IN recent years heart disease with eosinophilia has been called "eosinohilic
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1 A Case of Eosinophilic Heart Disease Diagnosed by Endomyocardial Biopsy Findings Hajime KAWAGOSHI, M.D., Masami SHIMIZU, M.D., Tetsuo SUEMATSU, M.D., Norihiko SUGIHARA, M.D., Yoshihito KITA, M.D., Kuniyoshi SHIMIZU, M.D., Masahiro MINAMOTO, M.D., Hiroto SANADA, M.D., Yoshiyuki ARAI, M.D., Hidekazu INO, M.D., Tsutomu ARAKI, M.D., and Ryoyu TAKEDA, M.D. SUMMARY A rare case of early stage eosinophilic heart disease was diagnosed by endomyocardial biopsy findings, despite the relatively low peripheral eosinophil blood count (640/mm3). Additional Indexing Words: Eosinophilic heart disease Cationic protein Degranulated eosinohil IN recent years heart disease with eosinophilia has been called "eosinohilic heart disease" and this disease has aroused great interest. However, the pathological findings of this disease are very scanty, especially during the early stages. We report a case in which eosinophilic invasion of myocytes, with resulting myocardial damage was verified by endomyocardial biopsy findings at an early stage. CASE REPORT History: A 22-year-old man was admitted to a nearby hospital with complaints of precordial pain. Cardiomegaly was detected on physical examination. For a more extensive examination he was transferred to our hospital. He had twice suffered from pneumothorax at the ages of 19 and 20. Soon after operation for the second pneumothorax, he complained of recordial pain at rest once a week. This has continued for the past 2 years. He had no history of allergic or parasitic disease. From the Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan. Address for reprints: Hajime Kawagoshi, M.D., Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920, Japan. Received for publication May 23, Accepted July 4,
2 260 KAWAGOSHI, ET AL. JPn. Heart J. March 1990 Fig. 1. Chest x ray and ECG on admission showing cardiomegaly (CTR: 60%) and high voltage. hysical examination: Height was 160cm. Body weight was 54kg. The heart rate was regular at 60beats/min. No rales were heard in either lung. Cardiac auscultation revealed no extra sounds and no murmurs. Abdominal examination disclosed no abnormal findings. Laboratory examination: The peripheral eosinophil blood count was not markedly elevated (640/mm3). Bone marrow puncture was performed after the diagnosis of "eosinophilic heart disease" was made, but the eosinophil count was normal. Stool examination for ova and parasites was negative. IgE count was 1360/ml. The chest roentgenogram revealed an abnormalsized heart (CTR: 60%); high voltage was the only abnormality apparent on the electrocardiogram (Fig. 1). MRI demonstrated no thrombus in the left ventricle (Fig. 2). Cardiac catheterization: Left ventriculography disclosed slight hypokinesis in the circumference (Fig. 3). Right ventriculography disclosed normal wall motion but enlargement of the right ventricle (Fig. 4). Coronary and ulmonary angiograms were normal. Left ventricular end-diastolic pressure was 14mmHg and the ejection fraction was 56%. Biopsy findings: Right ventricular endomyocardial biopsy showed a faintly stained thrombus adjacent to myocytes between which no endomyocardium existed. Numerous eosinophils invaded the thrombus and myocytes just under the thrombus. No eosinophils invaded normal myocytes (Fig. 5). Another specimen taken from the same lesion showed degeneration and disappearance of myocardium (Fig. 6). From these findings, we
3 Vol.31 EOSINOPHILIC HEART DISEASE 261 No.2 Fig. 2. MRI (magnetic resonance imaging) demonstrating no thrombus in a left ventricle. Fig. 3. Left ventriculography. Wall motion was slightly hypokinetic in the circumference. concluded that direct eosinophilic invasion of the myocardium was the cause of the myocardial necrosis.
4 262 KAWAGOSHI, ET AL. Jpn. Heart J. March 1990 ventricle Fig. 4. Right ventriculography. Wall motion was normal but right is dilated. Fig. 5. Right ventricular endomyocardial biopsy revealed thrombus adjacent to myocytes and numerous eosinophils invading the thrombus and myocytes (hematoxylin and eosin=160).
5 Vol.31 EOSINOPHILIC HEART DISEASE 263 No.2 Fig. 6. Right ventricular endomyocardial biopsy taken from the same lesion as Fig. 5 showing degeneration and disappearance of myocardium (azan ~100). DISCUSSION Since the first publication of heart disease with eosinophilia, Loffler's endomyocarditis,1) much knowledge has been obtained about the relationship between eosinophils and myocardial damage. At the present time it is believed that eosinophils invade not only myocytes but also the endocardium, and this disease is generally called "eosinophilic heart disease".2) The disease has three pathological stages, namely necrotic, thrombotic early stages and a late fibrotic stage.3) Eosinophilic invasion of myocytes is recognized only in the early stages. Cardiac lesions are present in a large number of hypereosinophilic syndrome cases,4) but eosinophilic invasion of myocytes has only rarely been documented on myocardial biopsy, even during the early stages. Therefore, little information is available about the relationship between eosinophils and the myocardium.5) In this case, even though the eosinophil count in the peripheral blood was only 640/mm3, many eosinophils invaded myocytes. So we concluded that this case was in an early stage, namely the "necrotic stage" or "thrombotic stage". Spry et al showed in vitro that eosinophils in the peripheral blood are activated by immune complexes and become degranulated, and that eosinophil granule proteins, mainly cationic protein, injure the myocardium in vivo.6) They suggested that the number of degranulated eosinophils in the peripheral blood is a clue to the early diagnosis of this disease. Un-
6 264 KAWAGOSHI, ET AL. Jpn. Heart J. March 1990 fortunately, we could not examine our case with regard to this point. Since steroids are known to prevent the worsening of this disease,7)-9) we administered prednisone to this patient and are now observing him carefully. REFERENCES 1. Loffler W: Endocarditis parietalis fibroplastica mit Blutosinophilie. Ein eigenartiges Krankheitsbild. Schweiz Med Wochenschr 66: 817, Olsen EGJ, Spry CJF: The pathogenesis of Loffler's endomyocardial disease and its relationship to endomyocardial fibrosis. Prog Cardiol 8: 281, Olsen EGJ: Pathological aspect of endomyocardial fibrosis. Postgrad Med J 59: 135, Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH (NIH conference): The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations. Ann Int Med 97: 78, Sekiguchi M, Yu Z, Take M, Hiroe M, Hirosawa K, Shirai T, Ishide T, Takahashi T: Ultrastructural features of the endomyocardium in patients with eosinophilic heart disease. An endomyocardial biopsy study. Jpn Circ J 48: 1375, Spry CJF: Eosinophils in eosinophilic endomyocardial disease. Postgrad Med J 62: 609, Kim CH: Steroid-responsive eosinophilic myocarditis: Diagnosis by endomyocardial biopsy. Am J Cardiol 53: 1472, Ikeda T, Tanaka Y, Shirai T, Aonuma K, Miyahara Y, Niwa A, Taniguchi K, Takeuchi J, Hiroe M, Sekiguchi M: A case of Loffler's endocarditis. Heart 16: 732, 1984 (in Japanese) 9. Davies J, Spry CJF, Sapsford R, Olsen EGJ, de Perez G, Oakley CM, Goodwin JF: Cardiovascular features of 11 patients with eosinophilic endomyocardial disease. QJ Med 52: 23, 1983
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