Curriculum Vitae MARIUS BIRLEA, MD, FAHS

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1 Curriculum Vitae MARIUS BIRLEA, MD, FAHS PERSONAL INFORMATION Work address: Citizenship: Marital status: University of Colorado Denver, Anschutz Medical Campus, AO East 19 th ave, room 5205 Tel: , Fax Romanian. USA permanent resident Married, 2 children CURRENT ACADEMIC POSITION Assistant professor- Department of Neurology, University of Colorado Denver SOM 2013-present Director Headache/Pain Program, Department of Neurology, University of Colorado Denver 2013-present Fellowship director- Headache Medicine, University of Colorado Denver 2015 Faculty - Pain Fellowship, University of Colorado Denver 2013-present EDUCATION Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania M.D. Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Internship, Internal Medicine Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Residency, Neurology Metropolitan Hospital, New York Medical College, New York, USA Internship, Internal Medicine University of Colorado Denver, Aurora, USA Residency, Neurology University of Colorado Denver, Aurora, USA Fellowship, NeuroVirology CERTIFICATIONS United Council for Neurological Subspecialties (UCNS) 2014 Headache Medicine American Board of Psychiatry and Neurology (ABPN) 2011 Neurology Educational Commission for Foreign Medical Graduates (ECFMG) 2006

2 Certified (USMLE Step1-99/247; USMLE Step2 CK - 99/250) Romanian Board of Ultrasonography 2002 Cerebral Vascular Doppler Ultrasonography Romanian Neurological Board 2000 Neurology Specialist Romanian College of Physicians 1995 Practicing physician LICENSURE Colorado 2011-present HONORS/AWARDS Dean s scholarship (Medical school) Iuliu Hatieganu University, Cluj Napoca, Romania Excellence in professionalism during residency training award 2008 Internal Medicine, Metropolitan Hospital, New York Resident outstanding research award 2011 Neurology Department, University of Colorado Denver SOM Travel award 2012 ANA annual meeting, Boston, USA PROFESSIONAL MEMBERSHIPS International Headache Society American Headache Society American Neurological Association American Academy of Neurology Center for NeuroScience, University of Colorado Denver. Colorado Alphaherpesviruses Latency Society RESEARCH PROJECTS Cefaly device for Chronic Migraine Prevention, Pilot study 2015 Principal investigator MOTS multicenter PCORI trial 2016 Medication Overuse Treatment Strategy Co-investigator The role of alphaherpesviruses infection in head and face pain 2016

3 Neurology intradepartmental grant Principal investigator QUALITY IMPROVEMENT PROJECTS Improved timeliness of Neurology residents response to call from consults 2011 from the Emergency Department - poster presented at 2012 ANA annual meeting Improved patients access to treatment of severe and prolonged migraine attacks in the Infusion Clinic at the University of Colorado Hospital ADMINISTRATIVE RESPONSIBILITIES AND COMMITTEE MEMBERSHIPS Clinical affairs task force Neurology Department, University of Colorado Member Headache/Pain Clinic, Department of Neurology, University of Colorado Denver Division Chief 2013-present 2013-present PREVIOUS PROFESSIONAL POSITIONS AND APPOINTMENTS Neurohospitalist - Zalau County Hospital, Romania Neurologist outpatient practice - Outpatient Gallenus Policlinic, Zalau, Romania Instructor of Neurology, General Neurology Division Associate Director, Outpatient Services, Neurology Department, Univ. of Co OTHER EDUCATIONAL ACTIVITIES Resident Director for weekly Neurology Core Curriculum Didactics University of Colorado Denver Facilitator of learning neurological exam for 2 nd year medical students University of Colorado Denver Co-director of Headache education to Neurology residents University of Colorado Denver PRESENTATIONS Migraine management 5/2003 Glaxo-Smithkline symposium Zalau, Romania Migraine management 8/2003 Glaxo-Smithkline symposium Baia Mare, Romania Heart Failure, review 4/2008 Internal Medicine residency program didactics session Metropolitan Hospital, New York, USA

4 2 nd International Classification of Headache Disorders (ICHD 2) 9/2010, 3/2011 Weekly didactics for Neurology residents and rotating students at UC SOM Alphaherpesviruses and Head Pain 5/2011 Neurology Grand Rounds, University of Colorado Denver Subclinical VZV reactivation in HIV patients 6/2011 Neurology Department Research Retreat, University of Colorado Denver Improved timeliness of Neurology consults in the Emergency Department 6/2011 Neurology Grand Rounds, Quality Improvement project, University of Colorado Denver Headache and dizziness 8/2011 Weekly didactics for UCD SOM Neurology residents and rotating students Insight into molecular pain, trigeminal system activation and alphaherpesviruses 1/2013 Neurology Grand Rounds, University of Colorado Denver Chronic active VZV trigeminal ganglionitis 5/ rd Annual Colorado Alphaherpesviruses Latency Society Meeting Vail, Colorado, USA Headache in the Emergency Department 7/2013; 7/2014; 7/22/2015 Emergency module didactics for Neurology residents and rotating students at UCD SOM Headache Program at the University of Colorado - An Introduction 8/2013 Neurology Grand Rounds, University of Colorado Denver Headache 9/2013; 9/2014; 9/2015 Neurology teaching module for 2 nd year medical students, UCD SOM Translational research opportunities in headache 11/2013 Annual meeting of Colorado Neuroscience Program Estes Park, Colorado, USA Headache diagnosis and management 12/2013 Pain Fellowship Program teaching session, University of Colorado Denver Intravenous treatment of migraine 2/12/2014 Nursing staff - Outpatient Infusion Center, University of Colorado Hospital

5 Improving access of migraine patients to intravenous treatment in the 2/26/2014 Outpatient Infusion Clinic Quality Improvement Project Neurology Grand Rounds, University of Colorado Denver Headache- overview on diagnosis and management 3/12/2014 Teaching session for PM&R residents at University of Colorado Denver Primary headaches 4/2014; 4/2015 Co-presenter, with Dr. Sita Kedia Teaching session for Neurology residents at University of Colorado Denver SOM Evaluation of the patient with headache, 1 st session 6/24/2014 Family Medicine Review-workshop Estes Park, Colorado, USA Patient with headache-evaluation and treatment 10/2014; 12/2015 Pain symposium for PM&R residents at University of Colorado Denver Aurora, Colorado Evaluation of the patient with headache, 2 nd session 11/1/2014 Family Medicine Review-workshop Primary headaches 11/19/2014 Teaching session for Pain Medicine fellows at the University of Colorado Denver Headache and Pregnancy 12/10/2014 Teaching session for Ob/Gyn fellows and faculty at the University of Colorado Denver University of Colorado Denver Trigeminal system modulation for migraine 6/17/2015 Annual Neurology Department research retreat, University of Colorado Denver Headache 9/10/2015 Neurology teaching module for 2 nd year medical students, University of Colorado Denver Chronic headache: common and under diagnosed, disabling and treatable 9/16/2015 Neurology Department Grand Rounds, University of Colorado Denver Cefaly device for prevention of Chronic Migraine: pilot study, preliminary results 11/21/2015 American Headache Society Annual symposium Scottsdale, Arizona, USA

6 Headache module for the Neurology residents 3/16/2016 Teaching session for Neurology residents at University of Colorado Denver SOM Headache overview for Pain Medicine fellows, Anesthesiology and PM&R residents 5/2016 Cefaly device for prevention of Chronic Migraine: pilot study, preliminary results 6/11/2016 American Headache Society Annual scientific meeting San Diego, California, USA Headache and cerebrovascular system 6/16/2016 Overview for UCH Stroke fellowship program Migraine: what is it and what matters for the patient? 10/5/2016 Monthly Behavioral Neurology&Neuropsychiatry Conference University of Colorado SOM, Neurology department Headache and Migraine 11/4/2016 Neuroscience conference for RNs and AAPs University of Colorado Hospital Alphaherpesviruses and headache: an update and single center experience 12/2016 Neurology department Grand Rounds Aurora, Co BIBLIOGRAPHY Peer-reviewed articles Birlea S, Birlea M, Cosgarea R, Cimponeriu D, Apostu P, Costin G, Das PK. Autoimmune diseases and vitamin D receptor Apa-I polymorphism are associated with vitiligo in a small inbred Romanian community. Acta Dermato Venereologica, 2006; 86 (3): Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson AR, David A. Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis CSF. Annals of Neurology, 2009; 65(6): Birlea M, Arendt G, Orhan E, Schmid DS, Bellini WJ, Schmidt C,, Gilden D, Cohrs RJ. Subclinical reactivation of varicella zoster virus in all stages of HIV infection. Journal of Neurological Sciences 2011; 304(1-2):22-4. Birlea M, Owens G, Eshleman E, Ritchie A, Traktinskyi I, Bos N, Seitz S, Mahalingam R, Gilden D and Cohrs RJ. Human recombinant anti-vzv antibody produced after Zostavax immunization recognizes gh/gl complex and neutralizes virus infection. Journal of Virology. 2013; 87 (1): Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D. Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology. 2014;82 (1): 90-92

7 Birlea M, Cohrs RJ, Bos N, Mehta S, Pierson DL and Gilden D. Search for varicella-zoster virus DNA in saliva of healthy individuals aged years. Journal of Medical Virology, 2014; 86 (2): Book chapters Birlea, M., Nagel, M.A., Cohrs, R.J., Mahalingam, R., James, S., Gilden, D. Varicella-zoster virus. In: Encyclopedia of Neurological Sciences 2E (M.J. Aminoff, R.D. Daroff, eds.), Elsevier Inc., San Diego, CA., 2014 Posters/Abstracts Birlea M, Bigal M. An assessment of headache prevalence at work place. Poster - The 11 th International Headache Society Congress, Rome, Italy, 9/2003 Birlea M. The Second International Classification of Cephalalgic Disorders (Jes Olesen). Poster - Annual National Romanian Neurology Conference, Bucharest, Romania, 10/2003 Birlea M, Strom L. Basilar type migraine and multiple cavernomas. Accepted for poster presentation at the 14 th International Headache Society Congress, Philadelphia, USA, September 2009 Birlea M, Schmid S, Arendt G, Christian S, Bennett J, Bautista K, Owens G, Hemmer B, Cepok S, Gilden D, Cohrs RJ. VZV reactivates sub clinically in 21% of HIV positive individuals. Poster - The 10 th International Symposium on NeuroVirology, Milan, Italy, 10/2010 Birlea M, Owens G, Eshleman E, Ritchie A, Traktinskyi I, Bos N, Seitz S, Yu X, Pointon T, Wellish M, Mahalingam M, Gilden D and Cohrs RJ. Human recombinant antibody against varicella-zoster virus (VZV). Poster - Neurology Research Retreat, University of Colorado School of Medicine, Denver, USA, 05/2012 Birlea M, Braun C, Kern D, Jones W, Ringel SP, Kenneth L Tyler KL. Improved Timeliness of Neurology Consults in the Emergency Department. Poster - The Annual Meeting of the American Neurological Association. Boston, USA, 10/2012. Travel award REVIEWER BMC Infectious Diseases: Ad-hoc Frontiers in Neurology: review editor American Family Physician: Ad-hoc SCIENTIFIC EVENTS PARTICIPATION 20 th European Conference of Microcirculation 1998 Paris, France 10 th International Headache Society Congress 2001 New York, USA 6 th Romanian Stroke Conference 2003

8 Bucharest, Romania 11 th International Headache Society Congress 2003 Rome, Italy Annual Romanian Neurology Society Conferences Bucharest, Romania 14 th International Headache Society Congress 2009 Philadelphia, USA 62 nd American Academy of Neurology Annual Meeting 2010 Toronto, Canada 10 th International Symposium on NeuroVirology 2010 Milan, Italy 1 st Colorado Alphaherpesviruses Latency Symposium 2011 Vail, Colorado, USA 2 nd Colorado Alphaherpesviruses Latency Symposium 2012 Vail, Colorado, USA 137 th American Neurological Association Annual Meeting 2012 Boston, USA 3 rd Colorado Alphaherpesviruses Latency Symposium 2013 Vail, Colorado, USA 17 th International Headache Society Congress/AHS congress 2013 Boston, USA Annual Meeting of Colorado Neuroscience Program 2013 Estes Park, Colorado, USA 56 th Annual scientific meeting of the American Headache Society 2014 Los Angeles, USA Annual American Headache Society Scottsdale Meeting 2013, 2014, 2015, 2016 Scottsdale, Arizona, USA 57 th Annual scientific meeting of the American Headache Society 2015 Washington DC, USA 58 th Annual scientific meeting of the American Headache Society 2016 San Diego, CA, USA LANGUAGES SPOKEN Fluent in English and Romanian. Conversational in Spanish. Knowledge of French, German, Italian, Hungarian INTERESTS. HOBBIES Music (rock, classical, jazz, hip-hop), reading, soccer, chess..

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