obesità nel bambino: epidemiologia e prevenzione
|
|
- Pierce Neal
- 5 years ago
- Views:
Transcription
1 Obesità, Nutrizione e Stili di vit. Trento 31 Mrzo 27 obesità nel bmbino: epidemiologi e prevenzione Cludio Mffeis Diprtimento Mterno Infntile e Biologi-Genetic Sezione di Peditri - Università di Veron PREVALENCE OF OVERWEIGHT AND OBESITY IN 2-6-YEAR-OLD ITALIAN CHILDREN Overweight 2,% 2,% 1,% 1,% mles femles totle,%,% Ntionl reference I.O.T.F. C.D.C. Obesity 18,% 16,% 14,% 12,% 1,% 8,% 6,% 4,% 2,%,% Ntionl reference I.O.T.F. C.D.C mles femles totle Mffeis C et l. Obes Res, 26 persistence of obesity from childhood into dulthood totl smple mesured in 2 dulthood norml weight over weight obese.6 reciprocl of dult BMI.4 r = -.2, P< reltive BMI t bseline Mffeis C et l. J Clin Endocrinol Metb 22;87:
2 reltion between obesity from childhood to dulthood nd the metbolic syndrome: popultion bsed study obese dults non-obese dults non-obese In childhood obese In childhood women 3 9 totl men Odds rtio BMI <27.7 m, <26.6 w. ; BMI <1.8 b, <1.6 g. Erikson JG, et l. BMJ 1999;318: dipose tissue: regultor of inflmmtion. Regultion of food intke Energy homeostsis Adipocyte differentition Body weight control IL;ILR,TNF,MCP1 Leptin, IL-6, IL-1/IL-1R Sensitivity to insulin TNF, IL6, IL1/ILR, Adiponectin, Leptin, Resistin WAT Metbolism Inflmmtion Energy storge Control of inflmmtion Vsculr inflmmtion? Crdiovsculr protection IL1/IL1R,TNF,IL6,IL8,MC P1, RANTES,IP1 IL8,MCP1,RANTES,IP1, Resistin Adiponectin, L1R,IL1 Juge-Aubry C et l., 2 Obesity nd Inflmmtion: Evidence for n Elementry Lesion Electron microscopic fetures of subcutneous dipose tissue in obese children. v g m l d d d d d v v m dipocytes m mcrophge v vessel g grnulocyte degenerting dipocytes l lymphocyte d lipid droplets Sbrbti A, Mffeis C et l. Peditrics 26 2
3 metbolic consequences of ft gin in children FAT MASS SAT INSULIN RESISTANCE VAT LIPOTOXICITY HIGH BLOOD PRESSURE IGT HIGH TRIGLYCERIDES DIABETES Mffeis C 27 the virtuous qurtet WAT pncres muscle liver bnormlities in FA metbolism my result in inpproprite ectopic ccumultion of lipids, which is involved in the development of insulin resistnce pregnncy first yer diposity rebound puberty 3 ft mss mle femle Age (yers) Dietz WH Am J Clin Nutr
4 birth weight nd type 2 dibetes in Pim Indin children nd young dults ge group (yers) birth weight (kg) < > 4. Prevlence (Mntel-Henszel X 2 test, controlled for ge nd sex) Dbele D et l. Dib Cre 1999;22:944 lrge mternl weight loss from obesity surgery prevents trnsmission of obesity to children who were followed for 2 to 18 yers 7 before mternl surgery fter mternl surgery prevlence childen: norml weight overweight, obese 3 Krl JG et l. Peditrics 27 rpid weight gin during infncy nd obesity in young dulthood in cohort of Africn Americns Adjusted nlysis obese in young dulthood: rpid weight gin ctegory ( to 4 months): sex (F) birth weight (kg) gesttionl ge (wk) firstborn sttus birth yer mternl BMI (kg/m 2 ) mternl ge (y) mternl eduction (y) OR 9% CI P , , ,14.3,1.68.4, , , ,1.3.69, Stettler N, et l. Am J Clin Nutr 23 4
5 diposity rebound dequte sleep mong dolescents in positively ssocited with helth sttus nd helth-relted behviors Independent vrible: dequte sleep (higher vs lower) OR (9% c.i.) Dependent vrible: Helth responsbility (higher vs lower) Stress mngment (higher vs lower) Nutrition (higher vs lower) Exercise (higher vs lower) Body size (Non-overweight vs Overweight) 1.6 ( ) 7.6 (.3-1.8) 3. ( ) 2.1 (1.6-3.) 1.7 ( ) Chen MY, et l. BMC Public Helth 26 GENE ENVIRONMENT NEUROENDOCRINE SYSTEM BEHAVIOUR NUTRIENT BALANCE Mffeis C, 26 OBESITY
6 long-term weight loss mintennce Definition: individuls who hve intentionlly lost t lest 1% of their body weight nd kept it off t lest one yer. 2% of overweight individuls re successful weight losers. THE NATIONAL WEIGHT CONTROL REGISTRY diet + physicl ctivity: 89% diet: 1% physicl ctivity: 1% strtegies very consistently reported: consuming low-clorie (18 kcl/dy), low-ft (2%) diet doing high levels of physicl ctivity (3 kcl/week) weighing themself frequently consuming brekfst dily ft mss 2 r =.28 P< lipid intke (% of energy intke) Klesges RC et l. AJCN 94 Gzznig JM, et l.ajcn 93 Mffeis C et l. Int J Obes 96 covert mnipultion of dietry ft nd energy density: effect on substrte flux nd food intke in men eting d libitum MJ ft blnce MJ energy blnce 2 2 high ft 1 1 medium ft low ft time (dys) time (dys) Stubb RJ, et l. AJCN 199; 62:
7 reduction in portion size nd energy density of foods re dditive nd led to sustined decreses in energy intke Dy 1 Dy 2 energy intke (kcl) 4 3 1% ED, 1% portion 1% ED, 7% portion 7% ED, 1% portion 7% ED, 7% portion 2 1 brekfst lunch dinner snck brekfst lunch dinner snck Rolls BJ et l., 26 high-fibre, low-ft diet predicts long-term weight loss nd decresed type 2 dibetes risk: the Finnish Dibetes Prevention Study low-ft/ high fibre low-ft/ low fibre high-ft/ high fibre high-ft/ low fibre weight chnge (kg) from bseline to yer three men djusted men - 4 Lindstrom J, et l. Dibetologi 26 group ssignment, ge, sex, bseline BW, ft, fibre, VLDL-use, & bseline nd follow-up period physicl ctivity high-fibre, low-ft diet predicts long-term weight loss nd decresed type 2 dibetes risk: the Finnish Dibetes Prevention Study Hzrd rtio for dibetes low-ft/ high fibre low-ft/ low fibre high-ft/ high fibre high-ft/ low fibre men djusted men djusted men # 2 1 group ssignment, ge, sex, bseline BW, ft & fibre intke, bseline 2-h glucose, bseline nd follow-up period physicl ctivity # + weight chnge Lindstrom J, et l. Dibetologi 26 7
8 Comprison of the Atkins, Ornish, Weight Wtchers, nd Zone diets for weight loss nd hert disese risk reduction Energy CHO Ft Prot Fiber (g) Atkins (n.4) Zone (n.4) Weight Wtchers (n.4) Ornish (n.4) weigh chnge - 2 (kg) months 6 months 12 months Dnsinger ML, et l. JAMA 2 4 energy intke 3 dily ptterns of energy intke in children 2 1 Morning Afternoon Brekfst Lunch Dinner snck snck Night snck Mffeis C, et l. Int J Obes
9 energy (kcl) energy intke energy expenditure thresold of energy expenditure yers Hill & Wytt J Appl Physiol, 2 PHYSICAL ACTIVITY AND BODY FAT FAT MASS PHYSICAL ACTIVITY LEVEL (PAL) AGE (yers) ssocition of fmily environment with children s TV viewing nd with low levels of physicl ctivity BMI z-score.8 Fmily cluster: FM, Ft intke, TV (h/dy) obesogenic.4. non obesogenic 8 11 dughter s ge (yers) Dvidson KK, et l. Obes Res 2 9
10 prents obesity-relted behviors predict girls chnge in BMI 7 percent overweight 3 fther cceptnce incresing fther cceptnce decresing 6 12 time (months) pternl but not mternl prenting style ws relted to child weight outcome fthers increse in cceptnce period my be especilly powerful becuse it is contrry to the usul developmentl trend t this ge, which is for children to perceive their prents s less ccepting over time Stein RI, et l. Obes Res 2 Nutrient oxidtion mesured during wlking t speeds of 4,, nd 6 km/h, respectively, in group of obese prepubertl children Mffeis, C. et l. J Clin Endocrinol Metb 2;9: viscerl bdominl ft is correlted with whole-body ft nd physicl ctivity mong 8-y-old children t risk of obesity viscerl dipose tissue (cm 3 ) r = -.43 P< totl physicl ctivity (ccelerometer hours/week) Selens BE et l. Am J Clin Nutr 27 1
11 improvement of erly vsculr chnges nd crdiovsculr risk fctors in obese children fter six-month exercise progrm len obese 14 P <.1 intervention control flow-medited vsodiltion P <.1 P = ns bseline fter 6 months Meyer AA et l. J Am Coll Crd 27 Recommnded Dietry Allownces: re they pproprite? 4 PAL = Energy requirement (kcl/dy) 2 PHYSICAL ACTIVITY PAL = 1.4 THERMOGENESIS 1 BASAL GROWTH ge, gender, ft-free mss, ft mss, thyroid function, food intke Mffeis C 27 Recommnded Dietry Allownces: re they pproprite? PAL = INDEX OF PHYSICAL ACTIVITY = TOTAL ENERGY EXPENDITURE / BASAL ENERGY EXPENDITURE = 1.7 SAFE LEVEL FOR WEIGHT MAINTENANCE IN ADULTS Cse 1: 1-yer-old boy, BW= 3 kg, BMR: 12 kcl/dy RDA: 22 kcl/dy. Estimted PAL: 22/12 = 1.8 Cse 2: 1-yer-old boy, BW= 4 kg, BMR: 14 kcl/dy RDA: 22 kcl/dy. Estimted PAL: 22/14 = 1.6 Cse 3: 1-yer-old boy, BW= 2 kg, BMR: 1 kcl/dy RDA: 22 kcl/dy. Estimted PAL: 22/1 = 2.2 However, the men PAL in 1-yer-old boys is 1.. Therefore, in ll the three cses the RDA overestimte requirements nd expose to ft gin. Mffeis C 27 11
12 TAKE HOME MESSAGE Approching prevention nd tretment of obesity in the single individul do not use the RDA to estimte energy requirements but use the fctoril method. Mffeis C 27 12
Does increasing physical activity reduce the excess risk of work disability among overweight individuals? 1
1 Does incresing physicl ctivity reduce the excess risk of work disbility mong overweight individuls? 1 by Jenni Ervsti, PhD, 2 Jkko Airksinen, PhD, Jn Pentti, MSc, Jussi Vhter, MD, PhD, Skri Suominen,
More informationCommunity. Profile Yellowstone County. Public Health and Safety Division
Community Helth Profile 2015 Yellowstone County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Lewis & Clark County. Public Health and Safety Division
Community Helth Profile 2015 Lewis & Clrk County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Missoula County. Public Health and Safety Division
Community Helth Profile 2015 Missoul County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationCommunity. Profile Powell County. Public Health and Safety Division
Community Helth Profile 2015 Powell County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationCommunity. Profile Big Horn County. Public Health and Safety Division
Community Helth Profile 2015 Big Horn County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl
More informationCommunity. Profile Anaconda- Deer Lodge County. Public Health and Safety Division
Community Helth Profile 2015 Ancond- Deer Lodge County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12
More informationThe Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes
Originl Article doi: 10.4093/kdj.2010.34.3.166 pissn 1976-9180 eissn 2093-2650 The Effects of Smll Sized Rice Bowl on Crbohydrte Intke nd Dietry Ptterns in Women with Type 2 Dibetes Hee-Jung Ahn 1, *,
More informationXII. HIV/AIDS. Knowledge about HIV Transmission and Misconceptions about HIV
XII. HIV/AIDS Knowledge bout HIV Trnsmission nd Misconceptions bout HIV One of the most importnt prerequisites for reducing the rte of HIV infection is ccurte knowledge of how HIV is trnsmitted nd strtegies
More informationCommunity. Profile Carter County. Public Health and Safety Division
Community Helth Profile 2015 Crter County Public Helth nd Sfety Division Tble of Contents Demogrphic Informtion 1 Communicble Disese 3 Chronic Disese 4 Mternl nd Child Helth 10 Mortlity 12 Behviorl Risk
More informationRandomized Controlled Trial to Improve Adiposity, Inflammation, and Insulin Resistance in Obese African-American and Latino Youth
nture publishing group rticles Rndomized Controlled Tril to Improve Adiposity, Inflmmtion, nd Insulin Resistnce in Obese -Americn nd Ltino Youth Rebecc E. Hsson 1, Tnj C. Adm 1, Jimie N. Dvis 1, Louise
More informationMetabolic Syndrome and Health-related Quality of Life in Obese Individuals Seeking Weight Reduction
Metbolic Syndrome nd Helth-relted Qulity of Life in Obese Individuls Seeking Weight Reduction Adm Gilden Tsi 1, Thoms A. Wdden 1, Dvid B. Srwer 1, Robert I. Berkowitz 1, Leslie G. Womble 1, Louise A. Hesson
More informationLongitudinal Association of Maternal Attempt to Lose Weight During the Postpartum Period and Child Obesity at Age 3 Years
nture publishing group Longitudinl Assocition of Mternl Attempt to Lose Weight During the Postprtum Period nd Child Obesity t Age 3 Yers Kendrin R. Sonneville 1,2, Sheryl L. Rifs-Shimn 3, Emily Oken 3,
More informationBMI and Mortality: Results From a National Longitudinal Study of Canadian Adults
nture publishing group BMI nd Mortlity: Results From Ntionl Longitudinl Study of Cndin Adults Hether M. Orpn 1, Jen-Mrie Berthelot 2,3, Mrk S. Kpln 4, Dvid H. Feeny 5,6, Bentson McFrlnd 7 nd Nncy A. Ross
More informationSerum γ-glutamyltransferase: Independent Predictor of Risk of Diabetes, Hypertension, Metabolic Syndrome, and Coronary Disease
nture publishing group Serum γ-glutmyltrnsferse: Independent Predictor of Risk of Dibetes, Hypertension, Metbolic Syndrome, nd Coronry Disese Altn Ont 1, Güny Cn 2, Ender Örnek 3, Gökhn Çiçek 4, Erkn Ayhn
More informationSESSIONE I: RELATORI. Ghrelin: from oroxigenic signal to metabolic master regulator?
SESSIONE I: RELATORI Ghrelin: from oroxigenic signl to metbolic mster regultor? Prof. Rocco Brzzoni Professore ssocito di Medicin Intern Università degli Studi di Trieste Ghrelin: d segnle oressizznte
More informationOriginal Article INTRODUCTION. Korean Diabetes J 2010;34: doi: /kdj pissn eissn
Originl Article doi: 1.493/kdj.21.34.6.34 pissn 1976-918 eissn 293-265 The Smll Rice Bowl-Bsed Mel Pln ws Effective t Reducing Dietry Energy Intke, Body Weight, nd Blood Glucose Levels in Koren Women with
More informationDietary Characteristics of Hong Kong Young Children: Implications for Nutrition Education
HK J Peditr (new series) 2006;11:255-262 Dietry Chrcteristics of Hong Kong Young Children: Implictions for Nutrition Eduction LL HUI, EAS NELSON Abstrct Key words Objectives: To exmine the dietry pttern
More informationAssociation between television viewing and obesity in Peruvian women
Rev Súde Públic Julio A Poterico I Antonio Bernbé-Ortiz I,II Christin Loret de Mol I,III,IV J Jime Mirnd I,V Assocition between television viewing nd obesity in Peruvin women ABSTRACT I Centro de Excelenci
More informationA Comparative Study of Eating Habits and Food Intake in Women with Gestational Diabetes according to Early Postpartum Glucose Tolerance Status
Originl Article http://dx.doi.org/10.4093/dmj.2011.35.4.354 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L A Comprtive Study of Eting Hbits nd Food Intke in Women with
More informationAssociation of Antepartum Suicidal Ideation during the Third Trimester with Infant Birth Weight and Gestational Age at Delivery
Assocition of Anteprtum Suicidl Idetion during the Third Trimester with Infnt Birth Weight nd Gesttionl Age t Delivery Amber Domingue 1 ; Bizu Gelye 1 ; Fernnd Rebelo 2 ; Chunfng Qiu 3 ; Miguel Angel Luque
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationInfluence of the Duration of Diabetes on the Outcome of a Diabetes Self-Management Education Program
Originl Article Clinicl Cre/Eduction http://dx.doi.org/10.4093/dmj.2012.36.3.222 pissn 2233-6079 eissn 2233-6087 D I A B E T E S & M E T A B O L I S M J O U R N A L Influence of the Durtion of Dibetes
More informationPrevalence and predicted ongoing rise of obesity among preschool children
Prevalence and predicted ongoing rise of obesity among preschool children de Onis M et al. Am J Clin Nutr 2010;92:1257-1264 Lakshman R, et al. Circulation 2012;126:1770-9. persistence of obesity from childhood
More informationSmall Rice Bowl-Based Meal Plan for Energy and Marcronutrient Intake in Korean Men with Type 2 Diabetes: A Pilot Study
Originl Article doi: 1.493/dmj.11.35.3.73 pissn 33-679 eissn 33-687 D I A B E T E S & M E T A B O L I S M J O U R N A L Smll Rice Bowl-Bsed Mel Pln for Energy nd Mrcronutrient Intke in Koren Men with Type
More informationUtility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension
Originl Article Endocrinol Metb 2017;32:221-229 https://doi.org/10.3803/enm.2017.32.2.221 pissn 2093-596X eissn 2093-5978 Utility of the Viscerl Adiposity Index nd Hypertriglyceridemic Wist Phenotype for
More informationThere has been little systematic
doi: 10.1377/hlthff.2009.0666 HEALTH AFFAIRS 29, NO. 3 (2010): 398 404 2010 Project HOPE The People-to-People Helth Foundtion, Inc. By Crmen Pierns nd Brry M. Popkin Trends In Sncking Among U.S. Children
More informationSupplementary Figure S1
Supplementry Figure S Tissue weights (g).... Liver Hert Brin Pncres Len mss (g) 8 6 -% +% 8 6 Len mss Len mss (g) (% ody weight) Len mss (% ody weight) c Tiilis nterior weight (g).6...... Qudriceps weight
More informationPaternal Contribution to Small for Gestational Age Babies: A Multicenter Prospective Study
nture publishing group Pternl Contribution to Smll for Gesttionl Age Bbies: A Multicenter Prospective Study Lesley ME McCown 1, Robyn A. North 2, Ee Min Kho 1, Michel A. Blck 3, Eliz HY. Chn 1, Gustf A.
More informationSeasonal influenza vaccination programme country profile: Ireland
Sesonl influenz vccintion progrmme country profile: Irelnd 2012 13 Seson Bckground informtion Influenz immunistion policy nd generl fcts bout Irelnd Volume indices of GDP per cpit in 2011 nd 2013 (EU-
More informationEffects of Weight Reduction on Serum Vaspin Concentrations in Obese Subjects: Modification by Insulin Resistance
nture publishing group rticles Effects of Weight Reduction on Serum Vspin Concentrtions in Obese Subjects: Modifiction by Insulin Resistnce Hye M. Chng 1, He J. Lee 1, Hye S. Prk 1, Je H. Kng 2, Kyung
More informationPotassium Intake of the U.S. Population
Food Surveys Reserch Group Dietry Dt Brief No. 10 September 2012 Highlights The verge potssium intke of the U.S. popultion 2 yers nd older ws 2640 mg per dy nd intke of the U.S. popultion hs remined reltively
More informationHypertension, hyperinsulinaemia and obesity in middle-aged Finns with impaired glucose tolerance
Journl of Humn Hypertension (1998) 12, 265 269 1998 Stockton Press. All rights reserved 0950-9240/98 $12.00 ORIGINAL ARTICLE Hypertension, hyperinsulinemi nd obesity in middle-ged Finns with impired glucose
More informationReports of cases of AIDS, HIV infection, and HIV/AIDS 1
Reports of cses of AIDS, HIV infection, nd HIV/AIDS 1 The HIV/AIDS Surveillnce Report is published nnully by the Division of HIV/AIDS Prevention Surveillnce nd Epidemiology, Ntionl Center for HIV, STD,
More informationA Comparison of Serum Magnesium Level in Pregnant Women with and without Gestational Diabetes Mellitus (GDM)
Brief Report J Bbol Univ Med Sci Vol 18, Issu 12; Dec 2016. P:71-75 A Comprison of Serum Mgnesium Level in Pregnnt Women with nd without Gesttionl Dibetes Mellitus (GDM) Z. Bouzri (MD) 1, F. Elmi(MD) 2,
More informationLifetime exercise activity and breast cancer risk among post-menopausal women
Article no. bjoc.1999.0610 Lifetime exercise ctivity nd brest cncer risk mong post-menopusl women CL Crpenter, RK Ross, A Pgnini-Hill nd L Bernstein Deprtment of Preventive Medicine, University of Southern
More informationReport of the Conference on Low Blood
1046 Report of the Conference on Low Blood Cholesterol: Mortlity Associtions Dvid Jcobs, PhD; Henry Blckburn, MD; Millicent Higgins, MD; Dwyne Reed, MD, PhD; Hiroysu Iso, MD; Grdner McMilln, MD, PhD; Jmes
More informationMetabolic syndrome (MetS) is defined by a group
ORIGINAL ARTICLE Prevlence of Metolic Syndrome in Lrge Integrted Helth Cre System in North Crolin Rohn Mhleshwrkr, Yhenneko J. Tylor, Melnie D. Spencer, Svet Mohnn ckground Metolic syndrome (MetS) is cluster
More informationAssociation between maternal folate concentrations during pregnancy and insulin resistance in Indian children
Dibetologi (2014) 57:110 121 DOI 10.1007/s00125-013-3086-7 ARTICLE Assocition between mternl folte concentrtions during pregnncy nd insulin resistnce in Indin children Ghttu V. Krishnveni & Srgoor R. Veen
More informationDIET HISTORY AND BIRTH WEIGHT RELATIONSHIP AMONG SAUDI PREGNANT WOMEN
Originl Article DIET HISTORY AND BIRTH WEIGHT RELATIONSHIP AMONG SAUDI PREGNANT WOMEN Ahmed A. Al-Shoshn 1 ABSTRACT Objective: The im of this study ws to see the reltionship between food intke pttern nd
More informationOverweight and health-related quality of life in adolescents of Florianópolis, Southern Brazil
Rev Súde Públic 2009;43(2) Nádi Kunkel Wlter Ferreir de Oliveir Mrco Aurélio Peres Overweight nd helth-relted qulity of life in dolescents of Florinópolis, Southern Brzil ABSTRACT OBJECTIVE: To ssess helth-
More informationMaternal thyroid function in pregnancy may program offspring blood pressure, but not adiposity at 20 y of age
nture publishing group Popultion Study Mternl thyroid function in pregnncy my progrm offspring blood pressure, but not diposity t 20 y of ge Dorte Rytter 1, Stine L. Andersen 2,3,4, Bodil H. Bech 1, Thorhllur
More informationClassic1,2 and recent3,4 studies present evidence
Correltes of Crdiorespirtory nd Musculr Fitness mong Brzilin Adolescents Vlter Cordeiro Brbos Filho, MS; Adir d Silv Lopes, PhD, MS; Rodrigo Bozz, MS; Cssino Ricrdo Rech, MS; Wgner de Cmpos, PhD, MS Objective:
More informationHuman protein requirements: nitrogen balance response to graded levels of egg protein in elderly men and women1 2
Humn protein requirements: nitrogen blnce response to grded levels of egg protein in elderly men nd women1 2 Ricrdo uy, MD, PhD, Nevin S Scrimshw, PhD, MD, nd Vernon R Young,3 PhD ABSTRAT Seven elderly
More informationOriginal Paper. Med Princ Pract 2017;26: DOI: /
Originl Pper Med Princ Prct 2017;26:146 151 Received: Mrch 28, 2016 Accepted: December 6, 2016 Published online: December 6, 2016 The Assocition of Vitmin D Sttus nd Vitmin D Replcement Therpy with Glycemic
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved patient labeling. Revised: 6/2016 FULL PRESCRIBING INFORMATION: CONTENTS*
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use BASAGLAR sfely nd effectively. See full prescribing informtion for BASAGLAR BASAGLAR (insulin glrgine
More informationOriginal Article Clinical Care/Education INTRODUCTION DIABETES & METABOLISM JOURNAL
Originl Article Clinicl Cre/Eduction http://dx.doi.org/10.4093/dmj.2014.38.6.439 pissn 2233-6079 eissn 2233-6087 DIABETES & METABOLISM JOURNAL Arteril Stiffness by Aerobic Exercise Is Relted with Aerobic
More informationof comorbid conditions, interventions Diagnosis and treatment, treatment reduction of risk factors for CVD to slow disease progression,
Tble 5.1. NKF Clssifiction of Chronic Kidney Disese nd Clinicl Fetures Stge Description GFR (ml/ min/1.73 m 2 ) U.S. Prevlence, b # Affected (%) Clinicl Fetures Action Pln c At incresed risk for CKD >60
More informationFactors influencing help seeking in mentally distressed young adults: a cross-sectional survey
L Biddle, D Gunnell, D Shrp nd J L Donovn Fctors influencing help seeking in mentlly distressed young dults: cross-sectionl survey Lucy Biddle, Dvid Gunnell, Debbie Shrp nd Jenny L Donovn SUMMARY Bckground:
More informationVisceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men
Viscerl ft ccumultion determines postprndil lipemic response, lipid peroxidtion, DNA dmge, nd endothelil dysfunction in nonobese Koren men Yngsoo Jng,*, Oh Yoen Kim, H Jung Ryu, Ji Young Kim, Sng Hoon
More informationPositive association between plasma homocysteine level and chronic kidney disease
University of Wollongong Reserch Online Fculty of Socil Sciences - Ppers Fculty of Socil Sciences 2008 Positive ssocition between plsm homocysteine level nd chronic kidney disese Anoop Shnkr Ntionl University
More informationLow Fasting Triglycerides: Hallmark of the Healthy Large Hip?
nture publishing group rticles Low Fsting Triglycerides: Hllmrk of the Helthy Lrge Hip? Johnnes B. Ruige 1 nd Luc F. Vn Gl 2 Body ft distribution modultes risk for type 2 dibetes mellitus. We evluted potentilly
More informationA series of recent studies and meta-analyses confirm
Originl Reserch Clinicl Medicine & Reserch Volume 11, Number 4: 210-218 2013 Mrshfield Clinic clinmedres.org Brest nd Prostte Cncer Survivors in Dibetic Cohort: Results from the Living With Dibetes Study
More informationChi-Hua Yen, 1,2,3 Shu-Ju Chen, 4 Jen-Tzu Liu, 5 Yu-Fen Tseng, 5 and Ping-Ting Lin 5,6. 1. Introduction
BioMed Reserch Interntionl Volume 213, Article ID 89234, 8 pges http://dx.doi.org/1.1155/213/89234 Clinicl Study Effects of Wter Extrcts of Grptopetlum prguyense on Blood Pressure, Fsting Glucose, nd Lipid
More informationFetal programming of coronary heart disease
364 Review Fetl progrmming of coronry hert disese Dvid J.P. Brker People who develop coronry hert disese grow differently from other people both in utero nd during childhood. Slow growth during fetl life
More informationBone mineral density is not diminished by mild to moderate
Kidney Interntionl, Vol. 61 (2002), pp. 1814 1820 Bone minerl density is not diminished by mild to moderte chronic renl insufficiency CHI-YUAN HSU, STEVEN R. CUMMINGS, CHARLES E. MCCULLOCH, nd GLENN M.
More informationEffects of 6-Month Sitagliptin Treatment on Insulin and Glucagon Responses in Korean Patients with Type 2 Diabetes Mellitus
Originl Article Others Dibetes Metb J 215;39:335-341 http://dx.doi.org/1.493/dmj.215.39.4.335 pissn 2233-679 eissn 2233-687 DIABETES & METABOLISM JOURNAL Effects of 6-Month Sitgliptin Tretment on Insulin
More informationHIV Surveillance in Women. National Center for HIV/AIDS, Viral Hepatitis, STD & TB Prevention Division of HIV/AIDS Prevention
HIV Surveillnce in Women Ntionl Center for HIV/AIDS, Virl Heptitis, STD & TB Prevention Division of HIV/AIDS Prevention Dignoses of HIV Infection mong Adult nd Adolescent Femles, by Rce/Ethnicity, 2006
More information2018 American Diabetes Association. Published online at
Supplementry Figure S1. Ft-1 mice exhibit reduced diposity when fed n HFHS diet. WT nd ft-1 mice were fed either control or n HFHS diet for 18 weeks. A: Representtive photogrphs for side-by-side comprison
More informationVitamin D, parathyroid hormone and metabolic syndrome the PORMETS study
Rposo et l. BMC Endocrine Disorders (2017) 17:71 DOI 10.1186/s12902-017-0221-3 RESEARCH ARTICLE Vitmin D, prthyroid hormone nd metbolic syndrome the PORMETS study Open Access Luís Rposo 1,2*, Sndr Mrtins
More informationEffect of Vitamin D Supplementation on C reactive Protein in Patients with Nonalcoholic Fatty Liver
www.ijpm.ir Effect of Vitmin D Supplementtion on C rective Protein in Ptients with Nonlcoholic Ftty Liver Mhdi Foroughi 1,2, Zhr Mghsoudi 1,2, Rez Ghisvnd 1,2,3, Bijn Irj 4, Gholmrez Askri 1,2, 1 Deprtment
More informationSupplementary Online Content
Supplementry Online Content Rieckmnn N, Kronish IM, Shpiro PA, Whng W, Dvidson KW. Serotonin reuptke inhibitor use, depression, nd long-term outcomes fter n cute coronry : prospective cohort study. JAMA
More informationBright Futures Medical Screening Reference Table 2 to 5 Day (First Week) Visit
Bright Futures Medicl Reference Tle 2 to 5 Dy (First Week) Visit Universl Action Metolic nd Verify documenttion of neworn metolic screening results, pproprite rescreening, nd needed follow-up. Document
More informationA novel Mediterranean diet index from Lebanon: comparison with Europe
DOI 10.1007/s00394-014-0801-1 ORIGINAL CONTRIBUTION A novel Mediterrnen diet index from Lebnon: comprison with Europe Frh Nj Nhl Hwll Leil Itni Shirine Blbki Abl Sibi Lr Nsreddine Received: 11 April 2014
More informationRegulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?
Originl rticle Obesity nd Metbolic Syndrome Dibetes Metb J 7;4:-7 https://doi.org/.493/dmj.7.4.. pissn 33-679 eissn 33-687 DIETES & METOLISM JOURNL Regulting Hypothlmus Gene Expression in Food Intke: Dietry
More informationThyroid-Stimulating Hormone, Degree of Obesity, and Metabolic Risk Markers in a Cohort of Swedish Children with Obesity
HORMONE RESEARCH IN PÆDIATRICS Originl Pper Received: Februry 10, 2017 Accepted: April 18, 2017 Published online: June 14, 2017 Thyroid-Stimulting Hormone, Degree of Obesity, nd Metbolic Risk Mrkers in
More informationDietary Sodium Intake in People with Diabetes in Korea: The Korean National Health and Nutrition Examination Survey for 2008 to 2010
Originl Article Epidemiology Dietes Met J 2016;40:290-296 http://dx.doi.org/10.4093/dmj.2016.40.4.290 pissn 2233-6079 eissn 2233-6087 DIABETES & METABOLISM JOURNAL Dietry Sodium Intke in People with Dietes
More informationHealth-Related Quality of Life and Symptoms of Depression in Extremely Obese Persons Seeking Bariatric Surgery
Oesity Surgery, 15, 3-39 Helth-Relted Qulity of Life nd Symptoms of Depression in Extremely Oese Persons Seeking Britric Surgery Anthony N. Frictore, PhD; Thoms A. Wdden, PhD; Dvid B. Srwer, PhD; Myles
More informationWater Consumption Increases Weight Loss During a Hypocaloric Diet Intervention in Middle-aged and Older Adults
nture publishing group Wter Consumption Increses Weight Loss During Hypocloric Diet Intervention in Middle-ged nd Older Adults Elizbeth A. Dennis 1, An Lur Dengo 1, Dn L. Comber 1, Kyle D. Flck 2, Jyoti
More informationAbstract ABSTRACT #69. Abstract. Introduction & Methods. Methods & Results. Results. Results & Conclusions
Effects of dietry β-glucn on Growth Performnce, Dirrhe, nd Gut Permeility of Wening Pigs Experimentlly Infected with Pthogenic E. coli Kwngwook Kim, Amy Ehrlich, Vivin Perng, Jennifer Chse, Helen Ryould,
More informationAlthough the prevalence of maternal smoking during pregnancy. Articles
nture publishing group Popultion Study Self-reported smoking sttus nd plsm cotinine concentrtions mong pregnnt women in the Norwegin Mother nd Child Cohort Study Liv G. Kvlvik 1, Roy M. Nilsen 2, Rolv
More informationExpression of Three Cell Cycle Inhibitors during Development of Adipose Tissue
Expression of Three Cell Cycle Inhiitors during Development of Adipose Tissue Jiin Zhng Deprtment of Animl Sciences Advisor: Michel E. Dvis Co-dvisor: Kichoon Lee Development of niml dipose tissue Hypertrophy
More informationIn the treatment of cardiovascular disease (CVD), national
n report n Beyond LDL Cholesterol: The Role of Elevted Triglycerides nd Low HDL Cholesterol in Residul CVD Risk Remining After Sttin Therpy Peter Algon Jr, MD, FACC In the tretment of crdiovsculr disese
More informationWill All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic
nture publishing group rticles Will All s Become Overweight or Obese? Estimting the Progression nd Cost of the US Obesity Epidemic Youf Wng 1, My A. Beydoun 1, Ln Ling 2, Benjmin Cbllero 1 nd Shiriki K.
More informationDiabesity & Associated Disorders in Australia
Diesity & Associted Disorders in Austrli - 2000 The Accelerting Epidemic The Austrlin Dietes, Oesity nd Lifestyle Study (AusDi) Authors Dr D Dunstn, Professor P Zimmet, Professor T Welorn, Dr R Sicree,
More informationJournal of Hainan Medical University 2017; 23(2): Journal of Hainan Medical University.
Journl of Hinn Medicl University 2017; 23(2): 151-155 151 Journl of Hinn Medicl University http://www.hnykdxxb.com Reltionship between DEXA bone minerl density mesurement results nd serum cytokines s well
More informationSymptoms of Sleep Disordered Breathing and Risk of Cancer: A Prospective Cohort Study
SYMPTOMS OF SDB AND RISK OF CANCER: A PROSPECTIVE COHORT STUDY http://dx.doi.org/10.5665/sleep.3030 Symptoms of Sleep Disordered Brething nd Risk of Cncer: A Prospective Cohort Study Anne Sofie Christensen,
More informationSafety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA
Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,
More informationDivision of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, 2
Originl Article Epidemiology http://dx.doi.org/1.493/dmj.214.38.1.51 pissn 2233-679 eissn 2233-687 DIABETES & METABOLISM JOURNAL Higher Prevlence nd Awreness, but Lower Control Rte of Hypertension in Ptients
More informationBone Mineral Density in Prediabetic Men
Originl Article doi: 10.4093/kdj.2010.34.5.294 pissn 1976-9180 eissn 2093-2650 Bone Minerl Density in Predibetic Men Ju Hee Lee 1, Yun Hyeong Lee 1, Kyoung Hye Jung 1, Min Kyeong Kim 1, Hye Won Jng 1,
More informationIncidence of proteinuria in type 2 diabetes mellitus in the Pima Indians
Kidney Interntionl, Vol. 35 (1989), pp. 681 687 Incidence of proteinuri in type 2 dibetes mellitus in the Pim Indins CHARLES L. KUNZELMAN,' WILLIAM C. KNOWLER, DAVID J. PETTITT, nd PETER H. BENNETT Dibetes
More informationJRHS Journal of Research in Health Sciences
JRHS Journl of Reserch in Helth Sciences journl homepge: www.umsh.c.ir/jrhs Originl Article Dietry Intke nd Its Reltionship to Different Body Mss Index Ctegories: A Popultion-Bsed Study Ali Asghr Rshidi
More informationAccuracy of reporting food energy intake: influence of ethnicity and body weight status in South African women
Accurcy of reporting food energy intke: influence of ethnicity nd ody weight sttus in South Africn women Mchiz ZJ, PhD Goedecke JH, PhD Lmert EV, PhD Knowledge Systems, Nutrition Unit, Humn Science Reserch
More informationA cross-sectional and follow-up study of leukopenia in tuberculosis patients: prevalence, risk factors and impact of anti-tuberculosis
Originl Article A cross-sectionl nd follow-up study of leukopeni in tuberculosis ptients: prevlence, risk fctors nd impct of nti-tuberculosis tretment Fei-Shen Lin 1 *, Mei-Ying Wu 2 *, Wen-Jun Tu 3, Hong-Qiu
More informationARTICLES. The potential role of biotin as dietary risk marker for hypertension in black South African children the THUSA BANA study
The potentil role of iotin s dietry risk mrker for hypertension in lck South Africn children the THUSA BANA study A E Schutte, J M vn Rooyen, H W Huismn, H S Kruger, N T Mln Ojective. To determine whether
More informationPrevalence of Prehypertension in a Rural District of Southern India
Interntionl Journl of Preventive Medicine Brief Communiction Open Access Prevlence of Prehypertension in Rurl District of Southern Indi Mrinyknkopplu R. Rvi, Ngrlu C. Ashok, M. Renuk Deprtment of Community
More informationEthnic Disparities in Stroke Recognition in Individuals with Prior Stroke
Reserch Articles Ethnic Disprities in Stroke Recognition in Individuls with Prior Stroke Chrles Ellis, PhD Leonrd E. Egede, MD, MS,c SYNOPSIS Ojective. Studies of stroke wreness suggest tht knowledge of
More informationT.S. Kurki a, *,U.Häkkinen b, J. Lauharanta c,j.rämö d, M. Leijala c
Europen Journl of Crdio-thorcic Surgery 20 (2001) 1183 1187 www.elsevier.com/locte/ejcts Evlution of the reltionship between preopertive risk scores, postopertive nd totl length of stys nd hospitl costs
More informationMeasurement Error in Diet and Physical Activity Epidemiology. Ross Prentice, October 22, 2015
Mesurement Error in Diet nd Physicl Activity Epidemiology Ross Prentice, October 22, 2015 Design of WHI CT=68,132 DM 48,835 WHI =161,808 HRT 27,347 CD 36,282 os 93,676 History: WHI Development nd Reserch
More informationClinical Study Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio
Journl of Obesity Volume 213, Article ID 49679, 9 pges http://dx.doi.org/1.1155/213/49679 Clinicl Study Metbolic Risk Susceptibility in Men Is Prtilly Relted to Adiponectin/Leptin Rtio Glori Len Veg nd
More informationAssociations of Psoriatic Arthritis and Cardiovascular Conditions in a Large Population
ville online: www.kp.org/permnentejournl Originl rticle Associtions of Psoritic Arthritis nd Crdiovsculr Conditions in Lrge Popultion Svetln Kondrtiouk, DO Ntli Udltsov, PhD Arthur L Kltsky, MD Astrct
More informationEpidemiological survey and analysis of asthma in children aged 0-14 years old in urban and rural areas of Chengdu region
Originl Article Epidemiologicl survey nd nlysis of sthm in children ged 0-14 yers old in urbn nd rurl res of Chengdu region Min Li 1, Qiong Zhng 2, Wei-Jun Shi 2, Ln Li 1, Yn Li 2, Ying Png 1, Bin Yo 1,
More informationDetecting Undiagnosed Type 2 Diabetes: Family History as a Risk Factor and Screening Tool. Rodolfo Valdez, Ph.D.
Journl of Dietes Science nd Technology Volume 3, Issue 4, July 2009 Dietes Technology Society SYMPOSIUM Detecting Undignosed Type 2 Dietes: Fmily History s Risk Fctor nd Screening Tool Rodolfo, Ph.D. Astrct
More informationAssessment of Depression in Multiple Sclerosis. Validity of Including Somatic Items on the Beck Depression Inventory II
Assessment of Depression in Multiple Sclerosis Vlidity of Including Somtic Items on the Beck Depression Inventory II Peggy Crwford, PhD; Noh J. Webster, MA Signs nd symptoms of multiple sclerosis (MS)
More informationPatterns of Single Gene Inheritance
M1 Humn Genetics Types of Genetic Disese Ptterns of Single Gene Inheritnce Virgini A. Pllnte, M.S. vpllnte@mcvh-vcu.edu Chromosoml Single gene (Mendelin) Multifctoril Tertogenic 1 2 3 4 A A A 1 2 homozygote
More informationEvaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin
e-issn 1643-3750 DOI: 10.12659/MSM.894926 Received: 2015.06.08 Accepted: 2015.07.29 Published: 2015.08.28 Evlution of Apelin nd Insulin Resistnce in Ptients with PCOS nd Therpeutic Effect of Drospirenone-Ethinylestrdiol
More informationImplications of iron deficiency/anemia on the classification of diabetes using HbA1c
OPEN Cittion: Nutrition & Dibetes (201), e166; doi:10.1038/nutd.201.16 www.nture.com/nutd ORIGINAL ARTICLE Implictions of iron /nemi on the clssifiction of dibetes using SM Attrd 1, AH Herring 2,3, H Wng
More informationNorthern blot analysis
Northern blot nlysis RNA SCD RNA SCD FAS C c-9 t-1 C c-9 t-1 PRE PI PDMI PRE PI PDMI PRE PDMI PIM An W c-9, t-11 t-1, c-12 C 5 2 4 1 um C 5 2 4 1 um Angus dipocytes expressed SCD higher thn Wgyu dipocyte
More information