Priscilla M. Clarkson Abbreviated Curriculum Vita

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1 Priscilla M. Clarkson Abbreviated Curriculum Vita Positions and Honors 2008 Distinguished Professor of Kinesiology 2008 Dean Commonwealth College, the Honors Colleges Professor, Department of Exercise Science (now called Kinesiology), University of Massachusetts Associate Professor, Department of Exercise Science, University of Massachusetts Assistant Professor, Department of Exercise Science, University of Massachusetts Board of Trustees of the American College of Sports Medicine, Lily Foundation Teaching Mentor for the University, President of the University Chapter of Sigma Xi, 1989 Fellow in the American Academy of Physical Education, April 1992 President of the New England Chapter of the American College of Sports Medicine, 1993 Vice President of the National American College of Sports Medicine, Presidents Lecture - National American College of Sports Medicine meeting, Cincinnati June 1996 Citation Award, The American College of Sports Medicine Chancellor s Medal, University of Massachusetts, 1997, Distinguished Faculty Lecturer President, American College of Sports Medicine, 2000 Honor Award, New England American College of Sports Medicine, 1999 Excellence in Education Award, Gatorade Sports Science Institute, 2001 Member of the Extended Duration Orbiter Program (NASA) - Exercise Countermeasures, Project Member of the Science Working Group NASA Member of the Advisory Board, International Life Science (ILSI), National Space Biomedical Research Institute, Board of Scientific Counselors, Committee on Military Nutrition: Assault Rations Subcommittee, Institute of Medicine, 2004 National Lipid Association Statin Safety: Muscle Expert Panel 2004 NCAA Competitive and Medical Safeguards Committee, Scientific Advisory Committee, The Cooperative International Neuromuscular Research Group 2003-present Director Collaborative Biomedical Research Program, UMass/Baystate Medical, Editor - International Journal of Sport Nutrition and Exercise Metabolism Member of the Pioneer Valley Life Science Board, 2008-present Editor-in-Chief Exercise and Sport Sciences Reviews 2005-present Honor Award National American College of Sports Medicine, 2005 Award for Outstanding Accomplishments in Research or Creative Activity, University of Massachusetts, 2005 Keynote, Wolffe Lecture, American College of Sports Medicine National, New Orleans, May 2007 Centennial Award, University of Massachusetts, 2008 Named Lecture, NEACSM 2010 B. Publications since 2000 (From Approximately 200) Decker EA, Clarkson PM. Dietary Sources and Bioavailability of Essential and Nonessential Antioxidants. In: Exercise and Oxygen Toxicity, 2nd edition. 2000, C.K.Sen, L.Packer, O. Hanninen. Elsevier:Amsterdam., pp , Clarkson PM. Trace minerals. International Olympic Committee. Encyclopaedia of Sports Medicine R.J. Maughan (ed.) Blackwell Science Ltd.: UK, pp , Clarkson PM, Manore MM. Nutritional and pharmacological ergogenic aids. In: Women in Sport. International Olympic Committee, Encyclopaedia of Sports Medicine. B.L. Drinkwater (ed.) Blackwell Science Ltd.: UK, pp , 2000.

2 Clarkson PM, Nutritional considerations for the active adolescent. In: Lifestyle Medicine, Ed. J. M. Rippe. Blackwell Science: Malden, MA, pp , Clarkson PM, Thompson H.. Antioxidants: What are they and what role do they play in physical activity and health? American Journal of Clinical Nutrition, 2000, 72:637S-646S. Rinard J, Clarkson PM, Smith LL, Grossman M. Response of males and females to high-force eccentric exercise. Journal of Sports Sciences, 2000, 18 (4): Taylor JM, Clarkson PM, Miles MP, Thompson HS, and DeSouza MJ. Hormonal responses to an acute bout of resistance exercise in weight trained and non-weight trained females. Journal of Strength and Conditioning Research, 2000, 14(2): Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJM, Williams MH. The physiological and health effects of oral creatine supplementation, Medicine and Science in Sports and Exercise, 2000, 32 (3): Clarkson PM, Maughan RJ. Growing into the new millennium. International Journal of Sport Nutrition, editorial, 2000, 10 (2): V. Rawson ES, Clarkson PM. Creatine supplementation: As athlete s friend or foe? International Sportmed Journal (on line e-journal) 1(1), 2000, March. Sacheck JM, EA Decker ES, Clarkson PM. The effect of diet on vitamin E intake and oxidative stress in response to acute exercise in female athletes European Journal of Applied Physiology, 2000, vol 83: pp Sayers SP, Clarkson PM, and Lee J. The effect of activity and immobilization following eccentric exercise: Part I. Recovery of muscle function. Medicine and Science in Sport and Exercise, 2000, 32: Sayers SP, Clarkson PM, and Lee J. The effect of activity and immobilization following eccentric exercise: Part II. Serum Creatine Kinase. Medicine and Science in Sport and Exercise, 2000, 32: Sayers SP and Clarkson PM. Force recovery after eccentric exercise in males and females. European Journal of Applied Physiology, 2001, 84: Sayers SP, Knight CA, Clarkson PM, van Wegen EH, Kamen G. Effect of ketoprofen on muscle function and semg activity after eccentric exercise, 2001, Medicine and Science in Sport and Exercise, I33: Rawson E, Gunn BA, Clarkson PM. The effects of creatine supplementation on exercise- induced muscle damage. Journal of Strength and Conditioning Research, 2001, 15: Burns J, Clarkson PM, et al. Why don t athletes drink enough during exercise, and what can be done about it? Sports Science Exchange Roundtable, , 1-4. Thompson HS, Scordilis SP, Clarkson PM, and Lohrer WA. A single bout of eccentric exercise increases HSP27 and HSC/HSP70 in human skeletal muscle. Acta Physiologica Scandinavica, 2001, 171: Clarkson PM, Hubal MJ. Are women less susceptible to exercise-induced muscle damage? Curr Opin Clin Nutr Metab Care Nov;4(6):

3 Rawson ES, Clarkson PM, Price TB, Miles MP. Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand Jan;174(1): Thompson HS, Clarkson PM, Scordilis SP. The repeated bout effect and heat shock proteins: intramuscular HSP27 and HSP70 expression following two bouts of eccentric exercise in humans. Acta Physiol Scand Jan;174(1): Sayers SP, Clarkson PM. Exercise-induced rhabdomyolysis. Current Sports Medicine Reports, 2002, 1: Sayers SP and Clarkson PM. Metabolic response to light exercise after exercise-induced rhabdomyolysis. European Journal of Applied Physiology, 2002, 86: Savage K and ClarksonP. Oral contraceptive use and exercise-induced muscle damage and recovery. Contraception, 2002, 66(1): Clarkson PM. Exertional rhabdomyolysis: myths and madness. Am. J. Med. Sports, 2002, 4: Clarkson, PM Does antioxidant supplementation reduce muscle damage from oxygen free radicals? IOC Handbook of Sports Nutrition, Clarkson PM. Fueling the Dancer. Position Statement, International Association for Dance Medicine & Science, Rawson E. and Clarkson PM. Ephedrine as an ergogenic aid. Performance-enhancing Substances in Sport and Exercise, Eds. M.S. Bahrke and C.E. Yesalis, Human Kinetics; Champaign, IL, pp , Clarkson PM and Persky A. Steroid misuse in athletes: effects on skeletal muscle. Skeletal Muscle: Pathology, Diagnosis, and Management of Disease. Eds. VR Preedy and TJ Peters, Greenwich Medical Media Limited, London, pp , Clarkson PM and Hubal MJ. Exercise-induced muscle damage in humans. Am. J. Phys. Med. Rehabil., 2002, 81 (11), S52-S69. Lee J. and PM Clarkson. Plasma creatine kinase activity and glutathione after eccentric exercise. Medicine & Science in Sports & Exercise, 2003, 35: Sayers SP, Knight CA, Clarkson PM. Neuromuscular variables affecting the magnitude of force loss after eccentric exercise. J Sports Sci., 2003, 21(5): Sayers SP, Peters BT, Knight CA, Urso ML, Parkington J, Clarkson PM. Short-term immobilization after eccentric exercise. Part I. contractile properties. Medicine and Science in Sports and Exercise, 2003, 35: Sayers SP and Clarkson PM. Short-term immobilization after eccentric exercise. Part II. CK and myoglobin. Medicine and Science in Sports and Exercise, 2003, 35: Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM. Molecular responses of human muscle to eccentric exercise. J Appl Physiol. 2003, Dec; 95(6)L Bakay M, Zhao P, Chen Y-W, ClarksonP, Schneiderman B, and Hoffman EP. Interactive color mosaic and dendrogram displays for signal/noice optimization in microarray data analysis. IEEE International Conference on Multimedia and Expo III: , 2003.

4 Thompson PD, Clarkson P, Karas RH. Statin associated myopathy. Journal of the American Medical Association. 2003, 289 (13): Clarkson PM and Urso M. Oxidative Stress, Exercise, and Antioxidant Supplementation. Antioxidant Nutrients and Environmental Health, Journal of Toxicology, 2003, 5;189(1-2): Rawson ES and Clarkson PM Scientifically debatable: Is creatine worth its weight. Sport Science Exchange, 2003, 16:1-5. Springer BL and Clarkson PM. Two cases of exertional rhabdomyolysis precipitated by personal trainers. Med Sci Sports Exerc., 2003, Sep;35(9): Molon A, DiGiovanni S, Chen Y-W, Clarkson P, Angelini C, Pegoraro E, and Hoffman, EP. Large-scale disruption of microtubule pathways in morphologically normal human spastin muscle. Neurology, 2004, 13;62(7): Rawson ES, Persky AM, Price TB, Clarkson PM. Effects of repeated creatine supplementation on muscle, plasma, and urine creatine levels. J Strength Cond Res., 2004, 18(1): Thompson PD, Moyna N, Seip R, Price T, Clarkson P, Angelopoulos T, Gordon P, Pescatello L, Visich P, Zoeller R, Devaney JM, Gordish H, Bilbie S, Hoffman EP. Functional polymorphisms associated with human muscle size and strength. Med Sci Sports Exerc., 2004, 36(7): Clarkson, PM., Devaney, JM., Gordish-Dressman, H., Thompson, PD., Hubal, MJ., Urso, M., Price, TB., Angelopoulos, TJ., Gordon, PM., Moyna, NM., Pescatello, LS., Visich, PS., Zoeller, RF., Seip, RL., Hoffman, EP. ACTN3 Genotype is Associated with Increases in Muscle Strength and Response to Resistance Training in Women. J Appl Physiol Jul;99(1): Clarkson, PM., Hoffman, EP., Zambraski, E., Gordish-Dressman, H., Kearns, A., Hubal, M., Harmon, B., Devaney, JM. ACTN3 and MLCK Genotype Associations with Exertional Muscle Damage. J Appl Physiol Aug;99(2): Hubal MJ, Gordish-Dressman H, Thompson PD, Price TB, Hoffman EP, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Clarkson PM. Variability in Muscle Size and Strength Gain after Unilateral Resistance Training. Med Sci Sports Exerc Jun;37(6): Gordon ES, Gordish-Dressman HA, Devaney J, Clarkson P, Thompson P, Gordon P, Pescatello LS, Hubal MJ, Pistilli EE, Gianetti G, Kelsey B, Hoffman EP. Nondisease genetic testing: reporting of muscle SNPs shows effects on self-concept and health orientation scales. Eur J Hum Genet Sep;13(9): Casa DJ, Clarkson PM, Roberts WO. American College of Sports Medicine roundtable on hydration and physical activity: Consensus statements. Curr Sports Med Rep Jun;4(3): Bergeron MF, McKeag DB, Casa DJ, Clarkson PM, Dick RW, Eichner ER, Horswill CA, Luke AC, Mueller F, Munce TA, Roberts WO, Rowland TW. Youth football: heat stress and injury risk. Med Sci Sports Exerc Aug;37(8): Clarkson, PM. Mentoring. ACSM Fellows Offer Advice to Students. American College of Sports Medicine publication, 2005.

5 Warren GL, O'farrell L, Rogers KR, Billings KM, Sayers SP, Clarkson PM. CK-MM autoantibodies: Prevalence, immune complexes, and effect on CK clearance. Muscle Nerve Sep;34(3): Pescatello LS, Kostek MA, Gordish-Dressman H, Thompson PD, Seip RL, Price TB, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Devaney JM, Hoffman EP. ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Exerc Jun;38(6): Urso ML, Scrimgeour AG, Chen YW, Thompson PD, Clarkson PM. Analysis of Human Skeletal Muscle after 48h Immobilization Reveals Alterations in mrna and Protein for Extracellular Matrix Components. J Appl Physiol Jun 8; Oct;101(4): Clarkson PM, Kearns AK, Rouzier P, Rubin R, Thompson PD. Serum creatine kinase levels and renal function measures in exertional muscle damage. Med Sci Sports Exerc Apr;38(4): Clarkson PM. Case report of exertional rhabdomyolysis in a 12-year-old boy. Med Sci Sports Exerc Feb;38(2): Urso ML, Clarkson PM, Price TB. Immobilization effects in young and older adults. Eur J Appl Physiol Mar;96(5): Urso ML, Clarkson PM, Hittel D, Hoffman EP, Thompson PD. Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins. Arterioscler Thromb Vasc Biol Dec;25(12): Thompson PD, Clarkson PM, Rosenson RS; The National Lipid Association Statin Safety Task Force Muscle Safety Expert Panel. An assessment of statin safety by muscle experts. Am J Cardiol Apr 17;97(8A):69C- 76C. Clarkson PM, Eichner ER. Exertional rhabdomyolysis: does elevated blood creatine kinase foretell renal failure? Curr Sports Med Rep Apr;5(2): Urso ML, Chen YW, Scrimgeour AG, Lee PC, Lee KF, Clarkson PM. Alterations in mrna Expression and Protein Products Following Spinal Cord Injury in Humans.J. Physiol Mar 15;579(Pt 3): Kostek MA, Pescatello LS, Seip RL, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Thompson PD, Hoffman EP, Price TB. Subcutaneous fat alterations resulting from an upper-body resistance training program. Med Sci Sports Exerc Jul;39(7): Pescatello LS, Kelsey BK, Price TB, Seip RL, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Gordish-Dressman HA, Bilbie SM, Thompson PD, Hoffman EP.The muscle strength and size response to upper arm, unilateral resistance training among adults who are overweight and obese. J Strength Cond Res May;21(2): Hubal MJ, Rubinstein SR, Clarkson PM.Mechanisms of variability in strength loss after muscle-lengthening actions.med Sci Sports Exerc Mar;39(3): Clarkson, PM. Exertional rhabdomyolysis and acute renal failure in marathon runners. Sports Med. 2007;37(4-5): Pistilli EE, Gordish-Dressman H, Seip RL, Devaney JM, Thompson PD, Price TB, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Hoffman EP, Gordon PM. Resistin polymorphisms are

6 associated with muscle, bone, and fat phenotypes in white men and women. Obesity (Silver Spring) Feb;15(2): Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM. IGF-II gene region polymorphisms related to exertional muscle damage. J Appl Physiol May;102(5): Uthurralt J, Gordish-Dressman H, Bradbury M, Tesi-Rocha C, Devaney J, Harmon B, Reeves EK, Brandoli C, Hansen BC, Seip RL, Thompson PD, Price TB, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Gordon PM, Hoffman E. PPPAR alpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males. BMC Med Genet Aug 16;8(1):55. Sewright KA, Clarkson PM, Thompson PD. Statin myopathy: incidence, risk factors, and pathophysiology. Curr Atheroscler Rep Nov;9(5): Sewright KA, Hubal MH, Kearns A, Holbrook MT, Clarkson PM. Sex differences in response to maximal eccentric exercise. Med Sci Sports Exerc Feb;40(2): Kearns AK, Bilbie CL, Clarkson PM, White CM, Sewright KA, O'Fallon KS, Gadarla M, Thompson PD. The creatine kinase response to eccentric exercise with atorvastatin 10mg or 80mg. Atherosclerosis Feb 6; Orkunoglu-Suer FE, Gordish-Dressman H, Clarkson PM, Thompson PD, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Harmon B, Seip RL, Hoffman EP, Devaney JM. INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men. BMC Med Genet Dec 23;9:117. Hubal MJ, Rubinstein SR, Clarkson PM. Muscle function in men and women during maximal eccentric exercise. J Strength Cond Res Jul;22(4): Pistilli EE, Devaney JM, Gordish-Dressman H, Bradbury MK, Seip RL, Thompson PD, Angelopoulos TJ, Clarkson PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Gordon PM, Hoffman EP. Interleukin-15 and interleukin-15r alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine Jul;43(1): Hubal MJ, Chen TC, Thompson PD, Clarkson PM. Inflammatory gene changes associated with the repeated-bout effect. Am J Physiol Regul Integr Comp Physiol May;294(5):R Rother M, Seidel EJ, Clarkson PM, Mazgareanu S, Vierl U, Rother I. Efficacy of epicutaneous Diractin (ketoprofen in Transfersome gel) for the treatment of pain related to eccentric muscle contractions. Drug Des Devel Ther Sep 21;3: Zoeller RF, Angelopoulos TJ, Thompson BC, Wenta MR, Price TB, Thompson PD, Moyna NM, Seip RL, Clarkson PM, Gordon PM, Pescatello LS, Devaney JM, Gordish-Dressman H, Hoffman EP, Visich PS. Vascular remodeling in response to 12 wk of upper arm unilateral resistance training. Med Sci Sports Exerc Nov;41(11): Lowndes J, Carpenter RL, Zoeller RF, Seip RL, Moyna NM, Price TB, Clarkson PM, Gordon PM, Pescatello LS, Visich PS, Devaney JM, Gordish-Dressman H, Hoffman EP, Thompson PD, Angelopoulos TJ. Association of age with muscle size and strength before and after short-term resistance training in young adults. J Strength Cond Res Oct;23(7):

7 Walsh S, Kelsey BK, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Seip RL, Bilbie S, Thompson PD, Hoffman EP, Price TB, Devaney JM, Pescatello LS. CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training. J Appl Physiol Oct;107(4): Moeckel-Cole SA, Clarkson PM. Rhabdomyolysis in a collegiate football player. J Strength Cond Res Jul;23(4): Devaney JM, Tosi LL, Fritz DT, Gordish-Dressman HA, Jiang S, Orkunoglu-Suer FE, Gordon AH, Harmon BT, Thompson PD, Clarkson PM, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Brandoli C, Hoffman EP, Rogers MB. Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element. J Cell Biochem Aug 15;107(6): Kostek MA, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Price TB, Seip RL, Thompson PD, Devaney JM, Gordish-Dressman H, Hoffman EP, Pescatello LS. Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. Med Sci Sports Exerc May;41(5): Yu JG, Sewright K, Hubal MJ, Liu JX, Schwartz LM, Hoffman EP, Clarkson PM. Investigation of gene expression in C(2)C(12) myotubes following simvastatin application and mechanical strain. J Atheroscler Thromb Mar;16(1):21-9. Hubal MJ, Clarkson PM. Counterpoint: Estrogen and sex do not significantly influence post-exercise indexes of muscle damage, inflammation, and repair. J Appl Physiol Mar;106(3):1012-4; discussion 1014, Thompson PD, Parker BA, Clarkson PM, Pescatello LS, White CM, Grimaldi AS, Levine BD, Haller RG, Hoffman EP. A randomized clinical trial to assess the effect of statins on skeletal muscle function and performance: rationale and study design. Prev Cardiol Summer;13(3): Kostek MC, Devaney JM, Gordish-Dressman H, Harris TB, Thompson PD, Clarkson PM, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Garcia M, Li R, Zmuda JM, Delmonico MJ, Kanaya A, Hoffman EP. A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study. Eur J Appl Physiol Sep;110(2): Hubal MJ, Devaney JM, Hoffman EP, Zambraski EJ, Gordish-Dressman H, Kearns AK, Larkin JS, Adham K, Patel RR, Clarkson PM. CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol Jun;108(6): Clarkson PM, Kaufman SA. Should resistance exercise be recommended during breast cancer treatment? Med Hypotheses Aug;75(2): Hyldahl RD, Keadle J, Rouzier PA, Pearl D, Clarkson PM. Effects of ibuprofen topical gel on muscle soreness. Med Sci Sports Exerc Mar;42(3): Orkunoglu-Suer FE, Harmon BT, Gordish-Dressman H, Clarkson PM, Thompson PD, Angelopoulos TJ, Gordon PM, Hubal MJ, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Hoffman EP, Devaney JM. MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females. Obesity (Silver Spring) Aug 19. [Epub ahead of print]

8 Reich KA, Chen YW, Thompson PD, Hoffman EP, Clarkson PM. 48 hours of Unloading and 24 hours of Reloading Leads to Changes in Global Gene Expression Patterns Related to Ubiquitination and Oxidative Stress in Humans. J Appl Physiol Aug 26. [Epub ahead of print] Hyldahl RD, O'Fallon KS, Schwartz LM, Clarkson PM. Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro model. J Appl Physiol Aug 26. [Epub ahead of print]