Quality of Life After Everolimus- Eluting Stents or Bypass Surgery for Treatment of Left Main Coronary Artery Disease:
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1 Quality of Life After Everolimus- Eluting Stents or Bypass Surgery for Treatment of Left Main Coronary Artery Disease: Results from the EXCEL Trial Suzanne J. Baron MD MSC on behalf of the EXCEL Investigators Saint Luke s Mid America Heart Institute University of Missouri, Kansas City October 30, 2017
2 Disclosures Within the past 12 months, I have had a financial interest with the organizations listed below: Consulting Fees: Edwards LifeSciences; St. Jude Medical Inc Travel Reimbursement: Medtronic The EXCEL trial was funded by Abbott Vascular, Inc.
3 Background The EXCEL trial randomized patients with left main coronary artery disease (LMCAD) and lowto-intermediate anatomical complexity to revascularization with PCI using 2 nd generation everolimus-eluting stents (XIENCE) or CABG Although rates of death, stroke, and myocardial infarction were similar in both groups at a median of 3 years, timing of clinical events and rates of repeat revascularization differed between the cohorts
4 Background Prior studies have shown that CABG is associated with greater angina relief when compared with PCI Utilized 1 st generation DES Not limited to LMCAD Whether treatment with PCI or CABG results in differences in quality of life (QoL) in patients with LMCAD treated in the contemporary era is unknown
5 Objectives To compare QoL outcomes among patients with LMCAD treated with either PCI or CABG To determine whether the QoL benefits of PCI vs. CABG vary over time To examine whether the QoL benefits of PCI vs. CABG in patients with LMCAD differ according to patient characteristics, including baseline angina frequency and anatomic disease patterns
6 EXCEL QoL Sub-Study Design 1905 Pts Randomized First 1800 Pts Eligible for QoL Substudy Missing baseline health status data N = 12 PCI with EES N = 892 CABG N = 896 QoL assessed at baseline, 1 month, 12 months and 36 months
7 Disease-Specific Health Status Instruments
8 Disease-Specific Health Status Instruments Instrument Seattle Angina Questionnaire (SAQ) Description/Role Assesses CAD-specific health status Domains: Angina Frequency; Physical Limitations; Quality of Life; Angina Stability; Treatment Satisfaction Scores: 0 to 100 with higher scores indicating less severe symptoms
9 Disease-Specific Health Status Instruments Instrument Seattle Angina Questionnaire (SAQ) Rose Dyspnea Scale (RDS) Description/Role Assesses CAD-specific health status Domains: Angina Frequency; Physical Limitations; Quality of Life; Angina Stability; Treatment Satisfaction Scores: 0 to 100 with higher scores indicating less severe symptoms Assesses patient s level of dyspnea with activity Scores: 0 to 4 (0 = no dyspnea; 4 = dyspnea with minimal activity)
10 Generic Health Status Instruments Instrument Medical Outcomes Study Short-Form-12 (SF-12) Description/Role Assesses general physical and mental health Physical & Mental Summary Scores standardized such that population mean is 50 with SD of 10 with higher scores indicating better QoL
11 Generic Health Status Instruments Instrument Medical Outcomes Study Short-Form-12 (SF-12) Patient Health Questionnaire-8 (PHQ-8) Description/Role Assesses general physical and mental health Physical & Mental Summary Scores standardized such that population mean is 50 with SD of 10 with higher scores indicating better QoL Assesses sx associated with clinical depression Scores: 0 to 24 with higher scores indicating worse depression PHQ-8 10 corresponds to significant clinical depression
12 Statistical Methods Between-group comparisons performed using longitudinal random-effect growth curve models Exploratory subgroup analyses performed to assess whether the effect of PCI vs. CABG on the SAQangina frequency scale at 12 and 36 months varies according to baseline patient characteristics Threshold for significance < 0.01 given multiple comparisons
13 Baseline Clinical Characteristics PCI (N = 892) CABG (N = 896) P Value Age (years) 66 ± ± Male 77% 78% 0.46 Diabetes 30% 29% 0.53 Clinical Presentation Stable angina Unstable angina MI within prior 7 days Silent ischemia SYNTAX Score * Low ( 22) Intermediate (23-32) High ( 33) 53% 24% 15% 7% 32% 43% 25% 54% 24% 15% 7% 39% 38% 23% * Core-lab defined
14 Baseline Quality of Life SAQ Angina Frequency Daily Weekly Monthly None PCI (N = 892) 10% 30% 38% 23% CABG (N = 896) 10% 31% 40% 19% P Value 0.29 Rose Dyspnea Scale 2 48% 47% 0.65 SF-12 Physical Component Summary Mental Component Summary 39 ± ± ± ± PHQ % 21% 0.90
15 Clinical Outcomes at 36 Months * For full trial population
16 SAQ-Angina Frequency 100 PCI CABG Δ = 1.5 p = 0.03 Δ = -0.3 p = Months Δ = -0.8 p = 0.21
17 Proportion of Surviving Patients SAQ-Angina Frequency None Monthly Daily/Weekly 100% 80% P = % 41% P < % 10% P = 0.58 P = % 5% 6% 4% 23% 20% 15% 16% 13% 15% 60% 40% 37% 40% 72% 70% 79% 80% 81% 82% 20% 23% 19% 0% PCI CABG PCI CABG PCI CABG PCI CABG Baseline 1 Month 12 Months 36 Months
18 Proportion of Surviving Patients Rose Dyspnea Scale 100% 80% 60% 40% 20% P = % 14% 13% 15% 19% 17% 24% 24% 27% 28% P < % 10% 4% 8% 7% 12% 16% 19% 60% 44% P = 0.40 P = % 5% 5% 5% 5% 4% 6% 6% 8% 9% 7% 7% 17% 16% 12% 14% 49% 46% 43% 42% % PCI CABG PCI CABG PCI CABG PCI CABG Baseline 1 Month 12 Months 36 Months
19 SF-12 Physical Summary Scale 50 PCI CABG Δ = 8.2 p < 0.01 Δ = -0.9 p = 0.05 Δ = -0.4 p = Months
20 SF-12 Mental Summary Scale 60 PCI CABG Δ = 2.0 p < 0.01 Δ = 0.7 p = 0.17 Δ = 0.8 p = Months
21 Proportion of Surviving Patients PHQ-8 Clinically Significant Depression * 30% PCI CABG P = 0.90 P < % P = % 21% 21% 19% P = % 8% 8% 9% 8% 0% Baseline 1 Month month 126 months Months Months months * PHQ-8 > 10
22 Subgroup Analyses SAQ-Angina Frequency Scale at 1 Year Sub-Group Age < 65 Age Age > 75 Male Female No Diabetes Diabetes SYNTAX Score 22 SYNTAX Score SYNTAX Score 33 No Involvement of LM Bifurcation Involvement of LM Bifurcation No Angina Monthly Angina Daily/Weekly Angina P Value for Interaction OR CABG Better PCI Better Mean Treatment Effect
23 Subgroup Analyses SAQ-Angina Frequency Scale at 3 Years Sub-Group Age < 65 Age Age > 75 Male Female No Diabetes Diabetes P Value for Interaction SYNTAX Score < 22 SYNTAX Score SYNTAX Score > 33 No Involvement of LM Bifurcation Involvement of LM Bifurcation No Angina Monthly Angina Daily/Weekly Angina CABG Better OR PCI Better Mean Treatment Effect
24 Comparison of QoL Outcomes with Other PCI vs. CABG Trials EXCEL SYNTAX 1 FREEDOM 2 1. Abdallah et al. JACC 2017; 69: Abdallah et al. JAMA 2013; 310:
25 Comparison of QoL Outcomes with Other PCI vs. CABG Trials EXCEL SYNTAX 1 FREEDOM 2 QoL at 1 Month Better with PCI Better with PCI Better with PCI 1. Abdallah et al. JACC 2017; 69: Abdallah et al. JAMA 2013; 310:
26 Comparison of QoL Outcomes with Other PCI vs. CABG Trials EXCEL SYNTAX 1 FREEDOM 2 QoL at 1 Month Better with PCI Better with PCI Better with PCI Long-Term Angina Relief No difference Better with CABG Better with CABG 1. Abdallah et al. JACC 2017; 69: Abdallah et al. JAMA 2013; 310:
27 Comparison of QoL Outcomes with Other PCI vs. CABG Trials EXCEL SYNTAX 1 FREEDOM 2 QoL at 1 Month Better with PCI Better with PCI Better with PCI Long-Term Angina Relief No difference Better with CABG Better with CABG Subgroup Effects No difference CABG better with greater anatomic complexity CABG better with greater anatomic complexity and with more baseline angina 1. Abdallah et al. JACC 2017; 69: Abdallah et al. JAMA 2013; 310:
28 Why the Discrepancies? Differences in stent type? Differences in patient populations? Differences in follow-up duration? Smaller absolute difference in repeat revascularization rates?
29 Summary and Conclusions In patients with unprotected LMCAD and low-tointermediate angiographic complexity, both PCI and CABG were associated with clinically meaningful and statistically significant improvements in disease-specific and generic health status that were sustained through 36 months PCI resulted in significantly better health status compared with CABG at 1 month on all quality of life scales
30 Summary and Conclusions In contrast to previous trials (e.g. FREEDOM, SYNTAX), there were no significant differences in long-term health status outcomes between PCI and CABG a finding that was consistent across subgroups Taken together with the 3-year clinical data from EXCEL, these results suggest that PCI and CABG provide comparable intermediate-term outcomes for appropriately selected patients with LMCAD
31 Baron SJ, Chinnakondepalli K, Magnuson EA, Kandzari DE, Puskas JD, Ben- Yehuda O, Es G-Av, Taggart DP, Morice M-C, Lembo NJ, Brown III WM, Banning A, Simonton CA, Kappetein AP, Sabik JF, Serruys PW, Stone GW, Cohen DJ, on behalf of the EXCEL Investigators. Quality of Life after Everolimus-Eluting Stents or Bypass Surgery for Treatment of Left Main Disease. J Am Coll Cardiol (2017); doi: /j.jacc
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