Angiographic dissection pattern and patency outcomes of post balloon angioplasty for SFA lesions -a retrospective multi center analysis-
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1 Angiographic dissection pattern and patency outcomes of post balloon angioplasty for SFA lesions -a retrospective multi center analysis- Masahiko Fujihara Kishiwada Tokushukai Hospital, Osaka, Japan
2 Disclosure Speaker name : Mashiko Fujihara I have the following potential conflicts of interest to report: Consulting Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Background Nitinol stent has been mainly used for the endovascular therapy (EVT) for superficial femoral artery disease (SFA) No detailed analysis of optimal balloon angioplasty was made in previous stent studies. Since the approval of drug-coated balloon (DCB), concept of nothing left behind is introduced However, definition of optimal balloon angioplasty are not clearly made and dissection pattern post balloon angioplasty are not reported
4 73 years old Male, R-2 Claudication Cutting Balloon 5x20mm Balloon 5x100mm
5 73 years old Male, R-2 Claudication Post balloon angioplasty IVUS Angioscopy
6 73 years old Male, R-2 Claudication 7 Months of Post balloon angioplasty
7 Aim Angiographic dissection pattern of post balloon angioplasty in SFA lesions were evaluated The clinical outcome of balloon alone procedure based on dissection pattern were examined
8 Material and Method Study Design A retrospective, multicenter, non randomized investigation at 4 cardiovascular centers Inclusion criteria Exclusion Criteria Age >20 years old Rutherford category class (RCC) 2 6 Angiographic evaluation was performed post balloon angioplasty In SFA stent restenosis Direct SFA stent CO2 Angiography Drug coated balloon Participated Hospital Kishiwada Tokushukai Hospital Kansai Rosai Hospital Saka General Hospital Tokyo Rosai Hospital Journal of Endovascular Therapy in Press
9 STUDY Scheme and Endpoints 748 PAOD patients with symptomatic SFA lesions Bare Balloon Angioplasty Dissection pattern Balloon Alone Procedure N=193 Bailout Stent Implantation N=555 Analysis of Clinical outcome (Patency and TLR)
10 Definition of Vessel Dissection A B C D E F
11 Patient and Lesion Characteristics All N=748 All N=748 Age (years old) 72.6± 9.5 Lesion Length (mm) 148.1±92.4 Male (%) 66.8 Ref vessel size (mm) 5.4±1.0 Hypertension(%) 88.2 TASC CD (%) 46.5 Diabetes (%) 58.4 CTO (%) 40.2 Dyslipidemia (%) 52.6 Calcification Obesity(%) 14.0 None 34.8 Regular Hemodialysis (%) 32.7 Moderate 26.6 Coronary Artery Disease (%) 63.2 Severe 38.6 Critical Limb Ischemia (%) 35.0 Non BTK run-off 15.8 Rutherford Classification 3.50±1.2
12 Procedure Characteristics All N=748 Bare Balloon (%) 97.6 Cutting Balloon (%) 2.4 Balloon Type inch (%) inch (%) inch (%) 15.6 Balloon Size Average Balloon size 4.7±0.8 Balloon size 5mm (%) 62.7 Average Inflation time (sec) 80.7±88 Inflation Time 2minutes (%) 30.7 IVUS use (%) 27.8
13 Dissection Pattern of Post Balloon Angioplasty C to F 40% D 24% E 9% F 6% None 13% A 24% None A and B 60% C 9% B 26%
14 Stent 87% POBA Stent Implantation rate between Dissection Pattern Stent 90% D Stent POBA 82% C E F POBA Stent None B Stent 57% 94% Primary or Stent 74% A POBA Stent 60% POBA Bailout Stent Implantation rate 74.1% Balloon Alone Procedure 25.8%
15 Hazard ratio for restenosis Hazard Ratio of restenosis comparison with dissection pattern No Severe Dissection Severe Dissection HR [95% CI] (p value) None 1.58 [0.79, 3.16] (p = 0.193) A 1.00 (Ref) B 1.81 [0.88, 3.73] (p = 0.108) 1 C 4.45 [1.22, 16.2] (p = 0.024) D 6.37 [2.99, 13.6] (p< 0.001) 0 None A B C D E F Dissection type E 22.9 [7.33, 71.6] (p< 0.001) F 297 [34.9, 2527] (p< 0.001) Data are unadjusted hazard ratios for restenosis relative to type A dissection, obtained from the Cox regression model with mixed effects, in which inter-subject variability was treated as random effects. Error bars indicate 95% confidence intervals. *Statistical analysis was performed by R version (R Core Team, Vienna, Austria).
16 Clinical Outcomes of Balloon Alone Procedure Primary Patency (PSVR<2.5) p < log-rank Non severe Dissection Free from Clinically Driven TLR p < log-rank Non severe dissection Severe Dissection Severe Dissection Follow up period (days) Days at risks (Category-1) % at risks (Category-2) % Follow up period (days) Days at risks (Category-1) % at risks (Category-2) %
17 Predictive factors for Severe dissection - Multivariate analysis Uni- Severe Dissection (Type C,D and F) Multivariate P value HR 95%CI P Value Non Hemodialysis CTO < <0.001* TASC CD < <0.001* Reference vessel diameter<5mm < * Non Severe Calc Large inch system balloon (0.035inch) Vessel/balloon size< IVUS usage *
18 Prevalence of severe dissection TASC CD and small vessel were strong predictor of severe dissection 100% 80% 60% 40% 20% 0% class D class C class B TASC II classification class A < 5 5 to 6 6 Data are prevalence of severe dissection in subgroups, calculated from the generalized linear mixed model with logit-link function, in which inter-subject variability was treated as random effects. *Statistical analysis was performed by R version (R Core Team, Vienna, Austria).
19 Conclusions Angiographic dissection pattern of post balloon angioplasty in SFA lesions were analyzed 42 % of cases resulted in C, D, E and F type severe dissection. Primary patency rate and freedom from clinically driven TLR rate were significantly lower in severe dissection The predictive factors of severe dissection were found in TASC(ll) CD, small vessel and total occlusion. Calcified lesion was not predictive factor. In case of severe dissection, balloon alone procedure has the limitation in regards to restenosis and CD-TLR
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