Physical activity and exercise in the regulation of adipose mass and function
|
|
- Julius Gregory
- 5 years ago
- Views:
Transcription
1 Physical activity and exercise in the regulation of adipose mass and function Key Questions What is the impact of exercise on adipose and fat metabolism? To what extent does exercise and physical activity change adipose tissue masses? What is the impact of chronic exercise (training) on adipose tissue function - independent of energy balance? Professor Dylan Thompson Department for Health University of Bath Fat mobilisation from adipose during exercise Fatty Acid Trafficking Frayn & Coppack (21) In: Adipose Tissue Protocols Springer Thompson et al (212) Physiol Rev. 92: Substrate utilisation during Exercise FFA Other Fat Plasma Glucose Muscle Glycogen Intensity (W max ) Exercise Absolute (25 VO2 max; ~6 kcal/min) 55 5 Lower Intensity Exercise 25 4 Absolute Contribution to EE (kcal/min) 1 4 Relative Contribution to EE () Relative Al Mulla et al (2) J. Physiol. 524: Intensity (W max ) 6 min exercise = ~3 g fat from AT Van Loon et al (21) J. Physiol. 536(1): Romijn et al (1993) Am. J. Physiol. 265: E38-E391 1
2 Summary 1 At most intensities, fat mobilized from subcutaneous adipose provides much of the energy for exercise At low intensities, FFA from adipose contributes ~9 to energy expenditure Impact of supervised exercise interventions on adipose masses and depots Diet -1 kcal/d Exercise Interventions Exercise 5 d/wk, 6 min Diet -7 kcal/d Exercise +7 kcal/d Change in Mass (kg) -5-1 Weight SCAT VAT Weight SCAT VAT Change in Mass (kg) Weight SCAT VAT Weight SCAT VAT Exercise: A preferential effect on visceral adipose tissue? weeks 16 weeks Ross et al. (1996) J. Appl. Physiol. 81: Ross et al. (2) Ann. Int. Med. 133:92-13 VAT & Exercise: Meta Analysis The principal finding of this review is that there is no compelling evidence of a weight loss intervention that targets visceral fat preferentially. Rather, it appears that preferential loss of visceral fat is associated with modest weight loss and the effect reduced with greater weight loss Verheggen et al (216) Obesity Reviews 17:
3 Summary 2 Supervised exercise alongside a controlled diet can lead to quantitatively important reductions in fat mass Fat will be lost from all adipose depots What about exercise in the real world? VAT shows the greatest relative change but the greatest absolute change will be in SCAT mass August 29 Intervention Studies? Systematic Reviews Our results show that isolated aerobic exercise is not an effective weight loss therapy. Isolated aerobic exercise provides modest benefits to blood pressure and lipid levels and may still be an effective weight loss therapy in conjunction with diets. Thorogood et al (211) Am J. Medicine 124(8)
4 Intervention Studies? Systematic Reviews Is this because of poor compliance or compensatory changes in other physical activity? Average weight loss of subjects completing a minimum 1-year weight-management intervention; based on review of 8 studies (N=26,455; 18,199 completers [69]). Franz et al (27) Journal of the American Dietetic Association, 17(1) Turner et al. (21) Am J Clin Nutr 92: Regular exercise and energy balance Regular exercise and energy balance Weight loss was ~5 predicted Potential energy deficit reduced by ~1 kcal/d (because of a compensatory ñ in EI) ~ 1 TEE Turner et al. (21) Am J Clin Nutr 92: Turner et al. (21) Am J Clin Nutr 92: Summary 3 Real world exercise interventions have a rather modest impact on weight (fat) loss in part because of counter forces such dietary compensation August 29 4
5 Perspectives kcal/d 1 5 M T W T F S S 15 minutes = 2 of a waking week NEAT NEAT Monday below 6 kcal/min comes from NEFA mobilised from adipose then = 774 kcal/d (~11 g of fat) Tuesday (NB above rest) Tuesday TEE = 28 kcal/d RMR = 166 kcal/d PAEE = 86 kcal/d PAL = 1.69 If 9 of the energy cost of physical activity Monday Wednesday TEE = 28 kcal/d RMR = 166 kcal/d PAEE = 86 kcal/d PAL = 1.69 Thursday Wednesday Thursday Friday Friday Saturday Saturday Sunday Sunday >5, kcal per year! Assumptions, assumptions What contributes to NEAT? 5 Energy Expenditure (kcal/d) >7kg (11 stone) fat (adipose) 4 DIT Levine et al. (26) Arterioscler Thromb Vasc Biol;26: PAEE BMR Ninety Middle-aged Men (Rank Order for TEE) Thompson et al (29) Plos ONE 4(2): p. e4337 5
6 Summary 4 Overall physical activity energy expenditure is incredibly important for energy and fat balance Other effects from exercise? Acute exercise affects adipose tissue Thompson et al (212) Physiol Rev. 92: Relative Gene Expression Adiponectin AMPK 6 min of moderate intensity exercise GLUT4 HSL IRS2 MCP1 PDK4 PGC1a PPARgamma SREBP1c AKT1 ATGL Chen et al (217) Am. J. Physiol. 313: E84-E93 Acute exercise affects adipose tissue Relative Gene Expression min of moderate intensity exercise # # # # # # Adiponectin AMPK GLUT4 HSL IRS2 MCP1 PDK4 PGC1a PPARgamma SREBP1c AKT1 ATGL Chen et al (217) Am. J. Physiol. 313: E84-E93 Exercise increases markers of angiogenesis in adipose Van Pelt et al (Online First) J. Appl. Physiol. 6
7 Exercise-induced release of adipokines (IL-6) Acute effects in other tissues? Exercise Lyngso et al (22) J. Physiol : Hojbjerre et al (27) Eur J Endocrin. 157: Chronic exercise-induced changes in adipose tissue Chronic exercise (training) increases adipose sensitivity 256 transcripts differentially affected by exercise 2-3 sessions per week no weight loss 4 months, 5d/wk, weight loss = 1.9kg de Glisezinski et al (23) Am J. Physiol. 285: E984-E99 4 months, 5d/wk, weight loss = 3kg Moro et al (25) MSSE 37(7): (CCL5) Chronic exercise and adipose inflammation No change in BMI Summary 4 Exercise causes acute physiological changes in adipose tissue Chronic exercise (training) improves adipose tissue physiology and function (e.g., improved sensitivity, lower inflammation) Are exercise-induced effects dependent on (modest) changes to energy balance? Baturcam et al (214) Mediators of Inflamm. doi: /214/
8 Impact of exercise on adipose without weight (fat) loss Energy surplus with and without exercise Impact of exercise on response to overfeeding EX EI EE 4 max EI EE 4 max Normal SUR Normal SUR+EX Group 1 Group 2 Walhin et al (213) J. Physiol. 591(24) Exercise maintained postprandial insulinaemia and glucose control Exercise maintained adipose gene expression (even during adipose expansion) ~17, Extra kcal Walhin et al (213) J. Physiol. 591(24) Walhin et al (213) J. Physiol. 591(24)
9 Summary 5 Other forms of exercise and overfeeding? Daily vigorous intensity exercise protects against the deleterious effects of an energy surplus Even in the tissue where excess energy is being actively stored (i.e., adipose) Insulin Response to OGTT ( Δ iauc ) SUR SUR+ ACE SUR+ MOD SUR+ BREAKs Key Questions What is the impact of exercise on adipose and fat metabolism? To what extent does exercise and physical activity change adipose tissue masses? What is the impact of chronic exercise (training) on adipose tissue function - independent of energy balance? James Betts Yung-Chih (Stanley) Chen Javier Gonzalez Will Trim James Turner Jean-Philippe Wahlin Keith Frayn (Oxford) Fredrik Karpe (Oxford) Max Lafontan (Toulouse) Anne Bouloumie (Toulouse) Acknowledgements 9
Glucose. Glucose. Insulin Action. Introduction to Hormonal Regulation of Fuel Metabolism
Glucose Introduction to Hormonal Regulation of Fuel Metabolism Fasting level 3.5-5 mmol (1 mmol = 18 mg/dl) Postprandial 6-10 mmol Amount of glucose in circulation is dependent on: Absorption from the
More informationSHEDDING NEW LIGHT ON CARBOHYDRATES AND EXERCISE
SHEDDING NEW LIGHT ON CARBOHYDRATES AND EXERCISE Dr Javier Gonzalez Department for Health, University of Bath, UK. j.t.gonzalez@bath.ac.uk Van Loon (2012) Energy Stores FAT: >100,000 kcal Van Loon (2012)
More informationEXERCISE PRESCRIPTION FOR OBESE PATIENT
EXERCISE PRESCRIPTION FOR OBESE PATIENT ASSOC. PROF. DR. MOHD NAHAR AZMI MOHAMED HEAD, SPORTS MEDICINE DEPARTMENT SENIOR MEDICAL LECTURER / CONSULTANT SPORTS PHYSICIAN UNIVERSITI MALAYA MEDICAL CENTER
More informationImpact of Exercise on Patients with Diabetes Mellitus
Impact of Exercise on Patients with Diabetes Mellitus Bret Goodpaster, Ph.D. Exercise Physiologist Assistant Professor of Medicine University of Pittsburgh Division of Endocrinology and Metabolism Learning
More informationAdipose tissue dysfunction in obesity. Gijs Goossens, PhD
Adipose tissue dysfunction in obesity -The role of adipose tissue oxygenation - Gijs Goossens, PhD NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Centre
More informationEdward Melanson, Ph.D., Associate Professor, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Denver
Edward Melanson, Ph.D., Associate Professor, Division of Endocrinology, Metabolism, and Diabetes University of Colorado Denver 45 y/o man Medications: none Social Hx: moderate alcohol intake (1-2 cans
More informationInteractions of exercise and diet in health prevention
Interactions of exercise and diet in health prevention Dr Jason Gill Institute of Cardiovascular and Medical Sciences University of Glasgow Physical activity and health outcomes does one size fit all?
More informationSedentary Behaviours and Body Weight: Should we be Preoccupied? Jean-Philippe Chaput, PhD
Sedentary Behaviours and Body Weight: Should we be Preoccupied? Jean-Philippe Chaput, PhD Appl Physiol Nutr Metab (2012) An Active Day? 30 min 30 min 4 hours 8 hours 30 min YES Are you an active couch
More informationTHE IMPORTANCE OF EXERCISE FOR THE OVERWEIGHT AND OBESE PATIENT. Anneliese Piazza, MS, CPT
THE IMPORTANCE OF EXERCISE FOR THE OVERWEIGHT AND OBESE PATIENT Anneliese Piazza, MS, CPT Benefits of Exercise Increases energy expenditure and may result in weight loss Helps maintain or build muscle
More informationSupplemental table 1. EPA and DHA concentrations at baseline in the postprandial and dietary supplementation studies ! 1!
Online Supplemental Material Supplemental table 1. EPA and DHA concentrations at baseline in the postprandial and dietary supplementation studies Fatty acid concentration (µmol*l -1) Lipid structure utag
More informationResponses of blood lipids to aerobic and resistance type of exercise
Responses of blood lipids to aerobic and resistance type of exercise Labros Sidossis, Ph.D. Laboratory of Nutrition and Clinical Dietetics Harokopio University of Athens, Greece Triacylglycerol structure
More informationWeight Loss and Resistance Training
Weight Loss and Resistance Training Weight loss is a factor of caloric balance, or more easily stated, energy-in, versus energyout. The seemingly simplistic equation suggests that if a person consumes
More informationThe Biggest Loser: Are Weight Loss Attempts Doomed?
The Biggest Loser: Are Weight Loss Attempts Doomed? Melinda M. Manore, PhD, RD, CSSD, FACSM College of Public Health and Human Sciences Oregon State University 1 Today s Focus 1. Biggest Loser What did
More information3/20/2011. Body Mass Index (kg/[m 2 ]) Age at Issue (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Mokdad A.H.
U.S. Adults: 1988 Nineteen states with 10-14% 14% Prevalence of Obesity (*BMI > 30, or ~ 30 lbs overweight for 5 4 woman) Metabolic John P. Cello, MD Professor of Medicine and Surgery, University of California,
More informationAppetite control, Food Choice and Physical Activity Implications for Energy Balance and Weight Control
Appetite control, Food Choice and Physical Activity Implications for Energy Balance and Weight Control John Blundell Chair of PsychoBiology University of Leeds Energy Balance and Active Living: Perspectives
More informationThe energetic cost of inactivity
The energetic cost of inactivity The energetic cost of inactivity The energetic cost of inactivity Incidence of inactivity Social causes of inactivity Biological causes of reduced energy expenditure Consequences
More informationMilk and weight management
Milk and weight management Angelo Tremblay Division of Kinesiology Human obesity: is insufficient calcium/dairy intake part of the problem? Risk factors for overweight and obesity in adulthood: Results
More informationPhysical Activity & Cancer What We Know, What We Don t Know. Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, WA
Physical Activity & Cancer What We Know, What We Don t Know Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, WA What We Know Extensive epidemiologic research on relationship between
More information11/17/2009. HPER 3970 Dr. Ayers (courtesy of Dr. Cheatham)
Weight Management Chapter 11 HPER 3970 Dr. Ayers (courtesy of Dr. Cheatham) Weight Loss Introduction Many athletes, although not overweight, seek to lose body weight (especially body fat) Increase Power
More informationDoes Physical Activity Have a Role in Reducing Obesity?
Does Physical Activity Have a Role in Reducing Obesity? James O. Hill, Ph.D. Executive Director, Anschutz Professor Anschutz Health and Wellness Center University of Colorado Denver, Colorado Changes
More informationLab Exercise 8. Energy Expenditure (98 points)
Lab Exercise 8 Energy Expenditure (98 points) Introduction To understand an individual s energy requirements, we must be able to estimate their usual energy expenditure. This is difficult to do in free
More informationUndoing the Damage of Sedentary Behavior Christine Wetzig, ACSM EP-C
Sitting Is the New Smoking: Undoing the Damage of Sedentary Behavior Christine Wetzig, ACSM EP-C GOALS Summarize research on sedentary behavior & physical activity Describe how Sedentary Behavior effects
More informationUnderstanding & Interpreting Body Composition Measures
BODY COMPOSITION Understanding & Interpreting Body Composition Measures Body composition = component of health-related fitness & = component of metabolic fitness Unlike other health-related fitness Not
More informationPart 3:Strategies for successful aging. Avoiding disease with physical activity
Part 3:Strategies for successful aging Avoiding disease with physical activity Causes of disability and disease with aging Causes of death for old individuals Atherosclerosis (CHD) CNS-vascular accidents
More informationSedentary behaviour and adult health. Ashley Cooper
Sedentary behaviour and adult health Ashley Cooper Physical activity and health in the 1950 s Jerry Morris compared heart attack incidence & severity in drivers vs conductors Morris et al (1953) "Coronary
More informationEnergy balance. Factors affecting energy input. Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain
1 Energy balance Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain Special implications Infancy, Illness, Pregnancy & Lactation, Sports Factors affecting energy input neuro-endocrine
More informationManagement Guidance HR72 On-Call Policy. The Trust s Approach to Compensatory Rest
Management Guidance HR72 On-Call Policy The Trust s Approach to Compensatory Rest General Principles Compensatory rest may be granted if either: An individual s daily or weekly rest requirements (as stated
More informationContinuous or Intermittent Calorie Deficits: Which is Better for Fat Loss?
Continuous or Intermittent Calorie Deficits: Which is Better for Fat Loss? Byrne et al., Int J Obes, September, 2017 [Epub ahead of print] James Krieger, M.S. Background As you lose weight, your body tries
More informationESPEN Congress Prague 2007
ESPEN Congress Prague 2007 Nutrition implication of obesity and Type II Diabetes Nutrition support in obese patient Claude Pichard Nutrition Support in Obese Patients Prague, 2007 C. Pichard, MD, PhD,
More informationThe use of fasting and glycogen depletion to enhance skeletal muscle adaptation to training
The use of fasting and glycogen depletion to enhance skeletal muscle adaptation to training Andrew Philp Ph.D. MRC-ARUK Centre for Musculoskeletal Ageing Research School of Sport, Exercise and Rehabilitation
More informationModule 2: Metabolic Syndrome & Sarcopenia. Lori Kennedy Inc & Beyond
Module 2: Metabolic Syndrome & Sarcopenia 1 What You Will Learn Sarcopenia Metabolic Syndrome 2 Sarcopenia Term utilized to define the loss of muscle mass and strength that occurs with aging Progressive
More informationAdipose Tissue Dysfunction and Diabetic Cardiovascular Disease
Adipose Tissue Dysfunction and Diabetic Cardiovascular Disease Xin-Liang Ma, MD, PhD Thomas Jefferson University Philadelphia, PA USA CVD As The #1 Causes of Death In USA Male Female Heart Disease and
More informationEnergy Imbalance: The End of the World as We Know It CPCP Colloquium March 8, 2013 University of South Carolina
Energy Imbalance: The End of the World as We Know It CPCP Colloquium March 8, 2013 University of South Carolina Steven N. Blair Professor, Arnold School of Public Health, University of South Carolina,
More informationObesity in the pathogenesis of chronic disease
Portoroz October 16th 2013 Obesity in the pathogenesis of chronic disease Rocco Barazzoni University of Trieste Department of Medical, Surgical and Health Sciences Obesity Trends* Among U.S. Adults BRFSS,
More informationExercise counteracts the effects of short-term overfeeding and reduced physical activity. Accepted Article
Exercise counteracts the effects of short-term overfeeding and reduced physical activity independent of energy imbalance in healthy young men Jean-Philippe Walhin 1, Judith D. Richardson 1, James A. Betts
More informationFructose in Insulin Resistance- Focused on Diabetes 순천향대학교부천병원 내분비내과 정찬희
Fructose in Insulin Resistance- Focused on Diabetes 순천향대학교부천병원 내분비내과 정찬희 Introduction Unique characteristics of Fructose Metabolism Mechanism for Fructose-Induced Insulin Resistance Epidemiological Studies
More informationIn The Name Of God. In The Name Of. EMRI Modeling Group
In The Name Of God In The Name Of God EMRI Modeling Group Cells work together in functionally related groups called tissues Types of tissues: Epithelial lining and covering Connective support Muscle movement
More informationOptimizing the Exercise Drug to Oppose Glucose Intolerance/T2D
University of Massachusetts Medical School escholarship@umms UMass Center for Clinical and Translational Science Research Retreat 2014 UMass Center for Clinical and Translational Science Research Retreat
More informationBody Mass Index Chart = overweight; = obese; >40= extreme obesity
Pathophysiology of type 2 diabetes mellitus R. Leibel Naomi Berrie Diabetes Center 25 February 2008 Body Mass Index Chart 25-29.9 = overweight; 30-39.9= obese; >40= extreme obesity 5'0" 5'2" Weight (lbs)
More informationBlood fatty acids understanding the relevance of different tissue fractions and interpreting circulating concentrations.
Blood fatty acids understanding the relevance of different tissue fractions and interpreting circulating concentrations Leanne Hodson Fatty acid composition as a biomarker of intake Complements dietary
More informationImportance of physical activity before and after bariatric surgery in patients with type 2 diabetes
UK ASO 8 th September 2017 Importance of physical activity before and after bariatric surgery in patients with type 2 diabetes Dr Richard M. Bracken (r.m.bracken@swansea.ac.uk) Associate Professor in Exercise,
More informationIL METABOLISMO EPATICO DEI CARBOIDRATI IN FISIOLOGIA E PATOLOGIA
UNIGASTRO Il fegato come centrale metabolica e i fattori di danno oltre ai virus epatitici IL METABOLISMO EPATICO DEI CARBOIDRATI IN FISIOLOGIA E PATOLOGIA Dr Elisabetta Bugianesi Divisione di Gastro-Epatologia
More informationInflammasome-mediated caspase-1 activity Gatekeeper of inflammation in the adipose tissue. Rinke Stienstra
Inflammasome-mediated caspase-1 activity Gatekeeper of inflammation in the adipose tissue Rinke Stienstra Obesity promotes the development of insulin resistance and type 2 diabetes County-level Estimates
More informationEffects of short-term exercise training on intestinal metabolism and gut microbiota
Effects of short-term exercise training on intestinal metabolism and gut microbiota Kumail K. Motiani M. Carmen Collado, Joonas J. Eskelinen, Kirsi A. Virtanen, Eliisa Löyttyniemi, Seppo Salminen, Pirjo
More informationWorksheet Questions, Chapter 8, Body Composition and Weight Control
Worksheet Questions, Chapter 8, Body Composition and Weight Control Exercise 1. True-False. Indicate whether each of the following statements is true or false by clicking on (or if you are using a printed
More informationHPHE 4450 Exercise Testing and Prescription. Fitness Assessment and Exercise Prescription Project
HPHE 4450 Exercise Testing and Prescription Fitness Assessment and Exercise Prescription Project Overview In pairs, students will perform a comprehensive fitness assessment on each other and develop and
More informationSome important concepts. 1. glucose requirement is < 130 g/d
A Protein-rich rich Diet as a Cornerstone of a Healthy Lifestyle Donald K. Layman, Ph.D. Professor of Nutrition Dept. Food Science & Human Nutrition University of Illinois at Urbana-Champaign Outline:
More informationMyth Busters. Dr Michael Mosley. Science Presenter #HCA2015
Myth Busters Dr Michael Mosley Science Presenter Busting myths about Food, Nutrition and Life style MEDICAL MAVERICKS The history of medicine told through self-experimenters Horizon: Eat,
More informationMyths, Presumptions and Facts about Obesity
1 Myths, Presumptions and Facts about Obesity Cátia Martins Associate Professor Obesity Research Group IKOM, Faculty of Medicine NTNU 2 Myth believe held true despite the existence of substantial refuting
More informationEnergy balance. Factors affecting energy input. Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain
1 Energy balance Energy input vs. Energy output Balance Negative: weight loss Positive: weight gain Special implications Infancy, Illness, Pregnancy & Lactation, Sports Factors affecting energy input neuro-endocrine
More informationSkeletal muscle metabolism was studied by measuring arterio-venous concentration differences
Supplemental Data Dual stable-isotope experiment Skeletal muscle metabolism was studied by measuring arterio-venous concentration differences across the forearm, adjusted for forearm blood flow (FBF) (1).
More informationThe influence of sex and obesity phenotype on meal fatty acid metabolism before and after weight loss 1 3
The influence of sex and obesity phenotype on meal fatty acid metabolism before and after weight loss 1 3 Sylvia Santosa, Donald D Hensrud, Susanne B Votruba, and Michael D Jensen ABSTRACT Background:
More informationAdipose Tissue as an Endocrine Organ. Abdel Moniem Ibrahim, MD Professor of Physiology Cairo University
Adipose Tissue as an Endocrine Organ Abdel Moniem Ibrahim, MD Professor of Physiology Cairo University Functions of Adipose Tissue Adipose tissue expresses and secretes a variety of bioactive peptides,
More informationThe art of tracing dietary fat in humans. Leanne Hodson
The art of tracing dietary fat in humans Leanne Hodson Dietary fat Other lipoproteins: IDL, LDL, HDL Hodson and Fielding linical Lipidology (2010) Relationship between blood & dietary fatty acids Typically:
More informationEffects of Exercise and Physical Activity on Diabetes Mellitus and Obesity
1 EXERCISE IS MEDICINE: The Science Behind the Movement Effects of Exercise and Physical Activity on Diabetes Mellitus and Obesity Rosa Allyn G. Sy, MD, FPCP, FPSEDM Endocrinology, Diabetes, Metabolism
More informationLipodystrophy: Metabolic and Clinical Aspects. Resource Room Slide Series
Lipodystrophy: Metabolic and Clinical Aspects Resource Room Slide Series Cellular Pathology of Insulin Resistance in Lipodystrophy Robert R. Henry, MD Professor of Medicine University of California, San
More informationDEVELOPMENTAL ORIGINS OF DIABETES AND CARDIOVASCULAR DISEASE. Goals
DEVELOPMENTAL ORIGINS OF DIABETES AND CARDIOVASCULAR DISEASE Goals Evolutionary paradox of obesity/diabetes Thrifty gene hypothesis Thrifty phenotype hypothesis Effects of small for gestational age (SGA)
More informationGlycemic control in type 2 diabetes. Exercise prescription in type 2 diabetes treatment. Target for diabetes intervention.
Exercise prescription in type 2 diabetes treatment Glycemic control in type 2 diabetes Prof. L.J.C. van Loon The level of glycemia is associated with the development of cardiovascular complications Glycemic
More informationExam Schedule Matrix: Spring 2017
Final examinations are held at the end of each term in accordance with the published scheduling matrix. INSTRUCTORS: Room assignments for non-standard course meetings, exam conflicts or makeup exams will
More informationHigh Protein Diets in Weight Reduction
High Protein Diets in Weight Reduction Effects on fat mass, muscle mass and risk factors of the metabolic syndrome Donald K. Layman and Layne E. Norton Department of Food Science & Human Nutrition University
More informationEndpoints And Indications For The Older Population
Endpoints And Indications For The Older Population William J. Evans, Head Muscle Metabolism Discovery Unit, Metabolic Pathways & Cardiovascular Therapy Area Outline Functional Endpoints and Geriatrics
More informationFundamentals of Exercise Physiology and T1D
COMPLIMENTARY CE Fundamentals of Exercise Physiology and T1D Jointly Provided by Developed in collaboration with 1 INTRODUCTION TO PHYSICAL ACTIVITY AND T1D 2 Many People with T1D Have Lower Levels of
More informationObesity, Metabolic Syndrome, and Diabetes: Making the Connections
Obesity, Metabolic Syndrome, and Diabetes: Making the Connections Alka M. Kanaya, M.D. Associate Professor of Medicine & Epi/Biostats University of California, San Francisco February 26, 21 Roadmap 1.
More informationEnergy Balance and Body Composition
Energy Balance and Body Composition THE ECONOMICS OF FEASTING THE ECONOMICS OF FEASTING Everyone knows that when people consume more energy than they expend, much of the excess is stored as body fat. Fat
More informationTable S2: Anthropometric, clinical, cardiovascular and appetite outcome changes over 8 weeks (baseline-week 8) by snack group
Table S1: Nutrient composition of cracker and almond snacks Cracker* Almond** Weight, g 77.5 g (5 sheets) 56.7 g (2 oz.) Energy, kcal 338 364 Carbohydrate, g (kcal) 62.5 12.6 Dietary fiber, g 2.5 8.1 Protein,
More informationEffects of growth hormone secretagogue receptor agonist and antagonist in nonobese type 2 diabetic MKR mice
Effects of growth hormone secretagogue receptor agonist and antagonist in nonobese type 2 diabetic MKR mice Rasha Mosa (MBCHC, M.D, PhD candidate) School of Biomedical Sciences University of Queensland
More informationEnergy Balance and Weight Management: Finding Your Equilibrium
Chapter 9 Energy Balance and Weight Management: Finding Your Equilibrium Key Terms 1. appetite: A psychological desire to eat that is related to the pleasant sensations often associated with food. 2. extreme
More informationHealth and Wellness of Stevia as a Sweetener
Health and Wellness of Stevia as a Sweetener Keith T. Ayoob, EdD, RDN, FADN Associate Professor Emeritus, Albert Einstein College of Medicine, New York October 17, 2017 Conflict of Interest Disclosure
More informationDietary fat, carbohydrates and inflammation. Ellen Blaak, PhD
Dietary fat, carbohydrates and inflammation Ellen Blaak, PhD of Human Biology NUTRIM School for Nutrition, Toxicology and Metabolism Maastricht University Medical Centre The Netherlands ILSI workshop,
More informationThe Effect of Intermittent High- Intensity Training and Phytochemicals on Fitness, Body Composition, and Cardiovascular Disease Risk
/6/2 The Effect of Intermittent High- Intensity Training and Phytochemicals on Fitness, Body Composition, and Cardiovascular Disease Risk Steve Boutcher PhD FACSM University of New South Wales Outline
More informationSaturday 8/26/2017 7:00am - 7:00pm Closed 11:00am - 9:00pm Closed Closed
Fall 2017 Opening Weekend Friday 8/25/2017 7:00am - 7:00pm Closed 8:30am - 2:00pm Closed Closed Saturday 8/26/2017 7:00am - 7:00pm Closed 11:00am - 9:00pm Closed Closed Sunday 8/27/2017 7:30 am - 2:00
More informationMETABOLISM of ADIPOSE TISSUE
METABOLISM of ADIPOSE TISSUE 2. LF UK Prof. Rudolf Poledne, PhD. TYPES OF ADIPOSE TISSUE brown adipose tissue subcutaneous adipose tissue visceral adipose tissue ADIPOSE TISSUE FUNCTIONS: thermal isolation
More informationBasic pathophysiology of recovery: the role of endocrine metabolic response. Franco Carli McGill University Montreal, Canada
Basic pathophysiology of recovery: the role of endocrine metabolic response Franco Carli McGill University Montreal, Canada ASER, Washington, 2016 postoperative recovery, 1950 Loss of body weight, less
More informationSweeteners and sweet taste: What is the evidence concerning the effects of sugar and low-calorie sweeteners on energy intake and body weight?
Sweeteners and sweet taste: What is the evidence concerning the effects of sugar and low-calorie sweeteners on energy intake and body weight? Peter Rogers School of Experimental Psychology, University
More informationCarlo Agostoni Fondazione IRCCS Department of Maternal and Pediatric Sciences University of Milan, Italy
Carlo Agostoni Fondazione IRCCS Department of Maternal and Pediatric Sciences University of Milan, Italy Energy Protein Fat quality docosahexaenoic acid Micronutrients Vitamin D Dieting during lactation?
More informationTHE LONG RIDE THRESHOLD RIDES HILLS
THE LONG RIDE 6/10 effort focusing on building your time on the bike and developing your aerobic capacity. Start off riding at 65% of MHR (conversational pace). Gradually this will build to 75% of MHR
More informationMETABOLISMO E VITAMINA D
CONVEGNO NAZIONALE GIBIS ROMA 14-15 MAGGIO 2015 METABOLISMO E VITAMINA D Alfredo Scillitani UO Endocrinologia Ospedale Casa Sollievo della Sofferenza Holick MF, NEJM 2007 Sindrome Metabolica E un cluster
More informationEnergy used in kilojoules (kj) per day
Diet and exercise. This question is about food and energy. (a) Which person is likely to need the least amount of food? Person Amount of exercise Temperature of country where person lives high warm 2 high
More informationDiet and Weight Control. The Fattening of America: World Wide Epidemic 11/26/2011. Eating More of Just About Everything: 30 Year Comparison
Diet and Weight Control The Fattening of America: World Wide Epidemic Prevalence of overweight and obesity among adults in the U.S. 1984 1994 compared with 1999 2002 130 million Americans 65% of the population
More informationProfessional Diploma. in Nutrition. Module 1. Lesson 1: Health is Your Wealth EQF Level 5. Professional Diploma
Professional Diploma in Nutrition Module 1 Lesson 1: Health is Your Wealth EQF Level 5 Professional Diploma What is Anthropometry? External measurement of body composition Tells you how much of your weight
More informationSalt, soft drinks & obesity Dr. Feng He
Salt, soft drinks & obesity Dr. Feng He Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK f.he@qmul.ac.uk BP Salt CVD Obesity
More informationabout Eat Stop Eat is that there is the equivalent of two days a week where you don t have to worry about what you eat.
Brad Pilon 1 2 3 ! For many people, the best thing about Eat Stop Eat is that there is the equivalent of two days a week where you don t have to worry about what you eat.! However, this still means there
More information* Author to whom correspondence should be addressed; Tel.: ; Fax:
Int. J. Mol. Sci. 2014, 15, 6184-6223; doi:10.3390/ijms15046184 Review OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Obesity and Its Metabolic Complications:
More informationMetabolic Syndrome in Asians
Metabolic Syndrome in Asians Alka Kanaya, MD Asst. Professor of Medicine, UCSF Asian CV Symposium, November 17, 2007 The Metabolic Syndrome Also known as: Syndrome X Insulin Resistance Syndrome The Deadly
More informationSupplemental Information Supplementary Table 1. Tph1+/+ Tph1 / Analyte Supplementary Table 2. Tissue Vehicle LP value
Supplemental Information Supplementary Table. Urinary and adipose tissue catecholamines in Tph +/+ and Tph / mice fed a high fat diet for weeks. Tph +/+ Tph / Analyte ewat ibat ewat ibat Urine (ng/ml)
More informationPerioperative pathophysiology and the objectives behind Enhanced Recovery Care
Perioperative pathophysiology and the objectives behind Enhanced Recovery Care Francesco Carli, MD, MPhil McGill University Montreal, Canada franco.carli@mcgill.ca 60 patients (74 yo) Open colon resection
More informationFinal Review Sessions. 3/16 (FRI) 126 Wellman (4-6 6 pm) 3/19 (MON) 1309 Surge 3 (4-6 6 pm) Office Hours
Final Review Sessions 3/16 (FRI) 126 Wellman (4-6 6 pm) 3/19 (MON) 1309 Surge 3 (4-6 6 pm) Office ours 3/14 (WED) 9:30 11:30 am (Rebecca) 3/16 (FRI) 9-11 am (Abel) Final ESSENTIALS Posted Lecture 20 ormonal
More informationClinical Guidelines for the Hospitalized Adult Patient with Obesity
Clinical Guidelines for the Hospitalized Adult Patient with Obesity 1 Definition of obesity: Obesity is characterized by an excess storage of adipose tissue that is related to an imbalance between energy
More informationMolecular Mechanisms of Intestinal Lipid Transport and Metabolism. July 6-11, 2014 Base Village Conference Center Snowmass, CO
Molecular Mechanisms of Intestinal Lipid Transport and Metabolism July 6-11, 2014 Base Village Conference Center Snowmass, CO Co-Organizers: Dennis Black, MD (Chair) University of Tennessee Health Science
More informationUpper-body obesity, especially when associated. Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women
BRIEF REPORT Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women Esben Søndergaard, 1 Birgitte Nellemann, 1 Lars P. Sørensen, 1 Lars C. Gormsen, 2 Jens S. Christiansen, 1 Erik
More informationMobilisation des lipides du tissu adipeux et insulinorésistance. Dominique Langin
Obesity Research Laboratory Institut Universitaire de France Franco-Czech Laboratory for Clinical Research on Obesity Mobilisation des lipides du tissu adipeux et insulinorésistance Dominique Langin Séminaire
More informationTHE LONG RIDE THRESHOLD RIDES HILLS
THE LONG RIDE 6/10 effort focusing on building your time on the bike and developing your aerobic capacity. Start off riding at 65% of MHR (conversational pace). Gradually this will build to 75% of MHR
More informationUpper-body obesity, especially when associated. Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women
BRIEF REPORT Similar VLDL-TG Storage in Visceral and Subcutaneous Fat in Obese and Lean Women Esben Søndergaard, 1 Birgitte Nellemann, 1 Lars P. Sørensen, 1 Lars C. Gormsen, 2 Jens S. Christiansen, 1 Erik
More informationSHAW ACADEMY NOTES. Diploma in Health and Fitness
SHAW ACADEMY NOTES Diploma in Health and Fitness Lesson 3 Cardiovascular Exercise (Steady State and Interval Training) Notes What is cardiovascular exercise? (Cardio) Cardiovascular exercise Any exercise
More informationDOES INSULIN RESISTANCE CAUSE HYPERANDROGENEMIA OR HYPERANDROGENEMIA CAUSES INSULIN RESISTANCE IN PCOS
DOES INSULIN RESISTANCE CAUSE HYPERANDROGENEMIA OR HYPERANDROGENEMIA CAUSES INSULIN RESISTANCE IN PCOS D R. G A N A P A T H I. B D E P T. O F E N D O C R I N O L O G Y S T. J O H N S M E D I C A L C O
More informationBlake Vajgrt. HHP 312 Exercise Prescription. April 23, 2012
Blake Vajgrt HHP 312 Exercise Prescription April 23, 2012 Hansen, E., Landstad, B., Gundersen, K., Torjesen, P., & Svebak, S. (2012). Insulin sensitivity after maximal and endurance resistance training.
More informationClinical Treatment of Obesity in Older Women. Barbara Nicklas J. Paul Sticht Center on Aging
Clinical Treatment of Obesity in Older Women Barbara Nicklas J. Paul Sticht Center on Aging In my day, people died. In my day, people died. Trajectory of physical ability Functional Independence Impairment
More informationThe Female Training Advantages 2018 By Len Kravitz, Ph.D.
I. Benefits of resistance training for women The Female Training Advantages 2018 By Len Kravitz, Ph.D. A. Increase in bone mineral density, increase in fat-free mass, increase in muscular strength and
More informationThe John Sutton Memorial Lectureship: Interval Training in Health and Disease
The John Sutton Memorial Lectureship: Interval Training in Health and Disease Martin Gibala, PhD McMaster University Hamilton, Ontario @gibalam gibalam@mcmaster.ca www.martingibala.com The John Sutton
More informationTHE LONG RIDE THRESHOLD RIDES HILLS
THE LONG RIDE 6/10 effort focusing on building your time on the bike and developing your aerobic capacity. Start off riding at 65% of MHR (conversational pace). Gradually this will build to 75% of MHR
More information