MICHAEL JOSEPH AYAD CURRICULUM VITAE

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1 Updated June 2009 MICHAEL JOSEPH AYAD CURRICULUM VITAE Program Address Department of Neurological Surgery Vanderbilt University T-4224 Medical Center North Nashville, TN Office (615) Education 7/94 6/98 UCLA School of Medicine M.D. May, /88 6/94 UCLA Department of Physiology Ph.D. June, 1994 Doctoral program in Neurophysiology 1/83 6/85 UCSF Department of Physiology Graduate program in cardiac physiology 9/78 6/81 Stanford University, Biological Sciences B.S. with distinction, 1981 Postgraduate Training 7/05 6/07 Endovascular/Cerebrovascular Neurosurgery Fellowship Vanderbilt University Dept of Neurological Surgery 7/99 6/05 Neurological Surgery Residency George Washington University Dept of Neurosurgery 7/98 6/99 General Surgery Internship George Washington University Dept of Surgery Academic Appointments 7/07 present Assistant Professor Vanderbilt University Dept of Neurological Surgery 7/07 present Assistant Professor Vanderbilt University Dept of Radiological Sciences 7/05 6/07 Clinical Instructor Vanderbilt University Dept of Neurological Surgery

2 7/05 6/07 Clinical Instructor Vanderbilt University Dept of Radiological Sciences Graduate Education Mentoring 7/07 5/09 Doctoral committee chairman for Christine Marasco M.S. Proposed thesis: Intraoperative monitoring to prevent brain retraction injury. Department of Biomedical Engineering graduate student Clinical Appointments 1/09 present Co-Director, Vanderbilt Stroke Center Academic Honors Jun 03 Jan 03 Jan 02 Nov 97 May 93 Singer Award for Excellence in Clinical Research Crutchfield-Thompson-Gage Clinical Award, Neurosurgical Society of the Virginias Crutchfield-Thompson-Gage Basic Science Award, Neurosurgical Society of the Virginias Alpha Omega Alpha Medical Honor Society, UCLA School of Medicine John Field Award for Outstanding Physiology Graduate Student, UCLA Certification American Board of Neurological Surgeons Written Exam: Mar 2003 pass United States Medical Licensing Examination, Step III: May 1999 pass United States Medical Licensing Examination, Step II: August 1997 pass United States Medical Licensing Examination, Step I: June 1996 pass 95 th percentile Patents Brain Retraction Sensor - U.S. Patent No. 6,916,294, approved 9/7/04. Continuation-In-Part: Brain Retraction Sensor U.S. Patent No. 7,153,279, approved 8/31/06. 2

3 Current Research Clinical Studies Principal Investigator: Brain Retraction Monitoring Sensor. Clinical investigation sites 1. Vanderbilt University Dept of Neurological Surgery. IRB # Inova Fairfax Hospital IRB Study # ongoing study. IRB approved. Principal Investigator: Carotid Revascularization with EV3 Arterial Technology Evolution Post Approval Study (CREATE-PAS) (Sponsored by EV3 Endovascular, Inc.). IRB approved # Principal Investigator: Penumbra Imaging Collaborative Study (PICS): Multicenter Trial Assess Outcome of Patients Revascularized by the Penumbra System. IRB # Sub-Investigator: Treatment and Outcome of Arteriovenous Malformations. Vanderbilt IRB # Sub-Investigator: Lipid Peroxidation in Subarachnoid Hemorrhage: Vanderbilt IRB # Sub-Investigator: SENTIS/SCION Stroke Trial (Evaluate safety and efficacy of Neuroflo treatment in improving outcome in ischemic stroke patients) Vanderbilt IRB # Sub-Investigator: MR RESCUE: MR and Recanalization of Stroke Clots using Embolectomy IRB # Sub-Investigator: Treatment of Intracranial Aneurysms and Outcome Analysis. IRB # Sub-Investigator: Carotid Occlusion Surgery Study (COSS). IRB approval pending. Sub-Investigator: VISSIT Trial: Vitesse Intracranial Stent Study for Ischemic Therapy. IRB approval pending. Basic Science Studies Principal Investigator: Biomarkers for Stroke Imaging. (Correlate expression of plasma and CSF biomarkers with MRI and MALDI-mass spectrometry in experimental focal ischemic infarction). IACUC approved #M/06/500. Sub-Investigator: Apeliotus polymeric stentgraft for the treatment of experimental intracranial aneurysms in rabbits. SBIR application #1 R43 NS IACUC # M/06/259. Sub-Investigator: Blood Flow Measurement Before and After Anastomosis of Carotid Arteries in Rat. IACUC # M/07/149. Sub-Investigator: Microsurgical Anastomosis Training. IACUC #M/06/045. 3

4 Prior Research 7/01 6/05 Principal investigator: Study of the pathophysiology of brain retraction injury. Clinical investigation sites 1. George Washington University IRB #050112ER. 2. Inova Fairfax Hospital IRB Study # Experimental study in rabbits (7/01 6/03) GW IACUC #34,7-1. George Washington Dept. of Neurosurgery. 4/94 6/05 Development of a sensor for intraoperative monitoring of cortical electrical activity and surface pressure from areas of brain retraction in neurosurgery. GW Dept of Neurosurgery, and UCLA Dept of Physiology. 6/95 10/96 Assessment of phenytoin neuroprotection from ischemic damage in the rabbit by microdialysis of amino acid release and recording of ischemic depolarization. UCLA Dept of Physiology. 6/95 8/96 Analysis of the suboccipital collateral circulation in the rabbit brain by angiography, corrosion casts and H 2 clearance measurement of blood flow. UCLA Dept of Physiology. 1/86 6/94 Doctoral research: Analysis of the correlation between cortical electrophysiology and histologic damage following cerebral circulatory arrest in rabbits, and evaluation of the neuroprotective efficacy of membrane stabilizing agents. Committee chair: Eduardo Rubinstein MD, PhD, UCLA Dept of Anesthesiology. 4/82 6/85 Graduate research and technician: Vascular contractility response of coronary arteries and aorta to halothane, capsaicin and other vasoactive agents. Scanning electron microscopy of canine coronary arterial corrosion casts. Picric acid, basic fuchsin & hemotoxylin staining for myocardial ischemia in canines. UCSF Depts of Physiology & Pharmacology. Publications Yao T, Eskioglu E, Ayad M, Ulm AJ, and Mericle RA. Improved image interpretation with combined superselective and standard Angiography (double injection technique) during embolization of arteriovenous malformations (AVM): Technical Note. Operative Neurosurgery 2008 Mar;62(3 Suppl 1):140-1 Ayad M, Ulm AJ, Yao T, Eskioglu E and Mericle RA. Real-time image guidance for open vascular neurosurgery using digital angiographic road mapping. Operative Neurosurgery 2007; 61(3 Suppl):55-61 Ayad M, Eskoglu E and Mericle RA. Onyx A unique neuroembolic agent. Expert Rev Med Dev 2006; 3(6) Polin RS, Ayad M, and Jane J. Decompressive craniectomy in pediatric patients. Crit Care 2003; Polin RS, Schmidt K, and Ayad M. Peripheral Nerve Injuries in Neurology. Medlink Neurology online. 4

5 Randolph Evans ed., 2002 and annual revisions. Ayad M, Vinuela F and Rubinstein EH. The suboccipital carrefour: Cervical and vertebral arterial anastomosis. AJNR 1998;19: Ayad M. Electrocortical concomitants of neuroprotection and ischemic damage following cerebral circulatory arrest. UCLA Doctoral dissertation Ayad M, Verity MA and Rubinstein EH. Lidocaine delays cortical ischemic depolarization: relationship to electrophysiologic recovery and neuropathology. J Neurosurg Anesthesiol 1994; 6: Hondeghem LM, Ayad MJ and Robertson RM. Verapamil, diltiazem and nifedipine block the depolarization-induced potentiation of norepinephrine contractions in rabbit aorta and porcine coronary arteries. J Pharmacol Exp Ther 1986;239: Manuscripts in preparation Ayad M, Spratt D and Mericle RA. Literature review of glucocorticoid efficacy in the management of subarachnoid hemorrhage. Ayad M and Jones RV. Brain retraction pressure versus duration: neurophysiological correlates of injury. Safa R and Ayad M. Non-PHACES associated intracranial dolichoectasia in young patients. Presentations & Posters Oct 2009 Sept 2008 Sept 2008 Oct 2007 Aug 2007 Aug 2007 Ophthalmic artery balloon test occlusion prior to endovascular treatment of ophthalmic aneurysms. Accepted poster Congress of Neurological Surgeons Meeting, New Orleans. MERCI device for retrieval of a migrated coil mass against tortuous vascular anatomy. Digital poster Congress of Neurological Surgeons Meeting, Orlando. Onyx embolization for definitive endovascular treatment of symptomatic fusiform aneurysms. Digital poster Congress of Neurological Surgeons Meeting, Orlando. Bioactive coils: Future advances in the embolization of intracranial aneurysms. Presentation, Meacham Society Neurosurgical Meeting, Nashville Endovascular management of carotid cavernous fistulae. Tennessee Neurosurgical Society Annual Meeting, Nashville Embolic cast migration during Onyx HD500 embolization of a vertebral artery aneurysm. Case presentation. Jackson Hole Annual Endovascular Meeting, Jackson Hole. 5

6 Oct 2006 Oct 2006 July 2006 Oct 2003 Oct 2003 Jan 2003 Jan 2002 Feb 2001 Oct 1997 June 1997 May 1997 Nov 1994 May 1994 Real-time image guidance for open vascular neurosurgery using digital angiographic road mapping. Select Poster. Congress of Neurological Surgeons meeting, Chicago. Improved image interpretation with combined superselective and standard angiography during embolization of arteriovenous malformations. Digital poster co-author. Congress of Neurological Surgeons meeting, Chicago. Delayed hemorrhage following Onyx AVM embolization. Case presentation. Jackson Hole Annual Endovascular Meeting, Jackson Hole, WY. Brain retraction pressure vs. duration: neurophysiological correlates of injury. Oral Poster, Congress of Neurological Surgeons meeting, Denver, CO. Dynamic flexion-extension computed tomography of cervical spine. Poster co-author: CNS meeting, Denver, CO. Brain retraction pressure versus time in the pathophysiology of injury. Neurosurgical Society of the Virginias annual meeting, Homestead, VA. Delay in ischemic depolarization by phenytoin and associated neuroprotection. Neurosurgical Society of the Virginias annual meeting, Homestead, VA. The role of hyperbaric oxygen in the management of subarachnoid hemorrhage induced focal ischemia. Poster co-author: 4 th annual AANS/CNS/ASITN joint conference on Cerebrovascular Disorders, Hawaii. Monitoring of brain retraction injury. Grand Rounds, Columbia-Presbyterian Department of Neurosurgery Brain retraction monitoring: background, rationale and proposal. Grand Rounds, UCLA Division of Neurosurgery. Phenytoin, cortical depolarization and neuroprotection from cerebral ischemic damage. Grand Rounds, Department of Neurology, UCLA VA Hospital. Membrane stabilizing agents: reversibility from cerebral circulatory arrest. Grand Rounds, UCLA Department of Anesthesiology. Electrocortical indices of neuroprotection & cerebral ischemic damage in rabbits. Doctoral dissertation defense. Employment and Professional Activities 11/01 1/03 Institutional Review Board Committee member, George Washington University. 10/01 9/02 Faculty Senate Committee, George Washington University School of Medicine, resident member. 6/00 1/03 GW Graduate Medical Education committee, Neurosurgery representative. 6

7 1/95 6/97 Coordinator of the Medical Scholars Program, UCLA School of Medicine. 7/95 12/95 Instructor, UCLA School of Medicine. Supplemental Instruction to Basic Neurology course in the freshman medical curriculum. 1/94 5/95 Instructor, UCLA School of Medicine. Supplemental Instruction to Physiology in the freshman medical curriculum. 3/93, 94 & 95 Instructor, UCLA School of Medicine. Cardiovascular Physiology Cat Laboratory for freshman medical students. 4/91 3/94 Senior EEG Technologist, UCLA Dept of Anesthesiology. Intraoperative EEG, EMG and evoked potential monitoring of neurosurgical patients. 9/91 3/04 Physiology Tutor, UCLA Schools of Medicine and Dentistry. 6/86 5/88 Surgical instrument technician, UCLA Main Operating Room. 7/85 12/87 Neurophysiology research apprentice, UCLA Dept of Physiology. 5/82 12/82 Research technologist, UCSF Dept of Pharmacology. 7/81 4/82 Research technologist, Dept of Medicine, San Francisco General Hospital. Memberships 2006 present AANS/CNS Cerebrovascular Section Fellow Member 2001 present Congress of Neurological Surgeons present American Association of Neurological Surgeons 7