Curriculum Vitae MARIUS BIRLEA, M.D.

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1 Curriculum Vitae MARIUS BIRLEA, M.D. PERSONAL INFORMATION Work address: Citizenship: Marital status: University of Colorado Denver, Anschutz Medical Campus, AO East 19 th ave, room 5205 Tel: , Fax Romanian. USA permanent resident Married, 2 children CURRENT ACADEMIC POSITION Assistant professor- Department of Neurology, University of Colorado Denver Director - Headache Clinic, Department of Neurology, University of Colorado Denver Faculty - Pain Fellowship, University of Colorado Denver July 2013-present July 2013-present July 2013-present EDUCATION Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania M.D. Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Internship, Internal Medicine Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Residency, Neurology Metropolitan Hospital, New York Medical College, New York, USA Internship, Internal Medicine University of Colorado Denver, Denver, USA Residency, Neurology University of Colorado Denver, Denver, USA Fellowship, NeuroVirology CERTIFICATIONS American Board of Psychiatry and Neurology (ABPN) 2011 Neurology Educational Commission for Foreign Medical Graduates (ECFMG) 2006 Certified (USMLE Step1-99/247; USMLE Step2 CK - 99/250) Romanian Board of Ultrasonography 2002 Certified in Cerebral Vascular Doppler Ultrasonography

2 Romanian Neurological Board 2000 Neurology Specialist Romanian College of Physicians 1995 Practicing physician LICENSURE Colorado 2011-present HONORS/AWARDS Dean s scholarship (Medical school) Iuliu Hatieganu University, Cluj Napoca, Romania Excellence in professionalism during residency training award 2008 Internal Medicine, Metropolitan Hospital, New York Resident outstanding research award 2011 Neurology Department, University of Colorado Travel award 2012 ANA annual meeting, Boston, USA PREVIOUS PROFESSIONAL POSITIONS AND APPOINTMENTS Neurohospitalist - Zalau County Hospital, Romania Neurologist outpatient practice - Outpatient Gallenus Policlinic, Zalau, Romania Instructor of Neurology, General Neurology Division University of Colorado Hospital, Outpatient Clinic OTHER EDUCATIONAL ACTIVITIES Resident Director for weekly Neurology Core Curriculum Didactics University of Colorado Denver Facilitator of learning neurological exam for 2 nd year medical students University of Colorado Denver Co-director of Headache education to Neurology residents University of Colorado Denver PROFESSIONAL MEMBERSHIPS International Headache Society present American Headache Society 2013-present International Society for NeuroVirology Center for NeuroScience, University of Colorado Denver present Colorado Alphaherpesviruses Latency Society present QUALITY IMPROVEMENT PROJECTS Improved timeliness of Neurology residents response to call from consults 2011 from the Emergency Department - poster presented at 2012 ANA annual meeting

3 Improved patients access to treatment of severe and prolonged migraine attacks in the Infusion Clinic at the University of Colorado Hospital ongoing ADMINISTRATIVE RESPONSIBILITIES AND COMMITTEE MEMBERSHIPS Clinical affairs task force Neurology Department, University of Colorado 2013 Member General Neurology Division Neurology Department, Anschutz Outpatient Clinic 2013 Division chief American Headache Society Peripheral nerve blocks and other interventional procedures 2013 special interest group Member PRESENTATIONS Migraine management 5/2003 Glaxo-Wellcome symposium Zalau, Romania Migraine management 8/2003 Glaxo-Wellcome symposium Baia Mare, Romania Heart Failure, review 4/2008 Internal Medicine residency program didactis session Metropolitan Hospital, New York, USA 2 nd International Classification of Headache Disorders 9/2010, 3/2011 Weekly didactics for Neurology residents and rotating students Denver, Colorado, USA Alphaherpesviruses and Head Pain 5/2011 Subclinical VZV reactivation in HIV patients 6/2011 Neurology Department Research Retreat, University of Colorado Denver Improved timeliness of Neurology consults in the Emergency Department 6/2011 Neurology Grand Rounds, Quality Improvement project, University of Colorado Denver Headache and dizziness 8/2011 Weekly didactics for Neurology residents and rotating students Insight into molecular pain, trigeminal system activation and alphaherpesviruses 1/2013

4 Chronic active VZV trigeminal ganglionitis 5/ rd Annual Colorado Alphaherpes Viruses Latency Society Meeting Headache emergencies 7/2013 Weekly didactics for Neurology residents and rotating students Headache Program at the University of Colorado - An Introduction 8/2013 Headache generalities 9/2013 Neurology teaching module for 2 nd year medical students, University of Colorado Denver Translational opportunities in headache 11/2013 Annual meeting of Colorado Neuroscience Program Estes Park, Colorado, USA Headache diagnosis and management overview 12/2013 Pain Fellowship Program teaching session, University of Colorado Denver Intravenous treatment of migraine- overview 2/12/2014 Nursing staff - Outpatient Infusion Center, University of Colorado Hospital Improving access of migraine patients to intravenous treatment in the 2/26/2014 Outpatient Infusion Clinic Quality Improvement Project Headache- overview on diagnosis and management 3/12/2014 Teaching session for PMNR residents at University of Colorado Denver BIBLIOGRAPHY Peer-reviewed articles Birlea S, Birlea M, Cosgarea R, Cimponeriu D, Apostu P, Costin G, Das PK. Autoimmune diseases and vitamin D receptor Apa-I polymorphism are associated with vitiligo in a small inbred Romanian community. Acta Dermato Venereologica, 2006; 86 (3): Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson AR, David A. Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis CSF. Annals of Neurology, 2009; 65(6):

5 Birlea M, Arendt G, Orhan E, Schmid DS, Bellini WJ, Schmidt C,, Gilden D, Cohrs RJ. Subclinical reactivation of varicella zoster virus in all stages of HIV infection. Journal of Neurological Sciences 2011; 304(1-2):22-4. Birlea M, Owens G, Eshleman E, Ritchie A, Traktinskyi I, Bos N, Seitz S, Mahalingam R, Gilden D and Cohrs RJ. Human recombinant anti-vzv antibody produced after Zostavax immunization recognizes gh/gl complex and neutralizes virus infection. Journal of Virology. 2013; 87 (1): Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D. Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology. 2014;82 (1): Birlea M, Cohrs RJ, Bos N, Mehta S, Pierson DL and Gilden D. Search for varicella-zoster virus DNA in saliva of healthy individuals aged years. Journal of Medical Virology, 2014; 86 (2): Book chapters Birlea, M., Nagel, M.A., Cohrs, R.J., Mahalingam, R., James, S., Gilden, D. Varicella-zoster virus. In: Encyclopedia of Neurological Sciences 2E (M.J. Aminoff, R.D. Daroff, eds.), Elsevier Inc., San Diego, CA., 2014, in press Abstracts Birlea M, Bigal M. An assessment of headache prevalence at work place. Poster - The 11 th International Headache Society Congress, Rome, Italy, 9/2003 Birlea M. The Second International Classification of Cephalalgic Disorders (Jes Olesen). Poster - Annual National Romanian Neurology Conference, Bucharest, Romania, 10/2003 Birlea M, Strom L. Basilar type migraine and multiple cavernomas. Accepted for poster presentation at the 14 th International Headache Society Congress, Philadelphia, USA, September 2009 Birlea M, Schmid S, Arendt G, Christian S, Bennett J, Bautista K, Owens G, Hemmer B, Cepok S, Gilden D, Cohrs RJ. VZV reactivates sub clinically in 21% of HIV positive individuals. Poster - The 10 th International Symposium on NeuroVirology, Milan, Italy, 10/2010 Birlea M, Owens G, Eshleman E, Ritchie A, Traktinskyi I, Bos N, Seitz S, Yu X, Pointon T, Wellish M, Mahalingam M, Gilden D and Cohrs RJ. Human recombinant antibody against varicella-zoster virus (VZV). Poster - Neurology Research Retreat, University of Colorado School of Medicine, Denver, USA, 05/2012 Birlea M, Braun C, Kern D, Jones W, Ringel SP, Kenneth L Tyler KL. Improved Timeliness of Neurology Consults in the Emergency Department. Poster - The Annual Meeting of the American Neurological Association. Boston, USA, 10/2012. Travel award SCIENTIFIC EVENTS PARTICIPATION 20 th European Conference of Microcirculation 1998 Paris, France 10 th International Headache Society Congress 2001 New York, USA 6 th Romanian Stroke Conference 2003

6 Bucharest, Romania 11 th International Headache Society Congress 2003 Rome, Italy Annual Romanian Neurology Society Conferences Bucharest, Romania 14 th International Headache Society Congress 2009 Philadelphia, USA 62 nd American Academy of Neurology Annual Meeting 2010 Toronto, Canada 10 th International Symposium on NeuroVirology 2010 Milan, Italy 1 st Colorado Alphaherpesviruses Latency Symposium nd Colorado Alphaherpesviruses Latency Symposium th American Neurological Association Annual Meeting 2012 Boston, USA 3 rd Colorado Alphaherpesviruses Latency Symposium th International Headache Society Congress/AHS congress 2013 Boston, USA Annual Meeting of Colorado Neuroscience Program 2013 Estes Park, Colorado, USA Annual American Headache Society Scottsdale Meeting 2013 Scottsdale, Arizona, USA LANGUAGES SPOKEN Fluent in English and Romanian. Conversational in Spanish. Knowledge of French, German, Italian, Hungarian INTERESTS. HOBBIES Music (rock, classic, jazz, hip-hop), soccer, chess, reading..

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