University College Cork (Ireland) Professor of Neonatal Physiology (Ireland)

Transcription

1 Curriculum vitae PERSONAL INFORMATION Geraldine Boylan WORK EXPERIENCE 2013 Present Co-Director Irish Centre for Fetal and Neonatal Translational Research (INFANT) University College Cork (Ireland) 2011 Present University College Cork Professor of Neonatal Physiology (Ireland) Senior Lecturer in Medical Education & Paediatrics Lecturer in Paediatrics & Child Care Research Fellow, Department of Paediatrics & Child Care Clinical Scientist, Neonatal Intensive Care Unit Kings College Hospital (United Kingdom) Chief Clinical Physiologist Middlesex University Hospital (United Kingdom) EDUCATION AND TRAINING 2008 MA (Education) UCC 2002 PhD (Clinical Neurophysiology) 1991 MSc (comparative physiology) 1989 BSc (physiology) ADDITIONAL INFORMATION Expertise Publications Publications Lloyd RO, O'Toole JM, Pavlidis E, Filan PM, Boylan GB. (2017). Electrographic Seizures during the 11/5/17 European Union, Page 1 / 5

2 Early Postnatal Period in Preterm Infants. J Pediatr. doi: /j.jpeds Goulding RM, Stevenson NJ, Murray DM, Livingstone V, Filan PM, Boylan GB. (2017). Heart rate variability in hypoxic ischemic encephalopathy during therapeutic hypothermia. Pediatr Res. Jan 18. doi: /pr Lloyd RO, O'Toole JM, Livingstone V, Hutch WD, Pavlidis E, Cronin AM, Dempsey EM, Filan PM, Boylan GB. Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring. Pediatr Res May Mathieson S, Rennie J, Livingstone V, Temko A, Low E, Pressler RM, Boylan GB In-depth performance analysis of an EEG based neonatal seizure detection algorithm. Clin Neurophysiol May;127(5): O'Toole JM, Boylan GB, Vanhatalo S, Stevenson NJ Estimating functional brain maturity in very and extremely preterm neonates using automated analysis of the electroencephalogram. Clin Neurophysiol Apr 16. pii: S (16) Korotchikova I, Stevenson NJ, Livingstone V, Ryan CA, Boylan GB Sleep-wake cycle of the healthy term newborn infant in the immediate postnatal period. Clin Neurophysiol Apr;127(4): Donovan MD, Griffin BT, Kharoshankaya L, Cryan JF, Boylan GB. Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives. Drugs Apr;76(6): Low E, Stevenson NJ, Mathieson SR, Livingstone V, Ryan AC, Rennie JM, Boylan GB Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates. Neonatology Mar 31;110(1): Ahearne CE, Boylan GB, Murray DM Short and long term prognosis in perinatal asphyxia: An update. World J Clin Pediatr Feb 8;5(1): Weeke LC, Toet MC, van Rooij LG, Groenendaal F, Boylan GB, Pressler RM, Hellström-Westas L, van den Broek MP, de Vries LS Lidocaine response rate in aeeg-confirmed neonatal seizures: Retrospective study of 413 full-term and preterm infants. Epilepsia Feb;57(2): Donovan MD, Schellekens H, Boylan GB, Cryan JF, Griffin BT In vitro bidirectional permeability studies identify pharmacokinetic limitations of NKCC1 inhibitor bumetanide. Eur J Pharmacol Jan 5;770: Hawkes GA, Kenosi M, Finn D, O'Toole JM, O'Halloran KD, Boylan GB, Ryan AC, Dempsey EM Delivery room end tidal CO2 monitoring in preterm infants <32 weeks. Arch Dis Child Fetal Neonatal Ed Jan;101(1):F Donovan MD, Boylan GB, Murray DM, Cryan JF, Griffin BT Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on antiepileptics. Br J Clin Pharmacol Jan;81(1): Mathieson SR, Stevenson NJ, Low E, Marnane WP, Rennie JM, Temko A, Lightbody G, Boylan GB Validation of an automated seizure detection algorithm for term neonates. Clin Neurophysiol Jan;127(1): Finn D, Boylan GB, Ryan CA, Dempsey EM Enhanced Monitoring of the Preterm Infant during Stabilization in the Delivery Room. Front Pediatr Mar 31;4: Pressler RM, Boylan GB, Marlow N, de Vries LS, Blennow M, Chiron C, Cross JH, Hallberg B, Hellström-Westas L, Jullien V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Toet MC, Zohar S; NEMO consortium (NEonatal seizure treatment with Medication Off-patent).Bumetanide for neonatal seizures-back from the cotside. Nat Rev Neurol Dec;11(12): Lynch NE, Stevenson NJ, Livingstone V, Mathieson S, Murphy BP, Rennie JM, Boylan GB The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia. Seizure Dec;33: Stevenson NJ, Clancy RR, Vanhatalo S, Rosén I, Rennie JM, Boylan GB.Interobserver agreement for neonatal seizure detection using multichannel EEG.Ann Clin Transl Neurol Oct 1;2(11): Kenosi M, O'Toole JM, Livingston V, Hawkes GA, Boylan GB, O'Halloran KD, Ryan AC, Dempsey EM Effects of Fractional Inspired Oxygen on Cerebral Oxygenation in Preterm Infants following Delivery J Pediatr Nov;167(5): e Rodriguez-Alvarez N, Jimenez-Mateos EM, Dunleavy M, Waddington JL, Boylan GB, Henshall DC Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice. Neurobiol Dis Nov;83: Murphy K, Stevenson NJ, Goulding RM, Lloyd RO, Korotchikova I, Livingstone V, Boylan GB Automated analysis of multi-channel EEG in preterm infants. Clin Neurophysiol /5/17 European Union, Page 2 / 5

3 Sep;126(9): Murphy BM, O'Driscoll C, Boylan GB, Lightbody G, Marnane WP Stream computing for biomedical signal processing: A QRS complex detection case-study. Conf Proc IEEE Eng Med Biol Soc Aug;2015: Looney AM, Walsh BH, Moloney G, Grenham S, Fagan A, O'Keeffe GW, Clarke G, Cryan JF, Dinan TG, Boylan GB, Murray DM Downregulation of Umbilical Cord Blood Levels of mir-374a in Neonatal Hypoxic Ischemic Encephalopathy. J Pediatr Aug;167(2): e Denihan NM, Walsh BH, Reinke SN, Sykes BD, Mandal R, Wishart DS, Broadhurst DI, Boylan GB, Murray DM The effect of haemolysis on the metabolomic profile of umbilical cord blood. Clin Biochem May;48(7-8): Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial Ronit M Pressler, PhD, Prof Geraldine B Boylan, PhD, Prof Neil Marlow, DM, Prof Mats Blennow, MD, Catherine Chiron, PhD, Prof J Helen Cross, PhD, Prof Linda S de Vries, PhD, Boubou Hallberg, PhD, Prof Lena Hellström-Westas, PhD, Vincent Jullien, PhD, Vicki Livingstone, PhD, Barry Mangum, PharmD, Brendan Murphy, MD, Deirdre Murray, PhD, Gerard Pons, PhD, Janet Rennie, MD, Renate Swarte, PhD, Mona C Toet, PhD, Sampsa Vanhatalo, PhD, Sarah Zohar, PhD, for the NEonatal seizure treatment with Medication Off-patent (NEMO) consortium Lancet Neurol May;14(5): Clinical Implementation of a Neonatal Seizure Detection Algorithm A. Temko, W. Marnane, G. Boylan, G. Lightbody (2015) 'Clinical Implementation of a Neonatal Seizure Detection Algorithm'. Decision Support Systems, 70 : Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field Niamh M Denihan, Geraldine B Boylan, Deirdre M Murray (2015) 'Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field'. BioMed research international, /2015/ The effect of haemolysis on the metabolomic profile of umbilical cord blood NM Denihan, BH Walsh, SN Reinke, BD Sykes, R Mandal, DS Wishart, DI Broadhurst, GB Boylan, DM Murray Clin Biochem Feb 16. pii: S (15) Heart rate variability in hypoxic ischaemic encephalopathy: correlation with EEG grade and twoyear neurodevelopmental outcome Goulding RM, Stevenson NJ, Murray DM, Livingstone V, Filan PM, Boylan GB (2015). Pediatric Research, /pr Overcoming the practical challenges of electroencephalography of very preterm infants in the neonatal intensive care unit Lloyd RO, Goulding RM, Filan PM, Boylan GB. Acta Paediatr Feb;104(2): Seizures and hypothermia: Importance of electroencephalographic monitoring and considerations for treatment Boylan GB, Kharoshankaya L, Wusthoff CJ. Semin Fetal Neonatal Med Apr;20(2): Epilepsy after neonatal seizures: Literature review Pisani F, Facini C, Pavlidis E, Spagnoli C, Boylan G (2015) European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 19 (1): Modulation Frequency Analysis Of Seizures In Neonatal EEG Temko A., Boylan GB, Marnane W. P., Lightbody G., EEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP'14, Florence, Italy, May Temko A., Marnane W., Boylan G, Lightbody G.EEG 'Diarization' for the Description of Neonatal Brain Injuries IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP'14, Florence, Italy, May Donovan M, O'Brien FE, Boylan GB, Griffin BT, Cryan JF A combined in vitro, in vivo and in silico approach to develop and optimise a novel antiepileptic strategy in neonatal seizures European Neuropsychopharmacology Supplement 1 S Kharoshankaya L., Filan P, Bogue C, Murray D, Boylan G Global suppression of electrocortical activity in unilateral perinatal thalamic stroke. Developmental Medicine and Child Neurology, 2014 Jan Walsh B, Boylan G, Dempsey E, Murray D. Association of nucleated red blood cells and severity of encephalopathy in normothermic and hypothermic infants. Acta Paediatrica, Volume 102,Issue 2, pages e64 e67, February N. J. Stevenson, I. Korotchikova, A. Temko, G. Lightbody, W. P. Marnane, G. B. Boylan. An Automated System for Grading EEG Abnormality in Term Neonates with Hypoxic-Ischaemic Encephalopathy. Annals of Biomedical Engineering. April 2013, Volume 41, Issue 4, pp /5/17 European Union, Page 3 / 5

4 38. GB Boylan, NJ Stevenson, S Vanhatalo, Monitoring neonatal seizures, Seminars in Fetal and Neonatal Medicine, SN Reinke, BH Walsh, GB Boylan, BD Sykes, LC Kenny, DM Murray, DI Broadhurst The 1H-NMR Derived Metabolomic Profile of Neonatal Asphyxia in Umbilical Cord Serum: Implications for Hypoxic Ischaemic Encephalopathy Journal of proteome research 40. NM Denihan, AM Looney, GB Boylan, BH Walsh, DM Murray Normative Levels of Interleukin 16 in Umbilical Cord Blood Clinical biochemistry 41. BH Walsh, GB Boylan, V Livingstone, LC Kenny, EM Dempsey, DM Murray Cord Blood Proteins and Multichannel-Electroencephalography in Hypoxic-Ischemic Encephalopathy*Pediatric Critical Care Medicine 14 (6), GB Boylan, R Pressler Neonatal seizures: The journey so far Seminars in Fetal and Neonatal Medicine RD O'Reilly, D Power, PD Healy, JP Morrison, GB Boylan ScrutiniseIT: A Search-Based Approach to EEG Seizure Detection etelemed 2013, The Fifth International Conference on ehealth, Telemedicine 44. Temko, G. Boylan, W. Marnane, G. Lightbody, "Robust Neonatal EEG Seizure Detection Through Adaptive Background Modelling," International Journal of Neural Systems, v. 23, i. 4, World Scientific, E. Thomas, A. Temko, W. Marnane, G. Boylan, G. Lightbody, "Discriminative and generative classification techniques applied to automated neonatal seizure detection," IEEE 46. Lynch NE, Stevenson NJ, Livingstone V, Murphy BP, Rennie JM, Boylan GB. The temporal evolution of electrographic seizure burden in neonatal hypoxic ischemic encephalopathy. Epilepsia Mar; 53(3): Low E,. Boylan GB, Mathieson SR, Murray DM, Korotchikova I, Stevenson NJ, Livingstone V, Rennie JM. Cooling and seizure burden in term neonates: an observational study. Arch Dis Child Fetal Neonatal Ed Jan 23. Projects Details of Most Relevant Research Funding as lead/co-applicant Boylan, G. Development of an automated seizure detection system for newborns using multimodal biological signal analysis. SFI Principal Investigator Career Advancement Award, Oct 2006-April Marnane, L., Boylan, G., Lightbody, G., and Rennie, J. Development and validation of clinically robust neonatal seizure detection systems. Translation Award from the Wellcome Trust, Co.-PI, July 2008-June Pressler R, Boylan G, 13 European Co-PI s. Treatment of Neonatal Seizures with Medication Off-Patent: evaluation of efficacy and safety of bumetanide. EU FP7, Co-PI, Oct 2009-Sept Boylan G & Lightbody G. Pattern Recognition Systems for Continuous Neurological Monitoring in Neonates (NeoPrism). SFI PI Award, PI March 2011 Feb Kenny L & Boylan G (Co-directors), 8 Co-PIs. Irish Centre for Fetal and Neonatal Translational Research. Scinece Foundation Ireland Research Centres Award, June 2013 May 2019 Memberships Other Relevant Information History of Mentoring and Supervision Post Doctorate Researchers Supervision of 8 post-doctorate researchers to date Post Graduate Students Supervised 15 post-graduates to award of PhD, 2 post-graduates to MD and 4 post-graduates to MSc by Research 11/5/17 European Union, Page 4 / 5

5 Current PhD Students: 9 current PhD/MD students Innovation and Commercialisation Activity A Method of Real-Time Identification of Seizures in an Electroencephalogram (EEG) Signal. WO 2010/ Publication date: 14 OCT 2010 Real Time Audification of Neonatal Electroencephalogram (EEG) Signals. WP/2016/ Publication date: 14 JAN 2016 A method of identifying a neonate at risk of having or developing Hypoxic-Ischemic Encephalopathy (HIE). WO 2016/ Publication date 01 DEC 2016 Faul, S., Temko, A., Marnane, W.P., Lightbody, G., and Boylan G.B. A Method of Analysing an Electroencephalogram (EEG) Signal. UK Patent Application No , April /5/17 European Union, Page 5 / 5