Peeling. Smooth out the skin. Remove the outer skin layers. Erase the fine wrinkles. The regenerated skin is smoother & Less wrinkled - Renewed

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2 If you foolishly ignore beauty, you will soon find yourself without it. Your life will be impoverished. But if you wisely invest in beauty, it will remain with you all the days of your life Frank Lloyd

3 Peeling Smooth out the skin. Remove the outer skin layers. Erase the fine wrinkles. The regenerated skin is smoother & Less wrinkled - Renewed

4 Skin layers Epidermis: melanocyte melanin Langerhans' cell immune system Dermis: collagen elastic tissue reticular fibers Hypodermis Fat Connective tissue

5 Physiopathology of Melanogenesis Hyperpigmentation Commonly know as brown spots Cause: excessive of melanogenesis

6 Synthesis of Melanin Stimulated by UV Melanin is synthesized in the melanocyte cells Enzymatic reactions L-tyrosine is the precursor

7 Tyrosinase Enzyme responsible of the Melanin formation. Tyrosinase is activated via 3 pathways MELANIN DOPAQUINONE DOPA L-TYROSINE TYROSINASE

8 Tyrosinase Tyrosinase is activated via 3 pathways: The protein kinase A The protein kinase C The copper ion (Cu ++ ) MELANIN DOPAQUINONE DOPA L-TYROSINE + Cu Kojic acid TYROSINASE Active PK A + + PK C - Ascorbic acid TYROSINASE Inactive

9 Different forms of Hyper-pigmentation Lentigines or sun spots Melasma / Chloasma Post-inflammatory hyper-pigmentation Acne Scars Scars / Burns

10 Depigmenting cares Laser (IPL machines, Normal laser skin resurfacing ) Cryotherapy Chemical peel (glycolic acid, TCA ) Creams (AHA, hydroquinone, retinoic acid, hydrocortisone ) And today MCcosmetics reveals melanopeel

11 laboratory is introducing

12 Package presentation Moisturizer Pre-treat Degreasing cream mask

13 Degreasing solution (10ml): Alcohol Aceton Pre-treatment solution (10ml): Salicylic acid Aqua

14 Melanopeel Mask (15g) Salicylic Acid Azealic Acid Kojic Acid Lactic Acid Citric Acid Phytic acid Ascorbic acid Arbutin Allantoin Glycyrrhiza Glabra Apricot oil Urea Moisturizers

15 Melanopeel Mask (15g) Salicylic acid Salicylic acid is used in skin-care products for the treatment of acne scars, psoriasis, corns, keratosis pilaris, and warts. It is a keratolytic agent.

16 Melanopeel Mask (15g) Salicylic acid When salicylic acid is used in combination with other medicines it takes off the upper layer of skin (EPIDERMIS) Strengths of salicylic acid preparations range from 0.5% up to 30%.

17 Melanopeel Mask (15g) Precautions High concentration of Salicylic acid causes an hyperpigmentation for those with dark skin types Some people present a hypersensibility to salicylic acid. (about 5 to 10%)

18 Melanopeel Mask (15g) Glycyrrhiza glabra is used to treat eczema, psoriasis & used to treat hyperpigmentation Allantoin keratolytic Lactic Acid AHA that reduces wrinkles

19 Melanopeel Mask (15g) Tyrosinase inhibitor Complex: Kojic Acid Ascorbic Acid Citric Acid Azealic Acid Arbutin: lightens the skin Apricot oil: softens the skin Urea: kerato-regulating Phytic acid: antioxidant Moisturizers : Glycerin, Propylene glycol & Urea

20 Melanopeel Cream (30g) Salicylic Acid Azealic Acid Kojic Acid Lactic Acid Citric Acid Phytic acid Ascorbic acid Arbutin Allantoin Glycyrrhiza Glabra Ascorbic Acid Apricot oil Urea Moisturizers Lower % in formulation + Sun protection

21 Melanopeel Moisturizer 50ml Hidrovitón - a hydrating complex with highly nutritive activity, based on amino acids, sodium lactate, urea and polyvalent alcohols. Vitamin E - a natural liposoluble antioxidant that prevents the oxidation of the cellular membranes. It improves the blood circulation, regenerates tissues.

22 Melanopeel Moisturizer 50ml Amniotic fluid - composed by organic salts which gives it extraordinary moisturizing, healing and tensor activities. Lactic Acid - Activate the production of collagen, elastin and other dermal substances; hydrating

23 Melanopeel Benefits Keratolytic action Reduces wrinkles Reduces fine lines ( scars) Lightens the skin Moisturizes the skin Softens the skin

24 Treatment Protocol 1 st step: Clean and Degrease Gently pass the cotton on the face to clean it using 1 to 1.5ml of the solution Just one pass

25 Treatment Protocol 2 nd step: Pre-treatment Gently pass the pre-treatment solution on the face (1 to 1.5ml on a cotton) Skip it if no severe acne problem Leave it 1-4 min

26 Treatment Protocol 3 rd step: treat Apply the melanopeel mask about 2mm layer thick

27 Treatment Protocol 4-8 hours later Based on the patient skin Phototype, we define the application time Clean the face with water

28 PHOTOTYPE I II III IV V VI Sunburn and Tan Always burns Usually burns Sometimes burns Rarely burns Never burns Never burns Tendency Rarely tans Sometimes tans Usually tans Always tans Always tans Always tans Skin, Hair and Eye Color White skin, freckles, blond or red hair, blue or green eyes White skin, blond hair, blue or green eyes White skin, usually dark hair and brown eyes Olive skin, Darker skin, usually dark hair and brown eyes Brown skin, brown or black hair; brown eyes Dark skin, browns or black hair, brown eyes Tanning and Sunburn History Develops red sunburn; painful swelling, skin peels Usually burns, pinkish or red coloring appears; skin can gradually develop light brown tan Rarely burns; skin shows moderately rapid tanning response Rarely burns; skin shows very rapid tanning response Rarely burns; skin shows very rapid tanning response Rarely burns; skin shows very tanning response melanopeel mask 3-4 hours 5-8 hours 9-12 hours

29 Treatment Protocol 4 th step: Maintain The next day, start applying the melanopeel cream day and night for two weeks to help to peel Then, apply the cream at night to keep the skin in good shape and this for 6 months

30 Important Info Apply sunblock Face begins to peel in 36hrs Use a Moisturizing Cream Medium peel containing salicylic acid can be done once every 6 months or even once a year Never before 6 months One box: 2 sessions

31 Important Info If the patient is undergone any previous treatments, especially with glycolic acid. Only start melanopeel at least 21 days after stop this treatments. Is not recommended to combine melanopeel treatment with any other depigmentation treatments.

32 Results Dark Skins (IV-V) Blemishes starting to disappear after 8-10 days with three daily applications of melanopeel Photo-skin type I-III Marks disappear after 8-21 days In most of the cases, the mark disappearance by 95%

33 Results Before After

34 Results Before After

35 Results Before After

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