BULLETIN # 66. Manitoba Drug Benefits and Interchangeability Formulary Amendments. The following amendments will take effect on November 24, 2011.

Transcription

1 BULLETIN # 66 Manitoba Drug Benefits and Interchangeability Formulary Amendments The following amendments will take effect on November 24, The amended Manitoba Specified Drug Regulation and Drug Interchangeability Formulary Regulation will be available on the Manitoba Health website on the effective date of November 24, Bulletin 66 is currently available for download: Inside This Issue Part 1 Additions Page 1-2 Part 2 Additions Page 3 Part 3 Additions Page 3-6 New Interchangeable Categories Page 6-10 New Interchangeable Products Page Product Deletions Page Category Deletions Page Interchangeable Product Price Changes Page Manufacturer Updates Page 25-26

2 Part 1 Additions Bulletin #66 DIN TRADE NAME GENERIC STRENGTH FORM MFR* Apo-Candesartan candesartan 4 mg 8 mg APX mg Apo-Dorzo-Timop dorzolamide/timolol maleate 20 mg/5 mg/ml Ophthalmic Drops APX Auro-Mirtazapine OD mirtazapine 15 mg 30 mg 45 mg Bicalutamide bicalutamide 50 mg ACC Champix varenicline 0.5 mg/1 mg 0.5 mg 1 mg Kit PFI CO Irbesartan CO Irbesartan HCT CO Olanzapine irbesartan irbesartan/hctz olanzapine 75 mg 150 mg 300 mg 150/12.5 mg 300/12.5 mg 300/25 mg 2.5 mg 5 mg 7.5 mg 10 mg 15 mg mg CO Ondansetron ondansetron mg COB CO Valacyclovir valacyclovir 500 mg COB mg mg CO Valsartan valsartan mg COB mg Mint-Risperidon risperidone 0.25 mg 0.5 mg 1 mg 2 mg 3 mg 4 mg Mirena (moved from Part 3) levonorgestrel 52 mg Implant BAY mg Mylan-Ranitidine ranitdine mg MYL Norvir ritonavir 100 mg ABB One Touch Delica - - Lancet LIF AUP COB COB COB MPH 1 of 26

3 pms-irbesartan pms-irbesartan HCTZ Ran-Enalapril Ran-Irbesartan HCTZ Ran-Valsartan ratio-irbesartan ratio-irbesartan HCTZ Sandoz Candesartan Sandoz Metoprolol (type L) Teva-Irbesartan Teva-Irbesartan HCTZ irbesartan irbesartan/hctz enalapril irbesartan/hctz valsartan irbesartan irbesartan HCTZ candesartan metoprolol irbesartan irbesartan/hctz Bulletin #66 75 mg 150 mg 300 mg 150/12.5 mg 300/12.5 mg 300/25 mg 2.5 mg 5 mg 10 mg 20 mg 150/12.5 mg 300/12.5 mg 300/25 mg 40 mg 80 mg 160 mg 75 mg 150 mg 300 mg 150/12.5 mg 300/12.5 mg 300/25 mg 4 mg 8 mg 16 mg 50 mg 100 mg 75 mg 150 mg 300 mg 150/12.5 mg 300/12.5 mg 300/25 mg Teva-Nevirapine nevirapine 200 mg TEV mg mg Teva-Valsartan valsartan mg TEV mg Teva-Valsartan HCTZ *Abbreviation of Manufacturers' Names valsartan/hctz 80/12.5 mg 160/12.5 mg 160/25 mg 320/12.5 mg 320/25 mg PMS PMS RAN RAN RAN RPH RPH SDZ SDZ TEV TEV TEV 2 of 26

4 Part 2 Additions Bulletin # Apo-Finasteride finasteride 5 mg APX For the treatment of symptomatic benign prostatic hyperplasia CO Finasteride finasteride 5 mg COB For the treatment of symptomatic benign prostatic hyperplasia Ran-Clarithromycin clarithromycin 250 mg 500 mg For treatment of patients: (a) Not responding to or intolerant of alternative antibiotics (eg. amoxicillin and erythromycin); (b) With mycobacterial infections due to mycobacterium avium and mycobacterium intracellular; and (c) In combination therapy in the treatment of H. Pylori. RAN Teva-Zolmitriptan zolmitriptan 2.5 mg TEV For the treatment of ACUTE migraine attacks in patients where standard therapy has failed - to a maximum of 144 tablets per benefit year Teva-Zolmitriptan OD zolmitriptan 2.5 mg TEV For the treatment of ACUTE migraine attacks in patients where standard therapy has failed - to a maximum of 144 tablets per benefit year. Part 3 Additions The following products will be considered for Pharmacare reimbursement upon an individual prescriber/patient request basis Accel-Pioglitazone pioglitazone 15 mg 30 mg 45 mg As per pioglitazone criteria ( ACC Apo-Lansoprazole lansoprazole As per PPI criteria (see Bulletin 50). 15 mg 30 mg APX 3 of 26

5 Apo-Risedronate risedronate 35 mg APX As per risedronate criteria ( CO Repaglinide repaglinide 0.5 mg 1 mg 2 mg As per repaglinide criteria ( COB Mint-Pioglitazone pioglitazone 15 mg 30 mg 45 mg As per pioglitazone criteria ( MPH Mylan-Galantamine ER galantamine 8 mg 16 mg 24 mg As per galantamine criteria ( Capsule MYL Orencia abatacept 250 mg/vial Injection BMS For treatment of patients over 18 years of age who have moderate to severe active rheumatoid arthritis and who have failed treatment with at least 3 DMARDs (disease-modifying antirheumatic drugs) therapies one of which is methotrexate and/or leflunomide unless intolerance or contraindications to these agents is documented. One combination therapy of DMARDs must also be tried. Request for coverage must be made by a Manitoba physician who is a specialist in rheumatology Prolia denosumab 60 mg/ml Injection AGA 1. Female patients with Post Menopausal Osteoporosis (PMO) at high risk for fracture and satisfy at least two of the following three criteria: Age > 75 years; A prior fragility fracture; A bone mineral density (BMD) T-score -2.5; or 2. Female patients with PMO with a serious intolerance to oral bisphosphonates or for who oral bisphosphonates are contraindicated Remicade infliximab 10 mg/ml Injection JAN Psoriatic Arthritis For treatment of patients over 18 years of age who have active psoriatic arthritis who have failed treatment with at least 3 DMARD therapies, one of which is methotrexate and/or leflunomide unless intolerance or contraindication to these agents is documented. One combination therapy of DMARD must also be tried. 4 of 26

6 Initial application information should include information on disease activity such as the number of tender joins, swollen joints, erythrocyte sedimentation rate and C-reactive protein value. Request for coverage must be made by a Manitoba physician who is a specialist in rheumatology. Ankylosing Spondylitis For the treatment of patients with active ankylosing spondylitis who have failed to respond to an adequate trial of at least three different non-steroidal anti-inflammatory drugs (NSAIDs) and, in patients with peripheral joint involvement, who have failed to respond to methotrexate or sulfasalazine. Request for coverage must be made by a Manitoba physician who is a specialist in rheumatology. Psoriasis For the treatment of adult patients with severe plaque psoriasis with one or more of the following: Psoriasis Area and Severity Index (PASI) 10; Body Surface Area (BSA) > 10 percent; Dermatology Life Quality Index (DLQI) > 10; Significant involvement of the face, hands, feet or genital region; AND Failure to respond to, contraindications to, intolerant of or unable to access methotrexate, cyclosporine and/or phototherapy. The initial request is approved for a maximum of 4 months. For continued coverage the physician must confirm the patient's response to treatment and demonstration of treatment clinical benefits: 50 percent reduction in the PASI score with point improvement in the DLQI; OR 75 percent reduction in the PASI score; OR 50 percent reduction in the BSA with significant improvement of the face, hands, feet or genital region. Request for coverage must be made by a Manitoba physician who is a specialist in dermatology. Ulcerative Colitis For the treatment of patients with moderately to severly active ulcerative colitis who have had an inadequate response to conventional therapy including 5-aminosalicylate compounds, corticosteroids and immunomodulators. Request for coverage must be made by a Manitoba physician who is a specialist in gastroenterology Sandoz Repaglinide repaglinide 0.5 mg 1 mg 2 mg As per repaglinide criteria ( SDZ mg Vesicare solifenacin ASP 10 mg For the treatment of overactive bladder in adults who cannot tolerate or have insufficient response to an adequate trial of immediate-release oxybutynin Xarelto rivaroxaban 10 mg BAY For the prophylaxis of venous thromboembolism following total knee replacement for up to two (2) weeks, and following total hip replacement surgery for up to five (5) weeks, as an alternative to low molecular weight heparins. 5 of 26

7 clostridium botulinum Xeomin 100 IU Injection MPG neurotox For the treatment of hypertonicity disorders of the 7th nerve such as blepharospasm including benign essential blepharospasm and hemifacial spasm in adults. To reduce the subjective symptoms and objective signs of cervical dystonia (spasmodic torticollis) in adults. New Interchangeable Categories The following new interchangeable categories and products were added: Generic Name - Strength - Form DIN Trade Name Manufacturer Price in Dollars Candesartan - 4 mg - $ Atacand AZC Apo-Candesartan APX Sadoz Candesartan SDZ Candesartan - 8 mg - $ Atacand AZC Apo-Candesartan APX Sadoz Candesartan SDZ Candesartan - 16 mg - $ Atacand AZC Apo-Candesartan APX Sadoz Candesartan SDZ Dorzolamide/Timolol Maleate - 20 mg/5 mg/ml - Ophthalmic Drops $ Cosopt MFX Apo-Dorzo/Timop APX Galantamine - 8 mg - Capsule $ Reminyl ER JAN Mylan-Galantamine ER MYL of 26

8 Galantamine - 16 mg - Capsule $ Reminyl ER JAN Mylan-Galantamine ER MYL Galantamine - 24 mg - Capsule $ Reminyl ER JAN Mylan-Galantamine ER MYL Irbesartan - 75 mg - $ Avapro SQU CO Irbesartan COB pms-irbesartan PMS ratio-irbesartan RPH Teva-Irbesartan TEV Irbesartan mg - $ Avapro SQU CO Irbesartan COB pms-irbesartan PMS ratio-irbesartan RPH Teva-Irbesartan TEV Irbesartan mg - $ Avapro SQU Irbesartan COB pms-irbesartan PMS ratio-irbesartan RPH Teva-Irbesartan TEV Irbesartan/hydrochlorothiazide - 150/12.5 mg - $ Avalide SQU CO Irbesartan/HCT COB pms-irbesartan-hctz PMS Ran-Irbesartan/HCTZ RAN ratio-irbesartan HCTZ RPH Teva-Irbesartan/HCTZ TEV 7 of 26

9 Irbesartan/hydrochlorothiazide - 300/12.5 mg - $ Avalide SQU CO Irbesartan/HCT COB pms-irbesartan-hctz PMS Ran-Irbesartan/HCTZ RAN ratio-irbesartan HCTZ RPH Teva-Irbesartan/HCTZ TEV Irbesartan/hydrochlorothiazide - 300/25 mg - $ Avalide SQU CO Irbesartan/HCT COB pms-irbesartan-hctz PMS Ran-Irbesartan/HCTZ RAN ratio-irbesartan HCTZ RPH Teva-Irbesartan/HCTZ TEV Nevirapine mg - $ Viramune BOE Teva-Nevirapine TEV Repaglinide mg - $ Gluconorm NOO Sandoz Repaglinide SDZ CO Repaglinide COB Repaglinide - 1 mg - $ Gluconorm NOO Sandoz Repaglinide SDZ CO Repaglinide COB Repaglinide - 2 mg - $ Gluconorm NOO Co Repaglinide COB Sandoz Repaglinide SDZ Valsartan - 40 mg - $ Diovan NVT CO Valsartan COB Ran-Valsartan RAN Teva-Valsartan TEV of 26

10 Valsartan - 80 mg - $ Diovan NVT CO Valsartan COB Ran-Valsartan RAN Teva-Valsartan TEV Valsartan mg - $ Diovan NVT CO Valsartan COB Ran-Valsartan RAN Teva-Valsartan TEV Valsartan mg - $ Diovan NVT CO Valsartan COB Teva-Valsartan TEV Valsartan/Hydrochlorothiazide - 80/12.5 mg - $ Diovan HCTZ NVT Teva-Valsartan HCTZ TEV Valsartan/Hydrochlorothiazide - 160/12.5 mg - $ Diovan HCTZ NVT Teva-Valsartan HCTZ TEV Valsartan/Hydrochlorothiazide - 160/25 mg - $ Diovan HCTZ NVT Teva-Valsartan HCTZ TEV Valsartan/Hydrochlorothiazide - 320/12.5 mg - $ Diovan HCTZ NVT Teva-Valsartan HCTZ TEV Valsartan/Hydrochlorothiazide - 320/25 mg - $ Diovan HCTZ NVT Teva-Valsartan HCTZ TEV of 26

11 Zolmitriptan mg - $ Zomig AZC Teva-Zolmitriptan TEV Zolmitriptan mg - Orally Disintegrating $ Zomig OD AZC Teva-Zolmitriptan OD TEV New Interchangeable Products The following products have been added to existing interchangeable drug categories: Bicalutamide - 50 mg - $ Bicalutamide ACH ** Clarithromycin mg - $ Ran-Clarithromycin RAN ** Clarithromycin mg - $ Ran-Clarithromycin RAN ** Enalapril mg - $ Ran-Enalapril RAN ** Enalapril - 5 mg - $ Ran-Enalapril RAN ** Enalapril - 10 mg - $ Ran-Enalapril RAN ** Enalapril - 20 mg - $ Ran-Enalapril RAN ** Finasteride - 5 mg - $ Apo-Finasteride APX ** CO Finasteride COB ** of 26

12 Lansoprazole - 15 mg - $ Apo-Lansoprazole APX ** Lansoprazole - 30 mg - $ Apo-Lansoprazole APX ** Metoprolol - 50 mg - $ Sandoz Metoprolol (type L) SDZ ** Metoprolol mg - $ Sandoz Metoprolol (type L) SDZ ** Mirtazapine - 15 mg - Orally Disintigrating $ Auro-Mirtazapine OD AUP ** Mirtazapine - 30 mg - Orally Disintigrating $ Auro-Mirtazapine OD AUP ** Mirtazapine - 45 mg - Orally Disintigrating $ Auro-Mirtazapine OD AUP ** Olanzapine mg - $ CO Olanzapine COB ** Olanzapine - 5 mg - $ CO Olanzapine COB ** Olanzapine mg - $ CO Olanzapine COB ** Olanzapine - 10 mg - $ CO Olanzapine COB ** Olanzapine - 15 mg - $ CO Olanzapine COB ** of 26

13 Ondansetron - 4 mg - $ CO Ondansetron COB ** Ondansetron - 8 mg - $ CO Ondansetron COB ** Pioglitazone - 15 mg - $ Accel-Pioglitazone ACC ** Mint-Pioglitazone MPH ** Pioglitazone - 30 mg - $ Accel-Pioglitazone ACC ** Mint-Pioglitazone MPH ** Pioglitazone - 45 mg - $ Accel-Pioglitazone ACC ** Mint-Pioglitazone MPH ** Ranitidine mg - $ Mylan-Ranitidine MYL ** Ranitidine mg - $ Mylan-Ranitidine MYL ** Risedronate - 35 mg - $ Apo-Risdronate APX ** Risperidone mg - $ Mint-Risperidon MPH ** Risperidone mg - $ Mint-Risperidon MPH ** Risperidone - 1 mg - $ Mint-Risperidon MPH ** of 26

14 Risperidone - 2 mg - $ Mint-Risperidon MPH ** Risperidone - 3 mg - $ Mint-Risperidon MPH ** Risperidone - 4 mg - $ Mint-Risperidon MPH ** Valacyclovir mg - $ CO Valacyclovir COB ** The following products have been deleted. Product Deletions Amantine midodrine 2.5 mg s Amantine midodrine 5 mg s Apo-Bisacodyl bisacodyl 10 mg Suppositories Apo-Cefaclor cefaclor 250 mg Capsules Apo-Cefaclor cefaclor 500 mg Capsules Apo-Cloxi cloxicillin 250 mg Capsule Apo-Cloxi cloxicillin 500 mg Capsule Apo-Cloxi cloxicillin 125 mg/5 ml Oral Suspension Apo-Flavoxate flavoxate 200 mg Apo-Naproxen SR naproxen 750 mg s BenOxyl benzoyl peroxide 20% Lotion Buspar buspirone 10 mg s Capoten captopril 50 mg s CO Fluconazole fluconazole 150 mg Capsule Desryl trazodone 100 mg s Diflucan-150 fluconazole 150 mg Capsule Duragesic fentanyl 12 mcg Patch Emo-Cort hydrocortisone 2.5% Scalp Lotion Euglucon glyburide 2.5 mg s FXT 40 fluoxetine 40 mg Capsule Gen-Bromazepam bromazepam 1.5 mg Gen-Bromazepam bromazepam 3 mg Gen-Bromazepam bromazepam 6 mg Gen-Medroxy medroxyprogesterone 2.5 mg 13 of 26

15 Gen-Medroxy medroxyprogesterone 5 mg Gen-Medroxy medroxyprogesterone 10 mg Gen-Nizatidine nizatidine 150 mg Gen-Nizatidine nizatidine 300 mg Gen-Pindolol pindolol 5 mg Gen-Pindolol pindolol 10 mg Gen-Pindolol pindolol 15 mg Gen-Piroxicam piroxicam 10 mg Gen-Piroxicam piroxicam 20 mg Hycomine ammonium chloride 1 mg/ml Syrup Lopid gemfibrozil 600 mg Lopid gemfibrozil 300 mg Capsule Lumigan bimatoprost 0.03% Ophthalmic Solution Minocin minocycline 100 mg Capsules Mylan-Buspirone buspirone 10 mg Mylan-Cyproterone cyproterone 50 mg s Mylan-Divalproex divalproex 125 mg Mylan-Divalproex divalproex 250 mg Mylan-Divalproex divalproex 500 mg Mylan-Fluconazole fluconazole 150 mg Capsule Mylan-Salbutamol salbutamol 5 mg/ml Inhalation Solution Mylan-Timolol timolol maleate 0.5% Ophthalmic Solution Mylan-Triazolam triazolam mg Mylan-Triazolam triazolam 0.25 mg Novo-Cyproterone cyproterone 50 mg s Novo-Purol allopurinol 100 mg Novo-Purol allopurinol 200 mg Novo-Purol allopurinol 300 mg Nu-Cefaclor cefaclor 250 mg Capsule Nu-Cefaclor cefaclor 500 mg Capsule Nu-Cloxi cloxicillin 250 mg Capsule Nu-Cloxi cloxicillin 500 mg Capsule Nu-Cloxi cloxicillin 125 mg/5 ml Oral Suspension Nu-Pentoxifylline SR pentoxifylline 400 mg Ovral ethinyl estradiol/norgestrel 50/250 mcg s Phyllocontin aminophylline 225 mg s Phyllocontin aminophylline 350 mg s pms-acetaminophen acetaminophen 500 mg s pms-cimetidine cimetidine 300 mg pms-cimetidine cimetidine 400 mg pms-cimetidine cimetidine 600 mg pms-clindamycin clindamycin 150 mg Capsule pms-clindamycin clindamycin 300 mg Capsule pms-desipramine desipramine 50 mg s 14 of 26

16 pms-desipramine desipramine 75 mg s pms-fluphenazine fluphenazine 25 mg/ml Injection pms-fluphenazine fluphenazine 100 mg/ml Injection pms-fosinopril fosinopril 10 mg pms-gentamicin gentamicin 0.3% Otic Solution pms-gentamicin gentamicin 0.3% Ophthalmic Solution pms-glyburide glyburide 2.5 mg pms- Medroxyprogesterone medroxyprogesterone 2.5 mg pms- Medroxyprogesterone medroxyprogesterone 5 mg pms- Medroxyprogesterone medroxyprogesterone 10 mg pms-methotrimeprazine methotrimeprazine 5 mg s pms-misoprostol misoprostol 200 mcg s pms-moclobemide moclobemide 150 mg s pms-moclobemide moclobemide 300 mg s pms-mometasone mometasone 0.1% Ointment pms-morphine SR morphine sulfate 15 mg s pms-morphine SR morphine sulfate 30 mg s pms-morphine SR morphine sulfate 100 mg s pms-propranolol propranolol 10 mg pms-propranolol propranolol 40 mg pms-propranolol propranolol 80 mg pms-salbutamol salbutamol 0.4 mg/ml Solution pms-sucralfate sucralfate 1 g pms-temazepam temazepam 15 mg Capsule pms-terbinafine terbinafine 250 mg pms-tiaprofenic tiaprofenic 300 mg pms-tryptophan tryptophan 500 mg s pms-tryptophan tryptophan 1 g Prezista darunavir 300 mg Provera medroxyprogesterone 100 mg ratio-amcinonide amcinonide 0.1% Lotion ratio-amcinonide amcinonide 0.1% Ointment ratio-pentoxifylline pentoxifylline 400 mg Stieva-A tretinoin 0.025% Liquid Teva-Spiroton spironolactone 25 mg Teva-Spiroton spironolactone 100 mg Teva-Spirozine spironolactone/ hydrochlorothiazide 25/25 mg Teva-Spirozine spironolactone/ hydrochlorothiazide 50/50 mg 15 of 26

17 Teva-Risderonate risedronate 5 mg Teva-Risderonate risedronate 30 mg Tofranil imipramine 25 mg Tofranil imipramine 50 mg Zantac ranitidine 15 mg/ml Oral Solution Category Deletions - Amoxicillin/Clavulanic Acid mg/57 mg/5 ml - - Medroxyprogesterone Acetate mg - Oral Suspension - Benzoyl Peroxide in Water - 5% - Gel - Minoxidil - 2% - Topical Solution - Bromazepam mg - s - Misoprostol mcg - s - Cholestyramine Resin - 4g/Dose - Oral Powder - Morphine - 10 mg/ml - Oral Liquid - Cloxicillin mg - Capsules - Oxaprozin mg - s - Cloxicillin mg - Capsules - Pentoxifylline mg - s - Cloxicillin mg/5 ml - Oral Suspension - Pimozide - 2 mg - s - Cyproterone - 50 mg - s - Pimozide - 4 mg - s - Dipryrudamole - 50 mg - s - Sodium Aurothiomalate - 10 mg/ml - Injection - Dpryridamole - 75 mg - s - Timolol Maleate - 0.5% - Ophthalmic Solution - Erythromycin Base mg - Enteric Pellet Capsules (Gel Forming) - Fluphenazine Decanoate mg/ml - Injection - Trentinoin % - Topical Cream - Gentamicin Sulfate - 0.3% - Ophthalmic Ointment - Trentinoin % - Topical Cream - Gliclazide - 30 mg - s - Triazolam mg - s - Imipramine - 50 mg - s - Trimethoprim Sulfate/Polymyxin B - 1 mg/ - Ketorolac - 30 mg/ml - Injection 10,000 U/mL - Ophthalmic Solution - Ketotifen - 1 mg/5 ml - Oral Liquid Interchangeable Product Price Changes The following changes in prices have occurred: ($) Accel-Amlodipine amlodipine 5 mg ** Accel-Amlodipine amlodipine 10 mg ** Actos pioglitazone 15 mg Actos pioglitazone 30 mg Actos pioglitazone 45 mg Agrylin anagrelide 0.5 mg Albalon naphazoline 0.1% Ophthalmic Solution Alertec modafinil 100 mg of 26

18 Aldactazide spironolactone/hctz 25 mg Aldactazide spironolactone/hctz 50 mg Aldactone spironolactone 25 mg Aldactone spironolactone 100 mg Alesse 21 levonorgestrel/ ethinyl estradiol 100/20 mcg Alesse 28 levonorgestrel/ ethinyl estradiol 100/20 mcg Altace ramipril 15 mg Capsule Amaryl glimipiride 1 mg Amaryl glimipiride 2 mg Amaryl glimipiride 4 mg Ansaid flurbiprofen 50 mg Ansaid flurbiprofen 100 mg Apo-Erythro EC erythromycin 250 mg Capsule ** Apo-Furosemide furosemide 20 mg ** Apo-Hydro hydrochlorothiazide 50 mg Apo-Hydroxyquine hydroxyquine 200 mg ** Arava leflunomide 10 mg Arava leflunomide 20 mg Ativan lorazepam 0.5 mg Ativan lorazepam 1 mg Ativan lorazepam 2 mg Aventyl nortriptyline 10 mg Capsule Aventyl nortriptyline 25 mg Capsule Benzac benzoyl peroxide 5% Gel Betaject betamethasone 6 mg/ml Injection ** Carbolith lithium carbonate 150 mg Carbolith lithium carbonate 300 mg Carbolith lithium carbonate 600 mg Cardizem CD diltiazem 120 mg Cardizem CD diltiazem 180 mg Cardizem CD diltiazem 240 mg Cardizem CD diltiazem 300 mg Cardura doxazosin 1 mg Cardura doxazosin 2 mg Cardura doxazosin 4 mg Casodex bicalutamide 50 mg Cefzil cefprozil 250 mg Cefzil cefprozil 500 mg Cefzil O.S cefprozil 125 mg/5 ml Oral Suspension Cefzil O.S cefprozil 250 mg/5 ml Oral Suspension Ciloxan ciprofloxacin 0.3% Ophthalmic Solution CO Olanzapine ODT olanzapine 5 mg ** CO Olanzapine ODT olanzapine 10 mg ** of 26

19 CO Olanzapine ODT olanzapine 15 mg ** CO Pramipexole pramipexole 0.25 mg ** CO Pramipexole pramipexole 0.5 mg ** CO Pramipexole pramipexole 1 mg ** CO Pramipexole pramipexole 1.5 mg ** Coradarone isosorbide dinitrate 200 mg Cortenema hydrocortisone 100 mg/60 ml Enema Coumadin warfarin 1 mg Coumadin warfarin 2 mg Coumadin warfarin 2.5 mg Coumadin warfarin 3 mg Coumadin warfarin 4 mg Coumadin warfarin 5 mg Coumadin warfarin 10 mg Dalacin C clindamycin 150 mg Capsule Dalacin C clindamycin 300 mg Capsule Dalacin T clindamycin 1% Topical Solution DDAVP desmopressin 10 mcg Spray DDAVP desmopressin 0.1 mg DDAVP desmopressin 0.2 mg Depakene valproic acid 250 mg Capsule Depakene valproic acid 50 mg/ml Syrup Depo-Provera medroxyprogesterone acetate 150 mg/ml Injection Desferal desferoxamine 500 mg Desmopressin desmopressin 10 mcg Spray Diabeta glyburide 2.5 mg Diabeta glyburide 5 mg Diflucan fluconazole 2 mg/ml Injection Dilantin phenytoin 125 mg Oral Suspension Diprolene betamethasone 15 g Cream Diprosalic betamethasone/ salicyclic acid 0.5/20/mg/g Lotion Duragesic MAT fentanyl 25 mcg Patch Duragesic MAT fentanyl 50 mcg Patch Duragesic MAT fentanyl 75 mcg Patch Duragesic MAT fentanyl 100 mcg Patch Effexor XR venlafaxine 37.5 mg Capsule Effexor XR venlafaxine 75 mg Capsule Effexor XR venlafaxine 150 mg Capsule Elocom mometasone 0.1% Ointment Epival divalproex 125 mg Epival divalproex 250 mg Epival divalproex 500 mg Eryc erythromycin 250 mg Capsule Estradot estradiol 17B 50 mcg Patch Estradot estradiol 17B 75 mcg Patch of 26

20 Famvir famciclovir 125 mg Famvir famciclovir 250 mg Famvir famciclovir 500 mg Femara letrozole 2.5 mg Fosamax alendronate 10 mg Garamycin gentamicin 5 mg/ml Ophthalmic Drops Garasone betamethasone/gentamicin 3 mg/1 mg/ml Ophthalmic/Otic Drops GD-Amlodipine amlodipine 5 mg GD-Amlodipine amlodipine 10 mg Gen-Ramipril ramipril 1.25 mg ** Gen-Ramipril ramipril 2.5 mg ** Gen-Ramipril ramipril 5 mg ** Gen-Ramipril ramipril 10 mg ** Gen-Venlafaxine XR venlafaxine 37.5 mg Capsule Gen-Venlafaxine XR venlafaxine 75 mg Capsule Gen-Venlafaxine XR venlafaxine 150 mg Capsule Glucophage metformin 500 mg Glucophage metformin 850 mg Hytrin terazosin 1 mg Hytrin terazosin 2 mg Hytrin terazosin 5 mg Hytrin terazosin 10 mg Imdur isosorbide-5-monohydrate 60 mg Imovane zopiclone 5 mg Imovane zopiclone 7.5 mg Isoptin SR verapamil 120 mg Isoptin SR verapamil 180 mg Isoptin SR verapamil 240 mg Jamp-Citalopram citalopram 20 mg ** Jamp-Citalopram citalopram 40 mg ** Kayaexalate sodium polystyrene 1 mcg/g Powder Kenalog triamcinolone 10 mg/ml Injection Kenalog triamcinolone 40 mg/ml Injection Keppra levetiracetam 250 mg Keppra levetiracetam 500 mg Keppra levetiracetam 750 mg Ketorolac ketorolac 30 mg/ml Injection ** Lasix furosemide 20 mg Lasix furosemide 40 mg Levaquin levofloxacin 250 mg Levaquin levofloxacin 500 mg Lipitor atorvastatin 10 mg Lipitor atorvastatin 20 mg Lipitor atorvastatin 40 mg Lipitor atorvastatin 80 mg Lioresal baclofen 10 mg of 26

21 Lioresal D.S baclofen 20 mg Lopressor metoprolol 50 mg Lopressor metoprolol 100 mg Lopressor SR metoprolol 100 mg Lopressor SR metoprolol 200 mg Losec omeprazole 20 mg Luvox fluvoxamine 50 mg Luvox fluvoxamine 100 mg Marvelon 21 desogestrel/ ethinyl estradiol 0.15/0.3 mg Marvelon 28 desogestrel/ ethinyl estradiol 0.15/0.3 mg Mefloquine mefloquine 250 mg ** Mevacor lovastatin 20 mg Mevacor lovastatin 40 mg Miacalcin NS synthetic calcium (salmon) 200 IU Nasal Spray Min-Ovral levonorgestrel/ ethinyl estradiol 150/30 mcg Modafinil modafinil 100 mg ** Mogadon nitrazepam 5 mg Mogadon nitrazepam 10 mg Monopril fosinopril 10 mg Monopril fosinopril 20 mg MS Contin morphine sulfate 15 mg MS Contin morphine sulfate 30 mg MS Contin morphine sulfate 60 mg MS Contin morphine sulfate 100 mg MS Contin morphine sulfate 200 mg MS IR morphine sulfate 5 mg MS IR morphine sulfate 10 mg Mylan-Amoxicillin amoxicillin 250 mg Mylan-Azithromycin azithromycin 250 mg Mylan-Cilazapril cilazapril 1 mg Mylan-Cilazapril cilazapril 2.5 mg Mylan-Cilazapril cilazapril 5 mg Mylan-Ciprofloxacin ciprofloxacin 250 mg Mylan-Ciprofloxacin ciprofloxacin 500 mg Mylan-Ciprofloxacin ciprofloxacin 750 mg Mylan-Citalopram citalopram 20 mg Mylan-Citalopram citalopram 40 mg Mylan-Clindamycin clindamycin 150 mg Mylan-Clindamycin clindamycin 300 mg Mylan-Fluconazole fluconazole 50 mg Mylan-Fosinopril fosinopril 10 mg Mylan-Fosinopril fosinopril 20 mg Mylan-Gabapentin gabapentin 100 mg Mylan-Gabapentin gabapentin 300 mg Mylan-Gabapentin gabapentin 400 mg of 26

22 Mylan-Gemfibrozil gemfibrozil 300 mg Mylan-Gliclazide gliclazide 80 mg Mylan-Lansoprazole lansoprazole 15 mg Mylan-Lansoprazole lansoprazole 30 mg Mylan-Minocycline minocycline 50 mg Mylan-Minocycline minocycline 100 mg Mylan-Naproxen EC naproxen 375 mg Mylan-Naproxen EC naproxen 500 mg Mylan-Ondansetron ondansetron 4 mg Mylan-Ondansetron ondansetron 8 mg Mylan-Paroxetine paroxetine 10 mg Mylan-Paroxetine paroxetine 20 mg Mylan-Paroxetine paroxetine 30 mg Mylan-Pravastatin pravastatin 10 mg Mylan-Pravastatin pravastatin 20 mg Mylan-Pravastatin pravastatin 40 mg Mylan-Propafenone propafenone 150 mg Mylan-Propafenone propafenone 300 mg Mylan-Quetiapine quetiapine 200 mg Mylan-Risperidone risperidone 0.25 mg Mylan-Risperidone risperidone 0.5 mg Mylan-Risperidone risperidone 1 mg Mylan-Risperidone risperidone 2 mg Mylan-Risperidone risperidone 3 mg Mylan-Risperidone risperidone 4mg Mylan-Salbutamol Sterinebs salbutamol 5 mg/2.5 ml Nebules Mylan-Sertraline sertraline 25 mg Mylan-Sertraline sertraline 50 mg Mylan-Sertraline sertraline 100 mg Mylan-Simvastatin simvastatin 5 mg Mylan-Simvastatin simvastatin 10 mg Mylan-Simvastatin simvastatin 20 mg Mylan-Simvastatin simvastatin 40 mg Mylan-Simvastatin simvastatin 80 mg Mylan-Sotalol sotalol 160 mg Mylan-Timolol timolol maleate 0.25% Ophthalmic Solution Mylan-Topiramate topiramate 25 mg Mylan-Topiramate topiramate 100 mg Mylan-Topiramate topiramate 200 mg Myochrysine sodium aurothiomalate 10 mg/ml Injection Myochrysine sodium aurothiomalate 50 mg/ml Injection Neurontin gabapentin 100 mg Capsule Neurontin gabapentin 300 mg Capsule Neurontin gabapentin 400 mg Capsule Nitrolingual nitroglycerin 200 DS Pumpspray of 26

23 Norvasc amlodipine 5 mg Norvasc amlodipine 10 mg Novo-Lansoprazole DR lansoprazole 15 mg Novo-Lansoprazole DR lansoprazole 30 mg Novo-Naratriptan naratriptan 1 mg ** Novo-Naratriptan naratriptan 2.5 mg ** Novo-Olanzapine OD olanzapine 5 mg Novo-Olanzapine OD olanzapine 10 mg Novo-Olanzapine OD olanzapine 15 mg ** Novo-Raloxifene raloxifene 60 mg ** Novo-Risedronate risedronate 5 mg ** Novo-Risedronate risedronate 35 mg ** Novo-Risedronate risedronate 30 mg ** Ondansetron ondansetron 4 mg/5 ml Oral Solution ** Pamidronate Disodium pamidronate disodium 9 mg/ml Injection Pediapred prednisolone 5 mg/5 ml Oral Liquid Pepcid famotidine 20 mg Pepcid famotidine 40 mg Percocet oxycodone/acetaminophen 5 mg/325 mg Plaquenil hydroxychloroquinine 200 mg Plendil felodipine 2.5 mg Plendil felodipine 5 mg Plendil felodipine 10 mg pms-fluorometholone fluorometholone 0.1% Ophthalmic Suspension pms-hydroxyzine hydroxyzine 5 mg/ml Syrup pms-lithium Carbonate lithium carbonate 600 mg Capsule pms-polytrimethoprim trimethoprim/polymyxin 0.1% Ophthalmic Solution ** pms-prednisolone prednisolone 5 mg/5 ml Liquid pms-sod Polystyrene sodium polystyrene 1 mcg/g Powder pms-sulfasalazine sulfasalazine 500 mg pms-tobramycin tobramycin 0.3% Ophthalmic Suspension Provera medroxyprogesterone acetate 2.5 mg Provera medroxyprogesterone acetate 5 mg Provera medroxyprogesterone acetate 10 mg Prinivil lisinopril 5 mg Prinivil lisinopril 10 mg Prinivil lisinopril 20 mg Prinzide lisinopril/hctz 10/12.5 mg Prinzide lisinopril/hctz 20/12.5 mg Ran-Fosinopril fosinopril 10 mg ** Ran-Fosinopril fosinopril 20 mg ** of 26

24 Renedil felodipine 2.5 mg ** Rhinocort Aqua budesonide 64 mcg Aerosol Inhaler Rifadin rifampin 150 mg Capsule Rifadin rifampin 300 mg Capsule Ritalin methylphenidate 10 mg Ritalin methylphenidate 20 mg Ritalin SR methylphenidate 20 mg Remeron mirtazapine 30 mg Remeron RD mirtazapine 15 mg Remeron RD mirtazapine 30 mg Remeron RD mirtazapine 45 mg Rhythmol propafenone 150 mg Rhythmol propafenone 300 mg Sandostatin octreotide 50 mcg Injection Sandostatin octreotide 100 mcg Injection ** Sandostatin octreotide 500 mcg Injection ** Sandostatin octreotide 200 mcg Injection ** Sandoz Cortimyxin polymyxin/neomycin/ hydrocortisone U/3.5 ml Otic Solution ** Sandoz Estradiol Derm estradiol 17B 50 mcg Patch ** Sandoz Estradiol Derm estradiol 17B 75 mcg Patch ** Sandoz Estradiol Derm estradiol 17B 100 mcg Patch ** Sandoz Gentamicin gentamicin 0.3% Ophthalmic Ointment Sandoz Olanzapine ODT olanzapine 5 mg Sandoz Olanzapine ODT olanzapine 10 mg Sandoz Olanzapine ODT olanzapine 15 mg Sectral acebutalol 100 mg Sectral acebutalol 200 mg Sectral acebutalol 400 mg Seroquel quetiapine 25 mg Seroquel quetiapine 100 mg Seroquel quetiapine 200 mg Seroquel quetiapine 300 mg Sinemet levodopa/carbidopa 100/10 mg Sinemet levodopa/carbidopa 100/25 mg Sinemet levodopa/carbidopa 250/25 mg Sofracort framycetin/gramicidin/ 5/0.5/0.5% Ophthalmic/Otic dexamethasone Drops Sulcrate sulcrafate 1 G Tegretol carbamazepine 200 mg Tegretol carbamazepine 100 mg Tegretol carbamazepine 200 mg Tegretol CR carbamazepine 200 mg of 26

25 Tegretol CR carbamazepine 400 mg Tenoretic atenolol/chlorthalidone 50/25 mg Tenoretic atenolol/chlorthalidone 100/25 mg Tenormin atenolol 50 mg Tenormin atenolol 100 mg Timoptic timlolol maleate 0.5% Ophthamlic Solution Timoptic-XE timlolol maleate 0.25% Ophthamlic Solution Timoptic-XE timlolol maleate 0.5% Ophthamlic Solution Tobradex tobramycin 0.3% Ophthalmic Suspension Trimebutine trimebutine 200 mg ** Tryptan l-tryptophan 500 mg Capsule Tryptan l-tryptophan 500 mg Tryptan l-tryptophan 1 G Urso ursodiol 250 mg Vaseretic enalapril/hctz 10/25 mg Vasotec enalapril 2.5 mg Vasotec enalapril 5 mg Vasotec enalapril 10 mg Vasotec enalapril 20 mg Visken pindolol 5 mg Visken pindolol 10 mg Visken pindolol 15 mg Vitamin A Acid tretinoin 0.1% Gel Vitamin A Acid tretinoin 0.025% Gel Vitamin A Acid tretinoin 0.05% Gel ** Voltaren diclofenac 50 mg Suppository Voltaren diclofenac 100 mg Suppository Voltaren diclofenac 50 mg Voltaren Rapide diclofenac 50 mg Wellbutrin SR bupropion 150 mg Xanax alprazolam 0.25 mg Xanax alprazolam 0.5 mg Xanax alprazolam 1 mg Xanax TS alprazolam 2 mg Xatral alfuzosin 10 mg Zestoretic lisinopril/hctz 10/12.5 mg Zestoretic lisinopril/hctz 20/12.5 mg Zestoretic lisinopril/hctz 20/25 mg Zestril lisinopril 5 mg Zestril lisinopril 10 mg Zestril lisinopril 20 mg Zithromax azithromycin 250 mg of 26

26 Zithromax azithromycin 600 mg Zithromax azithromycin 20 mg/ml Oral Suspension Zithromax azithromycin 40 mg/ml Oral Suspension Zocor simvastatin 5 mg Zoloft sertraline 25 mg Capsule Zoloft sertraline 50 mg Capsule Zoloft sertraline 100 mg Capsule Manufacturer Updates The following products have been transferred from Teva Canada to Sandoz Canada Inc Sandoz Oxycodone/ Acetaminophen (was Novo-Oxycodone Acet) Sandoz Morphine SR (was ratio-morphine SR) Sandoz Morphine SR (was ratio-morphine SR) Sandoz Morphine SR (was ratio-morphine SR) oxycodone/acetaminophen 5 mg/325 mg morphine sulfate 15 mg morphine sulfate 30 mg morphine sulfate 60 mg The following products have been transferred from Pharmascience to MM Therapeutics Olestyr (was pms-cholestyramine) Olestyr (was pms-cholestyramine) cholestyramine resin 4 g/dose Oral Powder cholestyramine resin 4 g/dose Oral Powder The following products have been transferred from Paladin to Teva Canada Zaditen ketotifen 1 mg Zaditen ketotifen 1 mg/5 ml Syrup The following products have been transferred from Bristol Myer Squibb to Valeant Canada Ultravate halobetasol 0.05% Cream Ultravate halobetasol 0.05% Ointment The following products have been transferred from Bayer to Pharmascience Androcur cyproterone 50 mg s 25 of 26

27 The following products have been transferred from Merck Frosst to Janssen Inc Remicade infliximab 100 mg/vial Injection Autoinjector mg/0.5 ml Simponi golimunab Pre-Filled mg/0.5 ml Syringe The following products have been transferred from Merck Frosst to Reckitt Benckiser Healthcare Ltd Suboxone buprenorphine/naloxone 2/0.5 mg Sublingual 8/2 mg The following products have been transferred from Pharmascience to Paladin Labs CyEstra-35 cyproterone/ethinyl estradiol 2/0.035 mg The following products have been transferred from Sanofi-Aventis to Sandoz Rho-Nitro Pumpsoray nitroglycerine 0.4 mg Spray The following product has had a name change: Lidex (was Topsyn) fluocinonide 0.05% Gel The following company has had a name change from Janssen-Ortho Inc. To Janssen Inc 26 of 26