BIOGRAPHICAL SKETCH. NAME Sanjay M. Reddy era COMMONS USER NAME

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1 Principal Investigator/Program Director (Last, First, Middle): Reddy, Sanjay M. BIOGRAPHICAL SKETCH NAME Sanjay M. Reddy era COMMONS USER NAME POSITION TITLE Associate Professor, Departments of Veterinary Pathobiology and Poultry Science, Texas A&M University EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Andhra Pradesh Agricultural University, India B.V.Sc Veterinary Medicine University of Maryland, College Park, MD M.S Virology University of Maryland, College Park, MD Ph.D Molecular Virology NIAID, National Institutes of Health, MD Post-Doc Molecular Virology A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee. Positions and Employment Technical Service Representative, Venkateshwara Hatcheries, Hyderabad, AP, India Research Assistant. VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD NIH fellowship, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Veterinary Medical Officer, Avian Disease and Oncology Laboratory, Agriculture Research Service, United States Department of Agriculture, East Lansing, MI Present. Associate Professor. Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX. Other Experience and Professional Memberships Diplomate, American College of Veterinary Microbiologists (ACVM) Member American society for Microbiologists Member Biosecurity task force, ACVM, American Veterinary Medical Association Member American Association of Avian Pathologists Editorial Board of Avian Diseases Honors Fogarty Intramural Research Training Award, NIH Bayer-Snoeyenbos New Investigator Award B. Selected peer-reviewed publications (in reverse chronological order). 1. Reddy S.M., Mozisek, B. and Lupiani, B. Development of a fluorescence microsphere immunoassay (FMI) for subtyping of chicken sera samples. Submitted to Proceedings of the 7 th International Symposium PHS 398/2590 (Rev. 09/04) Page 1 Continuation Format Page

2 on Avian Influenza. Athens, Georgia, April 5-8, Ajithdoss D., Reddy S.M., Suchodolski P.F., Lee L.F., Kung H.J. and Lupiani B In vitro characterization of the Meq proteins of Marek s disease virus vaccine strain CVI988. Virus Research 142 (1-2): Brahmakshatriya V., Lupiani B., Brinlee J.L., Cepeda M., Pillai S.D., and Reddy S.M Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry prorducts using electron beam irradiation. Avian Pathology 38 (3): Suchodolski, P., Izumiya, Y., Lupiani, B., Ajithdoss, D., Gilad, O., Lee, L.F., Kung, H-J., and Reddy, S.M Homodimerization of Marek s disease virus encoded Meq protein is not sufficient for transformation of lymphocytes in chicken. J. Virol. 83 (2): Watson D.S., Reddy S.M., Brahmakshatriya V. and Lupiani B. (2009) A multiplexed immunoassay for detection of antibodies against avian influenza virus. Journal of Immunological Methods 340 (2): Lee L.F., Lupiani B., Silva R.F., Kung H.J., and Reddy S.M. (2008). Recombinant Marek s disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV Vaccine 26(15): Lee L.F., Silva R.F., Cui, X., Zhang H., Heidari M., Reddy, S.M. (2007). Characterization of LORF11, a unique gene common to the three Marek s disease virus serotypes. Avian Diseases, 51 (4) Ding J., Cui Z., Jiang S., Reddy, S. (2006). The enhancement effect of pp38 gene product on the activity of its upstream bi-directional promoter in Marek s disease virus. Science in China: Series C Life Sciences 49 (1): Ding J., Cui, Z., Lee, L.F., Cui, X., Reddy, S.M. (2006). The role of pp38 in regulation of Marek s disease virus bi-directional promoter between pp38 and 1.8-kb mrna. Virus Genes, 32 (2): Lee L.F., Cui X., Cui Z., Gimeno I., Lupiani B., Reddy, S.M. (2005). Characterization of a very virulent Marek s disease virus mutant expressing the pp38 protein from the serotype 1 vaccine strain CVI988/Rispens. Virus Genes. 31 (1): Gimeno, I, Witter, R.L., Hunt. H.D., Reddy, S.M., Lee, L.F. Silva, R.F. (2005). The pp38 gene of Marek s disease virus (MDV) is necessary for cytolytic infection of B cells and the maintenance of the transformed state but not for cytolytic infection of feather follicle epithelium and the horizontal spread of MDV. Journal of Virology 79 (7): Cui X., Lee L.F., Hunt H.D., Reed W.M., Lupiani B., and Reddy S.M. (2005). A Marek s disease virus vil- 8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain. Avian Disease 49 (2): ). 13. Lupiani B., Lee L., Cui X., Gimeno I, Anderson A., Morgan R.W., Silva R.F., Witter R.L., Kung H-J., and Reddy S.M. (2004). Marek s disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication. Proceedings of National Academy of Sciences 101 (32): Cui X., Lee L., Reed W., Kung H-J., and Reddy S.M. (2004). Marek s disease virus encoded vil8 gene is involved in early cytolytic infection but dispensable for establishment of latency. Journal of Virology 78(9): Silva R.F., Reddy S.M., and Lupiani, B. (2004). Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation. Journal of Virology 78(2): Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M., and Reed, W.M. (2004). Biocharacteristics shared by highly protective vaccines against Marek s disease. Avian Pathology 33(1): Levy, A.M., Izumiya, Y., Brunovskis, P., Xia, L., Parcells, M., Reddy, S., Lee, L., Chen, H-W., and Kung, H-J. (2003). Characterization of the chromosomal binding sites and dimerization partners of the viral Oncoprotein Meq in Marek s disease virus transformed T-cells. Journal of Virology 77(23): PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page

3 18. Lee, L.F., Witter, R.L., Reddy. S.M, Wu, P., Yanagida, N., and Yoshida, S. (2003). Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek s disease virus. Avian Diseases 47: , 19. Sung, H.W., Kim, J.H., Reddy, S. and Fadly, A. (2002). Isolation of subgroup J avian leucosis virus in Korea. Journal of Veterinary Science 3 (2): Reddy, S.M., Lupiani,B., Gimeno, I, Silva, R., Lee, L., and Witter R. (2002). Rescue of a very virulent Marek s disease virus using overlapping cosmid DNAs: pp38 is not essential for oncogenesis. Proceedings of National Academy of Sciences 99 (10): Sung H.W., Reddy S.M., Fadly, A.M. (2002). High virus titer in feather pulp of chickens infected with subgroup J avian leukosis virus. Avian Diseases 46 (2): Schumacher, D, Tischer, B.K., Reddy, S.M., and Osterrieder, N. (2001). Glycoproteins E and I of Marek's disease virus serotype 1 are essential for virus growth in cultured cells. Journal of Virology 75 (23): Gimeno, I.M., Witter, R.L., Hunt, H.D., Lee, L.F., Reddy, S.M., and Neumann, U. (2001). Marek s disease virus infection in the brain: virus replication, cellular infiltration and major histocompatibility complex antigen expression. Veterinary Pathology 38: Gimeno, I.M., Witter, R.L., Hunt, H.D., Reddy, S.M., and Neumann, U. (2001). Differential attenuation of the induction by Marek's disease virus of transient paralysis and persistent neurological disease: a model for pathogenesis studies. Avian Pathology 30: Miles, A.M., Reddy, S.M. and Morgan, R.W. (2001) Coinfection of specific-pathogen-free chickens with Marek's disease virus (MDV) and chicken infectious anemia virus: effect of MDV pathotype. Avian Diseases 45: Reddy, S.M., Witter, R.L., and Gimeno, I. (2000). Development of a quantitative-competitive PCR assay for seroype 1 Marek s disease virus. Avian Diseases 44: Reddy, S.M., Sui, D., Wu, P. and Lee L. (1999) Identification and structural analysis of a MDV gene encoding a protein kinase. Acta. Virologica 43: Reddy, S.M*., Cox, E.M*., lofin, I., Soong, W., and Cohen, J.I. (1998). Varicella-Zoster virus (VZV) ORF32 encodes a phosphoprotein that is posttranslationally modified by the VZV ORF47 protein kinase. Journal of Virology 72 (10): (* Contributed equally). 29. Reddy, S.M., Williams, M. and Cohen, J.I. (1998). Expression of uracil DNA glycosylase (UNG) inhibitor in mammalian cells: Varicella-Zoster virus can replicate in vitro in the absence of detectable UNG activity. Virology 251: Cox, E.M*., Reddy, S.M*., Iofin, I., and Cohen, J.I. (1998). Varicella-Zoster virus ORF57, unlike its pseudorabies virus UL3.5 homolog, is dispensable for viral replication in cell culture. Virology 250: (* Contributed equally). 31. Lupiani, B., Reddy, S.M., and Samal, S.K. (1997). Sequence analysis of genome segment 10 encoding the major outer capsid protein (VP7) of genogroup B aquareovirus and its relationship with the VP7 protein of genogroup A aquareovirus. Archives of Virology 142(12): Lupiani, B., Reddy, S.M., Subramanian, K. and Samal, S.K. (1997). Cloning, sequence analysis and expression of the major outer capsid protein gene of an Aquareovirus. Journal of General Virology78: Reddy, S.M. (Mallipeddi, S.K.), and Samal, S. K. (1996). Mapping the domains on the Phosphoprotein of bovine respiratory syncytial virus required for N-P interaction using a two-hybrid system. Journal of General Virology 77: Reddy, S.M. (Mallipeddi, S. K.). and Samal, S. K. (1993). Analysis of the ovine respiratory syncytial virus (RSV) G glycoprotein gene defines a subgroup of ungulate RSV. Journal of General Virology 74: PHS 398/2590 (Rev. 09/04) Page 3 Continuation Format Page

4 Reddy, S.M. (Mallipeddi, S. K.) and Samal, S. K. (1993). Sequence variation in the glycoprotein gene of bovine respiratory syncytial virus. Journal of General Virology 74: Reddy, S.M. (Mallipeddi, S. K.) and Samal, S. K. (1993). Structural difference in the fusion protein among strains of bovine respiratory syncytial virus. Veterinary Microbiology 36: Reddy, S.M. (Mallipeddi, S. K.) and Samal, S. K. (1992). Sequence comparison between the phosphoprotein mrnas of human and bovine respiratory syncytial virus identified a divergent domain in the predicted protein. Journal of General Virology 73: Reddy, S.M. (Mallipeddi, S. K.) Samal, S. K. and Mohanty, S. B. (1990). Analysis of polypeptides synthesized in bovine respiratory syncytial virus-infected cells. Archives of Virology 115: Review Articles and Book chapters 1. Lupiani B., and Reddy S.M. (2008). The history of avian influenza. Comparative Immunology, Microbiology and Infectious Diseases 32 (4): Lupiani, B., Lee L.F. and Reddy S.M. (2000). Protein-coding content of the sequence of Marek s disease virus type 1. Current Topics in Microbiology and Immunology 255: C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co- Investigator, Consultant) in the research project. Do not list award amounts or percent effort in projects. ACTIVE: CSREES/NRI/USDA (Lupiani B, PI, Reddy, SM Co-PI) (Z507201). Development of highly sensitive and specific immunoassays for the detection and monitoring of AI The overall goals of this project are to develop immunoreagents for the development of diagnostic tests for the detection and control of avian influenza and the development of viral vector vaccines against avian influenza for their use in chickens. CSREES/NRI/USDA (Reddy SM, PI) (Z507226) Evaluation of E-beam pasteurization for inactivation of avian influenza virus in chicken meat and egg products. The overall objective of this project is to determine if E-beam pasteurization can be used for inactivation of avian influenza viruses in meat and egg products. USDA Formula Animal Health (1433). (Reddy SM, PI): AH-9248 In vivo characterization of avian influenza NS1 mutant viruses. The overall goal of this proposal is to identify the role of the NS1 protein in low pathogenic avian influenza viruses in chickens. CSREES/NRI/USDA (Reddy SM, PI, Lupiani B, Co-PI) Biochemical and biological characterization of the Meq protein from CVI988, a Marek s disease virus serotype 1 vaccine. The overall goal of this proposal is the biochemical and biological characterization of the Meq oncoprotein of vaccine and oncogenic strains of Marek s disease viruses to determine what makes vaccine viruses attenuated. CSREES/NRI/USDA (Reddy SM, PI, Lupiani B, Co-PI) Enhancing avian influenza vaccine efficacy using toll-like receptor ligands for rapid induction of immune response Cobb-Ventress Co. (Zhou H, PI, Reddy SM Co-PI) PHS 398/2590 (Rev. 09/04) Page 4 Continuation Format Page

5 Gene expression profiling of different Mx genotypes in avian influenza virus infected embryo and chickens The overall goal of this proposal is to identify chicken transcriptional profile of avian influenza virus infected respiratory epithelial cells in Mx specific genotypes of chickens. PHS 398/2590 (Rev. 09/04) Page 5 Continuation Format Page

The Threat of Marek s Disease Virus Is Expanding

The Threat of Marek s Disease Virus Is Expanding The virus responsible for this lymphoproliferative disease is growing more virulent and evading control by available vaccines Kyle S. MacLea and Hans H.