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1 Research OBSTETRICS Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia Justin Brewer, MD; Michelle Y. Owens, MD; Kedra Wallace, PhD; Amanda A. Reeves, MD; Rachael Morris, MD; Majid Khan, MD; Babbette LaMarca, PhD; James N. Martin Jr, MD OBJECTIVE: We sought to investigate the concurrence of posterior reversible encephalopathy syndrome (PRES) with eclampsia and to describe the obstetric, radiological, and critical care correlates. STUDY DESIGN: This was a single-center, retrospective cohort study of all patients with eclampsia who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. RESULTS: Forty-six of 47 of eclamptic patients (97.9%) revealed PRES on neuroimaging using 1 or more modalities: MRI without contrast, 41 (87.2%); MRI with contrast, 27 (57.4%); CT without contrast, 16 (34%); CT with contrast, 7 (14.8%); and/or magnetic resonance angiography/ magnetic resonance venography, 2 (4.3%). PRES was identified within the parietal, occipital, frontal, temporal, and basal ganglia/brainstem/ cerebellum areas of the brain. Eclampsia occurred antepartum in 23 patients and postpartum in 24 patients. Headache was the most common presenting symptom (87.2%) followed by altered mental status (51.1%), visual disturbances (34%), and nausea/vomiting (19.1%). Severe systolic hypertension was present in 22 patients (47%). CONCLUSION: The common finding of PRES in patients with eclampsia suggests that PRES is a core component of the pathogenesis of eclampsia. Therapy targeted at prevention or reversal of PRES pathogenesis may prevent or facilitate recovery from eclampsia. Key words: cerebral imaging, eclampsia, posterior reversible encephalopathy syndrome Cite this article as: Brewer J, Owens MY, Wallace K, et al. Posterior reversible encephalopathy syndrome in 46 of 47 patients with eclampsia. Am J Obstet Gynecol 2013;208:468.e1-6. From the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L. Wiser Hospital for Women and Infants (Drs Brewer, Owens, Wallace, Reeves, Morris, LaMarca, and Martin), and the Department of Radiology and Neurology/Neurosciences (Dr Khan), University of Mississippi Medical Center, Jackson, MS. Received Sept. 28, 2012; revised Jan. 4, 2013; accepted Feb. 5, This study was supported by the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center. The authors report no conflict of interest. Reprints not available from the authors /$ Mosby, Inc. All rights reserved. Posterior reversible encephalopathy syndrome (PRES) was first described in 1996 by Hinchey et al. 1 In this case series of 15 patients, the authors described a condition marked by headache, altered mental status, seizures, and visual changes. These patients were also found to display extensive white-matter changes suggestive of posterior cerebral edema. This group first named this syndrome reversible posterior leukoencephalopathy syndrome, but it has also been known by many other names including PRES, hyperperfusion encephalopathy, brain capillary leak syndrome, and hypertensive encephalopathy. 1 PRES has been associated with many conditions including eclampsia, severe hypertension, autoimmune disease, treatment with cytotoxic medications, posttransplantation immunosuppression, and infection with sepsis to name a few. 2 Generalized seizures are often the most common clinical manifestation of PRES, but patients will also present with signs of encephalopathy such as altered mental status, headaches, nausea, and vomitting. 2-4 Visual disturbances are also common, varying from mild blurry vision to complete cortical blindness. 3 Hypertension is associated with the majority of cases, although blood pressure may be normal or only mildly elevated in up to 20-30% of cases. 5 In the series of 36 patients presented by Lee et al, 3 the mean systolic blood pressure was 187 mm Hg (range, mm Hg) within 24 hours of presentation. Laboratory findings can also vary, depending on the underlying associated condition. Neuroimaging findings of PRES have been described in scores of eclamptic patients since the 1996 report of Hinchey et al, 1 usually in single case reports or small case series. How often PRES occurs in association with eclampsia is unknown. To our knowledge, there is no large patient series exploring the relationship between eclampsia and the concurrence of PRES. The purpose of this study was to determine what percentage of eclamptic women at our institution displayed findings of PRES when neuroimaging studies were undertaken. We also sought to determine which treatment modalities were used to manage these patients and to explore how well these interventions had an impact on overall patient outcome. MATERIALS AND METHODS This project was a single-center, retrospective cohort study inclusive of the years , which was approved by the institutional review board at the University of Mississippi Medical Center. Inclusion criteria were pregnancy or within 6 weeks postpartum; neuroimaging via magnetic resonance imaging (MRI) or MRI and/or magnetic reso- 468.e1 American Journal of Obstetrics & Gynecology JUNE 2013
2 Obstetrics Research TABLE 1 Patient demographics based on when seizure occurred Demographic Antepartum, n (%) (n 23) nance angiography (MRA) and/or computerized tomography (CT) performed during hospitalization; and diagnosis of eclampsia. Exclusion criteria included not being pregnant or longer than 6 weeks postpartum; no diagnosis of eclampsia; MRI or MRA neuroimaging not performed during hospitalization; diagnosis of cerebral hemorrhage; known seizure disorder; and later diagnosis of seizure from a source other than eclampsia. We investigated all women considered to have eclampsia who underwent neuroimaging studies upon admission to our tertiary care referral hospital. Cases to be investigated were determined based on a discharge diagnosis of eclampsia. The appropriate charts were collected, and the women who underwent neuroimaging were selected for study. The majority of these patients underwent imaging within the first 24 hours after admission. Postpartum, n (%) (n 24) P value Maternal race.729 African American 19 (83) 19 (79) White 3 (13) 4 (17) Hispanic 1 (4) 1 (4)... Maternal age, y Maternal BMI, kg/m Gravida.777 Nulliparous 12 (52) 13 (54) Multiparous 11 (48) 11 (46)... Gestational age, wks Mode of delivery.001 Vaginal 6 (26%) 16 (67%) Cesarean section 17 (74%) 8 (33%)... HTN (systolic), mm Hg (17) 4 (17) (44) a 7 (29) (26) 13 (54) b (13) c 0 (0)... Days in-house BMI, body mass index; HTN, hypertension. a Significant compared with women with postpartum eclampsia; b Significant compared with women with antepartum eclampsia; c Significant compared with women with postpartum eclampsia. Brewer. PRES and eclampsia. Am J Obstet Gynecol The medical records of patients with eclampsia who underwent cranial imaging were identified, evaluated, and pertinent data extracted. If neuroimaging was not undertaken for an eclamptic patient, no further data accrual was undertaken. Imaging analysis The imaging modalities used included MRI, MRA, and CT both with and without contrast. The diagnosis of PRES was made by radiologists using the standard radiological criteria for PRES. PRES has a unique MRI and CT imaging appearance, which is demonstrated as subcortical and gyral T2-weighted and fluid attenuated inversion recovery (FLAIR) signal hyperintensities that become more diffuse as the extent of edema increases. Focal areas include symmetric multilobar/hemispheric edema with predominant involvement of parietal and occipital lobes. In addition, frontal lobes and the inferior temporal-occipital junction are also focal areas, less commonly the cerebellum. 5 This group of women included both antepartum and postpartum eclampsia. Statistical analysis Maternal race, gravida, mode of delivery, systolic hypertension, imaging modality, site of lesions, and treatment modality was analyzed via a 2 analysis. Maternal age, body mass index (BMI), gestational age at delivery, days in-house, and the time to return to normalcy were analyzed using a Student t test. Data are expressed as mean SD. A P.05 was considered significant. RESULTS Forty-seven of 123 women considered to have eclampsia (38.2%) underwent neuroimaging studies during the 10 year period of at our academic institution. The findings from all 47 patients who underwent neuroimaging are reported in the current study. Among the 47 study subjects were 23 women with antepartum eclampsia and 24 women with postpartum eclampsia. In cases of postpartum eclampsia, on average, the patient experienced her first seizure on day 6 (range, 0 14 days). There was not a significant difference in self-reported maternal ethnicity between women with antepartum and postpartum eclampsia (P.729; Table 1). Neither were there any significant differences in maternal age (P.506), maternal BMI (P.143), or gravidity (P.777; Table 1) between the 2 groups. Women who had antepartum eclampsia primarily delivered via cesarean section (74%), whereas 67% of the women with postpartum eclampsia had vaginal deliveries (P.001; Table 1). Women with antepartum eclampsia also delivered earlier than women with postpartum eclampsia (P.002; Table 1) and had a longer hospital stay than women with postpartum eclampsia (P.026; Table 1). There was a significant difference in systolic pressures between women with antepartum or postpartum eclampsia (P.001; Table 1). Significantly more JUNE 2013 American Journal of Obstetrics & Gynecology 468.e2
3 Research Obstetrics TABLE 2 Results for MRI and CT for patients with PRES Variable Antepartum, n (%) (n 23) women with antepartum eclampsia (44%) had systolic blood pressures between 140 and 159 mm Hg (P.039; Table 1) compared with women with postpartum eclampsia, whereas 54% of women with postpartum eclampsia had systolic blood pressures between 160 and 180 mm Hg, which was significantly more compared with women with antepartum eclampsia (P.0001; Table 1). In addition, no women with antepartum eclampsia developed systolic pressures greater than 180 mm Hg, whereas 13% of women with antepartum eclampsia had systolic pressures greater than 180 mm Hg (P.002; Table 1). All study subjects had singleton gestations. There were no maternal deaths in the current study. Headache was the most common presenting symptom (87.2%) followed by altered mental status (51.1%), visual disturbance (34%), and nausea/vomiting (19.1%). A diagnosis of PRES was made in 46 of 47 women (97.9%) who were considered to have eclampsia. This diagnosis was made using 1 or more imaging modalities including MRI without contrast (n 41), MRI with contrast (n 27), CT without contrast (n 16), CT with contrast (n 7), and/or MRA/ magnetic resonance venography (n 2). There was not a significant difference in the imaging modality used when women with antepartum eclampsia were compared with women with postpartum eclampsia (P.984; Table 2). Radiological evidence of PRES was found in multiple sites between women who developed eclampsia in the antepartum (87%) and postpartum (88%) periods. There was not a significant difference in the site of lesions between the 2 groups (P.705; Table 2). Full data regarding the use of various treatment modalities were available for 38 of the 47 patients (80.8%) and is reported in Table 2. Magnesium sulfate given as an initial intravenous bolus followed by a continuous infusion was utilized all of these women. Supplemental therapies included intravenous antihypertensives (labetalol, hydralazine, or nifedipine), diuretic agents, and potent glucocorticoids. The corticosteroids used in these patients included either intravenous (IV) dexamethasone or betamethasone for enhanced fetal lung maturation or maternal treatment for concurrent hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. 6 There was a significant difference in treatment modality, in which women with antepartum eclampsia were treated with steroids significantly (P.001) more often than women with postpartum eclampsia. We made an intensive effort in this retrospective study to determine the length of time that it took for these women to return to normalcy following the initial eclamptic seizure and whether the use of various treatments altered this time period. Normalcy was defined clinically as the absence of visual problems, headache, nausea/vomiting, or altered sensorium. The mean time from seizure to normalcy was 36.5 hours when a diuretic was given, 34.8 hours when antihypertensives were given, and 32.9 hours when corticosteroids (IV dexamethasone) were Postpartum, n (%) (n 24) P value Imaging modality used.984 MRI without contrast 20 (87) 21 (88) MRI with contrast 14 (61) 13 (54) CT without contrast 8 (35) 8 (33) CT with contrast 3 (13) 4 (17) MRA/MRV 1 (4) 1 (4)... Site of lesion.705 Occipital lobe 18 (78) 17 (71) Parietal lobe 17 (74) 19 (79) Temporal lobe 6 (26) 7 (29) Frontal lobe 12 (52) 17 (71) Basal ganglia/cerebellum 5 (22) 6 (25) Multiple areas 20 (87) 21 (88)... Treatment modality used (results from patients reported) Magnesium sulfate 19 (100) 19 (100) Antihypertensives 17 (89) 16 (84) Diuretic 13 (68) 12 (63) Steriods a 13 (68) 6 (32)... CT, computerized tomography; MRA/MRV, magnetic resonance angiography/magnetic resonance venography; MRI, magnetic resonance imaging; PRES, posterior reversible encephalopathy syndrome. a Women with antepartum eclampsia were treated with steroids significantly more often than women with postpartum eclampsia. Brewer. PRES and eclampsia. Am J Obstet Gynecol utilized (range, hours for all interventions because the patients with the shortest and longest stays received all 3 treatments). For the 19 patients who received corticosteroids after the initial seizure, the mean time between steroid initiation and a return to normalcy was 17 hours. The Figure demonstrates the time to return to normalcy based on antepartum and postpartum eclampsia. There was not a significant difference between the groups when magnesium sulfate was administered (P.977), with or without antihypertensives (P.955), diuretics (P.778), or steroids (P.829; Figure). COMMENT The present series of patients is the largest single institutional series of imaged eclamptic patients with evidence of PRES in the United States that has been published to date. Consistent with the 468.e3 American Journal of Obstetrics & Gynecology JUNE 2013
4 Obstetrics Research FIGURE Treatment modality does not affect the time to return to normalcy The time to return to normalcy after the initial eclamptic seizure was compared between women with antepartum eclampsia and women with postpartum eclampsia. Data from 38 patients was collected and is represented as the mean time SD. Brewer. PRES and eclampsia. Am J Obstet Gynecol recently published summary of current knowledge about PRES by Sraykov and Schwab, 2 the current study revealed several important findings that are suitable for emphasis. First, advanced neuroimaging techniques such as magnetic resonance imaging and/or computerized tomography indicated the presence of PRES in every patient with eclampsia; a single patient without evidence of PRES was later determined to have an underlying seizure disorder. Second, although headache (87%) and visual disturbance (34%) were common symptoms presaging eclampsia and PRES, they were not universal nor was severe systolic hypertension (47%) a constant feature. Third, PRES was identified often in multiple areas of the brain, not just the occipital region, consistent with the findings of others. 7 In addition, the results from this study reconfirms a recent study from the Mayo Clinic, in which all eclamptic patients who underwent imaging had clinical and radiological findings of PRES. 8 Of great importance, the authors believe that aggressive comprehensive and meticulous medical management may have been a factor in facilitating complete maternal recovery over a usually brief hospitalization averaging 4 days without a single maternal death. The evidence from our report supports the hypothesis that PRES is the primary central nervous system injury in patients with eclampsia. Some of the changes in normal pregnancy include substantially increased levels of vasoangiogenic growth factors and cytokines into the maternal circulation. However, during normal pregnancy the blood-brain barrier (BBB) adapts to prevent these circulating permeability factors from entering the brain and leading to vasogenic brain edema. 9,10 Interestingly plasma from preeclamptic women has been found to increase BBB permeability, thereby suggesting that an increase in BBB permeability could permit passage of damaging antivasogenic and antiendothelial proteins into the brain to cause the neurological complications of eclampsia. 11 Because not all patients with eclampsia exhibit significant hypertension or substantial proteinuria prior to the first seizure and because brain imaging with MRI prior to seizure in eclamptic women has revealed evidence of vasogenic edema, 12,13 the primary explanation for the pathogenesis of neurological symptoms and cerebral edema formation during eclampsia is that it represents a form of PRES like that seen in other disease processes such as hypertensive encephalopathy. 14 With PRES there is a loss of autoregulatory capacity, BBB disruption, and subsequent vasogenic edema around cerebral arteries and arterioles. 15,16 Socalled normotensive eclampsia may actually represent a clinical state caused by diminished autoregulatory capacity or enhanced permeability of the BBB or both In addition, PRES has been demonstrated in a patient with severe preeclampsia without seizure, and it has been demonstrated to precede eclamptic convulsion. 22 These findings are suggestive of PRES as an antecedent to eclamptic seizure as opposed to the result of an eclamptic seizure. The cerebral pathology of patients with severe preeclampsia who suffer seizure(s) may be due to microangiopathy of the cerebral vessels, often with hypertension contributing. Microangiopathy and/or malfunction of the cerebral vasculature may be related to circulating levels of antiangiogenic factors such as soluble fms-like tyrosine-1 (sflt-1) and soluble endoglin (seng), which have been demonstrated to be at higher levels in patients with eclampsia compared with those with severe preeclampsia. 23,24 In some animals exposed to high levels of sflt-1 and seng, researchers have observed choroid plexus with the loss of endothelial fenestrae resembling the glomerular endotheliosis of preeclampsia. 25 Interestingly, a study by Fugate et al 26 found that 45% of women with PRES also had autoimmune disease, which implicates endothelial dysfunction as a possible pathophysiological mechanism. Women with preeclampsia and animal models of preeclampsia, in which endothelial dysfunction is a key feature, also have some of the characteristics of autoimmune disease, such as increases in interleukin-17 and T helper 17 lymphocytes. 27,28 Treatment of eclampsia, and thus PRES, is best accomplished using magnesium sulfate; however, the effect of magnesium sulfate in the prevention and treatment of eclampsia likely is multifactorial In the peripheral vasculature or cerebrovasculature, magnesium sul- JUNE 2013 American Journal of Obstetrics & Gynecology 468.e4
5 Research Obstetrics fate may act as a vasodilator to decrease peripheral resistance or relieve vasoconstriction. In the central nervous system, magnesium sulfate may also protect the BBB and thereby limit cerebral edema formation as well as act through a central anticonvulsant action. 29 Control of hypertension is also considered a core management component for PRES treatment. 2 Antihypertensive treatment using intravenous labetalol, hydralazine, or nicardipine is usually recommended for the prevention of severe systolic hypertension of more than 160 mm Hg and/or severe diastolic hypertension of more than mm Hg. 32,33 Gradual correction to target levels of mm Hg systolic and mm Hg diastolic are advisable to protect the mother and to avert compromised uteroplacental blood flow. Intravenous dexamethasone is widely used for the treatment of cerebral edema, especially in patients with intracranial tumors because of its long biological halflife, its low mineralocorticoid activity, and its well-described effect in minimizing vasogenic peritumoral edema In addition to these clinical data, studies in experimental animals have shown that administration of IV dexamethasone leads to a reduction of poststroke brain edema. 37 Thus, there is accumulating evidence to suggest a possible role for potent glucocorticoids along with magnesium sulfate and blood pressure control in pregnant patients with PRES/eclampsia. 38 This is supported by our findings in the present study showing faster normalization of central nervous system function following eclampsia when IV dexamethasone is given for HELLP syndrome or intramuscular betamethasone is given to enhance fetal lung maturation. The current study used MRI and CT imaging to identify the abnormal T2/ FLAIR signals associated with PRES. Diffusion-weighted imaging is also capable of distinguishing between vasogenic and cytotoxic edema and can be used to identify PRES. Differentiating the underlying etiology of PRES based on imaging alone is not possible at this time, despite the advanced imaging techniques (ie, brain perfusion imaging, magnetic resonance spectroscopy), but as the current study and others have shown, neuroimaging in conjunction with clinical diagnosis can help identify eclamptic patients with PRES. 8 Our study shares the same shortcomings of any retrospective investigation, including selection bias. Because of logistical, cost, or consideration of value to patient management in individual cases, only 47 of 123 eclamptic patients had neuroimaging requested by the physicians who were caring for this patient group. In addition, we do not have information regarding women with severe preeclampsia who had neuroimaging. There was no consistent protocol in place to direct who would or who would not undergo neuroimaging, which introduces a selection bias in regard to the patients who were neuroimaged; utilization increased during the last half of the decade that spanned the course of study as greater interest in the information provided led to more frequent ordering of the test. It is possible that a smaller percentage of eclamptic patients may have exhibited PRES had all patients been studied uniformly. Every medical record for patients discharged with a diagnosis of eclampsia were scrutinized carefully to identify all those who underwent neuroimaging; the same research nurse recorded the data from the medical records of all patients and the same physicians (J.B. and A.A.R.) interpreted the radiological reports for consistency and accuracy. Another limitation to our study is the fact that radiologists were not blind to the diagnosis of the patient because this study was done retrospectively. Future studies will include a reanalysis of images by a radiologist blinded to patient diagnoses. For patients with eclampsia/pres, critical care providers inclusive of obstetrician-gynecologists and maternal-fetal medicine subspecialists must be cognizant of similar mechanisms of disease development between eclampsia and PRES. In the authors opinion, this knowledge should be translated into a rapidly initiated, comprehensive management program including intravenously infused magnesium sulfate, blood pressure control, intensive maternal-fetal surveillance, meticulous medical care, timely delivery, and potent glucocorticoids, especially if evidence of HELLP syndrome is also present. Because PRES was found in almost 100% of patients with probable eclampsia, a randomized, prospective, placebo-controlled, and blinded trial is now underway for patients with eclampsia to receive IV dexamethasone or placebo soon after an eclamptic seizure and to assess benefit if any when given in combination with magnesium sulfate therapy. f ACKNOWLEDGMENT We thank Pamela Blake, the research nurse in the Department of Obstetrics-Gynecology at the University of Mississippi Medical Center, for her hard work in reviewing and collecting data from the patient charts. REFERENCES 1. Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996;334: Sraykov D, Schwab S. Posterior reversible encephalopathy syndrome. J Intensive Care Med 2012;27: Lee V, Wijdicks EFM, Manno E, Rabinstein A. Clinical spectrum of reversible posterior leukoencaphalopathy syndrome. Arch Neurol 2008; 65: Garg RK. Posterior leukoencephalopathy syndrome. 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Pregnancy reverses hypertensive remodeling of cerebral arteries. Hypertension 2008;51: e5 American Journal of Obstetrics & Gynecology JUNE 2013
6 Obstetrics Research 11. Aubergey OA, Chapman AC, May V, Bernstein IM, Cipolla MJ. Plasma from preeclamptic women increases blood-brain barrier permeability: role of vascular endothelial growth factor signaling. Hypertension 2010;56: Schwartz RB, Feske SK, Polak JF, et al. Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. Radiology 2000;217: Dahmus MA, Barton JR, Sibai BM. Cerebral imaging in eclampsia: magnetic resonance imaging versus computed tomography. Am J Obstet Gynecol 1992;167: Mirza A. Posterior reversible encephalopathy syndrome (PRES): a variant of hypertensive encephalopathy. J Clin Neurosci 2006;13: Pula JH, Eggenberger E. Posterior reversible encephalopathy syndrome (PRES). Curr Opin Ophthalmol 2008;19: Bartynski WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol 2008;29: Katz VL, Farmer R, Kuller JA. Preeclampsia into eclampsia: toward a new paradigm. Am J Obstet Gynecol 2000;182: Wassef S. Mechanisms of convulsion in eclampsia. Med Hypotheses 2009;72: Cipolla MJ. Cerebrovascular function in pregnancy and eclampsia. Hypertension 2007; 50: Cipolla MJ, Li R, Vitullo L. Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia? Am J Physiol Heart Circ Physiol 2004;286:H Cipolla MJ, Smith J, Bishop N, Bullinger LV, Godfrey JA. Pregnancy reverses hypertensive remodeling of cerebral arteries. Hypertension 2008;51: Ekawa Y, Shiota M, Toblume T, et al. Reversible posterior leukoecephalopathy syndrome accompanying eclampsia: correct diagnosis using preoperative MRI. Tohoku J Exp Med 2012;226: Karumanchi SA, Lindheimer MD. Advances in the understanding of eclampsia. Curr Hypertens Rep 2008;10: Vaisbuch E, Whitty JE, Hassan SS, et al. Circulating angiogenic and antiangiogenic factors in women with eclampsia. Am J Obstet Gynecol 2011;204:152.e Maharaj AS, Walshe TE, Saint-Geniez M, et al. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med 2008;205: Fugate JE, Claassen DO, Cloft HJ, Kallmes DF, Kozak OS, Rabinstein AA. Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc 2010;85: Darmochwal-Kolarz D, Kludka-Sternik M, Tabarkiewicz J, et al. The predominance of Th17 lymphocytes and decreased number and function of TReg cells in preeclampsia. J Reprod Immun 2012;93: Wallace K, Richards S, Dhillon P, et al. CD4 T helper cells stimulated in response to placental ischemia mediate hypertension during pregnancy. Hypertension 2011;57: Euser AG, Cipolla MJ. Magnesium sulfate for the treatment of eclampsia: a brief review. Stroke 2009;40: LaMarca B, Brewer J, Wallace K. IL-6-induced pathophysiology during preeclampsia: potential therapeutic role for magnesium sulfate? Int J Infereron Cytokine Mediator Res 2011;2011: Demir BC, Ozerkan K, Ozbek SE, Yildirim EN, Ocakoglu G. Comparison of magnesium sulfate and mannitol in treatment of eclamptic women with posterior reversible encephalopathy syndrome. Arch Gynecol Obstet 2012;286: Martin JN Jr, Thigpen BD, Moore RC, Rose CH, Cushman J, May WL. Stroke and severe preeclampsia/eclampsia: a paradigm shift focusing on systolic blood pressure. Obstet Gynecol 2005;105: American College of Obstetricians and Gynecologists. Emergent therapy for acute-onset, severe hypertension with preeclampsia or eclampsia. ACOG Committee Opinion no. 514, December Wallace K, Martin Jr JN, Tam Tam K, et al. Seeking the Mechanism(s) of Action for Corticosteroids in HELLP Syndrome: SMASH Study. Am J Obstet Gynecol 2013 Feb 1. doi: /j.ajog [Epub ahead of print]. 35. Kotsarini C, Griffiths PD, Wilkinson ID, Hoggard N. A systematic review of the literature on the effects of dexamethasone on the brain from in vivo human-based studies: implications for physiological brain imaging of patients with intracranial tumors. Neurosurg 2010;67: Bebawy JF. Perioperative steroids for peritumoral intracranial edema: a review of mechanisms, efficacy, and side effects. J Neurosurg Anesthesiol 2012;24: Tam Tam KB, Keiser SD, Sims S, Brewer J, Owens MY, Martin JN Jr. Antepartum eclampsia 34 weeks case series: advisable to postpone delivery to administer corticosteroids for fetal pulmonary benefit? J Perinatol 2011;31: Keiser SD, Owens MY, Parrish MR, et al. HELLP syndrome with and without eclampsia. Am J Perinatol 2011;28: JUNE 2013 American Journal of Obstetrics & Gynecology 468.e6
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