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1 introduction 98 < pre- & post-esrd preventive care 1 < diabetic care 12 < cancer screening 14 < chapter summary 16 Chapter Five preventive health care measure SSo neither ought you to attempt to cure the body without the soul; and this is the reason why the cure of many diseases is unknown to the physicians of Hellas, because they are ignorant of the whole which ought to be studied also; for the part can never be well unless the whole is well... For this is the great error of our day in the treatment of the human body, that physicians separate the soul from the body. PLATO, Dialogues <

2 introduction Five Chapter P Preventive healthcare measures in all patient populations have begun to receive increased attention from the medical community, as researchers and health plans demonstrate that influenza and pneumonia vaccinations, as well as risk factor interventions for cardiovascular disease and diabetes, are associated with improved patient outcomes. This is especially important in individuals with chronic illnesses. Since patients are at high risk for infectious events such as pneumonia, and for complications from diabetes and ischemic heart disease, we investigated whether these measures are being utilized in this high-risk population. In this chapter we first compare preventive care given to patients before and after the start of therapy for end-stage renal disease, including influenza vaccinations, pneumococcal pneumonia vaccinations, and diabetic preventive care. We then expand our analysis of diabetic care, looking at diabetic eye exams, lipid monitoring, and glycosylated hemoglobin (HbA1c) testing in both the and general Medicare populations. And, finally, we present data on screening for breast, cervical, and prostate cancers. Since preventive health care measures have 5.1 Percent of patients receiving influenza vaccinations hemodialysis patients initiating therapy before September 1, 1999 & alive on December 31, 1999, by HSA, unadjusted. Part A & B claims searched for CPT codes 9724, 9657, 9658, 9659, or 966, or HCPCS code G8, from September 1 through December 31, Patients enrolled in an HMO or with Medicare as secondary payor are excluded. 98 been assessed in the Medicare population for a considerable period of time, we map data from both the and Medicare populations. The maps on this page illustrate geographic differences in preventive measures and outcomes related to influenza. Figure 5.1, for example, shows that in some areas of the country more than two-thirds of hemodialysis patients are vaccinated against influenza. In other regions, however, an average of only 38 percent receive these vaccinations, indicating significant regional differences in clinical practice. There is a 9 percent difference between the lowest and highest quintiles. Since the current recommended practice is that all patients with chronic disease be vaccinated in order to reduce the risk of complications, these findings are of particular note. Influenza vaccinations in non- patients have been shown to reduce morbidity and mortality related to influenza and respiratory conditions. Many studies also show a reduction in all-cause and cardiovascular hospitalizations and death. As shown in Chapter Six, the population is particularly vulnerable to these outcomes. Geographic patterns in hospitalization during the winter months vary across the country (Figure 5.2). During this period a larger proportion of patients is hospitalized in the eastern half of the country compared to the western states, with rates between the highest and low66.3+ (71.3) est quintiles differ6.2 to <66.3 ing by 24 percent to <6.2 While these geo47.2 to <55.2 below 47.2 (37.6) graphic differences may be due in part to the varying rates of influenza vaccinations, there are clearly other factors involved as well, and these

3 should be investigated further. The clustering of high hospitalization rates in the Southwest may, for example, reflect complications experienced by the Native American population or by other patient groups. The apparent lack of correlation between vaccination rates and overall rates of hospitalization suggests that further work is needed in this area. Geographic patterns in mortality during the winter months vary in a manner different from the hospitalization and vaccination rates (Figure 5.3). The percent of patient deaths during the winter months is highest in the Northwest, the Northeast, and the Great Lakes states. Overall patterns of mortality appear to show some associations between vac- cinations and lower death rates, particularly in the southern and south central states. These patterns are similar to those seen with the distribution of diabetes (see Figure 1.17). The impact of vaccinations may vary among patients of different races and ethnicities, a possibility deserving further exploration. The low vaccination rates in the northwestern part of the country, and the slightly higher mortality rates, may not be clinically important, but these areas should also be more closely evaluated. More details on vaccination rates and their use in the preand post-dialysis period are presented in the next section. These data may provide more insight into the activities of and non- providers. 5.2 Percent of patients hospitalized hemodialysis patients initiating therapy before September 1, 1999 & alive on December 31, 1999, by HSA, unadjusted. Hospitalizations between January 1 & March 31,. Patients enrolled in an HMO, with Medicare as secondary payor, or dying between January 1 & March 31, are excluded (31.5) 29.2 to < to < to <28.2 below 26.8 (25.4) 5.3 Percent of patients dying hemodialysis patients initiating therapy before September 1, 1999 & alive on December 31, by HSA, unadjusted. Deaths between January 1 & March 31,. Patients enrolled in an HMO or with Medicare as secondary payor are excluded (6.98) 6.6 to < to < to <6.41 below 6.13 (5.89) 99

4 Chapter Five pre- & post-esrd preventive care Preventive healthcare measures have been widely recommended for the general population, specifically the elderly and those with chronic illnesses. On this spread we look at preventive healthcare received by patients, age 67 and older, before and after the start of therapy. Patients with chronic kidney disease and those with should receive an influenza vaccination each year. In 1999, however, fewer than one-third of the patients studied received a vaccination in the year prior to treatment, and fewer than 6 percent received it the autumn after treatment began (Figure 5.4). Rates did, however, almost double between the preand post- periods. Influenza vaccination rates vary considerably across racial and ethnic groups. The lowest pre- rates, and the greatest increase between pre- and post- rates, are seen in the Native American patient population. These rates should be interpreted with caution, however, since influenza vaccinations may not always be billed to Medicare. This is particularly true for Native American patients, who may receive care at Indian Health Service facilities. Even fewer patients are vaccinated for pneumonia. We found that only 12 percent of patients receive this vaccination in the two years prior to treatment, and only 18 percent in the two years after (Figure 5.5). Pre- rates are again lowest in Native American patients. Figure 5.6 shows the percent of patients receiving vaccinations during the four-year period surrounding the start of treatment. Rates are clearly higher in the northern half of the country, particularly the Midwest, and there is a 6 percent difference in rates between the lowest and highest quintiles. While pneumococcal pneumonia vaccinations are given only once every five to ten years, pneumonia is a major infectious complication in patients, and it appears that preventive care aimed at its reduction is significantly underutilized. The provision of preventive care to diabetic patients does not vary as widely as vaccination rates do in the pre- and post- periods, nor, in general, do testing rates vary as greatly by race or ethnicity. Approximately 5 percent of diabetic patients receive diabetic eye exams; rates are highest for white patients, and lowest for Native Americans (Figure 5.7). These rates have remained relatively stable since Lipid testing tends to be less frequent after the start of therapy, with 6 percent of patients tested prior to, and 49 percent after (Figure 5.8). Testing is, 5.4 Pre- & post- patients (age 67+) receiving influenza vaccinations, by age & race/ethnicity Percent vaccinated Percent vaccinated Pre- Post- All Pneumococcal pneumonia vaccinations (patients age 67+) All Pre- & post- patients receiving vaccine, by age & race/ethnicity Pre- Post- 5.6 Geographic variations in vaccination rates in the two years pre- & two years post (37.7) 31.4 to < to < to <29. below 26.5 (23.5) 1

5 Diabetic preventive care, pre- & post- (patients age 67+) 5.7 Trends in pre- & post- patients receiving diabetic eye exams, by race/ethnicity All White Black Pre- Post- Native American Asian Hispanic All White Black Pre- Post- Native American Asian Hispanic Trends in pre- & post- patients receiving lipid testing, by race/ethnicity Trends in pre- & post- patients receiving glycosylated hemoglobin testing, by race/ethnicity All White Black once again, least frequent among Native American patients. Glycosylated hemoglobin testing tends to occur at similar rates before and after the start of, with the exception of Native Americans, for whom testing is more frequent after the start of therapy (Figure 5.9). Approximately 6 percent of all patients receive testing, and these rates have increased steadily since Of the preventive healthcare measures examined here, only influenza and pneumococcal pneumonia vaccinations are pursued more actively after the start of therapy than before. Since cardiovascular disease and death are extremely common in the diabetic population, these data suggest that there is a lack of active risk factor monitoring after the development of. All figures patients age 67 or older; patients enrolled in an HMO or with Medicare as secondary payor are excluded. Figure 5.4 patients initiating therapy between January 1 & August 31, 1999, & alive on December 31, Pre- vaccinations: between September 1 & December 31, 1998; post- vaccinations: between September 1 & December 31, Figures patients initiating therapy between January 1 & December 31, 1997, & alive two years after initiation. Part A & B claims searched for CPT code 9669 or 9732 & for HCPCS code J665 or G9. Pre- vaccinations: two years prior to initiation; post- vaccinations: two years after initiation. Figure 5.7 patients initiating therapy in each year from 1995 to 1998, with diabetes one year prior to initiation, & alive two years after initiation. For patients with diabetes as the primary cause of, claims examined for one year prior to (pre-) or following (post-) initiation; for other diabetic patients, claims examined for two years prior to or following the intiation of. Figures patients initiating therapy in each year from 1995 to 1999, with diabetes one year prior to initiation, & alive one year after initiation. Claims examined one year prior to (pre- ) or following (post-) initiation Pre- Post- Native American Asian Hispanic

6 Racial differences in testing rates are also clear. The lower rates in Native Americans may be attributed to patients receiving care from the Indian Health Service, as this care does not appear in the Medicare billing information. 6.+ (62.8) 59.4 to < to < to <59. below 58.5 (57.7) 6.+ (64.8) 59.4 to < to < to <59. below 58.5 (54.8) 5.11 Testing, by age, race/ethnicity, & modality All The most striking differences in diabetic preventive care between and general Medicare patients occur with lipid and glycemic control testing (Figures ). patients, particularly those on dialysis, are markedly under-served in both of these basic components of care. Also clear from these figures is that the frequency of testing recommended by the ADA is not being addressed in the population. These guidelines suggest glycosylated hemoglobin monitoring at least twice per year in less complicated diabetics, and four times per year for patients with more complex disease burdens. Since diabetics with are considered more complicated, the lack of more intensive monitoring requires far more attention from providers. Lipid monitoring in diabetic patients All figures patients enrolled in an HMO or with Medicare as secondary payor are excluded Testing, by age, race/ethnicity, & modality Figure 5.1 population: patients age initiating therapy prior to January 1, 1998, alive on December 31, 1999, & with diabetes in 1999; by HSA, unadjusted. Non- population: general Medicare patients age entering Medicare before January 1, 1998, in the program through December 31, 1999, & with diabetes in 1999; patients enrolled in an HMO or diagnosed with are excluded. Claims from 1998 & 1999 searched for eye exam codes. Figure 5.11 dialysis & transplant patients age initiating therapy prior to January 1, 1999, alive on December 31,, & with diabe Geographic variations in percent of patients tested Fewer diabetic eye examinations are performed in the population than in general Medicare patients, though geographic patterns are somewhat similar (Figure 5.1). There are slight differences in examination rates between dialysis and transplant patients by age and racial groups (Figure 5.11).The fact that younger diabetics receive fewer examinations is paradoxical, since young patients are likely to have Type I diabetes, which has long been addressed by guidelines from the American Diabetes Association. It is possible that examinations may be performed and reimbursed by other insurers, but since Medicare is usually the primary payor this seems unlikely. Diabetic eye exams in & non- patients White Black N Am Asian Hispanic 5.12 Geographic variations in percent of patients tested (68.9) 6.4 to < to < to <56.4 below 42.9 (NA) (72.) 6.4 to < to < to <56.4 below 42.9 (35.9) 1 8 diabetic care Five Chapter I n this spread we compare diabetic care in the and general Medicare populations. The diabetic care measures assessed by the National Committee for Quality Assurance (NCQA) in its HEDIS 2 program include diabetic eye examinations, lipid monitoring (for the treatment of large vessel complications), and glycemic control monitoring (to assess small vessel complications). 6 4 All White Black N Am Asian Hispanic

7 Glycosylated hemoglobin (HbA1c) testing in diabetic patients 5.14 Geographic variations in percent of patients tested (81.1) 75.1 to < to < to <72.2 below 61.5 (51.5) (8.5) 75.1 to < to < to <72.2 below 61.5 (6.7) tes in. For patients with diabetes as the primary cause of, claims from searched for eye exam codes; for other diabetics, claims searched from both 1999 &. Figures 5.12, 5.14, & 5.16 population: patients age initiating therapy before January 1, 1999, alive on December 31, 1999, & with diabetes in Non- population: general Medicare patients age entering Medicare before January 1, 1999, in the program through December 31, 1999, & with diabetes in 1999; patients enrolled in an HMO or diagnosed with are excluded. Claims from 1999 searched for either lipid or glycosylated hemoglobin codes. Maps by HSA, unadjusted. Figures 5.13 & 5.15 dialysis & transplant patients age initiating therapy prior to January 1,, alive on December 31,, & with diabetes in. Claims from searched for either lipid or glycosylated hemoglobin codes Testing, by age, race/ethnicity, & modality All Testing, by number of tests in & general Medicare diabetics No tests 1 test 2 tests 3 tests 4+ tests 13

8 cancerchapter screeining Five C linical practice guidelines for the general population include cancer screening for high-risk populations, and health plans are frequently assessed on their provision of this screening. Such guidelines and assessments do not, however, receive similar attention in the community. Only 4 percent of female patients receive mammograms, with the test slightly more frequent in the Northeast (Figure 5.17). The number is similar for Pap smears, though rates are more variable nationwide (Figure 5.18). Screening for prostate cancer shows no clear geographic pattern, and rates vary almost 82 percent between the highest and lowest quintiles (Figure 5.19). patients are more likely than those on dialysis to receive mammograms, but less likely to receive cervical or prostate cancer screening (Figures 5., 5.22, 5.24). Patients in the general Medicare population are more likely than patients to receive breast or prostate cancer screening, but less apt to be tested for cervical cancer. All figures patients enrolled in an HMO or with Medicare as secondary payor are excluded. Figure 5.17 female patients age initiating therapy prior to January 1, 1999 & alive on December 31,, by HSA, unadjusted. Patients with bilateral mastectomies are excluded. Figure 5.18 female patients age initiating therapy prior to January 1, 1998 & alive on December 31,, by HSA, unadjusted. Patients with hysterectomies are excluded. Figure 5.19 male patients age 5 & older initiating therapy prior to January 1, 1998 & alive on December 31,, by HSA, unadjusted. Patients with prostatectomies are excluded. Figure 5. female patients age initiating therapy prior to January 1, 1999 & alive on December 31, ; patients with bilateral mastectomies are excluded. Figure 5.21 : female patients age initiating therapy prior to January 1, 1998 & alive on December 31, 1999; patients with bilateral mastectomies are excluded. Non-: general Medicare patients age entering Medicare before January 1, 1998 & in the program through December 31, 1999; patients & patients with bilateral mastectomies are excluded. Figure 5.22 female patients age initiating therapy prior to January 1, 1998 & alive on December 31, ; patients with hysterectomies are excluded. Figure 5.23 : female patients age initiating therapy prior to January 1, 1997 & alive on December 31, 1999; patients with hysterectomies are excluded. Non-: general Medicare patients age entering Medicare before January 1, 1997 & in the program through December 31, 1999; patients & patients with hysterectomies are excluded. Figure 5.24 male patients age 5 & older initiating therapy prior to January 1, 1998 & alive through December 31, ; patients with prostatectomies are excluded. Figure 5.25 : male patients age 5 & older initiating therapy prior to January 1, 1997 & alive through December 31, 1999; patients with prostatectomies are excluded. Non: general Medicare patients age 5 & older entering Medicare before January 1, 1997 & in the program through December 31, 1999; patients & patients with prostatectomies are excluded Geographic variations in the percent of patients receiving breast cancer screening (43.9) 41.8 to < to < to <41. below 39.9 (38.6) 5.18 Geographic variations in the percent of patients receiving cervical cancer screening (43.1) 39.3 to < to < to <37.6 below 36.7 (35.5) 5.19 Geographic variations in the percent of patients receiving prostate cancer screening (43.) 32.7 to < to < to <29.9 below 26.6 (23.6)

9 Breast cancer screening Prostate cancer screening 5. by age, race/ethnicity, & modality 5.24 by age, race/ethnicity, & modality All by age, race/ethnicity, & patient population All All White Black Other 1 Cervical cancer screening 5.25 by age, race/ethnicity, & patient population 5.22 by age, race/ethnicity, & modality All by age, race/ethnicity, & patient population 6 All All White Black Other White Black Other 15

10 Chapter Five chapter summary Maps: National means & patient populations Figure number no no no Overall value for all patients Total patients 154, , ,279 11,743 17,684 89,331 24,868 98,185 24,868 98,185 29,114 Overall value for patients mapped Pts dropped due to missing HSA/state 2,479 2,35 2, , , , Figure number Overall value for all patients Total patients 41,669 42,882 Overall value for patients mapped Pts dropped due to missing HSA/state Patient populations & analytical methods With the exception of figures that show pre- versus post- rates, we analyzed prevalent rather than incident populations for this chapter. All patients should be receiving preventive health screening regardless of the time elapsed since renal failure. For figures on diabetic eye exams, glycosylated hemoglobin testing, and breast and cervical cancer screening, we followed HEDIS 2 (Health Plan Employer Data and Information Set) specifications. HEDIS measures are generally used by health plans to assess the quality of care delivered to their enrollees. Figures that include data from the general Medicare population are created using the Medicare five percent files, which contain a random sample of five percent of all Medicare beneficiaries, and include Part A and Part B claims. Individuals with are excluded from calculations using these data. Results for patients younger than 65 are for disabled individuals whose care is covered by Medicare. Since Native American patients may receive care from the Indian Health Services that is not billed to Medicare, data for these patients may not be available. Conclusions In many areas fewer than 5 percent of hemodialysis patients are vaccinated against influenza, and vaccination rates vary widely across the country. From January to March more patients are hospitalized in the eastern half of the country, a pattern that may be only partially explained by influenza vaccination rates. In the first three months of the year, rates of all-cause mortality vary almost percent across the country. Once they have begun therapy, patients are 4 percent more likely to be vaccinated against pneumococcal pneumonia than they are before the start of treatment. Rates of pneumococcal pneumonia vaccinations vary 6 percent between the southern states, where rates are low, and the northern half of the country. Rates of diabetic eye examinations have remained stable since 1995, and are comparable in the pre- and post- periods. Lipid monitoring of diabetic patients has become more frequent since 1995, and is performed more often prior to the start of treatment than after. The frequency of monitoring glycosylated hemoglobin levels has increased since 1995 by almost 4 percent. Rates are comparable in the pre- and post- periods. Diabetic eye examinations are used to a greater extent among transplant patients than in the dialysis population, and transplant patients are 45 percent more likely to receive lipid monitoring. Patients in the two populations are, however, equally likely to receive glycosylated hemoglobin monitoring. Geographic patterns in the provision of diabetic eye examinations are similar in the and non- populations. Both lipid monitoring and glycosylated hemoglobin testing are used more widely in the general Medicare population than in patients, and the number of glycosylated hemoglobin measurements per year is greater in the general population. 16

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