THE NEW ARMENIAN MEDICAL JOURNAL
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1 THE NEW ARMENIAN MEDICAL JOURNAL Vol.8 (2014), Nо 3 p Publication of Young Scientists EPIDEMIOLOGY OF TYPE 1 DIABETES IN CHILDREN AND ADOLESCENTS IN THE REPUBLIC OF ARMENIA Department of Endocrinology, Yerevan State Medical University, Yerevan, Armenia Received 06/17/2014; accepted for printing 07/14/2014 Abstract Data from numerous large-scale epidemiologic studies shows that the incidence of type 1 diabetes is increasing worldwide by 2% to 5% in pediatric population. Up to nowadays, there is lack of studies on the epidemiology of type 1 diabetes mellitus in the Republic of Armenia, while the epidemiological characteristics is limited to official statistical data according to the special reporting form. Current study aimed to reveal the main epidemiologic features, such as prevalence, incidence, and urban-rural ratio of type 1 diabetes mellitus in children and adolescents in the Republic of Armenia in a 6-year period: Within the research, data on the increase in incidence of type 1 diabetes mellitus in children and adolescents during the specified period was obtained; the growth rate was approximately 33% in In 2012, the mean annual incidence rate of type 1 diabetes mellitus in children and adolescents was 9.08 per 100,000 of pediatric population with male predominance, while the prevalence of type 1 diabetes mellitus made 53.3 per 100,000. A difference in urban-rural disease prevalence was found: the prevalence of type 1 diabetes mellitus in the urbanized capital city Yerevan was 2.6 times higher than in regions of Armenia (р<0.05). In the mean age of type 1 diabetes mellitus manifestation had tendency to decrease, but it did not reach statistical significance (p>0.05). Based on findings of the regional analysis the map of the prevalence of type 1 diabetes mellitus in children and adolescents of Armenia was created as the platform and the first step for the formation of the National Registry of Diabetes Mellitus in the specified population group. Creation of the Registry and carrying out continuous epidemiologic studies will give an opportunity to obtain more detailed standardized data on epidemiology of diabetes mellitus, its complications and associated diseases, as well as prognostic features. Keywords: type 1 diabetes mellitus, children, adolescents, prevalence, incidence, cardiovascular complications. Introduction Childhood and adolescent onset of diabetes mellitus was a rare condition at the start of the 20th century. However, from the middle of the 20th century the ever-growing number of works on epidemiological features of type 1 diabetes mellitus (T1DM) has shown an upturn in incidence of childhood T1DM that continues up to the present day [Gale E., 2002; Zhao Z. et al., 2014]. According to the official data, 382 million people in the world have diabetes mellitus; by 2035 this will rise to 592 million. Diabetes caused 5.1 million deaths in 2013, mostly due to its micro- and macro- Address for Correspondence: Department of Endocrinology Yerevan State Medical University after M. Heratsi 2 Koryun Street, 0025, Yerevan, Armenia Tel.: lusinevnavasardyan@gmail.com vascular complications [Gerstein H. et al., 2010; Harjutsalo V. et al., 2011 b; Joergensen C. et al., 2011], diabetic cardiopathy [Nathan D. et al., 2005; van Dieren S. et al., 2011] and other cardiovascular [Vinik A., Ziegler D., 2007] and atherosclerotic complications [Buse J. et al., 2007; Margeirsdottir H. et al., 2010; Harjutsalo V. et al., 2011 a; Purnell J. et al., 2012]. More than 79,000 children developed T1DM in The mainstream of trends urgent for epidemiologic studies involve investigation of specific features of diabetes mellitus related to prevention and treatment of T1DM and its complications [Borchers A. et al., 2010; Murthy V. et al., 2012]. These studies their implication not only in endocrinology, but also in the cardiovascular area [Genuth S., 2006; Lind M. et al., 2011]. This paper first time describes the epidemiol- 89
2 ogy of T1DM in children and adolescents in the Republic of Armenia. The epidemiological study was mainly aimed at the identification of incidence, prevalence and some other epidemiologic features of T1DM in children and adolescents in Armenia during the period of The T1DM is a heterogeneous disorder, which is characterized by destruction of pancreatic beta cells, resulting in absolute insulin deficiency [Redondo M. et al., 2008]. It has an autoimmune origin resulting in formation of autoantibodies, which cause destruction of insulin-producing beta cells [Gillespie K., 2006; American Diabetes Association, 2010]. T1DM accounts for 5-10% of the total cases of diabetes worldwide. It may present at any age, but most typically presents in childhood or adolescence with a peak around the time of puberty [Basevi. V. et al., 2011]. A great number of studies were done to evaluate the epidemiologic features of T1DM. Among children under 15, from 1960 until 1996, 3% more children were diagnosed with T1DM each year, on average, worldwide. Europe has by far the most reliable and complete data on T1DM incidence. In the 1980s, European countries set up a Europewide T1DM Registry to keep track of newly diagnosed children and to standardize relevant data. In 2000 there were 44 European centers contributing to that Registry (called EURODIAB for Europe and Diabetes) [Variation and trends, 2000]. This registry includes about 30 million children in most areas of Europe. Another network, the DIAMOND network, is a T1DM Registry that includes 112 centers from 57 countries around the world, including some parts of the U.S. and most of the EU- RODIAB countries [Soltesz G. et al., 2007]. The World Health Organization initiated the DIA- MOND project in 1990 with an objective to reveal the incidence of T1DM in children. An initial report in 2000 described the incidence of T1DM in children under 14 years of age in 50 countries worldwide totally 19,164 cases among a population of 75.1 million children (an estimated 4.5% of the world s population in this age range) from 1990 to 1994 [Karvonen M. et al., 2000; Berhan Y., 2011]. Data from Africa, Asia, and South America are sparse [Diamond Project Group, 2006; National diabetes fact sheet, 2011]. The 2013 International Diabetes Federation (IDF) Atlas (6th edition) estimated the worldwide prevalence of T1DM in children below 15 years old [IDF Diabetes Atlas, 2013]. Data availability was the highest in the countries of Europe (76%) and the lowest in sub-saharan African countries (8%). The study indicated almost 500,000 children under 15 with T1DM worldwide, the largest numbers being registered in Europe (129,000) and North America (108,700). Countries with the highest estimated numbers of new cases (incidence rate) annually were the United States (13,000), India (10,900) and Brazil (5,000) [ISPAD, 2009; Maahs D. et al., 2010; IDF Diabetes Atlas, 2013; Patterson C. et al., 2014]. Summarizing the available standardized data, the average annual incidence rate varies greatly from 3.2/100,000 in Macedonia to 40.2/100,000 in two regions of Finland [Andersen M. et al., 2013; Tamayo T. et al., 2014]. The annual increase in T1DM incidence rate was 3.4% (95% CI %), although the rate of increase was noted to be higher in some Central European countries [Rawshani A. et al., 2014]. The rates of increase were found to be the highest in the youngest age group: ages 0-4 years (6.3%, 95% CI %), 5-9 years (3.1%, 95% CI %), and years (2.4%, 95% CI %), with earlier onset implying a longer burden of disease, as well as the more immediate challenge of caring for T1DM in a toddler [Maahs D. et al., 2010; Imkampe A., Gulliford M., 2011; Barat P., 2014]. In the Republic of Armenia there is no Registry of T1DM in children and adolescents and thus there is no available data according to epidemiological features of the disease. This study aimed to reveal the main epidemiologic characteristics, such as prevalence, incidence, urban-rural ratio of T1DM in children and adolescents in the Republic of Armenia. The Republic of Armenia is a country located in the South Caucasus region of Eurasia at the crossroads of Western Asia and Eastern Europe. The country has surface area of 29,800 km 2 and 3,274,286 general population and 781,917 pediatric population (0-18 years of age) according to data of The only urbanized city is the capital of the Republic of Armenia Yerevan, where the population is 1,127,293. The aim of this investigation was to reveal the actual prevalence and some epidemiologic features of T1DM in children and adolescents in all regions of the Republic of Armenia. 90
3 Material and Methods Taking into account that T1DM patients National Registry is lacking in the Republic of Armenia, the indices on incidence and prevalence of the disease in children and adolescents were established based on data obtained from all pediatric diabetological centers (dispensaries), as well as from all endocrinology clinics where patients with onset of T1DM could be admitted (new cases). In Armenia, there are functioning three Pediatric Centers of Diabetology and four Endocrinology Clinics, where all new cases of diabetes manifestation are admitted from all the regions of the country. Appropriate data was received from the National Statistical Service of the Republic of Armenia (ARMSTAT). During the period of , 345 new cases of T1DM in patients under 18 years of age were evaluated. In 2012, 372 patients with T1DM were examined for the evaluation of disease prevalence. Statistical analyses of study data were done by the programs EXCEL 2007 and SPSS 16.0, the cases at р<0.05 were accepted as statistically significant. Results and Discussion A documented rise in T1DM incidence was noted in the study: the growth rate made approximately 33% in (Fig. 1). Similar data was also described in the literature in many countries worldwide [Jarosz-Chobot P., 2011]. The average incidence rate of T1DM in children and adolescents of Armenia was 6.99 per 100,000 of pediatric population in In 2007 mean annual incidence rate was 5.99 per 100,000 (0-14 years age group), which corresponded to the low incidence of the disorder, but in 2012 it made 9.85 per 100,000, which corresponded to the medium incidence rate. There are several evidences that the increase of T1DM incidence in the 0-14-year-old age group has been particularly compensated by its decrease in young adults, so that the cumulative incidence by the age of 30 years remains unchanged. However, there is evidence that the proportion of children with the highest risk HLA haplotypes has declined over time. This statement and the growth rate of the actual incidence within genetically stable populations strongly suggest environmental influences, which are not explained in full [Pundziute-Lycka A., 2002; Weets I. et al., 2002]. The increasing incidence of T1DM suggests a number of specific environmental factors such as viruses, the role of which also remains controversial till present. It should be mentioned that sex difference in diabetes incidence rate was found in the specified population (Table): males were predominant with statistical significance 7.75±0.55/100,000 versus 6.09±0.51/100,000 (р<0.002). This data does not completely correspond to data from some other countries [Holmberg M. et al., 2013]. Figure 2 demonstrates the age-related features of T1DM onset in As it is shown the mean age of T1DM manifestation has tendency to decrease, but it does not reach statistical significance (p>0.05). Incidence rate Mean age Years Figure 1. Dynamics of incidence rate of type 1 diabetes mellitus in children and adolescents in the Republic of Armenia per 100,000 population ( ) Years Figure 2. Dynamics of mean age of type 1 diabetes mellitus manifestation in children and adolescents: Republic of Armenia,
4 Table 1 The dynamics of type 1 diabetes mellitus incidence rate in children and adolescents according to sex and age: Republic of Armenia, Years Sex N Gp I SD boys girls total boys girls total boys girls total boys , girls total boys , girls total boys girls total Notes: N - Number of type 1 diabetics under 18 years of age (diabetes onset), Gp - General population under 18 years of age, I - Incidence of type 1 diabetes per 100, 000, SD - Standard deviation. SHIRAK Gyumri LORI ARAGATSOTN Hrazdan 47.5 Ashtarak KOTAYK Gavar 33.9 GEGHARKUNIK 6.6 Armavir ARMAVIR Artashat ARARAT VAYOTS DZOR Yeghegnadzor Yerevan Based on the investigation-related data the map of T1DM prevalence in Armenia was created (Fig.3). According to data for 2012, in the Republic of Armenia 372 patients with T1DM under 18 years of age were registered, and 259 patients were under 14 years of age. The prevalence of T1DM in these population groups was 53.3 and 45.6 per 100,000, respectively. The region-based analysis revealed that in the capital city Yerevan the T1DM prevalence in children and adolescents was significantly higher (75.6 per 100,000) than in rural population (29.3 per 100,000). Hence, we can document that in Yerevan as the urbanized city the T1DM prevalence is 2.6 times higher than in re- Figure 3. The map of the type 1 diabetes mellitus prevalence in children and adolescents: Republic of Armenia, gions of the Republic of Armenia (p<0.0001). This data corresponds to international findings about urban-rural ratio related to incidence and prevalence of T1DM in many countries of the world [Tamayo T. et al., 2014]. Conclusion Vanadzor TAVUSH Idjevan SYUNIK Kapan Thus, the incidence of T1DM in children and adolescents in the Republic of Armenia has tendency to increase: the growth rate was 33% during The T1DM incidence among children and adolescents in the Republic of Armenia has male predominance. In 2012, the prevalence of T1DM in children in Republic of Armenia was 45.6 per 100,000, while the index related to children and adolescents was 53.3 per 100,000, respectively. The prevalence of T1DM in urban pediatric population was 2.6 times higher than in population of the Republic of Armenia. Data obtained signify to the necessity to create the State Registry on diabetes mellitus in children and adolescents in order to ensure further research and revealing the epidemiological situation and features of the disorder in pediatric population of the Republic of Armenia. 92
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