Estrogen and Stroke Risk : The Mechanism of Action

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1 Women and Stroke SYMPOSIUM Estrogen and Stroke Risk : The Mechanism of Action KOREAN STROKE SOCIETY _9

2 SYMPOSIUM Women and Stroke 10_

3 Estrogen and Stroke Risk: The Mechanism of Action KOREAN STROKE SOCIETY _11

4 SYMPOSIUM Women and Stroke 12_

5 Estrogen and Stroke Risk: The Mechanism of Action References 1. Barrett-Connor,E., Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys Lecture, Circulation, 95 (1997) Hulley,S., Grady,D., Bush,T., Furberg,C., Herrington,D., Riggs,B., and Vittinghoff,E., Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group, JAMA, 280 (1998) Rossouw,J.E., Anderson,G.L., Prentice,R.L., LaCroix,A.Z., Kooperberg,C., Stefanick,M.L., Jackson,R.D., Beresford,S.A., Howard,B.V., Johnson,K.C., Kotchen,J.M., and Ockene,J., Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial, JAMA, 288 (2002) Grady,D., Herrington,D., Bittner,V., Blumenthal,R., Davidson,M., Hlatky,M., Hsia,J., Hulley,S., Herd,A., Khan,S., Newby,L.K., Waters,D., Vittinghoff,E., and Wenger,N., Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II), JAMA, 288 (2002) Kuller,L.H., Hormone replacement therapy and risk of cardiovascular disease: implications of the results of the Women's Health Initiative, Arterioscler. Thromb. Vasc. Biol., 23 (2003) Reckelhoff,J.F., Gender differences in the regulation of blood pressure, Hypertension, 37 (2001) Huang,A. and Kaley,G., Gender-specific regulation of cardiovascular function: estrogen as key player, Microcirculation., 11 (2004) Harshfield,G.A., Alpert,B.S., Pulliam,D.A., Somes,G.W., and Wilson,D.K., Ambulatory blood pressure recordings in children and adolescents, Pediatrics, 94 (1994) Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial, JAMA, 273 (1995) da Costa,L.S., de Oliveira,M.A., Rubim,V.S., Wajngarten,M., Aldrighi,J.M., Rosano,G.M., Neto,C.D., and Gebara,O.C., Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women, Am. J. Cardiol., 94 (2004) Miller,K.W. and Lane,M.D., Estradiol-induced alteration of very-low-density lipoprotein assembly. Possible competition among apoproteins for incorporation into nascent very-low-density lipoprotein, J. Biol. Chem., 259 (1984) Walsh,B.W., Schiff,I., Rosner,B., Greenberg,L., Ravnikar,V., and Sacks,F.M., Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins, N. Engl. J. Med., 325 (1991) Mackey,R.H., Kuller,L.H., Sutton-Tyrrell,K., Evans,R.W., Holubkov,R., and Matthews,K.A., Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women Study, Arch. Intern. Med., 165 (2005) Henderson,V.W., Estrogen-containing hormone therapy and Alzheimer s disease risk: understanding discrepant inferences from observational and experimental research, KOREAN STROKE SOCIETY _13

6 SPECIAL LECTURE Neuroscience, 138 (2006) Curb,J.D., Prentice,R.L., Bray,P.F., Langer,R.D., Van Horn,L., Barnabei,V.M., Bloch,M.J., Cyr,M.G., Gass,M., Lepine,L., Rodabough,R.J., Sidney,S., Uwaifo,G.I., and Rosendaal,F.R., Venous thrombosis and conjugated equine estrogen in women without a uterus, Arch. Intern. Med., 166 (2006) Canonico,M., Oger,E., Plu-Bureau, Conard,J., Meyer,G., Levesque,H., Trillot,N., Barrellier,M.T., Wahl,D., Emmerich,J., and Scarabin,P.Y., Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study, Circulation, 115 (2007) Rexrode,K.M. and Manson,J.E., Are some types of hormone therapy safer than others? Lessons from the Estrogen and Thromboembolism Risk study, Circulation, 115 (2007) _

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