Evolution continues. Year: 1940 Fuel: Electricity Speed: 32 km/h. Year: 1998 Fuel: Electricity Speed: 118 km/h

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1 Year: 1940 Fuel: Electricity Speed: 32 km/h Year: 1998 Fuel: Electricity Speed: 118 km/h Year: 2008 Fuel: Electricity Speed: 210 km/h Year: 2016 Fuel: Electricity Speed: 250 km/h Evolution continues

2 The Faster Formulation has become Fastest New with is five times faster 1 than standard paracetamol tablet. Moreover, super-disintegrates such as Alginic acid and Calcium Carbonate help start to disintegrate within just two seconds sec

Complete disintegration within just 2 minutes

3 Standard paracetamol slowly disintegrates in the stomach Napa ly disintegrates in the stomach Complete disintegration within just 2 minutes New Paracetamol 500 mg Caplet Absorption, Faster Relief

New Paracetamol amol 500 mg Caplet Absorption, Faster Relief Super Ingredients make the super-fast caplet 3 Alginic Acid: A naturally occurring substance that makes the caplet act like a sponge so

4 New Paracetamol amol 500 mg Caplet Absorption, Faster Relief Super Ingredients make the super-fast caplet 3 Alginic Acid: A naturally occurring substance that makes the caplet act like a sponge so when it reaches the stomach it soaks up water swells then breaks apart. Calcium Carbonate: Ingredients used in caplet formulation that, on contact with the stomach acids, releases small amounts of carbon dioxide which helps the tablet to disintegrate quickly. Super-Disintegrants: Exhibit high capillary activity and remarkable hydration capacity which causes the caplet to swell even more, and disintegrate quickly to get accelerated higher dissolution. Faster absorption, faster relief

5 New Paracetamol 500 mg Caplet Absorption, Faster Relief Comparative Dissolution profile of Napa vs Panadol Advance Caplet Napa Panadol Advance min 3 min 5 min 10 min 15 min 30 min Similar efficacy as innovator brand

6 HAT IF HE FASTEST FORMULATION WENT EVEN FASTER New Easy to Swallow: Oval Shape and Film Coating make the caplet easy to swallow Unique shape ensures better compliance

7 New Paracetamol 500 mg Caplet Absorption, Faster Relief Dosage and Administration: Age Caplets How Often 7-12 ½-1 Every 4-6 hours with water as required (maximum 4 Caplets in 24 hours) 12-Adult 1-2 Every 4-6 hours with water as required (maximum 8 Caplets in 24 hours)

New Paracetamol 500 mg Caplet Absorption, Faster Relief Prescribing Information Description: Napa caplet is an advanced formulation of Paracetamol that contains.

8 New Paracetamol 500 mg Caplet Absorption, Faster Relief Prescribing Information Description: Napa caplet is an advanced formulation of Paracetamol that contains. It dissolves up to five times faster than standard Paracetamol tablets. Napa caplet is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics. Indications: All conditions requiring relief from pain and fever such as neuritis, neuralgia, headache, earache, toothache, pain due to rheumatic disorder, cold, influenza, dysmenorrhoea, migraine, backache, pain due to arthritis etc. Dosage and Administration: Adults and children (aged 12 years and over): Take 1 to 2 caplets every four to six hours as needed. Do not take more than 8 caplets in 24 hours. Children (7 to 11 years): Take ½-1 caplet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years. Pregnancy and Lactation: Epidemiological studies in human pregnancy have shown no ill effects due to paracetamol used in the recommended dosage, but patients should follow the advice of the doctor regarding its use. Paracetamol is excreted in breast milk but not in a clinically significant amount. Available published data do not contraindicate breast feeding. Contraindications: Paracetamol is contraindicated in patients with severe renal function impairment and hepatic disease (Viral Hepatitis). Precautions: Paracetamol should be given with care to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver. Side Effects: Side effects of Paracetamol are usually mild, including thrombocytopenia, leukopenia, breathing problem. Pancreatitis, skin rashes, and other allergic reactions occur occasionally. Overdosage: Symptoms of Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. Pharmaceutical Precautions: Keep in a cool & dry place. Protect from light. Keep out of the reach of children. Commercial Pack: Napa Caplet: Box containing 270 caplets in 9x30 s blister strips. Each caplet contains Paracetamol BP 500 mg. Ref: 1. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, Volume 4, Issue 1, Data on file. 3. International Journal for Pharmaceutical Research Scholars (IJPRS), V-5, I-4, 2016 BEXIMCO PHARMACEUTICALS LTD. Dhaka, Bangladesh Napa is a registered trademark of Beximco Pharmaceuticals Ltd. For more information visit: PTG /08-17/160,000 BMTF

2. QUALITATIVE AND QUANTITATIVE COMPOSITION. Each capsule contains PARACETAMOL 500mg For a full list of excipients, see section 6.1.

SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT PARACETAMOL 500mg CAPSULES Boots Paracetamol 500mg Capsules 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each capsule contains PARACETAMOL