High Power CO2 Laser + Micro-needle Fractional RF

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1 High Power CO2 Laser + Micro-needle Fractional RF Micro-needle RF Gynolaser (Optional) CO2 Laser

2 What is Fraxis Duo? Fraxis Duo combines CO2 laser and micro-needle fractional RF technology for optimal result for scar removal and photo-aging treatments. CO2 fractional laser enables intense superficial heating stimulation while micro-needle fractional RF provides high volumetric heating that can reach to the skin tissue inside of body. This dual function allows safe and effective treatment on all skin types with maximum versatility of application areas. The combining therapy could be an effective and better choice for striae distensae by both effective dermal remodeling and skin resurfacing at the same time.

3 Combination Therapy CO₂ fractional is enabling intense superficial stimulation and micro-needle fractional RF provides higher volumetric heating and deeper heat diffusion to 3.5mm based on treatment target areas, depending on the skin s condition. Such complementary effects could encourage physicians to combine two technologies for an effective treatment for various indications. CO2 Laser Micro-needle RF

4 The Clinical Difference of CO₂ & Micro-needle RF Vimentin Immunohistochemical analyses at 15 days after application CO2 Laser vs. Micro-needle RF - Biopsies courtesy of Michael Naouri MD Post CO₂ Laser Post Micro-needle RF The histology analyses show an intense superficial fibroblast stimulation with CO₂ but a middle and deep fibroblast stimulation using micro-needle fractional RF.

5 The Clinical Differnce of Co₂ & Micro-needle RF A before B after Thickened epidermis and dermal remodeling post micro-needle RF with CO₂laser treatment - Biopsies courtesy of Michael Naouri MD Note the thickened epidermis(b) and increased and thickened collagen bundles in the dermis(d), compared to base line(a, C), respectively. C before D after (A, B: hematoxylin and eosin, X 100; C, D: Masson trichrome stain, x 40).

6 The Benefits of Dual Modalities Seborrheic Keratosis Freckle Wart Lentigines Etc. Ultra Pulse Non-surgical face lifting Photo-aging Scars Hyperhidrosis Striae distensae Scanner Micro-needle RF Skin rejuvenation Scars Fine lines Etc. CW Surgical Operation With dual energies and various modes it enables physicians to easily select the most effective mode and energy depending on a variety of conditions on all skin types with very low risk of skin burns and PIH.

7 Features of CO2 Laser Fractional Normal 30 watt CO2 Laser with high power RF tube generates uniformed and stable laser beam with 100~120μm spot size, which minimizes thermal damage and any unpredictable side effect. Smart surgical Hand pc with multiple spot sizes enable physicians to easily treat superficial lesions (Seborrheic Keratosis, lentigines ) or more accurate treatment on wart.

8 Features of CO2 Laser Fractional Shape Various Shape and scanning modes Scan Normal Adjustable hand piece size 0.2 mm CIRCLE ELLIPSE Convergence Sequence Diagonal Even/odd 0.3 mm 0.5 mm 0.7 mm SQUARE RECTANGULAR 0.9 mm 1.1 mm Random / Scatter Sequence Diagonal Even/odd 1.3 mm TRIANGLE HALF CIRCLE Shape : more than 6 types / Scan Mode : 9 types Available to provide customized treatment Minimizing thermal damage and side effect Maximizing treatment effect 7 Adjustable spot sizes 4 types of surgical mode: CW, Pulse single, Pulse, Ultra pulse Easy to select spot size and pulse mode

9 Features of Micro-needle RF FACE BODY 0.5~1.0mm 1.0~2.0mm 2.0~3.5mm / wrinkle reduction / pore minimization / acne / acne scars / scars / decolleter tightening stretch mark / Hyperhidrosis Micro-needle penetration depth can be adjusted from 0.5 to 3.5mm based on treatment target areas for the treatment of skin lifting, tightening and rejuvenation e.g., hyperpigmentation, wrinkle, acne, acne scar and pore treatments. Delivered RF energy is tightly focused at the edge/tip of the Micro-Needles, leading to far less trauma to the surrounding epidermis. This leads to far less down time and pain for the patient as compared to a conventional CO₂ fractional laser.

10 Features of Micro-needle RF Fraxis Duo s RF system uses 31G micro needles which is the optimum needle thickness to treat most indications. 31G needles assure minimum pain, short downtime with almost no scars or bruises, and low risks of side effects while offering maximum treatment result. Other Product VS. Superior Quality Needles! 31G Needle depth can be adjusted from 0.5 to 3.5mm based on treatment areas. 25 Pin uninsulated (Rejuvenation, Redness, Melasma, Pores) Fraxis Duo also provides uninsulated needles, which are more effective for rejuvenation and collagen generation. Using 31G micro-fine needles, perfectly safe uninsulated treatment is possible. 10 Pin uninsulated 10 Pin insulated (Stretch marks, Deep wrinkles)

11 Specification CO2 Fractional Laser System Micro-needle Fractional RF System Wave length 10,600nm (TEM00) RF Frequency 2MHz ±10% Laser power Up to 30W (Up to 175mJ) RF Power Up to 25W ±10% Pulse duration 20-5,000us Treatment duration (RF Emission) 50ms ~ 950ms Overlap 1-10 th Pixel size 100 micron Intensity Level (2/5/10 Step) Distance mm Needle thickness 31G (0.25mm) Treatment area 1x1-20x20mm Needle figure 25 electrode needle (5x5), 10 electrode needle (1x10) Option Pixel quantity Up to 40,401 Repetition Normal handpiece (option) Sec / Single 0.2, 0.3, 0.5, 0.7, 0.9, 1.1, 1.3mm Treatment area Adjustable depth Repetition 25Pin (7.8 x 7.8mm), 10Pin (0.25 x 16mm) 0.5 ~ 3.5mm (0.1 step) 0.2 / 0.5 / 1 / 2 Sec / Single Electrical power 100 ~ 240VAC, 50/60Hz

12 Gynolaser (Optional) Fraxis Duo offers optional Gynolaser handpiece for non-surgical treatment of vaginal rejuvenation and urinary incontinence. Disposable external slide 90 probe set Distance gauge Indications Vaginal laxity Stress incontinence Recurrent thrush Itchiness & burning Dryness Vaginal/vulvar pain Dyspareunia

13 Features of Gynolaser (Optional) Probe(vaginal tip) has a mirrored surface at 45 that reflects CO2 laser beam perpendicularly (90 ) on the vaginal wall inside. Disposable external slide can prevent the entire probe from sticking to the internal tissue.

14 Features of Gynolaser (Optional) Vaginal relaxation describes weakness and laxity of the vagina caused by aging, childbirth, vaginal injury, etc. Gynolaser is capable of improving this condition with treatment called vaginal rejuvenation. Fibroblasts will be stimulated by thermal effect of laser radiation and start regenerate collagen. Elasticity of vaginal mucosa is improved and enlarged vagina will be tightened.

15 Case Studies Michaël NAOURI, M. D. Centre Laser International de la Peau - Paris, Centre Laser - Nogent sur Marne, Nogent sur Marne, France Using micro-needle fracitonal RF - Atrophic Scars - Acne Scars - Photo-aging Jae-We Cho, M.D., PhD. Department of Dermatology, Laser and Esthetic Center, Keimyung University School of Medicine Using combination therapy - Striea Distensae - Burn Scars Using CO2 laser - Onychodystrophy - Wart

16 [ DR. M. NAOURI ] Hypertrophic Scars Using Micro-needle RF Before After 2 sessions [ DR. M. NAOURI ] Atrophic Scars Using Micro-needle RF Before After 1 sessions

17 [ DR. M. NAOURI ] Acne Scars & Enlarged Pores Using Micro-needle RF Before After 3 sessions [ DR. M. NAOURI ] Periorbital & Nasolabial Fold Using Micro-needle RF Before After 3 sessions

18 [ DR. M. NAOURI ] Onychodystrophy Using Co2 Laser Before After 4 sessions [ DR. M. NAOURI ] Wart Using Co2 Laser Before After

19 [DR. Jae-We Cho] Striae Distensae On The Buttock Using Combination Therapy Photo countesy of Jae-We Cho M.D. Photo countesy of Jae-We Cho M.D. Before 6months after final treatment [DR. Jae-We Cho] Striae Distensae On The Calf Using Combination Therapy Photo countesy of Jae-We Cho M.D. Photo countesy of Jae-We Cho M.D. Before 6months after final treatment

20 [DR. Jae-We Cho] Burn Scars Using Combination Therapy Photo countesy of Jae-We Cho M.D. Photo countesy of Jae-We Cho M.D. Before After 3 Sessions

21 WALNUT OFFICE 675 Brea Canyon Rd. #8, Walnut, CA PHONE. (909) LA OFFICE 3600 Wilshire Blvd. #1016, Los Angeles, CA PHONE. (213)

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