Genetic Terms DNA. Proteins. Genes. Variations. Epigenetics. Alleles

Transcription

1 Name: SAMPLE REPORT Consult with a licensed healthcare professional before making changes based upon any information contained within this report. These recommendations and explanations are based upon clinical observation by Maximized Genetics, LLC and current medical research. These results are for educational purposes only and not intended to diagnose, treat or cure any disease or condition. The use of this test and its recommendations have not been approved by the FDA. Maximized Genetics, LLC and its staff are not responsible for how this test is used or any damages resulting from its use.

2 Genetic Terms DNA DNA can be described as your own personal cookbook. Full of recipes that create you as a human being, each page contains specific details about every cellular process in your body. Genes Genes should be considered the recipes of your cookbook. Each recipe is designed to produce a fully functional product. In this case, your product is a protein. You inherit your genes from your parents. Your recipes need the appropriate ingredients. In this case, ingredients are called alleles. Alleles Alleles are the nitrogenous bases: adenine (A), thymine (T), cytosine (C), and guanine (G). When sequenced together correctly, they create the final product: proteins. Alleles also determine the visual expression of your genes. For example: curly hair, green eyes, etc. This is known as your phenotype. Proteins Proteins are created by a series of amino acids that all code for specific functions in cells, tissues, and organs. Variations Variations (or single nucleotide polymorphism SNP) in allele pairing create regulatory issues within the body. Variations can be considered slight changes to your ingredients in the recipe. When you inherit genes from your parents, your alleles may join in a specific pattern. We call these patterns wild type, heterozygous, and homozygous. Wild type simply means that the pairing is most commonly found in nature. Heterozygous means you have one variation from a parent (different alleles). Homozygous means you have two variations (the same allele) from both parents. Epigenetics Epigenetics is the study of how the environment influences genetic expression. While we may have variations in our genetic code, our environment controls whether our genes are switched on or off. Our test does not account for environmental influences. We report genetic variations only. Work with a trained provider if you need help understanding the epigenetic influences.

3 Skinny Gene Basics

4 You are genetically sensitive to refined carbs. This means that you should avoid highly refined carbs such as breads, pastas, and processed foods. You show no potential benefit to a high carb diet You have multiple genes associated with diabetes, insulin resistance, or metabolic syndrome. Limit your consumption of refined carbohydrates. Increase your consumption of vegetables and healthy fats. You should also avoid foods sweetened with refined sugar/high fructose corn syrup. Work with a healthcare provider to monitor blood glucose, insulin, and leptin levels.

5 You may benefit from increased consumption of monounsaturated fats. You show normal benefit from the consumption of polyunsaturated fats. You are genetically sensitive to saturated fats. This means you should avoid them whenever possible. You have an increased risk of elevated LDL and Total Cholesterol levels You do not have an increased risk of elevated triglyceride levels. You do not have an increased risk of lower HDL levels. Consumption of animal products will not lower your HDL. Based on your genetic profile, you could follow a high fat, low carbohydrate diet (aka Ketogenic). This diet is high in healthy fats, such as avocado, olive oil, nuts, seeds, and fatty fish. Consult with your healthcare provider about this option..

6 You tested positive for lactose intolerance.. You tested positive for potential gluten intolerance. If you have symptoms, consult with a healthcare provider to consider further testing and possible interventions. You could also take the proactive approach and avoid gluten all together. You do not have an increase risk for developing autoimmune gastrointestinal diseases.

7 You are not prone to eating more calories than needed. You have a lower resting metabolism. You are likely to lose fat in response to exercise. You may be able to use calorie restriction for weight loss. You are genetically prone to addictive or emotional eating. Make sure you have a healthy psychological relationship with food. You are prone to weight issues when eating late at night. You may do well with eating between the hours of 12-6pm and fasting during the other hours of the day. Discuss this option with a healthcare practitioner. You are able to taste bitter foods. This may make you less likely to eat green vegetables due to taste. Be sure to consume at least 9 servings per day. You are less able to feel full when you eat. Be sure to watch portion control, as you may consume more calories than needed. Consume additional fiber and water with meals.

8 There is no genetic indication for B12 supplementation. FUT2 Secretor. You tested positive for one copy of the A1298C MTHFR Mutation. This is the least influential MTHFR mutation and is of little effect on the activity of the MTHFR enzyme. It Is still recommended to avoid synthetic folic acid. Avoiding synthetic folic acid and ensuring a diet full of green leafy vegetables is important. Methyl-folate may still help some people with anxiety and other symptoms. You tested positive for a marker associated with potential risk for lower vitamin B6 levels. Taking a daily supplement or increasing B6 containing foods should be considered. You have no genetic indication for lower B2.

9 You tested as potentially having issues in creating the retinol form of Vitamin A. Consider testing and supplementation with retinyl palmitate. You tested positive (homozygous) for the mutation in the GC (rs ) gene associated with moderate potential risk for lower Vitamin D levels. Normal potential Vitamin E levels Normal potential Vitamin C levels

10 You tested positive for one copy of the A1298C MTHFR Mutation. This results in a need for methyl-folate, the type found in Skinny Gene's Multivitamin. You tested as potentially having issues in creating the retinol form of Vitamin A. Consider supplemetation with retinyl palmitate, the type of Vitamin A found in Skinny Gene's Multivitamin. You have genes associated with diabetes, insulin resistance, or metabolic syndrome. Metabolic shakes like Skinny Gene Max Fit Metabolic Shake would greatly benefit your weight loss goals. 2 scoops of Skinney Gene Max Fit Metabolic shake every morning would aid in achieving a healthy weight.

11 You are genetically prone to addictive or emotional eating. Skinny Gene Ultra Slim Appetite Curb is designed just for you! For the best results, take 4 pills every morning on an empty stomach. If you smoke, it might be a good time to break that habbit too! You will benefit greatly from caloric restriction. Lean Fiber will help lower your daily calloric intake. You are less able to feel full when you eat, taking 4 to 6 capsules 15 min. before a meal will help you feel full earlier and lower your caloric intake without feeling hungry!

12 You have tested positive for one copy of the MTHFR C677T. This can result in up to a 40% decrease in conversion of dietary folate into Methyl-Folate. Supplementing with methyl-folate, like Super Lean B Complex, could potentially improve symptoms.

13 Client: SAMPLE REPORT SNP Report Gene RS# Result Patient Risk Short Description Diet Section FABP2 Ala54Thr rs Heterozygous TC C moderately increased potential refined carb sensitivity KCTD10 rs Heterozygous CG C normal potential HDL levels on high carb diet PLIN rs Wild Type C T x-normal complex carb/obesity correlation LIPC rs Heterozygous CT T BMI and waist potential decrease on high carb diet FADS1(MYRF) rs Wild Type G T x-normal Omega-6 levels APOA2 rs Heterozygous GA A normal dietary fat intake recommended FABP2 Ala54Thr rs Heterozygous TC C moderately increased potential sensitivity to saturated fats FABP2 Ala54Thr rs Heterozygous TC C normal fatty acid response to dietary fat FABP2 Ala54Thr rs Heterozygous TC C normal triglycerides ADIPOQ rs Wild Type G A It is not recommended to avoid a high fat diet. PPARG rs Heterozygous GC G increased benefit from monounsaturated fat ADIPOQ rs Wild Type G A normal benefit from monounsaturated fats (avocados, nuts, olive oils, etc.). PPARG rs Heterozygous GC G normal benefit from polyunsaturated fats APOA2 rs Heterozygous GA A faster, more complete blood lipid metabolism Vitamin Risks FUT2 rs Wild Type G A x-normal B12 levels FUT2 rs Wild Type G A x-normal B12 levels MTHFR C677T rs Wild Type G A x-normal folate pathway MTHFR A1298C rs Heterozygous GT G moderate potential risk for decreased folate levels BCMO1 rs Heterozygous TA T intermediate potential risk for decreased Vitamin A levels BCMO1 rs Wild Type C T x-normal potential Vitamin A levels MTHFR rs Wild Type G A x-normal potential Vitamin B2 levels NBPF3 rs Wild Type C T potential risk for lower vitamin B6 (pyridoxine) levels SLC23A1 rs Wild Type C T x-normal potential Vitamin C levels GC rs Homozygous G G potential risk for vitamin D levels INTERGENIC rs Homozygous C C normal potential Vitamin E levels. (Homozygous, isn't always bad) Food Intolerances CCR3 rs Homozygous C C normal potential gluten tolerance HLA-DQ2.5 rs Wild Type C T x-normal potential gluten tolerance IL21 rs Wild Type A G x-normal potential gluten tolerance IL21 rs Wild Type G T x-normal potential gluten tolerance MYO9B rs Wild Type A G x-normal potential gluten tolerance MCM6 rs Wild Type G A Possible lactose intolerance APOA2 rs Heterozygous GA A normal BMI with high dairy intake Disease Risks MYO9B rs Wild Type A G x-normal risk for ulcerative colitis MYO9B rs Wild Type A G x-normal risk for inflammatory bowel disease MYO9B rs Wild Type A G Normal risk for Barrett's Esophagus and Esophageal Adenocarcinoma Eating Habits FTO rs Homozygous A A normal potential food intake MC4R rs Heterozygous CT C higher potential total energy intake MC4R rs Heterozygous CT C risk of higher potential %fat in total energy intake ANKK1/DRD2 rs Homozygous A A increased risk for addictive eating behavior

14 FTO rs Homozygous A A risk of increased appetite LEPR rs Heterozygous GA A lower 24 hour energy expenditure NMB rs Wild Type G T x-normal hunger response FTO rs Homozygous A A risk of increased intake needed for satiety LEPR rs Heterozygous GA A normal snacking behavior MC4R rs Heterozygous CT C normal potential snacking desire FTO rs Homozygous A A Increased risk of binge eating behavior, higher emotional eating risk. FTO rs Homozygous A A increased risk for disorder of corporeality and emotional eating TAS2R38 rs Heterozygous GC G more able to taste bitter flavors in healthy foods such as broccoli and cabbage. Obesity & Weight loss ADRB3 rs Wild Type A G x-normal FTO rs Homozygous A A increased risk for obesity MC4R rs Heterozygous CT C moderate risk for higher BMI ITGB2 rs Homozygous G G normal risk of obesity on Western Diet ADIPOQ rs Wild Type G A x-normal BMI potential APOA2 rs Heterozygous GA A normal BMI potential FTO rs Homozygous A A increased risk for higher BMI FTO rs Homozygous A A normal fat mass and weight loss in response to exercise FTO rs Wild Type A G x-normal potential for weight loss BCAA associated P rs Heterozygous CT C potential risk for decreased weight loss and insulin sensitivity response to diet ADIPOQ rs Wild Type G A x-normal risk of regaining weight after losing it PPARG rs Heterozygous GC G potential normal diet response ACSL5 rs Wild Type C T x-potential normal diet response PLIN rs Wild Type C T x-normal potential for fat loss during calorie restriction diet PLIN rs Wild Type C T eating late with lower weight loss effectiveness. Blood Sugar & Diabetes ADRA2A rs Wild Type G T x-normal risk of elevated blood sugar IRS1 rs Heterozygous CT T increased potential risk for insulin sensitivity, type 2 diabetes, hyperinsulinemia. ADIPOQ rs Wild Type G A increased risk of insulin resistance, high glucose levels and metabolic syndrome. PPARG rs Heterozygous GC G increased risk of insulin sensitivity ADRB2 rs Homozygous G G decreased risk of diabetes FTO rs Homozygous A A normal risk of type 2 diabetes FTO rs Homozygous A A increased risk of type 2 diabetes PPARG rs Heterozygous GC G normal risk of type 2 diabetes ADIPOQ rs Wild Type G A normal risk of overweight and obesity in uncontrolled type 2 diabetes Blood Lipids FADS1 rs Wild Type G T increased risk for higher "bad" cholesterol and total cholesterol LPL rs Wild Type C G normal risk for higher triglyceride levels KCTD10 rs Heterozygous CG C normal risk of reduced HDL LIPC rs Heterozygous CT T normal HDL levels with lower animal fat intake Client: Your genotype. Minor: The genotype that is found least in nature. Wild Type: The genotype that is found most often in nature, this is reported as green. This isn't always ideal. Homozygous: This means you tested for both copies of the minor type allele. This typically has more severe issues. Heterozygous: This means you tested for one copy of the minor allele and one copy of the wild type allele. Gene: This is the specific gene we are looking at for variations. RS#: This is the specific variation within the gene. There are multiple locations within a gene for potential variations, all of