2017 CST-Astellas Canadian Transplant Fellows Symposium
|
|
|
- Edward Doyle
- 5 years ago
- Views:
Transcription
1 2017 CST-Astellas Canadian Transplant Fellows Symposium The Future of Transplantation Atul Humar, MD Atul Humar is a Professor in the Department of Medicine, University of Toronto. Dr. Humar received his medical degree from the University of Ottawa. He completed his residency and did further training in Transplant Infectious Diseases in Toronto and Boston. Dr. Humar s research interests are in virology with a focus on the pathogenesis of herpesvirus infections post-transplant. He is involved in both basic and clinical research assessing immunologic and virologic determinants of infection. Dr. Humar is the Director of Multi Organ Transplant Program at the University Health Network and the University of Toronto Transplant Institute. He is also active in the Canadian Society of Transplantation as a President and has been very active in both the AST and TTS. Dr. Humar operates a joint research lab with his wife, Dr. Deepali Kumar, who is also a faculty member at the University of Toronto.
2 The Future of Transplantation Atul Humar, MD
3
4
5 Herrick twins 1954
6 Acute rejection/graft survival (%) Amazing Accomplishments Who would have believed it? % 80 Acute rejection 60 ~60% MMF Sirolimus % 1-year graft survival Basiliximab Everolimus Azathioprine Prednisone ATG CsA Year of transplant Tacrolimus 5 20% CsA, ciclosporin; ATG, anti-thymocyte globulin; MMF, mycophenolate mofetil 1. Morris PJ. N Engl J Med. 2004;351: ; 2. Sayegh MH, et al. N Engl J Med. 2004;351:2761 6; 3. Khurana A, Brennan D. Current concepts of immunosuppression and side effects in Pathology of Solid Organ Transplantation,
7 Benchmarking: One year Graft Survival Rate One Year Transplant Survival comparison to available benchmark 0 Kidney DD Kidney LD Liver DD Liver LD Lung Heart Pancreas 1 year (%) UHN 1 year (%) US/International Data source: OTTR, UNOS (SRTR) and ISHLT
8 Benchmarking: Ten year Graft Survival Rate Ten Year Transplant Survival comparison to available benchmark 0 Kidney DD Kidney LD Liver DD Liver LD Lung Heart Pancreas 10 year (%) UHN 10 year (%) US/International Data source: OTTR, UNOS (SRTR) and ISHLT
9 Transplant Waiting List Will the waiting list go down with new treatments for disease?
10 The FUTURE OF TRANSPLANTATION Solving organ failure New sources / technologies Organ Donation Organ Utilization Regenerative medicine / bioengineering
11
12
13
14 Organ Repair Lab Lung Heart Kidney Liver
15 The Holy Grail..Immune Tolerance Ray Owen
16
17 Regenerative medicine: Cellular Transplantation, stem cells, bioengineering Islet Transplan t
18
19 Scheme of beta cell development insulin + glucagon + NKX6.1 - first transition population 'primitive cells' glucagon + alpha cells 2 nd Transition insulin + glucagon - NKX6.1 + PDX-1 +?NKX6.1 - CD142 - PDX-1 + NKX6.1 + Human pluripotent stem Definitive endoderm +additional factors Pancreatic progenitors
20 Islet structures derived from human ESCs INS GCG DAPI INS SST DAPI
21 Decellularize: perfusion with detergents and phosphate buffered saline Recellularize: epithelial and endothelial cell seeding followed by transplantation Nature Medicine 2010 Aug 16 (8):
22 STEM CELLS, REGENERATIVE MEDICINE, BIOENGINEERING Growing Organs in the Lab Ott, H. Nature Medicine, 2010 Ott, H. Nature Medicine, 2008
23 BLASTOCYST COMPLEMENTATION: INTERSPECIES ORGANOGENESIS
24 What is CRISPR? Genome-editing tool originally discovered in prokaryotes Consist of specialized guide RNAs (crrnas) that are linked to a nuclease (cas9) crrnas are complimentary to target regions of the genome If annealing takes place, nuclease causes double stranded breaks in DNA Gene inactivation
25 (A) Image of the first born PERVinactivated pig (B) PERV inactivation at genomic DNA level
26 Transplantation-The Future First 50 years of Transplantation ( ) Solid organ transplantation (SOT) is now recognized as a highly effective therapy for patients with end stage organ injury. The next 50 years in Transplantation Opportunities to solve organ donor shortage Tolerance is achievable..at least in some New Technologies offer unparalleled opportunities specifically the Regenerative Medicine field is poised to revolutionize all aspects of medicine Research Funding is now improving both for basic and translational research programs
27 Thanks you! Questions? 27
28 28
2017 CST-Astellas Canadian Transplant Fellows Symposium. EBV Post Transplantation Implications and Approach to Management
2017 CST-Astellas Canadian Transplant Fellows Symposium EBV Post Transplantation Implications and Approach to Management Atul Humar, MD Atul Humar is a Professor in the Department of Medicine, University
2017 CST-Astellas Canadian Transplant Fellows Symposium. Optimizing use of organs from Increased Risk Donors
2017 CST-Astellas Canadian Transplant Fellows Symposium Optimizing use of organs from Increased Risk Donors Atual Humar, MD Atul Humar is a Professor in the Department of Medicine, University of Toronto.
Victims of success: Do we still need clinical trials? Robert S. Gaston, MD CTI Clinical Trials and Consulting University of Alabama at Birmingham
Victims of success: Do we still need clinical trials? Robert S. Gaston, MD CTI Clinical Trials and Consulting University of Alabama at Birmingham Disclosure Employee: CTI Clinical Trials and Consulting
Overview of New Approaches to Immunosuppression in Renal Transplantation
Overview of New Approaches to Immunosuppression in Renal Transplantation Ron Shapiro, M.D. Professor of Surgery Surgical Director, Kidney/Pancreas Transplant Program Recanati/Miller Transplantation Institute
Immunosuppressants, Organ Transplants, and Potential of Regenerative Medicine: Market Size, Competitive Landscape, and Pipeline Analysis
Immunosuppressants, Organ Transplants, and Potential of Regenerative Medicine: Market Size, Competitive Landscape, and Pipeline Analysis Introduction This report examines treatment protocols evolved over
Pediatric Kidney Transplantation
Pediatric Kidney Transplantation Vikas Dharnidharka, MD, MPH Associate Professor Division of Pediatric Nephrology Conflict of Interest Disclosure Vikas Dharnidharka, MD, MPH Employer: University of Florida
2017 CST-Astellas Canadian Transplant Fellows Symposium. Optimizing use of organs from Increased Risk Donors
2017 CST-Astellas Canadian Transplant Fellows Symposium Optimizing use of organs from Increased Risk Donors Atual Humar, MD Atul Humar is a Professor in the Department of Medicine, University of Toronto.
Literature Review: Transplantation July 2010-June 2011
Literature Review: Transplantation July 2010-June 2011 James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver Kidney Transplant Top 10 List: July Kidney
Transplantation in Australia and New Zealand
Transplantation in Australia and New Zealand Matthew D. Jose MBBS (Adel), FRACP, FASN, PhD (Monash), AFRACMA Professor of Medicine, UTAS Renal Physician, Royal Hobart Hospital Overview CKD in Australia
Re: Final Appraisal Determination - Immunosuppressive therapy for kidney transplant in adults (review of technology appraisal guidance 85)
January 19 th, 2016 Dr Margaret Helliwell Vice chair National Institute for Health and Care Excellence 10 Spring Gardens London SW1A 2BU Dear Margaret Re: Final Appraisal Determination - Immunosuppressive
2017 CST-Astellas Canadian Transplant Fellows Symposium. Management of Renal Dysfunction in Extra Renal Transplants
2017 CST-Astellas Canadian Transplant Fellows Symposium Management of Renal Dysfunction in Extra Renal Transplants Jeffrey Schiff, MD Dr. Jeffrey Schiff is an Assistant Professor of Medicine at the University
Heart Transplant: State of the Art. Dr Nick Banner
Heart Transplant: State of the Art Dr Nick Banner Heart Transplantation What is achieved Current challenges Donor scarcity More complex recipients Long-term limitations Non-specific Pharmacological Immunosuppression
OBJECTIVES. Phases of Transplantation and Immunosuppression
Transplant and Immunosuppression: Texas Transplant Center April 29, 2017 Regina L. Ramirez, Pharm.D., BCPS PGY1 Pharmacy Residency Program Director Clinical Practice Specialist Solid Organ Transplant and
BK virus infection in renal transplant recipients: single centre experience. Dr Wong Lok Yan Ivy
BK virus infection in renal transplant recipients: single centre experience Dr Wong Lok Yan Ivy Background BK virus nephropathy (BKVN) has emerged as an important cause of renal graft dysfunction in recent
UEMS & EBS: DIVISION OF TRANSPLANT SURGERY
CURRICULUM AND SYLLABUS TRANSPLANTATION Module 1: Multi-organ retrieval Ability to evaluate donor suitability Ability to retrieve abdominal organs for transplantation Evaluation of donor/ organs suitability
Islet Cell Allo-Transplantation. Disclosure. Objectives
Islet Cell Allo-Transplantation Gregory P. Forlenza, MD MCR Assistant Professor Barbara Davis Center University of Colorado Denver Special thanks to Melena Bellin, MD at The University of Minnesota who
What is the Best Induction Immunosuppression Regimen in Kidney Transplantation? Richard Borrows: Queen Elizabeth Hospital Birmingham
What is the Best Induction Immunosuppression Regimen in Kidney Transplantation? Richard Borrows: Queen Elizabeth Hospital Birmingham SYMPHONY Study Ekberg et al. NEJM 2008 Excluded: DCD kidneys; CIT>30hours;
DIVISION OF NEPHROLOGY
The Division s funding from the NIH has increased from $3.7 Million in 2001 to over $11 Million in 2006. DIVISION OF NEPHROLOGY DR. BARBARA MURPHY was voted President-Elect of the American Society of Transplantation
BLAZING TRAILS IN TRANSPLANTATION. Danielle Fritze, MD
BLAZING TRAILS IN TRANSPLANTATION Danielle Fritze, MD BETTER TODAY THAN YESTERDAY BETTER TOMORROW THAN TODAY. Jim Harbaugh,via Twitter (and others) Transplant s Joseph Murray Legacy The Herrick Twins NPR,
Progress in Pediatric Kidney Transplantation
Send Orders for Reprints to reprints@benthamscience.net The Open Urology & Nephrology Journal, 214, 7, (Suppl 2: M2) 115-122 115 Progress in Pediatric Kidney Transplantation Jodi M. Smith *,1 and Vikas
9/30/ DISCLOSURES. + First: Why immunosuppress? Transplant Immunosuppression and Prophylaxis
Transplant Immunosuppression and Prophylaxis Sarah Fitz, APN, MSN, ACNP-BC Loyola University Medical Center DISCLOSURES I am not being paid by any entity to endorse a specific product. Any mention of brand
Heart Transplantation ACC Middle East Conference Dubai UAE October 21, 2017
Heart Transplantation ACC Middle East Conference Dubai UAE October 21, 2017 Randall C Starling MD MPH FACC FAHA FESC FHFSA Professor of Medicine Kaufman Center for Heart Failure Department of Cardiovascular
Innovation In Transplantation:
Innovation In Transplantation: Improving outcomes Thomas C. Pearson Department of Surgery Emory Transplant Center CHOA Symposium October 22, 2016 Disclosures Belatacept preclinical and clinical trial were
New onset diabetes after transplant (NODAT)
New onset diabetes after transplant (NODAT) Information for families Great Ormond Street Hospital for Children NHS Foundation Trust This information sheet from Great Ormond Street Hospital (GOSH) explains
For Immediate Release Contacts: Jenny Keeney Astellas US LLC (847)
For Immediate Release Contacts: Jenny Keeney Astellas US LLC (847) 317-5405 Lauren McDonnell GolinHarris (312) 729-4233 ASTELLAS RECEIVES FDA APPROVAL FOR USE OF PROGRAF (TACROLIMUS) IN CONJUNCTION WITH
CURRICULUM VITAE July 5, Name Chang-Kwon Oh. Date of Birth August 15, 1961
CURRICULUM VITAE July 5, 2014 Name Chang-Kwon Oh Date of Birth August 15, 1961 Present Academic & Hospital Appointment Professor, Department of Surgery Ajou University, School of Medicine Chief, Department
Transplant Hepatology
Transplant Hepatology Certification Examination Blueprint Purpose of the exam The exam is designed to evaluate the knowledge, diagnostic reasoning, and clinical judgment skills expected of the certified
LTBI Treatment in non HIV immunosuppressed patients. Richard Zuckerman, MD, MPH, FIDSA
LTBI Treatment in non HIV immunosuppressed patients Richard Zuckerman, MD, MPH, FIDSA Disclosures AiCuris, Medpace DSMB for acyclovir-resistant HSV Case 67 yo M with cirrhosis due to NASH, hepatocellular
SELECTED ABSTRACTS. All (n) % 3-year GS 88% 82% 86% 85% 88% 80% % 3-year DC-GS 95% 87% 94% 89% 96% 80%
SELECTED ABSTRACTS The following are summaries of selected posters presented at the American Transplant Congress on May 5 9, 2007, in San Humar A, Gillingham KJ, Payne WD, et al. Review of >1000 kidney
Tolerance Induction in Transplantation
Tolerance Induction in Transplantation Reza F. Saidi, MD, FACS, FICS Assistant Professor of Surgery Division of Organ Transplantation Department of Surgery University of Massachusetts Medical School Percent
Atul Humar, MD, MSc Director, Transplant Program, University Health Network, University of Toronto
TIME PROGRAM TITLE 7:30 8:15 Registration and Continental Breakfast 8:15 8:30 Welcoming Remarks TOPIC: VIRUSES Session Chair: Shahid Husain CMV: What is New, What s Hot Atul Humar, MD, MSc Director, Transplant
Post-Transplant Monitoring for the Development of Anti-Donor HLA Antibodies
Post-Transplant Monitoring for the Development of Anti-Donor HLA Antibodies Lorita M Rebellato, Ph.D., D (ABHI) Associate Professor Department of Pathology The Brody School of Medicine at ECU Scientific
TRANSPLANT IMMUNOLOGY. Shiv Pillai Ragon Institute of MGH, MIT and Harvard
TRANSPLANT IMMUNOLOGY Shiv Pillai Ragon Institute of MGH, MIT and Harvard Outline MHC / HLA Direct vs indirect allorecognition Alloreactive cells: where do they come from? Rejection and Immunosuppression
Xenotransplantation. Pig as an organ donor
Xenotransplantation Pig as an organ donor Xenotransplantation Transplantation of solid organs Heart, Kidney, Liver Transplantation of live animal cells Pig neuronal and pig pancreatic islet cells Use of
BK Virus (BKV) Management Guideline: July 2017
BK Virus (BKV) Management Guideline: July 2017 BK virus has up to a 60-80% seroprevalence rate in adults due to a primary oral or respiratory exposure in childhood. In the immumocompromised renal transplant
Considering the early proactive switch from a CNI to an mtor-inhibitor (Case: Male, age 34) Josep M. Campistol
Considering the early proactive switch from a CNI to an mtor-inhibitor (Case: Male, age 34) Josep M. Campistol Patient details Name DOB ESRD Other history Mr. B.I.B. 12 January 1975 (34yo) Membranous GN
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids Ling Huang 1, Audrey Holtzinger 1,2,11, Ishaan Jagan 1,11, Michael BeGora 1, Ines
Pancreas and Pancreas-Kidney Transplantation By: Kay R. Brown, CLCP
Pancreas and Pancreas-Kidney Transplantation By: Kay R. Brown, CLCP Pancreas transplant recipients are usually under age 50. The majority of pancreas transplants are performed on diabetics, who are generally
Preliminary Program Outline
Saturday, June 2, 2018 1:00 pm 5:30 pm Pre-Meeting Symposia Advanced Immunology Basic Science for the Clinician The Immunology of Kidney Transplantation Transplant Center QAPI and Advanced Leadership:
PUO in the Immunocompromised Host: CMV and beyond
PUO in the Immunocompromised Host: CMV and beyond PUO in the immunocompromised host: role of viral infections Nature of host defect T cell defects Underlying disease Treatment Nature of clinical presentation
MPB333:Molecular Endocrinology of Obesity and Diabetes
MPB333:Molecular Endocrinology of Obesity and Diabetes The Use of Stem Cells as a Cure for Type 1 Diabetes January 15, 2010 Trish Labosky 9415C MRBIV trish.labosky@vanderbilt.edu In theory. 2. ~Easy and
Cell Therapy for Diabetes: Generating Functional Islets from Human Exocrine Tissue
Cell Therapy for Diabetes: Generating Functional Islets from Human Exocrine Tissue Kevin Docherty University of Aberdeen ELRIG Drug Discovery 2016 ACC Liverpool 14 th October 2016 Autoimmune destruction
NAPRTCS Annual Transplant Report
North American Pediatric Renal Trials and Collaborative Studies NAPRTCS 2010 Annual Transplant Report This is a privileged communication not for publication. TABLE OF CONTENTS PAGE I INTRODUCTION 1 II
NAPRTCS Annual Transplant Report
North American Pediatric Renal Trials and Collaborative Studies NAPRTCS 2014 Annual Transplant Report This is a privileged communication not for publication. TABLE OF CONTENTS PAGE II TRANSPLANTATION Section
Controversies in Renal Transplantation. The Controversial Questions. Patrick M. Klem, PharmD, BCPS University of Colorado Hospital
Controversies in Renal Transplantation Patrick M. Klem, PharmD, BCPS University of Colorado Hospital The Controversial Questions Are newer immunosuppressants improving patient outcomes? Are corticosteroids
Marta Farrero Torres₁, Marcelo Pando₂, Dolly Tyan₂, Hannah Valantine₃, Spenser Smith₃, Kiran Khush₃
Development of HLA donor specific antibodies after heart transplantation: importance of a new method to detect the first component of the complement cascade Marta Farrero Torres₁, Marcelo Pando₂, Dolly
New Ways to Tackle a Growing Health Care Dilemma - ESRD
New Ways to Tackle a Growing Health Care Dilemma - ESRD J. Keith Melancon, M.D., F.A.C.S. George Washington University Professor of Surgery Chief, Transplant Surgery and Transplant Institute Thanks to
Deceased Organ Transplant Waiting List SECTION 11
Deceased Organ Transplant Waiting List SECTION 11 This chapter brings together waiting list data for the various organs. This data is not directly collected by ANZOD, but has been provided by the relevant
Technology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta481
Immunosuppressive e therapy for kidney transplant in adults Technology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta481 NICE 2018. All rights reserved. Subject to Notice of rights
SUPPLEMENTARY DATA. Supplementary Table 2. Antibodies used for Immunofluoresence. Supplementary Table 3. Real-time PCR primer sequences.
Supplementary Table 2. Antibodies used for Immunofluoresence. Antibody Dilution Source Goat anti-pdx1 1:100 R&D Systems Rabbit anti-hnf6 1:100 Santa Cruz Biotechnology Mouse anti-nkx6.1 1:200 Developmental
clevelandclinic.org/transplant
carolyn spiotta Pancreas/Kidney Transplant Recipient I feel so fortunate and thankful that I have received a second chance at life. Carolyn Spiotta, 44, Pittsburgh. Carolyn needed a new pancreas and kidney
Nephrology Grand Rounds
Nephrology Grand Rounds PTLD in Kidney Transplantation Charles Le University of Colorado 6/15/12 Objectives Background Pathogenesis Epidemiology and Clinical Manifestation Incidence Risk Factors CNS Lymphoma
Table S1. Clinical outcomes of the acceptable mismatch allocation model.
Table S1. Clinical outcomes of the acceptable mismatch allocation model. Recipient Age PRA Waiting Time (months) HLA mismatch (A/B/DR) HLAMatchmaker acceptable mismatch (years) (%) Actual Simulation Change
ASSESSMENT OF THE PAEDIATRIC NEEDS IMMUNOLOGY DISCLAIMER
European Medicines Agency Evaluation of Medicines for Human Use London, September 2006 Doc. Ref.: EMEA/381922/2006 ASSESSMENT OF THE PAEDIATRIC NEEDS IMMUNOLOGY DISCLAIMER The Paediatric Working Party
Making Mature Human Islet Cells from Stem Cells to Model Disease and Treat Diabetes
University of British Columbia Departments of Surgery and Cellular & Physiological Sciences Making Mature Human Islet Cells from Stem Cells to Model Disease and Treat Diabetes 2016 International Conference
("T-Lymphocytes, Regulatory"[Mesh]) AND "Immunosuppression"[Mesh] ("T-Lymphocytes, Regulatory"[Mesh]) AND "Immunosuppressive Agents"[Mesh]
![(T-Lymphocytes, Regulatory[Mesh]) AND Immunosuppression[Mesh] (T-Lymphocytes, Regulatory[Mesh]) AND Immunosuppressive Agents[Mesh]](/thumbs/78/78435006.jpg "(T-Lymphocytes, Regulatory[Mesh]) AND Immunosuppression[Mesh] (T-Lymphocytes, Regulatory[Mesh]) AND Immunosuppressive Agents[Mesh]")
SEARCH STRATEGY PubMed: ("T-Lymphocytes, Regulatory"[Mesh]) AND "Immunosuppression"[Mesh] ("T-Lymphocytes, Regulatory"[Mesh]) AND "Immunosuppressive Agents"[Mesh] ("T-Lymphocytes, Regulatory"[Mesh]) AND
Organ Waiting Lists in Australia and New Zealand
Chapter 7 Organ Waiting Lists in and New Zealand 2015 ANZOD Registry Annual Report Data to 31-Dec-2014 This chapter brings together waiting list data for the various organs. This data is not directly collected
Heart and Lung Transplantation in the United States,
American Journal of Transplantation 2007; 7 (Part 2): 1390 1403 Blackwell Munksgaard No claim to original US government works Journal compilation C 2007 The American Society of Transplantation and the
3/6/2017. Prevention of Complement Activation and Antibody Development: Results from the Duet Trial
Prevention of Complement Activation and Antibody Development: Results from the Duet Trial Jignesh Patel MD PhD FACC FRCP Medical Director, Heart Transplant Cedars-Sinai Heart Institute Disclosures Name:
Chapter 4 Section Simultaneous Pancreas-Kidney (SPK), Pancreas-After-Kidney (PAK), And Pancreas-Transplant-Alone (PTA)
Surgery Chapter 4 Section 24.7 Simultaneous Pancreas-Kidney (SPK), Pancreas-After-Kidney (PAK), And Pancreas-Transplant-Alone Issue Date: February 5, 1996 Authority: 32 CFR 199.4(e)(5) 1.0 CPT 1 PROCEDURE
Intruduction PSI MODE OF ACTION AND PHARMACOKINETICS
Multidisciplinary Insights on Clinical Guidance for the Use of Proliferation Signal Inhibitors in Heart Transplantation Andreas Zuckermann, MD et al. Department of Cardio-Thoracic Surgery, Medical University
Pathways to Protecting from Autoimmunity the Resurrected/Regenerated Beta Cells. Jeffrey Bluestone, PhD Diabetes Center at UCSF
Pathways to Protecting from Autoimmunity the Resurrected/Regenerated Beta Cells Jeffrey Bluestone, PhD Diabetes Center at UCSF Number of Transplants Is islet replacement a viable option? 2000 1800 1600
- Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ.
Immunology Lecture num. (21) Transplantation - Transplantation: removing an organ from donor and gives it to a recipient. - Graft: transplanted organ. Types of Graft (4 types): Auto Graft - From a person
Lung Transplantation: Overview and the MUSC Program
Lung Transplantation: Overview and the MUSC Program Timothy P.M. Whelan MD Associate Professor of Medicine Medical Director of Lung Transplantation History of Lung Transplant James Hardy Univ of Mississippi
Chapter 4 Section 24.7
Surgery Chapter 4 Section 24.7 Simultaneous Pancreas-Kidney (SPK), Pancreas-After-Kidney (PAK), And Pancreas-Transplant-Alone (PTA), And Pancreatic Islet Cell Transplantation Issue Date: February 5, 1996
Chronic Kidney Disease (CKD) Stages. CHRONIC KIDNEY DISEASE Treatment Options. Incident counts & adjusted rates, by primary diagnosis Figure 2.
Chronic Kidney Disease (CKD) Stages Stage 1 GFR > 90 (evidence of renal disease) Stage 2 GFR 60-89 Stage 3 GFR 30-59 Stage 4 GFR 15-29 Stage 5 GFR
Solid Organ Transplantation 1. Chapter 55. Solid Organ Transplant, Self-Assessment Questions
Solid Organ Transplantation 1 Chapter 55. Solid Organ Transplant, Self-Assessment Questions Questions 1 to 9 are related to the following case: A 38-year-old white man is scheduled to receive a living-unrelated
This study is currently recruiting participants.
A Two Part, Phase 1/2, Safety, PK and PD Study of TOL101, an Anti-TCR Monoclonal Antibody for Prophylaxis of Acute Organ Rejection in Patients Receiving Renal Transplantation This study is currently recruiting
Value of Medicine in Solid Organ Transplantation. Authored by Xcenda L.L.C. on behalf of Astellas Pharma US.
Value of Medicine in Solid Organ Transplantation Authored by Xcenda L.L.C. on behalf of Astellas Pharma US. Executive Summary Solid organ transplantations have been performed for decades, with the first
Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications
Original Article Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications G. R. Pourmand 1, S. Dehghani 1*, A. Saraji 1, S. Khaki 1,2, S. H. Mortazavi
Better than Google- Click on Immunosuppression Renal Transplant. David Landsberg Oct
Better than Google- Click on Immunosuppression Renal Transplant David Landsberg Oct 3 2008 OUTLINE History of Immunosuppression Trends in Immunosupression FK vs CYA Steroid Minimization CNI Avoidance Sirolimus
Chapter 8. Acknowledgements, Curriculum Vitae and List of publications
Chapter 8 Acknowledgements, Curriculum Vitae and List of publications Acknowledgements, Curriculum Vitae and List of publications 123 ACKNOWLEDGEMENTS I would like to express my gratitude to all the contributors
Health technology Two prophylaxis schemes against organ rejection in renal transplantation were compared in the study:
An economic and quality-of-life assessment of basiliximab vs antithymocyte globulin immunoprophylaxis in renal transplantation Polsky D, Weinfurt K P, Kaplan B, Kim J, Fastenau J, Schulman K A Record Status
Stem Cell Transplantation for Severe Aplastic Anemia
Number of Transplants 10/24/2011 Stem Cell Transplantation for Severe Aplastic Anemia Claudio Anasetti, MD Professor of Oncology and Medicine Chair, Blood and Marrow Transplant Dpt Moffitt Cancer Center
Efficacy and Safety of Thymoglobulin and Basiliximab in Kidney Transplant Patients at High Risk for Acute Rejection and Delayed Graft Function
ArtIcle Efficacy and Safety of Thymoglobulin and Basiliximab in Kidney Transplant Patients at High Risk for Acute Rejection and Delayed Graft Function Guodong Chen, 1 Jingli Gu, 2 Jiang Qiu, 1 Changxi
TransplantUpdate. A Report From Baylor Regional Transplant Institute Volume 1 Number 4
TransplantUpdate A Report From Baylor Regional Transplant Institute Volume 1 Number 4 Alcoholic Liver Disease 2 Alcoholic liver disease is the second leading indication for liver transplantation in the
Technology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta482
Immunosuppressive e therapy for kidney transplant in children and young people Technology appraisal guidance Published: 11 October 2017 nice.org.uk/guidance/ta482 NICE 2018. All rights reserved. Subject
(Stem) cells to treat type 1 diabetes
(Stem) cells to treat type 1 diabetes Prof. Robert Hilbrands Diabetologist - Nephrologist Diabeteskliniek UZBrussel Type 1 diabetes Insulitis = inflammatory infiltrate involving Ilsets of Langerhans *Willy
Immunosuppressive Strategies in Liver Transplantation for Hepatitis C
Trends in Transplantation Transplant. 2010;4:78-85 Immunosuppressive Strategies in Liver Transplantation for Hepatitis C Timothy M. Clifford 1-3, Michael F. Daily 1,3 and Roberto Gedaly 1,3 1 UK HealthCare,
Immunosuppressants. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Immunosuppressants Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Immunosuppressive Agents Very useful in minimizing the occurrence of exaggerated or inappropriate
Glossary. Anesthesiologist A doctor who puts you or parts of your body to sleep during surgery.
1-Glossary Glossary Acute rejection A type of rejection that occurs when immune cells from your body attack the transplanted organ(s). Acute rejection may occur at any time after a transplant. But it usually
Kidneytransplant pathologyrelatedto immunosuppressiveagents
Kidneytransplant pathologyrelatedto immunosuppressiveagents Helmut Hopfer Pathologie Women, 53 years old. 16 months after kidney transplantation for diabetic nephropathy. Metabolicsyndromeandcoronaryheartdisease.
Divya Jain Arwindekar, DO Transplant Nephrologist Advocate Christ Medical Center & Associates in Nephrology
Divya Jain Arwindekar, DO Transplant Nephrologist Advocate Christ Medical Center & Associates in Nephrology Not a cure to kidney disease, but it is a very effective treatment Patients still have chronic
Liver Transplant Immunosuppression
Liver Transplant Immunosuppression Michael Daily, MD, MS, FACS Surgical Director, Kidney and Pancreas Transplantation University of Kentucky Medical Center Disclosures No financial disclosures I will be
Public Health, Infections and Transplantation
Public Health, Infections and Transplantation Dr Kerry Chant Chief Health Officer & Deputy Director General Population and Public Health NSW Ministry of Health May2014 Public Health Infection and Transplantation
Transplant Overview. Timothy J. Schroeder President and CEO CTI Clinical Trial and Consulting Services November 10, 2005
Transplant Overview Timothy J. Schroeder President and CEO CTI Clinical Trial and Consulting Services November 10, 2005 CTI Clinical Trial and Consulting Services Drug Development Company focused in key
Vascular Remodelling in Pancreas Transplantation
Vascular Remodelling in Pancreas Transplantation Prof Steve White Consultant HPB/Transplant Surgeon The Freeman Hospital Newcastle President Elect EPITA European Pancreas Transplants Pancreas Transplants
Donor-derived Cell-free DNA Improves DSA-informed Diagnosis of ABMR in Kidney Transplant Patients
Donor-derived Cell-free DNA Improves DSA-informed Diagnosis of ABMR in Kidney Transplant Patients Stanley C. Jordan, MD Director, Division of Nephrology Medical Director, Kidney Transplant Program Medical
KIDNEY TRANSPLANTATION
Program and Surgical Director: David A. Goldfarb, MD Medical Director: Emilio Poggio, MD 216.444.6996 clevelandclinic.org/kidneytx Kidney KIDNEY TRANSPLANTATION A year of two milestones In, Cleveland Clinic
NEWS RESEARCH STUDENTS ALUMNI ARTS SPORTS HARVARDIANA OPINION MULTIMEDIA CLASSIFIEDS. Images courtesy of Douglas Melton. . Like.
1 of 6 29/3/2015 10:11 PM Your independent source for Harvard news since 1898 DONATE CURRENT ISSUE CLASS NOTES OBITUARIES CONTACT Search... NEWS RESEARCH STUDENTS ALUMNI ARTS SPORTS HARVARDIANA OPINION
1. Discuss the basic pathophysiology of end-stage liver and kidney failure.
TRANSPLANT SURGERY ROTATION (PGY1, 2) A. Medical Knowledge Goal: The resident will achieve a detailed knowledge of the evaluation and treatment of a variety of disease processes. The resident will be exposed
REACH Risk Evaluation to Achieve Cardiovascular Health
Dyslipidemia and transplantation History: An 8-year-old boy presented with generalized edema and hypertension. A renal biopsy confirmed a diagnosis of focal segmental glomerulosclerosis (FSGS). After his
Transplantation: Year in Review
Transplantation: Year in Review Alexander Wiseman, MD Medical Director, Kidney and Pancreas Transplant Program Associate Professor, Division of Renal Diseases and Hypertension University of Colorado Outline:
Rabbit Antithymocyte Globulin (Thymoglobulin Ò )
REVIEW ARTICLE Drugs 2010; 70 (6): 691-732 0012-6667/10/0006-0691/$55.55/0 ª 2010 Adis Data Information BV. All rights reserved. Rabbit Antithymocyte Globulin (Thymoglobulin Ò ) 25 Years and New Frontiers
Chronic Kidney Disease & Transplantation. Paediatrics : 2004 FRACP
Chronic Kidney Disease & Transplantation Paediatrics : 2004 FRACP ANZDATA Registry Mode of First Treatment - Paediatric 14 12 10 8 6 4 2 0 0-4 y 5-9 y 10-14 y 15-19 y Hospital CAPD Hospital HD Hospital
American Journal of Transplantation 2009; 9 (Suppl 3): S1 S157 Wiley Periodicals Inc.
American Journal of Transplantation 2009; 9 (Suppl 3): S1 S157 Wiley Periodicals Inc. 2009 The Authors Journal compilation 2009 The American Society of Transplantation and the American Society of Transplant
HBV, HCV, HIV and Kidney Transplantation. Simin Goral MD University of Pennsylvania Medical Center Philadelphia, Pennsylvania
HBV, HCV, HIV and Kidney Transplantation Simin Goral MD University of Pennsylvania Medical Center Philadelphia, Pennsylvania Objectives Prevalence of hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency
Increased Early Rejection Rate after Conversion from Tacrolimus in Kidney and Pancreas Transplantation
Increased Early Rejection Rate after Conversion from Tacrolimus in Kidney and Pancreas Transplantation Gary W Barone 1, Beverley L Ketel 1, Sameh R Abul-Ezz 2, Meredith L Lightfoot 1 1 Department of Surgery
Day-at-a-Glance. Saturday, June 2, 2018
Saturday, June 2, 2018 1:00 pm 5:30 pm Pre-Meeting Symposia (Additional Fee) Advanced Immunology Basic Science for the Clinician The Immunology of Kidney Transplantation Transplant Center QAPI and Advanced
Summary of Results for Laypersons
What was the Study Called? Summary of Results for Laypersons A Multi-center, Randomized, Open-label, Pilot and Exploratory Study Investigating Safety and Efficacy in OPTIMIZEd Dosing of Advagraf Kidney