The Plan for a World without T1D

Transcription

1 The Plan for a World without T1D Presented by: Kathy Spain RN, BSN, CDE, CPT Turning TypeOne to

2 My Story...

3 JDRF s Vision for the Future LESS UNTIL NONE

4 LESS LESS LESS LESS Burden UNTIL Invasive Complexity Danger NONE LESS UNTIL NONE

5

6 Artificial Pancreas A series of systems that will automate insulin dosing and additional hormone delivery

7 Artificial Pancreas Uses the Familiar Systems QuickTime and a AVC Coding decompressor are needed to see this picture.

8 Outpatient Studies in Progress Prevention of hypo Unawareness Jones - Perth Predictive Low Glucose Suspend Buckingham - Stanford Control-to- Range Kovatchev University of Virginia Beacon Hill Study (Bihormonal) Damiano Boston Univ. Overnight Closed Loop Hovorka - Cambridge 8

9 Control-to-Range Outpatient Pilot: Padova

10 Increasingly Sophisticated Systems in the Future QuickTime and a AVC Coding decompressor are needed to see this picture.

11 Artificial Pancreas Artificial Smart Pancreas Insulin A Single series dose of systems of insulin that that will delivers automate insulin insulin only dosing where and additional when hormone needed delivery

12 Smart Insulin will Deliver Insulin Only When and Where Needed QuickTime and a AVC Coding decompressor are needed to see this picture.

13 One Daily Dose Delivers Perfect Control All Day and Night QuickTime and a AVC Coding decompressor are needed to see this picture.

14 JDRF is Making Smart Insulin a Reality QuickTime and a AVC Coding decompressor are needed to see this picture.

15 Leading Public and Private Sector Scientists Around the World Researching Smart Insulin Approaches

16 Artificial Pancreas Encapsulation Smart Insulin Smart Insulin Implantable, Single dose beta of cell insulin replacement that delivers therapies insulin restoring only where insulin and independence when without needed the need for intensive immune suppression

17 Islet Encapsulation Protecting Transplanted Beta Cells from Attack 17

18 Encapsulation Protects Beta Cells from Immune Attack

19 Nutrients and Glucose Flow Freely Autoimmune Attack Stays Out QuickTime and a AVC Coding decompressor are needed to see this picture.

20 Beta Cell Encapsulation Could Mean Life without T1D for up to 24 Months

21 JDRF Partnering to Drive Towards Human Trials

22 Encapsulation Prevention Artificial Pancreas Smart Insulin Encapsulation Implantable, Slow or stop beta the cell progression replacement of T1D therapies before insulin restoring dependence insulin independence and ultimately without eliminate the need the for intensive immune possibility suppression of ever developing T1D

23 Diagnoses of T1D Increasing 4% a Year

24 Diagnosis of Children Increasing

25 Halting the Progression T1D

26 Stopping T1D

27 Educating the Body

28 Antiviral Vaccine

29 Researching Digestive System Bacteria

30 Restoration Prevention Artificial Pancreas Smart Insulin Encapsulation Prevention Beta Slow cell or stop growth the protected progression from of T1D immune before attack insulin restoring dependence insulin and independence ultimately eliminate without the immune possibility suppression of ever developing T1D

31 Restoration is the True Biologic Cure

32 Two-Fold Challenge QuickTime and a AVC Coding decompressor are needed to see this picture.

33 Helping the Body Heal Itself QuickTime and a AVC Coding decompressor are needed to see this picture.

34 Restoring and Protecting Beta Cells QuickTime and a AVC Coding decompressor are needed to see this picture.

35 Stopping the Immune Attack

36 Artificial Pancreas Restoration Smart Insulin Encapsulation Prevention Restoration Beta cell growth protected from immune attack restoring insulin independence without immune suppression

37 Long Term Mid Term Near Term Continuous Therapeutic Improvements Complications Diabetic Eye Disease Predictive Diagnostics Artificial Pancreas Low Glucose Suspend Treat-to-Range Artificial Pancreas Encapsulation Smart Insulin Prevention Treat-to-Target Multihormone Implantable Islets Control Secondary Prevention Prevention Primary: Vaccine Complications Comprehensive Prevention Therapy Restoration New Beta Cell Growth Protected from Immune Attack

38 What You Can Do To Continue Helping Stay informed about the latest research: Consider participating in clinical trials (see JDRF Clinical Trials Connection at JDRF website - Get more involved to help grow your chapter volunteers are the key to our success Give generously to help us close the research funding gap

39 Vision Plan Capabilities Your Support