Daniel Hadfield Critical Care Nurse NIHR / HEE Clinical Doctoral Research Fellow King s College Hospital
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1 Daniel Hadfield Critical Care Nurse NIHR / HEE Clinical Doctoral Research Fellow King s College Hospital
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3 Baby 2 Moving house Funding??????? Baby 1 NHS support Me My research
4 Baby 2 Moving house Funding??????? Baby 1 NHS support Me My research
5 1. A monitor of electrical diaphragmatic activity (Edi) 2. A proportional mode of ventilation Edi is amplified, filtered and processed Diaphragm electrical activity (Edi) Multiplied by a proportionality factor (NAVA level) Used to trigger and shape pressure supported breaths Modified from Sinderby C, Navalesi P, Beck J, et al: Neural control of mechanical ventilation in respiratory failure, Nat Med 5: , 1999
6 1. A monitor of electrical diaphragmatic activity (Edi) 2. A proportional mode of ventilation Here, used as a monitor in PSV mode, highlighting dysynchrony Pressure (yellow) Expected NAVA pressure (white) Flow Volume Diaphragmatic electrical activity
7 1. A monitor of electrical diaphragmatic activity (Edi) 2. A proportional mode of ventilation Here, used as a mode, delivering synchronous, proportional pressure support Pressure Flow Volume Diaphragmatic electrical activity
8 1. A monitor of electrical diaphragmatic activity (Edi) 2. A proportional mode of ventilation PSV NAVA Pressure Flow Diaphragmatic electrical activity
9 Known benefits Improved synchronisation Greater natural breathing variability Physiologic prevention of over-assistance Theoretical benefits Monitoring Reduced time on ventilation Reduced sedation Current clinical use Not widely adopted (clinical effectiveness not yet demonstrated) What is needed Large multi-centre RCTs 1. Eldridge, S.M., et al., Defining Feasibility and Pilot Studies in Preparation for Randomised Controlled Trials. PLoS One, (3): p. e Eldridge, S.M., et al., CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ, : p. i5239.
10 Question: Can we conduct a randomised controlled trial to assess the affect of NAVA on the duration of mechanical ventilation? Objectives: 1. To evaluate the feasibility of conducting a randomised controlled trial 2. To evaluate the feasibility of using NAVA technology in PMV Design: Randomised controlled feasibility/pilot study Outcomes: Adherence to NAVA mode, reasons for non-compliance, recruitment rate, acceptability INCLUSIONS 1. Intubated and ventilated 2. COPD / heart failure / ARDS 3. Prediction >48hrs ventilation SCREENING Intubated with COPD / heart failure / ARDS ADVICE / ASSENT Personal or Nominated Consultees MAIN EXCLUSIONS 1. NG/OG tube contra-indication. 2. Neurological cause of ventilator dependence 1. STANDARD CARE n=38 Use of Pressure Support for weaning RANDOMISATION N= NAVA n=38 Edi monitoring & NAVA mode weaning
11 RCT recruitment to 30/08/ Number recruited 3 patients per month 2 patients per month
12 5. TECHNOLOGY STABILITY PSV backup mode Catheter performance Signal quality 1. TRIAL FEASIBILITY Compliance Acceptability Ability to recruit 2. CLINICAL OUTCOMES Duration of ventilation Gas exchange Ventilation parameters 4. PATIENT EXPERIENCE Agitation Sedation THESIS NAVA uncertainties 3. STAFF PERSPECTIVE Barriers to use Knowledge / education Views on trial DISCUSSION AND CONCLUSIONS Trial design, population, setting, intervention, randomisation, outcomes, statistical methods, stopping rules, separation of groups, blinding, allocation concealment.
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