
55 The evolution of virulence Example: rabbits and the myxoma virus in Australia in 1859, 12 rabbits were bought by Mr. Thomas Austin.
56 The evolution of virulence Example: rabbits and the myxoma virus in Australia in 1859, 12 rabbits were bought by Mr. Thomas Austin. 6 years later, there were 30,000!
57 The evolution of virulence Example: rabbits and the myxoma virus in Australia in 1859, 12 rabbits were bought by Mr. Thomas Austin. 6 years later, there were 30,000! they escaped from his farm and exploded in abundance all over the country.
58 The evolution of virulence Example: rabbits and the myxoma virus in Australia in 1859, 12 rabbits were bought by Mr. Thomas Austin. 6 years later, there were 30,000! they escaped from his farm and exploded in abundance all over the country. the myxoma virus was introduced in the 1950 s to control the rabbit population.
59 The evolution of virulence Example: rabbits and the myxoma virus in Australia Virulence grade high low I II IIIa IIIb IV V
60 The evolution of virulence Example: rabbits and the myxoma virus in Australia Virulence grade high low I II IIIa IIIb IV V
61 The evolution of virulence Example: rabbits and the myxoma virus in Australia Virulence grade high low I II IIIa IIIb IV V
62 The evolution of virulence virulence is a term that describes the effect a pathogen has on its host. high virulence major effect on host s fitness low virulence minor effect on its host s fitness three models have been proposed to account for the evolution of virulence.
63 1. The coincidental evolution hypothesis
64 1. The coincidental evolution hypothesis the virulence of many human pathogens is a result of selection acting on that pathogen in a different environment.
65 1. The coincidental evolution hypothesis the virulence of many human pathogens is a result of selection acting on that pathogen in a different environment. Example: tetanus
66 1. The coincidental evolution hypothesis the virulence of many human pathogens is a result of selection acting on that pathogen in a different environment. Example: tetanus caused by a soil bacteria Clostridium tetani.
67 1. The coincidental evolution hypothesis the virulence of many human pathogens is a result of selection acting on that pathogen in a different environment. Example: tetanus caused by a soil bacteria Clostridium tetani. produces a deadly toxin not directed at humans but at something in the soil.
68 2. The short-sighted evolution hypothesis
69 2. The short-sighted evolution hypothesis since pathogens reproduce within hosts, traits that increase their short-term fitness may actually be detrimental.
70 2. The short-sighted evolution hypothesis since pathogens reproduce within hosts, traits that increase their short-term fitness may actually be detrimental. the virus is short-sighted and virulence higher than expected.
71 2. The short-sighted evolution hypothesis since pathogens reproduce within hosts, traits that increase their short-term fitness may actually be detrimental. the virus is short-sighted and virulence higher than expected. Example: poliovirus.
72 2. The short-sighted evolution hypothesis since pathogens reproduce within hosts, traits that increase their short-term fitness may actually be detrimental. the virus is short-sighted and virulence higher than expected. Example: poliovirus. normally infects cells that line the digestive tract and cause few symptoms.
73 2. The short-sighted evolution hypothesis since pathogens reproduce within hosts, traits that increase their short-term fitness may actually be detrimental. the virus is short-sighted and virulence higher than expected. Example: poliovirus. normally infects cells that line the digestive tract and cause few symptoms. occasionally, the virus infects cells of the nervous system with tragic consequences.
74 3. The trade-off hypothesis
75 3. The trade-off hypothesis pathogens should evolve to the point where fitness costs to the host are balanced by its capacity to propagate itself to other hosts.
76 3. The trade-off hypothesis pathogens should evolve to the point where fitness costs to the host are balanced by its capacity to propagate itself to other hosts. pathogens may thus evolve to where they harm their hosts considerably.
77 3. The trade-off hypothesis pathogens should evolve to the point where fitness costs to the host are balanced by its capacity to propagate itself to other hosts. pathogens may thus evolve to where they harm their hosts considerably. An experiment: E. coli and the phage f1 by Messenger et al. (1999).
78 3. The trade-off hypothesis pathogens should evolve to the point where fitness costs to the host are balanced by its capacity to propagate itself to other hosts. pathogens may thus evolve to where they harm their hosts considerably. An experiment: E. coli and the phage f1 by Messenger et al. (1999). phage f1 can propagate both vertically (parent to daughter cell) and horizontally (to a new host).
79 Treatment 1: 8 day vertical () + brief horizontal ()
80 Treatment 1: 8 day vertical () + brief horizontal () Treatment 2: 1 day vertical () + brief horizontal ()
81 Treatment 1: 8 day vertical () + brief horizontal () Treatment 2: 1 day vertical () + brief horizontal () After 24 days measured:
82 Treatment 1: 8 day vertical () + brief horizontal () Treatment 2: 1 day vertical () + brief horizontal () After 24 days measured: 1. Phage virulence (growth rate of infected hosts).
83 Treatment 1: 8 day vertical () + brief horizontal () Treatment 2: 1 day vertical () + brief horizontal () After 24 days measured: 1. Phage virulence (growth rate of infected hosts). 2. Phage growth rate (rate of virion secretion from infected hosts).
84 Trade-off between virulence and reproductive rate in phage f1
85 What factors can select for increased virulence?
86 What factors can select for increased virulence? 1. Live host not needed for transmission
87 What factors can select for increased virulence? 1. Live host not needed for transmission Examples: ebola virus, parasitic fungi
88 What factors can select for increased virulence? 1. Live host not needed for transmission Example: ebola virus, parasitic fungi 2. Multiple infections in same host
89 What factors can select for increased virulence? 1. Live host not needed for transmission Example: ebola virus, parasitic fungi 2. Multiple infections in same host leads to competition among pathogens within hosts
90 What factors can select for increased virulence? 1. Live host not needed for transmission Example: ebola virus, parasitic fungi 2. Multiple infections in same host leads to competition among pathogens within hosts 3. Transmission is horizontal (i.e., from individual to individual), not vertical (i.e., parent to offspring)
Lecture 18 Evolution and human health
Lecture 18 Evolution and human health Evolution and human health 1. Genetic factors 2. Infectious diseases Evolution and human health 1. Genetic factors Evolution and human health 1. Genetic factors P
More informationNovember 9, 2009 Bioe 109 Fall 2009 Lecture 19 Evolution and human health. The evolution of flu viruses
November 9, 2009 Bioe 109 Fall 2009 Lecture 19 Evolution and human health The evolution of flu viruses - the potential harm of disease epidemics in human populations has received considerable attention
More informationEvolution of influenza
Evolution of influenza Today: 1. Global health impact of flu - why should we care? 2. - what are the components of the virus and how do they change? 3. Where does influenza come from? - are there animal
More informationPhylogenetic Methods
Phylogenetic Methods Multiple Sequence lignment Pairwise distance matrix lustering algorithms: NJ, UPM - guide trees Phylogenetic trees Nucleotide vs. amino acid sequences for phylogenies ) Nucleotides:
More informationOverview: Chapter 19 Viruses: A Borrowed Life
Overview: Chapter 19 Viruses: A Borrowed Life Viruses called bacteriophages can infect and set in motion a genetic takeover of bacteria, such as Escherichia coli Viruses lead a kind of borrowed life between
More informationLESSON 4.5 WORKBOOK. How do viruses adapt Antigenic shift and drift and the flu pandemic
DEFINITIONS OF TERMS Gene a particular sequence of DNA or RNA that contains information for the synthesis of a protien or RNA molecule. For a complete list of defined terms, see the Glossary. LESSON 4.5
More information2000 and Beyond: Confronting the Microbe Menace 1999 Holiday Lectures on Science Chapter List
2000 and Beyond: Confronting the Microbe Menace 1999 Holiday Lectures on Science Chapter List Lecture One Microbe Hunters: Tracking Infectious Agents Donald E. Ganem, M.D. 1. Start of Lecture One 2. Introduction
More informationInfluenza A virus subtype H5N1
Influenza A virus subtype H5N1 Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species.
More informationHS-LS4-4 Construct an explanation based on evidence for how natural selection leads to adaptation of populations.
Unit 2, Lesson 2: Teacher s Edition 1 Unit 2: Lesson 2 Influenza and HIV Lesson Questions: o What steps are involved in viral infection and replication? o Why are some kinds of influenza virus more deadly
More informationPatricia Fitzgerald-Bocarsly
FLU Patricia Fitzgerald-Bocarsly October 23, 2008 Orthomyxoviruses Orthomyxo virus (ortho = true or correct ) Negative-sense RNA virus (complementary to mrna) Five different genera Influenza A, B, C Thogotovirus
More informationIntroduction to Avian Influenza
Introduction to Avian Influenza David L. Suarez D.V.M., Ph.D. Research Leader Exotic and Emerging Avian Viral Disease Research Unit Agricultural Research Service United States Department of Agriculture
More informationThe prokaryotic domains
Diversity of Bacteria, Archaea, and Viruses Chapter 19 The prokaryotic domains Bacteria Three types of structure Spherical, rod-shaped, and spiral Archaea Many are extremophilic Prefer to live in very
More informationPatterns of hemagglutinin evolution and the epidemiology of influenza
2 8 US Annual Mortality Rate All causes Infectious Disease Patterns of hemagglutinin evolution and the epidemiology of influenza DIMACS Working Group on Genetics and Evolution of Pathogens, 25 Nov 3 Deaths
More informationSegments 7 codes for M1 and M2 proteins (Matrix proteins)
One Flu over the Cuckoo s nest Dr Rachel Jones Department of Virology NPHS Microbiology Cardiff Whistlestop tour through Flu The virus Some history The Novel Virus Recent events The disease The control
More informationUnit 2: Lesson 2 Case Studies: Influenza and HIV LESSON QUESTIONS
1 Unit 2: Lesson 2 Case Studies: Influenza and HIV LESSON QUESTIONS What steps are involved in viral infection and replication? Why are some kinds of influenza virus more deadly than others? How do flu
More informationAcute respiratory illness This is a disease that typically affects the airways in the nose and throat (the upper respiratory tract).
Influenza glossary Adapted from the Centers for Disease Control and Prevention, US https://www.cdc.gov/flu/glossary/index.htm and the World Health Organization http://www.wpro.who.int/emerging_diseases/glossary_rev_sept28.pdf?ua=1
More informationPandemic Influenza influenza epidemic: realization of a worst-case scenario
Pandemic Influenza October 9, 2006 1918 influenza epidemic: realization of a worst-case scenario First case: Albert Mitchell, Camp Funston, KS, March 11, 1918 Up to 20% of all humans infected 20-50 million
More informationAn Evolutionary Story about HIV
An Evolutionary Story about HIV Charles Goodnight University of Vermont Based on Freeman and Herron Evolutionary Analysis The Aids Epidemic HIV has infected 60 million people. 1/3 have died so far Worst
More informationBiology 350: Microbial Diversity
Biology 350: Microbial Diversity Strange Invaders: Viruses, viroids, and prions. Lecture #27 7 November 2007-1- Notice handouts and announcements for today: Outline and study questions A 1999 paper discussing
More informationInfluenza: The past, the present, the (future) pandemic
Influenza: The past, the present, the (future) pandemic Kristin Butler, MLS (ASCP) cm Department of Clinical Laboratory Sciences Louisiana Health Sciences Center - Shreveport Fall 2017 Objectives 1) Detail
More informationGrade Level: Grades 9-12 Estimated Time Allotment Part 1: One 50- minute class period Part 2: One 50- minute class period
The History of Vaccines Lesson Plan: Viruses and Evolution Overview and Purpose: The purpose of this lesson is to prepare students for exploring the biological basis of vaccines. Students will explore
More informationLESSON 4.4 WORKBOOK. How viruses make us sick: Viral Replication
DEFINITIONS OF TERMS Eukaryotic: Non-bacterial cell type (bacteria are prokaryotes).. LESSON 4.4 WORKBOOK How viruses make us sick: Viral Replication This lesson extends the principles we learned in Unit
More informationInfluenza Viruses A Review
Influenza Viruses A Review AVIAN INFLUENZA: INTERSECTORAL COLLABORATION Larnaca, Cyprus 20 22 July 2009 Kate Glynn Scientific and Technical Department, OIE Influenza Viruses C. Goldsmith,1981 Influenza
More informationInfluenza viruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Influenza viruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Enveloped particles, quasi-spherical or filamentous Diameter 80-120 nm Envelope is derived
More informationCurrent Vaccines: Progress & Challenges. Influenza Vaccine what are the challenges?
Current Vaccines: Progress & Challenges Influenza Vaccine what are the challenges? Professor John S. Tam The Hong Kong Polytechnic University Asia-Pacific Alliance for the Control of Influenza (APACI)
More informationModeling the Antigenic Evolution of Influenza Viruses from Sequences
Modeling the Antigenic Evolution of Influenza Viruses from Sequences Taijiao Jiang Center of Systems Medicine, Chinese Academy of Medical Sciences Suzhou Institute of Systems Medicine October 8-10, 2015.
More informationJ. A. Sands, 21 October 2013 Lehigh University
J. A. Sands, 21 October 2013 Lehigh University Cryptococcus, Candidiasis, Aspergillosis Tuberculosis Cholera Plague Bact. Meningitis Salmonella Listeria Leptospirosis Staph. (MRSA) E. coli Clostridium
More informationLecture 11. Immunology and disease: parasite antigenic diversity
Lecture 11 Immunology and disease: parasite antigenic diversity RNAi interference video and tutorial (you are responsible for this material, so check it out.) http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html
More informationINFLUENZA-2 Avian Influenza
INFLUENZA-2 Avian Influenza VL 7 Dec. 9 th 2013 Mohammed El-Khateeb Overview 1. Background Information 2. Origin/History 3. Brief overview of genome structure 4. Geographical Distribution 5. Pandemic Nature
More informationEpidemiology Treatment and control Sniffles and Sneezes Mortality Spanish flu Asian flu Hong Kong flu The Swine flu scare
Epidemiology Treatment and control Sniffles and Sneezes Mortality Spanish flu Asian flu Hong Kong flu The Swine flu scare Epidemiology The Flu Virus Influenza is commonly called the flu. The most deadly
More informationLecture 2 Evolution in action: the HIV virus
Lecture 2 Evolution in action: the HIV virus Peter and Rosemary Grant Barry Sinervo The HIV/AIDS pandemic Life expectancy in Botswana What is HIV? What is HIV? HIV is a retrovirus (i.e., RNA-based) with
More informationRalph KY Lee Honorary Secretary HKIOEH
HKIOEH Round Table: Updates on Human Swine Influenza Facts and Strategies on Disease Control & Prevention in Occupational Hygiene Perspectives 9 July 2009 Ralph KY Lee Honorary Secretary HKIOEH 1 Influenza
More informationAvian Influenza: Armageddon or Hype? Bryan E. Bledsoe, DO, FACEP The George Washington University Medical Center
Avian Influenza: Armageddon or Hype? Bryan E. Bledsoe, DO, FACEP The George Washington University Medical Center Definitions: Epidemic The occurrence of cases of an illness in a community or region which
More informationWhere Health Care Meets Policy. with Dr. Mike Magee
Where Health Care Meets Policy with Dr. Mike Magee The Threat of Bird Flu Understanding Bird Flu and the Influenza Virus 3 types of the influenza virus: A, B and C reflect differences in the M protein
More informationA secret about creationism
A secret about creationism Even among ardent creationists, most believe in evolution Why? Natural selection is a provable biological process. Selection causes evolution critical in medicine, agriculture
More informationWhat is influenza virus? 13,000 base RNA genome: 1/ the size of the human genome
What is influenza virus? 13,000 base RNA genome: 1/246153 the size of the human genome CDC Principles of Virology, 4e Neumann et al. Nature. 2009. Influenza virus is one of the most deadly viral pathogens
More informationChapter 19: The Genetics of Viruses and Bacteria
Chapter 19: The Genetics of Viruses and Bacteria What is Microbiology? Microbiology is the science that studies microorganisms = living things that are too small to be seen with the naked eye Microorganisms
More information4/28/2013. The Ever-Evolving Flu p The 1918 Flu p. 617
The Ever-Evolving Flu p. 615 1. Influenza (Fig 18.10) rapidly evolves each year, and processes such as reassortment give rise to new genotypes. 2. Flu virus evolves rapidly to evade our immune system (Fig
More informationدکتر بهروز نقیلی استاد بیماریهای عفونی مرکس تحقیقات بیماریهای عفونی و گرمسیری پاییس 88
دکتر بهروز نقیلی استاد بیماریهای عفونی مرکس تحقیقات بیماریهای عفونی و گرمسیری پاییس 88 FLU.. How often can you escape? Three viral types are distinguished by their matrix and nucleoproteins Type Host Clinical
More informationCristina Cassetti, Ph.D.
NIAID Extramural Research Update: Recombinant Influenza Viruses and Biosafety Cristina Cassetti, Ph.D. Influenza Program Officer Division of Microbiology and Infectious Diseases NIAID Influenza virus DMID
More informationInfluenza. Gwen Clutario, Terry Chhour, Karen Lee
Influenza Gwen Clutario, Terry Chhour, Karen Lee Overview Commonly referred to as the flu Defined as a highly contagious viral infection where it starts at the upper respiratory tract and attacks the nose,
More informationOrigins and evolutionary genomics of the novel avian-origin H7N9 influenza A virus in China: Early findings
Origins and evolutionary genomics of the novel 2013 avian-origin H7N9 influenza A virus in : Early findings Jiankui He*, Luwen Ning, Yin Tong Department of Biology, South University of Science and Technology
More informationVIROLOGY OF INFLUENZA. Subtypes: A - Causes outbreak B - Causes outbreaks C - Does not cause outbreaks
INFLUENZA VIROLOGY OF INFLUENZA Subtypes: A - Causes outbreak B - Causes outbreaks C - Does not cause outbreaks PATHOGENICITY High pathogenicity avian influenza (HPAI) Causes severe disease in poultry
More informationAgricultural Outlook Forum Presented: February 16, 2006 THE CURRENT STATE OF SCIENCE ON AVIAN INFLUENZA
Agricultural Outlook Forum Presented: February 16, 2006 THE CURRENT STATE OF SCIENCE ON AVIAN INFLUENZA David L. Suarez Southeast Poultry Research Laboratory, Exotic and Emerging Avian Viral Diseases Research
More informationBroadly protective influenza vaccines for pandemic preparedness. Suresh Mittal Department of Comparative Pathobiology Purdue University
Broadly protective influenza vaccines for pandemic preparedness Suresh Mittal Department of Comparative Pathobiology Purdue University Influenza A Virus Orthomyxovirus Consist of s/s (-) sense RNA 8 segments
More informationAvian influenza Avian influenza ("bird flu") and the significance of its transmission to humans
15 January 2004 Avian influenza Avian influenza ("bird flu") and the significance of its transmission to humans The disease in birds: impact and control measures Avian influenza is an infectious disease
More informationEmerging Diseases. Biosciences in the 21 st Century Dr. Amber Rice October 26, 2012
Emerging Diseases Biosciences in the 21 st Century Dr. Amber Rice October 26, 2012 Outline Disease emergence: a case study Introduction to phylogenetic trees Introduction to natural selection How do pathogens
More informationEVOLUTION. Reading. Research in my Lab. Who am I? The Unifying Concept in Biology. Professor Carol Lee. On your Notecards please write the following:
Evolution 410 9/5/18 On your Notecards please write the following: EVOLUTION (1) Name (2) Year (3) Major (4) Courses taken in Biology (4) Career goals (5) Email address (6) Why am I taking this class?
More informationTopic 7 - Commonality
II. Organism Topic 7 - Commonality From Viruses to Bacteria to Genetic Engineering Prebiotic Period Refers to before life Early Earth contained little O 2 O 2 prevents complex molecules Complex organic
More informationEbola Virus. Emerging Diseases. Biosciences in the 21 st Century Dr. Amber Rice December 4, 2017
Ebola Virus Emerging Diseases Biosciences in the 21 st Century Dr. Amber Rice December 4, 2017 Outline Disease emergence: a case study How do pathogens shift hosts? Evolution within hosts: The evolution
More information1/29/2013. Viruses and Bacteria. Infectious Disease. Pathogens cause disease by: Chapters 16 and 17
Viruses and Bacteria Chapters 16 and 17 Infectious Disease Caused by the invasion of a host by agents whose activities harm the host s tissues Can be transmitted to others Pathogen microorganisms that
More informationInfluenza Infection In Human. Dr. Zuhaida A. Jalil Surveillance Sector Disease Control Division, MOH Malaysia 3 May 2018
Influenza Infection In Human Dr. Zuhaida A. Jalil Surveillance Sector Disease Control Division, MOH Malaysia 3 May 2018 Objective of the session: After completing this session, you will be able to: Understand
More informationINFLUENZA A VIRUS. Structure of the influenza A virus particle.
INFLUENZA INFLUENZA A VIRUS Structure of the influenza A virus particle. TYPE A VIRUS HAS TWO TYPES OF SPIKES, THE HEMAGGLUTININ (H) AND THE NEURAMINIDASE (N), PROTRUDING FROM THE VIRAL ENVELOPE THE HEMAGGLUTININ
More information19 Viruses BIOLOGY. Outline. Structural Features and Characteristics. The Good the Bad and the Ugly. Structural Features and Characteristics
9 Viruses CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson Outline I. Viruses A. Structure of viruses B. Common Characteristics of Viruses C. Viral replication D. HIV Lecture Presentation
More informationNanoparticulate Vaccine Design: The VesiVax System
Nanoparticulate Vaccine Design: The VesiVax System Gary Fujii, Ph.D. President and CEO Molecular Express, Inc. May 16, 2006 Orlando, Florida Influenza Each year up to 20% of the world's population contracts
More informationAvian Influenza Virus H7N9. Dr. Di Liu Network Information Center Institute of Microbiology Chinese Academy of Sciences
Avian Influenza Virus H7N9 Dr. Di Liu Network Information Center Institute of Microbiology Chinese Academy of Sciences Avian Influenza Virus RNA virus, Orthomyxoviruses Influenza A virus Eight Gene segments
More informationInfluenza surveillance and pandemic preparedness - a global challenge Anne Kelso
Influenza surveillance and pandemic preparedness - a global challenge Anne Kelso WHO Collaborating Centre for Reference and Research on Influenza Melbourne, Australia Three global health challenges 243
More informationExistence of reassortant A (H1N2) swine influenza viruses in Saitama Prefecture, Japan
International Congress Series 1263 (2004) 749 753 Existence of reassortant A (H1N2) swine influenza viruses in Saitama Prefecture, Japan Shin ichi Shimada a, *, Takayasu Ohtsuka b, Masayuki Tanaka b, Munehito
More informationMINI-REVIEW. Protein & Cell. The emergence of pandemic influenza viruses
2010, 1(1): 9 13 DOI 10.1007/s13238-010-0008-z MINI-REVIEW The emergence of pandemic influenza viruses Yi Guan ( ), Dhanasekaran Vijaykrishna, Justin Bahl, Huachen Zhu, Jia Wang, Gavin J. D. Smith State
More informationLecture 2: Virology. I. Background
Lecture 2: Virology I. Background A. Properties 1. Simple biological systems a. Aggregates of nucleic acids and protein 2. Non-living a. Cannot reproduce or carry out metabolic activities outside of a
More informationEVOLUTION: WHY DOES IT MATTER? What did evolution ever do for me?
EVOLUTION: WHY DOES IT MATTER? What did evolution ever do for me? www.christs.cam.ac.uk/darwin200 Evolution is change in living things through descent with modification Evolution is change in living things
More informationAlphabet Soup of Flu Strains
1 of 6 16.03.2015 15:47 Author: Laurie Garrett, Senior Fellow for Global Health February 4, 2015 The year 2015 may be the most complicated influenza year in history. So many new types of flu, including
More informationNovel H1N1 Influenza. It s the flu after all! William Muth M.D. Samaritan Health Services 9 November 2009
Novel H1N1 Influenza It s the flu after all! William Muth M.D. Samaritan Health Services 9 November 2009 Influenza A Primer.. What is the flu? How do you get it? What s a virus anyhow? Can the flu be prevented,
More informationLecture 2 The Darwinian Revolution
Lecture 2 The Darwinian Revolution Theories of evolution first developed by the Greek philosophers. Theories of evolution first developed by the Greek philosophers. Anaximander (610-546 BC) wrote about
More informationClass 34: Computing with Life (and the Chicken Flu)
Class 34: Computing with Life (and the Chicken Flu) CS150: Computer Science University of Virginia Computer Science David Evans http://www.cs.virginia.edu/evans DNA Sequence of nucleotides: adenine (A),
More informationChapter 18. Viral Genetics. AP Biology
Chapter 18. Viral Genetics 2003-2004 1 A sense of size Comparing eukaryote bacterium virus 2 What is a virus? Is it alive? DNA or RNA enclosed in a protein coat Viruses are not cells Extremely tiny electron
More informationEmergence of distinct avian-like influenza A H1N1 viruses in pigs in Ireland and their reassortment with cocirculating H3N2 viruses
International Congress Series 1263 (2004) 209 213 Emergence of distinct avian-like influenza A H1N1 viruses in pigs in Ireland and their reassortment with cocirculating H3N2 viruses Y.P. Lin a, *, M. Bennett
More informationHousing of Different Infected Mice in the Same Room: How to Prevent Roommate Conflicts? Jocelyn Beaucher, PhD, microbiologist Biosafety Officer
Housing of Different Infected Mice in the Same Room: How to Prevent Roommate Conflicts? Jocelyn Beaucher, PhD, microbiologist Biosafety Officer L Université de Sherbrooke Located in the Eastern Townships,
More informationAvian Influenza (Bird Flu) Fact Sheet
What is an avian influenza A (H5N1) virus? Influenza A (H5N1) virus also called H5N1 virus is an influenza A virus subtype that occurs mainly in birds. It was first isolated from birds (terns) in South
More informationInfluenza: The Threat of a Pandemic
April, 2009 Definitions Epidemic: An increase in disease above what you what would normally expect. Pandemic: A worldwide epidemic 2 What is Influenza? Also called Flu, it is a contagious respiratory illness
More informationStudy the Evolution of the Avian Influenza Virus
Designing an Algorithm to Study the Evolution of the Avian Influenza Virus Arti Khana Mentor: Takis Benos Rachel Brower-Sinning Department of Computational Biology University of Pittsburgh Overview Introduction
More informationAdvances in Viral Immunity Stemming from the 1918 Flu Pandemic
Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/clinicians-roundtable/advances-in-viral-immunity-stemming-from-the-
More informationECMO and the 2013 Influenza A H1N1 Epidemic
ECMO and the 2013 Influenza A H1N1 Epidemic Jonathan Kozinn, MD Department of Cardiac Anesthesiology and Critical Care Why Is an Anesthesiologist Talking About the flu? In susceptible individuals, influenza
More information11/15/2011. Outline. Structural Features and Characteristics. The Good the Bad and the Ugly. Viral Genomes. Structural Features and Characteristics
Chapter 19 - Viruses Outline I. Viruses A. Structure of viruses B. Common Characteristics of Viruses C. Viral replication D. HIV II. Prions The Good the Bad and the Ugly Viruses fit into the bad category
More informationHuman Influenza. Dr. Sina Soleimani. Human Viral Vaccine Quality Control 89/2/29. November 2, 2011 HVVQC ١
Human Influenza Dr. Sina Soleimani Human Viral Vaccine Quality Control 89/2/29 November 2, 2011 HVVQC ١ Presentation outline 1. Introduction 2. Virology 3. Classification 4. Hosts 5. Antigenic Specifications
More informationComputational Analysis and Visualization of the Evolution of Influenza Virus
Computational Analysis and Visualization of the Evolution of Influenza Virus A DISSERTATION SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY Ham Ching, Lam IN PARTIAL FULFILLMENT
More informationUniversity of Colorado Denver. Pandemic Preparedness and Response Plan. April 30, 2009
University of Colorado Denver Pandemic Preparedness and Response Plan April 30, 2009 UCD Pandemic Preparedness and Response Plan Executive Summary The World Health Organization (WHO) and the Centers for
More informationChapter 19. Viruses. Concept 19.1 A virus consists of a nucleic acid surrounded by a protein coat.
Chapter 19 Viruses Lecture Outline Overview: A Borrowed Life Viruses are the simplest biological systems. Most viruses are little more than aggregates of nucleic acids and protein genes in a protein coat.
More informationORTHOMYXOVIRUSES INFLUENZA VIRUSES. (A,B and C)
ORTHOMYXOVIRUSES INFLUENZA VIRUSES (A,B and C) Orthomyxoviridae Influenza Viruses Epidemiology: Influenza A virus is so subjected to major antigenic changes that cause occasional world wide pandemics when
More informationUpdate: Porcine epidemic diarrhoea and swine influenza. Eric Neumann DVM PhD Epi-Insight Limited Palmerston North, New Zealand
Update: Porcine epidemic diarrhoea and swine influenza Eric Neumann DVM PhD Epi-Insight Limited Palmerston North, New Zealand Approach Review of the pathogen Review of the outbreak Research outcomes in
More informationProtein Modeling Event
Protein Modeling Event School Name: School Number: Team Member 1: Team Member 2: : Pre-Build Score: On-Site Build Score: Test Score: Tie Breaker: Total: Final Rank: Part I: Pre-Build (40% of total score)
More informationInfluenza. Giovanni Maciocia
Influenza Giovanni Maciocia Zhang Zhong Jing (about 150-219AD) Ye Tian Shi (1667-1746) Wu Ju Tong (1758-1836) 1. WESTERN MEDICINE VIEW a) INFLUENZA INFLUENZA IN CHINESE MEDICINE Epidemiologists predict
More informationIn April 2009, a new strain of
managing and reducing Uncertainty in an Emerging Influenza Pandemic 2. Brundage JF, Shanks GD. Deaths from bacterial pneumonia during 1918 19 influenza pandemic. Emerg Infect Dis 2008;14:1193-9. 3. Update:
More informationApplication of Reverse Genetics to Influenza Vaccine Development
NIAID Application of Reverse Genetics to Influenza Vaccine Development Kanta Subbarao Laboratory of Infectious Diseases NIAID, NIH Licensed Vaccines for Influenza Principle: Induction of a protective
More informationInfluenza. By Allison Canestaro-Garcia. Disease Etiology:
Influenza By Allison Canestaro-Garcia Disease Etiology: The flu is an infectious disease caused by a subset of viruses of the family Orthomyxoviridae. There are 7 different viruses in this family, four
More informationSwine influenza surveillance among pigs in Nan Province
Swine influenza surveillance among pigs in Nan Province National Institute of Animal Health Department of Livestock Development Nan province 30 Aug 2011 การเฝ าระว งโรคไข หว ดใหญ ส กรในส กร จ งหว ดน าน
More informationYour Body's Defenses
Your Body's Defenses For follow up on these notes read: Holt: pages 710 720 MSLS: pages 410 420 Blue writing indicates a video is linked to the picture. Click the pictures! Links to Videos are listed on
More informationINFLUENZA VIRUS. INFLUENZA VIRUS CDC WEBSITE
INFLUENZA VIRUS INFLUENZA VIRUS CDC WEBSITE http://www.cdc.gov/ncidod/diseases/flu/fluinfo.htm 1 THE IMPACT OF INFLUENZA Deaths: PANDEMICS 1918-19 S p a n is h flu 5 0 0,0 0 0 U S 2 0,0 0 0,0 0 0 w o rld
More informationInfluenza A virus infections of mink in Denmark a follow up report April 2012
Influenza A virus infections of mink in Denmark 2009-11 a follow up report April 2012 Lars E Larsen 1, Solvej Ø. Breum 1, Ramona Trebbien 1 ; Karolina Bradstad 2 ; Lars Peter Nielsen 2 ; Mariann Chriél
More informationDr. Ahmed K. Ali. Outcomes of the virus infection for the host
Lec. 9 Dr. Ahmed K. Ali Outcomes of the virus infection for the host In the previous few chapters we have looked at aspects of the virus replication cycle that culminate in the exit of infective progeny
More informationTITLE: Influenza A (H7N9) virus evolution: Which genetic mutations are antigenically important?
TITLE: Influenza A (H7N9) virus evolution: Which genetic mutations are antigenically important? AUTHORS: Joshua G. Petrie 1, Adam S. Lauring 2,3 AFFILIATIONS: 1 Department of Epidemiology, University of
More informationViral reproductive cycle
Lecture 29: Viruses Lecture outline 11/11/05 Types of viruses Bacteriophage Lytic and lysogenic life cycles viruses viruses Influenza Prions Mad cow disease 0.5 µm Figure 18.4 Viral structure of capsid
More informationBIOLOGY. Viruses CAMPBELL. Reece Urry Cain Wasserman Minorsky Jackson. Lecture Presentation by Nicole Tunbridge and Kathleen Fitzpatrick TENTH EDITION
CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson 19 Viruses Lecture Presentation by Nicole Tunbridge and Kathleen Fitzpatrick Figure 19.1 Are the viruses (red) budding from this
More informationWhat is Influenza? Patricia Daly MD, FRCPC Medical Health Officer and Medical Director of Communicable Disease Control
Vancouver Coastal Health & The Vancouver Coastal Health Research Institute presents: On Call with VGH Experts Lecture Series The Flu and You What is Influenza? Patricia Daly MD, FRCPC Medical Health Officer
More informationBefore and during influenza pandemics
before and during influenza pandemics Klaus Stöhr Department for Communicable Diseases Surveillance and Response Before and during influenza pandemics Before pandemics: interpandemic period New human influenza
More informationEarly Diagnosis: A Critical Step in Bird Flu Prevention
Early Diagnosis: A Critical Step in Bird Flu Prevention If avian influenza (bird flu) mutates sufficiently to jump from chickens and migratory birds to people, early diagnosis and identification of the
More informationInfluenza A Viruses (Evolution and Current Status) AND H3N2v Outbreak Update
Influenza A Viruses (Evolution and Current Status) AND 2012 H3N2v Outbreak Update Scott Epperson Influenza Division National Center for Immunization and Respiratory Diseases Centers for Disease Control
More informationDo First: Answer in your DFAD
Do First: Answer in your DFAD Answer each question with a short answer. Haveouts Guided Notes Pen/pencil CAV Card 1. What body system does HIV attack? 2. What cells does HIV attack? 3. Is HIV a virus or
More informationAP Biology. Viral diseases Polio. Chapter 18. Smallpox. Influenza: 1918 epidemic. Emerging viruses. A sense of size
Hepatitis Viral diseases Polio Chapter 18. Measles Viral Genetics Influenza: 1918 epidemic 30-40 million deaths world-wide Chicken pox Smallpox Eradicated in 1976 vaccinations ceased in 1980 at risk population?
More informationEpidemiology: who, what, when, where and why? The first twenty patients examined tested positive for S. enteriditis.
Epidemiology: who, what, when, where and why? February 1996: an outbreak of Salmonella infections in Denver, Colorado. The first twenty patients examined tested positive for S. enteriditis. This Salmonella
More information