Lessons learned From The National PCI Registry
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- Nathan Simmons
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1 Lessons learned From The National PCI Registry w a v e On Behalf of The Publication Committee of the National PCI Registry
2 Objectives & Anticipated Achievements To determine the epidemiology of patients who undergo PCI To determine safety and effectiveness of PCI in Thailand (short- and long-term) To benchmark with the rest of the world To determine factors that influence outcomes To compare with other treatment modalities To monitor rapidly evolving trends of PCI practice Effects of new devices or medication Effects of new public health policy To monitor and evaluate (new) cath labs performances To create the culture of multicenter collaboration
3 = PCI Registry sites 2 2 = Not in PCI Registry 2 = New cath lab since 2006
4 Results From May st October 3 st, 2006 (6 month period): 4,46 PCI procedures were performed in 27 participating sites 6,4 lesions attempted from 4,46 procedures
5 Number of PCI performed in each center (6-month period) N = 4,46 from 27 sites Government Private
6 Baseline Characteristics Clinical characteristics Mean age (yrs) Women (%) Mean BMI (kg/m 2 ) Diabetes mellitus (%) Hypertension (%) Dyslipidemia (%) Current smoking (%) Chronic renal failure (%) Previous MI (%) Previous PCI %) Previous CABG (%) N=4,
7 Indications for PCI Indications for PCI N = 4,46 STEMI 4.0 % - Primary PCI % - Rescue PCI ACS = 5 % % NSTEMI.6 % Unstable angina 25.4 % Stable angina 29.0 % Asymptomatic CAD 5.5 % PCI as staged procedure 5.8 %
8 Reimbursement Status Company paid (%) Social security (4%) National health care (24%)? Government civil servant (46%) Private insurance (3%) Self paid (22%)
9 Angiographic Characteristics Angiographic characteristics % Extent of CAD (%): vessel vessel vessel 3.5 Left main stenosis > 50% 4.6 Location of lesion (%): LAD 45.5 LCX 20.6 RCA 32.5 Left main.5 Bypass graft.0 Previously treated lesions (%) 6.9 ACC/AHA lesion classification: Type B2 / C (%) 70.4 Bifurcation (%) 8.9 CTO (%) 9.2
10 Procedures Procedure characteristics Single vessel PCI (%) 78. Multi vessel PCI (%) 2.9 Average number of lesions attempted per procedure (lesion).5 > 2 lesions attempted in the same procedure (%) 35.4 Intravascular ultrasound (%) 7. Rotational atherectomy (%).8 Average amount of contrast used (ml)
11 Stent Usage Procedure characteristics (stent usage) Balloon angioplasty only (%).8 Stent placement (%) Bare metal stent (BMS) (%) Average number of BMS / procedure (stent).42 - Drug eluting stent (DES) (%) Average number of DES / procedure (stent).82 Average number of stents per lesion (stent).20 Direct stenting (%) 20.3
12 Stent Usage DES + BMS (%) OTHERS (4%) Balloon only (2%) BMS (3%) DES (52%) N = 6,4 lesions
13 Success Rate Angiographic success* 94.2 % Procedural success** 90. % * = Diameter stenosis < 50% with TIMI 2-3 flow ** = Angiographic success without MACE
14 In-hospital Complications % Death Q Wave MI Stroke CABG Unplanned PCI Major entry Non-entry site site bleeding complications Renal Failure MACE
15 Logistic regression for factors predicting in-hospital MACE (Death, MI, stroke, unplanned PCI or urgent/emergent CABG) Variables Adjusted OR (95%CI) p-value STEMI 6.8 ( ) <0.00 CHF within 2 wks 3.7 ( ) <0.00 Age > 75.9 ( ) 0.00 GP IIbIIIa inhibitors.8 ( ) 0.00 Female.5 ( ) 0.00 Mulitvessel CAD.5 ( ) EF < 40%.2 ( ) 0.00 B2 and C lesion.2 ( ) DM.2 ( ) Chronic renal failure.2 ( ) 0.35 Previous MI. ( ) Multivessel PCI. ( ) Use of stent 0.4 ( ) <0.00
16 Variables national PCI Registry DES vs BMS Baseline Clinical Characteristics BMS(%) (N =,387) DES(%) (N = 2,090) P-value Age (mean + SD) <0.00 Male Smoking <0.00 Hypertension <0.00 Dyslipidemia <0.00 Diabetes Mellitus < Insulin treated DM Family history of CAD <0.00 Previous MI <0.00 Previous PCI <0.00
17 DES vs BMS Indications Variables BMS(%) (N =,387) DES(%) (N = 2,090) P-value STEMI < Primary PCI Rescue PCI UA/NSTEMI Stable angina <0.00 Asymptomatic CAD <0.00
18 DES vs BMS Reimbursment Status Variable (% in all PCI procedure) BMS(%) (N =,387) DES(%) (N = 2,090) P-value Government official ***(46%) <0.00 Healthcare : 30 baht (24%) <0.00 Self paid (22%) <0.00 Social security (4%) <0.00 Private insurance (3%) Company paid (%) *** DES is fully reimbursed for government officials
19 DES vs BMS Procedural Characteristics Variable Coronary disease extent BMS(%) (,387) DES(%) (2,090) P-value - vessel vessel vessel < Left main > 50 % stenosis Average number of lesions attempted per procedure > 2 lesions attempted in the same procedure <0.00
20 DES vs BMS Procedural Characteristics Variable BMS (%) (N = 927) DES (%) (N = 383) P- value Total number of stent(s) used 220 stents 3806 stents Average number of stent(s) per patient Average number of stent(s) per procedure Direct stenting <0.00 Intravascular ultrasound usage <0.00 Adjunctive rotational atherectomy <0.00 -
21 DES vs BMS 6-month Outcomes Variable BMS (%) (N =,82) DES (%) (N =,773) P-value Death <0.00 MI <0.00 Stent thrombosis Repeat PCI of previously treated lesion (TLR) CABG Repeat revascularization Stroke
22 Conclusions: wave Clinical, angiographic, procedural characteristics & immediate outcomes of PCI in Thailand Over 6 month period, there were 4,46 PCI performed in 27 centers (Projected national number of PCI / yr 0,000 procedures) Significant proportion of high-risk patients undergoing PCI DM Previous MI Multi-vessel CAD ACS (esp. STEMI) Complex lesion types
23 Conclusions: wave Clinical, angiographic, procedural characteristics & immediate outcomes of PCI in Thailand Stent usage was associated with lower in-hospital MACE Stent utilization rate is high (85%), but DES usage was rather limited (62%) compared to western countries Relatively small proportion of the patients were under government universal health care system. Of these patients, only 0% received DES (selection of DES was heavily influenced by reimbursement status). DES was used in more often in DM, restenotic lesion, multivessel CAD and complex lesion types
24 Conclusions: wave Clinical, angiographic, procedural characteristics & immediate outcomes of PCI in Thailand 6 month outcomes showed lower all-cause mortality and MI in DES treated patients However, TLR and repeated revascularization is not differed between DES and BMS The reason for the above findings is not yet explored.
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