Freiburg Medical Laboratory ME LLC, P.O.Box 3068, Dubai Tel: Fax:

Transcription

1 Autoantibodies acetylcholine receptor alveolar basal membrane C3-nephritis factor cold agglutinin cytoplasmatic antigen (parotis) DNA, double stranded (ds DNA) DNA, single stranded (ss DNA) endomysium, IgA endothelium of cardiac muscle epidermal basal membrane (EBM99A), skin antibodies extractable nuclear antigens (ENA) Glomerular basal membrane (GBMA) histones intercellular substance intrinsic factor islet cells Mi 1, Mi 2 microsomal thyroidal antigen, (anti-tpo) mitochondria (AMA)/ M2 parietal cells (PCA) reticulin myasthenia gravis Goodpasture syndrome, hemorrhagia of lung, rapidly progressive glomerulonephritis membraneous proliferative glomerulonephritis acral circulation disorder, monoclonal gammopathy, mycoplasma pneumonia Sjoegren syndrome systemic lupus erythrematodes drug induced LE, rheumatic arthritis, leukosis dermatitis herpetiformis, gluten sensitive enteropathia, celiac s disease infectious bacterial endocarditis bulloid dermatosis (pemphigoid, herpes gestationis, linear IgA dermatosis) see Auto-Abs against extractable nuclear antigens/ ENAS autoimmune interstitial nephritis, Goodpasture syndrome, rapidly progressive glomerulonephritis, autoimmune glomerulonephritis drug induced LE, systemic LE Pemphigus Pernicious anemia suspicion of diabetes type I Dermatomyositis Hashimoto thyreoiditis, M. Basedow, endocrine orbitopathia primary biliary cirrhosis perniciosa, malignant anemia, chronic gastritis, ulcera Celiac s disease, dermatitis herpetiformis Duhring

2 RNA RNP sarcolemma of heart muscle Scl 70 smooth muscles (ASMA) spermatozoae SS A (Ro) SS-B (La) striated muscles TSH receptors TPO and thyreoglobulin U-nRNP warm agglutinins (indirect Coombs test) unspecific MCTD, SHARP syndrome postcarditis syndrome, perimyocarditis, rheumatic carditis, endocarditis progressive systemic sclerosis, diffuse type chronic aggressive hepatitis, autoimmune hepatitis Infertility Sjoegren syndrome, LE, neonatal lupus syndrome Sjoegren syndrome, LE thymoma, myasthenia gravis Grave s disease, M. Basedow, endocrine orbitopathy Hashimoto thyreoiditis MCTD, SHARP syndrome hemolytic anemia Classified according to disorder/suspicion Blood Anemia, autoimmune Malignant anemia/ perniciosa Auto immune thrombocytopenia (e.g. Morbus Werlhof) Heparin induced thrombocytopenia (type II) Rel. thromboses, thrombophilia Cold agglutinins, warm agglutinins Antiparietal cell antibody, H+K+ATPase Ab, Ab against intrinsic factor Thrombocyte antibody (free Abs against fibrinogen receptor glycoproteins GPIIb/IIIa, bound against collagenous receptor GPIa/IIa, bound against Willebrand receptors GP Ib/V/IX, IV and HLA class 1) Heparin (PF-4)-complex-Ab Lupus anticoagulant, β2-glycoprotein-1-igg, -IgA, -IgM, cardiolipin-igg, -IgM-antibody Stomach Chronic-atrophic gastritis, Perniciosa Malignant anemia, Perniciosa Antiparietal cell antibody, H+K+ATPase Ab, Anti-intrinsic factor

3 Liver Chronic active hepatitis, type I Chronic active hepatitis, type II Primary biliary cirrhosis Primary sclerosing cholangitis Ab against smooth muscle (actin), atyp. ANCA (X- ANCA), ANA Anti-LKM antibody, Ab against soluble liver antigen (SLA), anticytosol antibody (LC1), Ab against liver membrane (asialoglycoprotein) Antimitochondrial Ab (AMA /AMA-M2), Spl00 (nuclear dots), Abs against the nuclear membrane (gp210,lamin), centromere Ab Atypical ANCA (X-ANCA) Pancreas Diabetes mellitus type I LADA Diabetes mellitus, insulin resistant Islet cell Ab, insulin Ab, glutamate decarboxylase Ab (GAD-Ab) Insulin Ab, GAD-Ab Insulin receptors Intestinal diseases Morbus Crohn Colitis ulcerosa Celiac disease (endemic sprue) Ab against exocrine pancreas, Ab against Saccharomyces cerevisae Goblet cell antibody, Ab against colon epithelium, atypical ANCA (X-ANCA) Antiendomysium Ab (IgA/IgG), T-transglutaminase-Ab (IgG/IgA), antigliadin Ab (IgA/IgG), anti-reticulin Ab (IgA/IgG) Diseases of the kidney Goodpasture syndrome Progressive glomerulonephritis IgA-nephropathy Ab against glomerular basal membrane, Ab against alveolar basal membrane p-anca (MPO. further subspecifities), c-anca (PR3), C3-nephritis factor c-/p-anca

4 Diseases of the blood vessels Morbus Wegener Polyarteritis nodosa Churg-Straus syndrome Giant-cell arteritis Other vasculitides Thromboses c-anca, Proteinase-3-AB, FVIII-associated Ag p-anca, MPO, cathepsin G, elastase p-anca, MPO, Lactoferrin, lysozyme F VIII-associated Ag Endothelium antibody Anticardiolipin Ab, (IgG/IgM), other antiphospholipid Abs Diseases of endocrine organs Hashimoto thyroiditis Morbus Basedow Diabetes mellitus type I Morbus Addison Idiopathic hypoparathyroidism Antimicrosomal Ab, antithyreoglobulin Ab, Ab against colloid II Anti-TSH receptor Ab Islet cell Ab, Ab against glutamate decarboxylase (GAD II), insulin Ab Antiadrenal cortex Ab Ab against parathyroid gland Diseases of the skin Pemphigus Paraneoplastic pemphigus Pemphicus vulgaris Bullous pemphigoid, Herpes gestationes Dermatitis herpetiformis Epidermolysis bullosa SLE, collagenoses LE, bullous Ab against cell desmosomes Ab against hemidesmosomes, BPAG2 (collagen XII) Ab against prickle cell desmosomes, if positive, then desmoglein-3 and desmoglein-1-ab Ab against epidermal basal membrane (screening), if screening positive, then further clarification: BPAG1, BP180, BPAG2, BP230 Endomysium Ab (IGA/IGG), TTG-IGG/IGA Ab against epidermal basal membrane (screening), if screening positive, then further clarification: collagen-7 antibody Antinuclear Ab ANA,ENA,DNA-Ab, nucleosome Ab, Ab against ribosomal protein, Ab against histones, antiphospholipid Ab Ab against epidermal basal membrane of the collagen type 7

5 Diseases of the nervous system, neuromuscular diseases Sensory polyneuropathy Paraneoplastic syndromes Motor polyneuropathy Myasthenia gravis Lambert-Eaton syndrome Stiffman syndrome Cerebral thromboses MS / Guillain-Barre syndrome Amyotrophic lateral sclerosis Ab against neuronal nuclei (Hu-Ab,Ri-Ab) Ab against Purkinje cells (Yo), antimyelin Ab Antiganglioside Ab Antiacetylcholine receptor Ab, Ab against striated muscles (myosin) Ab against Ca-channels Ab against GAD I, Ab against amphiphysin Ab against cardiolipin, Ab against β2-glycoprotein I (IgG/IgM) Ab against myelin-associated glycoprotein Ab against myelin-bas. protein M. Alzheimer, M. Parkinson, etc Ganglioside Ab, Ab against neuroendothelium, Ab against neurofilaments Fibromyalgia ANA, serotonin Ab, gangliosid Ab Heart diseases Postmyocardial infarction Cardiomyopathy Congenital heart block Myocarditis Rheumatoid factors (IgM, IgA) ANA SSA/Ro-Ab Ab against heart muscle Arthritis Rheumatoid arthritis Juvenile chronic arthritis ANA, cyclic citrullinized Ab (CCP-AB), COMP, Ab against RA33, rheumatoid factor IgM ANA, cyclic citrullinized Ab (CCP-AB), RF IgM, IgA Reproductive organs Infertility Abortion tendency Ab against spermatozoae, Ab against Leydig cells, Ab against ovary Ab against cardiolipin, phospholipid screen IgG/IgM, Lupus anticoagulants