Report Date: 11/20/2017

Transcription

1 Name: Sample Report Report Date: 11/20/2017 Consult with a licensed healthcare professional before making changes based upon any information contained within this report. These recommendations and explanations are based upon clinical observation by Maximized Genetics, LLC and current medical research. These results are for educational purposes only and not intended to diagnose, treat or cure any disease or condition. The use of this test and its recommendations have not been approved by the FDA. Maximized Genetics, LLC and its staff are not responsible for how this test is used or any damages resulting from its use.

2 DNA DNA can be described as your own personal cookbook. Full of recipes that create you as a human being, each page contains specific details about every cellular process in your body. Genes Genes should be considered the recipes of your cookbook. Each recipe is designed to produce a fully functional product. In this case, your product is a protein. You inherit your genes from your parents. Your recipes need the appropriate ingredients. In this case, ingredients are called alleles. Alleles Alleles are the nitrogenous bases: adenine (A), thymine (T), cytosine (C), and guanine (G). When sequenced together correctly, they create the final product: proteins. Alleles also determine the visual expression of your genes. For example: curly hair, green eyes, etc. This is known as your phenotype. Proteins Proteins are created by a series of amino acids that all code for specific functions in cells, tissues, and organs. Variations Variations (or single nucleotide polymorphism SNP) in allele pairing create regulatory issues within the body. Variations can be considered slight changes to your ingredients in the recipe. When you inherit genes from your parents, your alleles may join in a specific pattern. We call these patterns wild type, heterozygous, and homozygous. Wild type simply means that the pairing is most commonly found in nature. Heterozygous means you have one variation from a parent (different alleles). Homozygous means you have two variations (the same allele) from both parents. Epigenetics Epigenetics is the study of how the environment influences genetic expression. While we may have variations in our genetic code, our environment controls whether our genes are switched on or off. Our test does not account for environmental influences. We report genetic variations only. Work with a trained provider if you need help understanding the epigenetic influences.

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4 You are genetically sensitive to refined carbs. This means that you should avoid highly refined carbs such as breads, pastas, and processed foods. You may have a lower BMI on a high complex carb diet. Consume at least 9 servings of vegetables a day. Limit high amounts of simple or refined carbs, as they will increase BMI. You have genes associated with diabetes, insulin resistance, or metabolic syndrome. Limit your consumption of refined carbohydrates. Increase your consumption of vegetables and healthy fats. You should also avoid foods sweetened with refined sugar/high fructose corn syrup. Work with a healthcare provider to monitor blood glucose, insulin, and leptin levels.

5 You would not benefit from increased consumption of monounsaturated fats. You would benefit from the consumption of polyunsaturated fats. You are not sensitive to saturated fats. While they can still be inflammatory when consumed in excess, you can safely eat them in moderation. You do not have an elevated risk for total cholesterol or LDL levels. You do not have an increased risk of elevated triglyceride levels. You do not have an increased risk of lower HDL levels. Consumption of animal products will not lower your HDL. Based on your genetic profile, you could follow a high fat, low carbohydrate diet (aka Ketogenic). This diet is high in healthy fats, such as avocado, olive oil, nuts, seeds, and fatty fish. Consult with your healthcare provider about this option. Research suggests it is a good choice for neurological disorders, male infertility, and weight loss. Do not follow a high fat diet if you are a female with thyroid issues.

6 You are not genetically lactose intolerant. You may have a higher BMI with dairy intake. Consider avoiding dairy products as part of a weight loss program. You tested positive for potential gluten intolerance. If you have symptoms, consult with a healthcare provider to consider further testing and possible interventions. You could also take the proactive approach and avoid gluten all together. You do not have an increase risk for developing autoimmune gastrointestinal diseases.

7 You are prone to eating more calories than needed for daily energy expenditure. Consult with a healthcare practitioner to discuss your resting metabolic rate. You have a lower resting metabolism. You are less likely to lose fat in response to exercise. You will benefit greatly from caloric restriction. Consider using fiber and limiting portion sizes. You are not genetically prone to emotional eating. You do not have genetic issues with eating late at night and weight management. You are not able to taste bitter foods. This generally makes you more willing to eat vegetables. Make sure you are consuming at least 9 servings a day. You should eat normal portions to feel full.

8 You tested positive for the FUT2 mutation associated with potential risk for lower vitamin B12 levels. Consider supplementation.. You have tested as having compound heterozygous mutations for MTHFR A1298C and C677T. This can result in a 40% decrease in conversion of dietary folates into Methyl- Folate. Consider homocysteine or methylation testing. Avoiding synthetic folic acid and possibly supplementing with methyl-folate could potentially improve symptoms. Please discuss supplementation with a nutritionally trained practitioner. You tested positive for a marker associated with potential risk for lower vitamin B6 levels. Taking a daily supplement or increasing B6 containing foods should be considered. You have tested for a marker that potentially requires additional B2. Consider testing and supplementation.

9 You tested as potentially having issues in creating the retinol form of Vitamin A. Consider testing and supplementation with retinyl palmitate. You tested positive (homozygous) for the mutation in the GC (rs ) gene associated with moderate potential risk for lower Vitamin D levels. Normal potential Vitamin E levels Normal potential Vitamin C levels

10 Client: Sample Report SNP Report Gene RS# Result Patient Risk Short Description Diet Section FABP2 Ala54Thr rs Heterozygous TC C moderately increased potential refined carb sensitivity KCTD10 rs Heterozygous CG C normal potential HDL levels on high carb diet PLIN rs Homozygous T T High complex carb diet will lower risk of obesity/lower complex carb diet high risk. LIPC rs Wild Type C T no predicted increased benefit from a high carb diet. FADS1(MYRF) rs Homozygous T T lower arachidonic acid and other poluunsaturated fats(except linoleic acid) APOA2 rs Wild Type G A should be able to consume a higher than normal amount of fats. FABP2 Ala54Thr rs Heterozygous TC C moderately increased potential sensitivity to saturated fats FABP2 Ala54Thr rs Heterozygous TC C normal fatty acid response to dietary fat FABP2 Ala54Thr rs Heterozygous TC C normal triglycerides ADIPOQ rs Wild Type G A It is not recommended to avoid a high fat diet. PPARG rs Wild Type C G normal benefit from monounsaturated fats (avocados, nuts, olive oils, etc.). ADIPOQ rs Wild Type G A normal benefit from monounsaturated fats (avocados, nuts, olive oils, etc.). PPARG rs Wild Type C G increased benefit from consumption of polyunsaturated fats APOA2 rs Wild Type G A faster,more complete blood lipid metabolism. Vitamin Risks FUT2 rs Heterozygous GA A normal potential B12 levels FUT2 rs Heterozygous GA A normal potential B12 levels MTHFR C677T rs Heterozygous GA A moderate potential risk for decreased folate levels MTHFR A1298C rs Heterozygous GT G moderate potential risk for decreased folate levels BCMO1 rs Heterozygous TA T intermediate potential risk for decreased Vitamin A levels BCMO1 rs Wild Type C T x-normal potential Vitamin A levels MTHFR rs Heterozygous GA A moderate potential risk for decreased Vitamin B2 levels NBPF3 rs Heterozygous CT T moderate potential risk for lower B6 levels SLC23A1 rs Wild Type C T x-normal potential Vitamin C levels GC rs Homozygous G G potential risk for vitamin D levels INTERGENIC rs Homozygous C C normal potential Vitamin E levels. (Homozygous, isn't always bad) Food Intolerances CCR3 rs Homozygous C C normal potential gluten tolerance HLA-DG2.5 rs Wild Type C T x-normal potential gluten tolerance IL21 rs Wild Type A G x-normal potential gluten tolerance IL21 rs Wild Type G T x-normal potential gluten tolerance MYO9B rs Heterozygous GA G moderate risk for gluten intolerance/celiac disease MCM6 rs Heterozygous GA A lactose persistence APOA2 rs Wild Type G A higher potential BMI with high dairy intake Disease Risks MYO9B rs Heterozygous GA G normal risk for ulcerative colitis MYO9B rs Heterozygous GA G normal risk for inflammatory bowel disease MYO9B rs Heterozygous GA G normal risk for Barretts esophagus and esophageal cancer Eating Habits FTO rs Heterozygous CA A increased potential food intake MC4R rs Wild Type T C x-normal potential total energy intake MC4R rs Wild Type T C x-normal potential %fat in total energy intake ANKK1/DRD2 rs Wild Type G A x-normal food desire FTO rs Heterozygous AT A risk of increased appetite

11 LEPR rs Heterozygous GA A lower 24 hour energy expenditure NMB rs Wild Type G T x-normal hunger response FTO rs Heterozygous AT A normal potential satiety levels LEPR rs Heterozygous GA A normal snacking behavior MC4R rs Wild Type T C x-normal potential snacking desire FTO rs Heterozygous AT A normal risk of binge eating behavior, higher emotional eating and higher IDEA score (IDen FTO rs Heterozygous AT A normal risk for disorder of corporeality and emotional eating TAS2R38 rs Homozygous G G less able to taste bitter flavors in healthy foods such as broccoli and cabbage abl Obesity & Weightloss ADRB3 rs Wild Type A G x-normal FTO rs Homozygous A A increased risk for obesity MC4R rs Wild Type T C x-normal risk for higher BMI ITGB2 rs Heterozygous GA G normal risk of obesity on Western Diet ADIPOQ rs Wild Type G A x-normal BMI potential APOA2 rs Wild Type G A increased risk for higher BMI. FTO rs Heterozygous AT A increased risk for higher BMI FTO rs Heterozygous CA A less fat mass and weight loss in response to exercise FTO rs Wild Type A G x-normal potential for weight loss BCAA associated PPrs Wild Type T C normal weight loss and insulin sensitivity response to diet ADIPOQ rs Wild Type G A x-normal risk of regaining weight after losing it PPARG rs Wild Type C G x-potential normal diet response ACSL5 rs Wild Type C T x-potential normal diet response PLIN rs Homozygous T T increased potential for fat loss during calorie restricted diet PLIN rs Homozygous T T normal risk for eating late related to lower weight loss effectiveness Blood Sugar & Diabetes ADRA2A rs Heterozygous GT T intermediate risk for elevated blood sugar IRS1 rs Heterozygous CT T increased potential risk for insulin sensitivity, type 2 diabetes, hyperinsulemia ADIPOQ rs Wild Type G A increased risk of insulin resistance, high glucose levels and metabolic syndrome PPARG rs Wild Type C G x-normal risk of insulin sensitivity ADRB2 rs Heterozygous CG G normal risk of diabetes FTO rs Heterozygous CA A increased risk of type 2 diabetes FTO rs Heterozygous AT A increased risk of type 2 diabetes PPARG rs Wild Type C G x-normal risk of type 2 diabetes ADIPOQ rs Wild Type G A normal risk of overweight and obesity in uncontrolled type 2 diabetes Blood Lipids FADS1 rs Homozygous T T normal risk levels of LDL and total cholesterol LPL rs Wild Type C G normal risk for higher trigylceride levels KCTD10 rs Heterozygous CG C normal risk of reduced HDL LIPC rs Wild Type C T Normal HDL cholesterol association with fat intake Client: Your genotype. Minor: The genotype that is found least in nature. Wild Type: The genotype that is found most often in nature, this is reported as green. This isn't always ideal. Homozygous: This means you tested for both copies of the minor type allele. This typically has more severe issues. Heterozygous: This means you tested for one copy of the minor allele and one copy of the wild type allele. Gene: This is the specific gene we are looking at for variations. RS#: This is the specific variation within the gene. There are multiple locations within a gene for potential variations, all of