Blood pressure and total cholesterol level are critical risks especially for hemorrhagic stroke in Akita, Japan.
|
|
- Justin Henderson
- 6 years ago
- Views:
Transcription
1 Blood pressure and total cholesterol level are critical risks especially for hemorrhagic stroke in Akita, Japan. Manabu Izumi, Kazuo Suzuki, Tetsuya Sakamoto and Masato Hayashi Jichi Medical University Research Institute for Brain and Blood vessels-akita
2 Background Stroke is one of the leading causes of death and disability in Akita, Japan, same as all over the world. Stroke prevention is considered one of the best strategies for improving public health. Hypertension, diabetes mellitus, hyperlipidemia, obesity, smoking, and drinking are well known as risk factors for stroke all over the world. While, differences of the distribution of risk factors exist in stroke subtypes, countries, and races. To prevent stroke in target populations, it is important to identify specific risk factors by stroke subtype, location, and race.
3 Purpose We performed a retrospective cohort study to assess risk factors for stroke depending on the subtypes in Akita, northern territory of Japan. Japanese World Map
4 Where is Akita? And what is characteristics of Akita? Weather ; (Summer is like Rome and winter is like Stockholm) Almost one race Japanese and health-insurance system that covers all of its citizens Stroke subtype; (Cerebral infarction; CI, Cerebral hemorrhage; CI and Subarachnoid hemorrhage; SAH) The rose line means latitude of 40 degrees north.
5
6 Characteristics of Akita Prefecture The climate in Akita is characteristically marked by long winters and short summers. we have a heavy fall of snow in winter. Akita Prefecture shares the same latitude with Beijing, Madrid and New York. Area Population Mortality of stroke 11,434 km2 5th in Japan 1,142,799 people 5th in Japan 1613 /million 1st in Japan Research Institute for Brain and Vessels-Akita, Specialist Hospital for Stroke
7 Methods: Mass health screening data was collected from the Akita Prefectural Federation of Agricultural Cooperative for Health and Welfare from 1991 to Cerebrovascular events were determined from the Akita stroke registry from 1991 to Then, clinical risk factors for stroke, such as hypertension, hyperlipidemia and diabetes mellitus, were assessed in the different subtypes of stroke. Disease classifications were made using the international Classification of ICD9 and classifications were follows: cerebral infarction (CI), cerebral hemorrhage (CH), and subarachnoid hemorrhage (SAH). The Akita stoke registry consisted of the basis of informed consent from all patients with stroke event who were admitted to a hospital and included all stroke events and stroke related deaths that required immediate hospitalization in all emergency medical facilities of Akita Prefecture.
8 Methods: A first-ever stroke occurring less than 3 years after the screening examination (i.e., from 1991 to 2001) was defined as a stroke event. As stroke risk factors, age, sex, history of DM, blood pressure (BP), serum total cholesterol (TC), body mass index (BMI), smoking, and drinking were assessed. Significant risk factors were detected by multivariable logistic regression analysis. Reductions in risk and 95% CI were estimated with use of the Cox proportional-hazards model. We also assessed interactions with a p value of <0.001 (two-sided test) being considered statistically significant.
9 Result: Table 1 Number of subject and stroke event by age and sex. Men Age(y.o.) Non stroke CH CI SAH Total total Women Age(y.o.) Non stroke CH CI SAH Total Total
10 Result: Table 2 Age-specific stroke incidence /100,000 by sex Men Age(y.o.) CH CI SAH ALL Women Age CH CI SAH ALL
11 Result: Table 3 Risk factors comparison by stroke event and sex Men Women Factors Non-stroke Stroke Non-stroke Stroke Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Age (years old) 53.1 (53.0, 53.2) 64.5 (63.7, 65.2) 54.8 (54.7, 54.9) 66.7 (65.8, 67.5) SBP (mmhg) (130.6, 130.9) (143.2, 146.1) (127.4, 127.7) (143.8, 147.1) DBP (mmhg) 80 ( 79.9, 80.1) 85.6 ( 84.7, 86.5) 76.1 ( 76.0, 76.2) 83.3 ( 82.4, 84.3) BMI 23.5 ( 23.4, 23.6) 23.3 ( 23.1, 23.5) 23.5 ( 23.4, 23.6) 24.1 ( 23.8, 24.4) TC (mg/dl) (197.1, 197.6) 191 (188.5, 193.5) (205.0, 205.5) (207.6, 213.8) Drinking (number) No p< p=0.129 Yes Smoking (number) No p< p= /day /day >= DM (number) No p< p<0.001 Yes TC; Total Cholesterol, BMI; Body mass index, DM; Diabetes mullitus, SBP; Systolic BP and DBP; Diastolic BP
12 Relative risk of the risk factors of stroke subtypes by multi logistic regression analysis Factors Intracranial Brain Subarachnoid Total hemorrhage(95%ci) infarction(95%ci) hemorrhage(95%ci) Stroke(95%CI) Sex Male Female 0.7( 0.6, 0.9) 0.6( 0.5, 0.7) 1.8( 1.3, 2.5) 0.7 (0.6, 0.8) Age 30-49yo ( 2.3, 5.4) 4.0( 2.8, 5.8) 1.3( 0.8, 1.9) 2.9 (2.3, 3.6) ( 3.4, 7.7) 9.4( 6.7,13.2) 2.4( 1.7, 3.5) 5.6 (4.6, 6.9) ( 4.6,10.9) 22.5(16.0,31.6) 2.1( 1.3, 3.3) 10.1 (8.1,12.5) ( 5.2,17.0) 36.4(24.3,54.7) 1.7( 0.7, 4.3) 14.7(11.0,19.6) Classification of BP Optimal Normal 1.7( 0.9, 3.4) 1.4( 1.0, 1.9) 2.8( 1.5, 5.4) 1.6 (1.2, 2.1) Normal high 3.7( 2.0, 6.7) 1.8( 1.3, 2.4) 2.8( 1.5, 5.4) 2.2 (1.7, 2.9) Mild HT 6.6( 3.7,11.7) 2.2( 1.6, 2.9) 6.4( 3.5,11.5) 3.3 (2.6, 4.2) Medium HT 13.1( 7.2,23.7) 2.6( 1.9, 3.6) 10.0( 5.3,18.7) 4.9 (3.8, 6.3) Severe HT 24.9(13.2,46.9) 5.0( 3.4, 7.3) 16.1( 7.7,33.5) 9.1 (6.8,12.2)
13 Relative risk of the risk factors of stroke subtypes by multi logistic regression analysis Factors Intracranial Brain Subarachnoid Total hemorrhage(95%ci) infarction(95%ci) hemorrhage(95%ci) Stroke(95%CI) Body mass index less than ( 0.8, 2.1) 0.6( 0.4, 0.9) 1.5( 0.9, 2.6) 0.9 (0.7, 1.2) ( 0.8, 1.3) 1.2( 1.0, 1.4) 0.7( 0.5, 1.0) 1.0 (0.9, 1.2) more than ( 1.2, 2.9) 1.1( 0.7, 1.7) 1.2( 0.6, 2.2) 1.3 (1.0, 1.8) Total cholesterol <160mg/dl ( 0.5, 0.9) 0.9( 0.7, 1.1) 0.4( 0.3, 0.6) 0.7 (0.6, 0.8) ( 0.4, 0.8) 0.9( 0.7, 1.2) 0.5( 0.4, 0.8) 0.7 (0.6, 0.9) ( 0.4, 0.9) 0.9( 0.7, 1.2) 0.4( 0.2, 0.7) 0.9 (0.6, 1.4) >=280mg/dl 0.6( 0.3, 1.3) 1.7( 1.1, 2.6) 0.2( 0.0, 0.8) 0.9 (0.8, 1.1) Drinking No Yes 1.2( 0.9, 1.7) 0.8( 0.7, 1.1) 1.0( 0.6, 1.7) 1.0 (0.8, 1.1) Smoking No <10/day 0.9( 0.5, 1.6) 1.7( 1.3, 2.3) 1.5( 0.7, 3.1) 1.5 (1.1, 1.9) 11-20/day 1.0( 0.6, 1.5) 1.9( 1.5, 2.5) 1.3( 0.7, 2.3) 1.5 (1.3, 1.9) >=21 1.2( 0.6, 2.5) 1.5( 0.9, 2.5) 2.4( 1.1, 5.3) 1.5 (1.1, 2.2) Diabetes mellitus No Yes 0.9( 0.5, 1.5) 1.6( 1.2, 2.1) 0.4( 0.1, 1.2) 1.2 (0.9, 1.6)
14 Relative risk Relative risk of the combinations with blood pressure and cholesterol against the lowest in hemorrhagic stroke < >240 Total cholesterol mg/dl normal preht HT-1 HT-2 JNC7 classification of blood pressure
15 Discussion: Hypertension is the strongest risk factor for stroke, especially for hemorrhagic stroke. Our results support the idea that stroke incidence will be increased along with higher BP level. Interestingly, however, this phenomenon is observed not only among hypertensive categories but also within normal BP levels. Our register showed that 40% of all stroke events occurred in either mildly hypertensive cases who were not receiving any pharmacologic therapy or normal BP cases. Even though high BP is associated with high stroke risk, mildly high BP is still a risk factor for stroke. Therefore, we should put the eyes on the hidden or untreated normal high BP person for reducing stroke incident.
16 Discussion: Our data also suggest that TC <160 mg/dl is a risk factor for hemorrhagic stroke, whereas levels >280 mg/dl are a risk factor for CI. The reasons for this phenomenon seem to be related to the high incidence of CH and low incidence of CI in our study compared with Western countries. The interaction of BP and TC is an important factor for CH among Japanese subjects. Our study showed that the highest BP combined with the lowest TC level was the strongest risk factor for CH. Low TC contributed to the risk of CH across all BP levels. We could reveal the synergic effect on hemorrhagic stroke between low TC and hypertension.
17 Conclusion: Japanese subjects in this study showed a high proportion of hemorrhagic stroke. The relative risk of all stroke subtypes are increasing with higher blood pressure. Moreover, high blood pressure and low TC (<160 mg/dl) were the strongest risk factor for hemorrhagic stroke. Future studies are needed to determine if typical Japanese food consumption causes high blood pressure and low TC and is associated with the incidence of stroke.
Current status on other health effects:
Current status on other health effects: Changes in Cardiovascular Risk Factors after the Great East Japan Earthquake Tetsuya Ohira, MD, PhD. Department of Epidemiology, Fukushima Medical University School
More informationEpidemiologic Measure of Association
Measures of Disease Occurrence: Epidemiologic Measure of Association Basic Concepts Confidence Interval for population characteristic: Disease Exposure Present Absent Total Yes A B N 1 = A+B No C D N 2
More informationWhy Do We Treat Obesity? Epidemiology
Why Do We Treat Obesity? Epidemiology Epidemiology of Obesity U.S. Epidemic 2 More than Two Thirds of US Adults Are Overweight or Obese 87.5 NHANES Data US Adults Age 2 Years (Crude Estimate) Population
More informationUniversity of Padova, Padua, Italy, and HARVEST Study Group, Italy
University of Padova, Padua, Italy, and HARVEST Study Group, Italy ISOLATED SYSTOLIC HYPERTENSION IN THE YOUNG DOES NOT IMPLY AN INCREASED RISK OF FUTURE HYPERTENSION NEEDING TREATMENT Mos L, Saladini
More informationESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study
ESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study Statistical modelling details We used Cox proportional-hazards
More informationPrevalence of cerebrovascular accidents (CVA) in obese hypertensives among inpatients of Govt.General Hospital, Guntur
Original article Prevalence of cerebrovascular accidents (CVA) in obese hypertensives among inpatients of Govt.General Hospital, Guntur 1 Dr. Dr.Uday Shankar Sanakayala, 2 Dr. T. V. Adi Seshu Babu, 3 Dr.
More informationJoint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up
1169 Original Article Hypertens Res Vol.30 (2007) No.12 p.1169-1175 Joint Impact of Smoking and Hypertension on Cardiovascular Disease and All-Cause Mortality in Japan: NIPPON DATA80, a 19-Year Follow-Up
More informationSupplementary Online Content
Supplementary Online Content Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis. JAMA Intern Med. Published online November 7, 2016.
More informationStatin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography
Statin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography Hyo Eun Park 1, Eun-Ju Chun 2, Sang-Il Choi 2, Soyeon Ahn 2, Hyung-Kwan Kim 3,
More informationRetrospective Cohort Study for the Evaluation of Life- Style Risk Factors in Developing Metabolic Syndrome under the Estimated Abdominal Circumference
Original Asian Pacific Journal of Disease Management 2007; 1(2), 55-63 Retrospective Cohort Study for the Evaluation of Life- Style Risk Factors in Developing Metabolic Syndrome under the Estimated Abdominal
More informationSupplement materials:
Supplement materials: Table S1: ICD-9 codes used to define prevalent comorbid conditions and incident conditions Comorbid condition ICD-9 code Hypertension 401-405 Diabetes mellitus 250.x Myocardial infarction
More informationDepok-Indonesia STEPS Survey 2003
The STEPS survey of chronic disease risk factors in Indonesia/Depok was carried out from February 2003 to March 2003. Indonesia/Depok carried out Step 1, Step 2 and Step 3. Socio demographic and behavioural
More informationTotal risk management of Cardiovascular diseases Nobuhiro Yamada
Nobuhiro Yamada The worldwide burden of cardiovascular diseases (WHO) To prevent cardiovascular diseases Beyond LDL Multiple risk factors With common molecular basis The Current Burden of CVD CVD is responsible
More informationSmall dense low-density lipoprotein is a risk for coronary artery disease in an urban Japanese cohort: The Suita study
Small dense low-density lipoprotein is a risk for coronary artery disease in an urban Japanese cohort: The Suita study Hidenori Arai 1, Yoshihiro Kokubo 2, Makoto Watanabe 2, Tatsuya Sawamura 3, Tomonori
More informationMagnetic resonance imaging, image analysis:visual scoring of white matter
Supplemental method ULSAM Magnetic resonance imaging, image analysis:visual scoring of white matter hyperintensities (WMHI) was performed by a neuroradiologist using a PACS system blinded of baseline data.
More informationEpidemiology of Obesity in Japan
Obesity Epidemiology of Obesity in Japan JMAJ 48(1): 34 41, Heizo TANAKA* and Yoshihiro KOKUBO** *Director-General, National Institute of Health and Nutrition **Department of Preventive Medicine and Mass
More informationUW MIRT 2005 ABSTRACTS
UW MIRT 2005 ABSTRACTS Factors of Hypertension and Correlates of Blood Pressure and Mean Arterial Pressure among Thai Population.*M. Lee, *L. Entzminger, V Lohsoonthorn, MA Williams. (University of Washington,
More informationEffect of Medicine Adherence on the Occurrence of Cerebrovascular Disorders in Diabetes Mellitus Patients
Epidemiology and Health Epidemiology and Health Volume: 33, Article ID: e2011001, 6 pages DOI 10.4178/epih/e2011001 ORIGINAL ARTICLE Effect of Medicine Adherence on the Occurrence of Cerebrovascular Disorders
More information5. Cardiovascular Disease & Stroke
5. Cardiovascular Disease & Stroke 64: Self-Reported Heart Disease 66: Heart Disease Management 68: Heart Disease Mortality 70: Heart Disease Mortality Across Life Span 72: Stroke Mortality 185: Map 3:
More informationVomiting Should Be a Prompt Predictor of Stroke Outcome
Vomiting Should Be a Prompt Predictor of Stroke Outcome Kazuo Shigematsu, Osamu Shimamura, Hiromi Nakano, Yoshiyuki Watanabe, Tatsuyuki Sekimoto, Kouichiro Shimizu, Akihiko Nishizawa, Masahiro Makino Emerg
More informationUsefulness of a large automated health records database in pharmacoepidemiology
Environ Health Prev Med (2011) 16:313 319 DOI 10.1007/s12199-010-0201-y REGULAR ARTICLE Usefulness of a large automated health records database in pharmacoepidemiology Hirokuni Hashikata Kouji H. Harada
More informationA n aly tical m e t h o d s
a A n aly tical m e t h o d s If I didn t go to the screening at Farmers Market I would not have known about my kidney problems. I am grateful to the whole staff. They were very professional. Thank you.
More informationFelix Vallotton Ball (1899) LDL-C management in Asian diabetes: moderate vs. high intensity statin --- a lesson from EMPATHY study
Felix Vallotton Ball (1899) LDL-C management in Asian diabetes: moderate vs. high intensity statin --- a lesson from EMPATHY study Conflict of interest disclosure None Committee of Scientific Affairs Committee
More informationHeart Disease and Stroke Statistics 2010 Update. 2009, American Heart Association. All rights reserved.
Heart Disease and Stroke Statistics 21 Update Questions on statistics? mailto:nancy.haase@heart.org Audio-visual questions? mailto:david.brentz@heart.org Please keep the red wave and logo attached to these
More informationHypertension is a major risk factor for stroke in developed
Prediction of Stroke by Self-Measurement of Blood Pressure at Home Versus Casual Screening Blood Pressure Measurement in Relation to the Joint National Committee 7 Classification The Ohasama Study Kei
More informationT. Suithichaiyakul Cardiomed Chula
T. Suithichaiyakul Cardiomed Chula The cardiovascular (CV) continuum: role of risk factors Endothelial Dysfunction Atherosclerosis and left ventricular hypertrophy Myocardial infarction & stroke Endothelial
More informationΑΡΥΙΚΗ ΠΡΟΔΓΓΙΗ ΤΠΔΡΣΑΙΚΟΤ ΑΘΔΝΟΤ. Μ.Β.Παπαβαζιλείοσ Καρδιολόγος FESC - Γιεσθύνηρια ιζμανόγλειον ΓΝΑ Clinical Hypertension Specialist ESH
ΑΡΥΙΚΗ ΠΡΟΔΓΓΙΗ ΤΠΔΡΣΑΙΚΟΤ ΑΘΔΝΟΤ Μ.Β.Παπαβαζιλείοσ Καρδιολόγος FESC - Γιεσθύνηρια ιζμανόγλειον ΓΝΑ Clinical Hypertension Specialist ESH Hypertension Co-Morbidities HTN Commonly Clusters with Other Risk
More information(n=6279). Continuous variables are reported as mean with 95% confidence interval and T1 T2 T3. Number of subjects
Table 1. Distribution of baseline characteristics across tertiles of OPG adjusted for age and sex (n=6279). Continuous variables are reported as mean with 95% confidence interval and categorical values
More informationHypertension in 2015: SPRINT-ing ahead of JNC-8. MAJ Charles Magee, MD MPH FACP Director, WRNMMC Hypertension Clinic
Hypertension in 2015: SPRINT-ing ahead of JNC-8 MAJ Charles Magee, MD MPH FACP Director, WRNMMC Hypertension Clinic Conflits of interest? None Disclaimer The opinions contained herein are not to be considered
More informationSmoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol
Atherosclerosis 190 (2007) 306 312 Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol Sun Ha Jee a,b,c,, Jungyong Park b, Inho Jo d, Jakyoung Lee a,b, Soojin
More informationTennessee Department of Health in collaboration with Tennessee State University and University of Tennessee Health Science Center
Tennessee Department of Health in collaboration with Tennessee State University and University of Tennessee Health Science Center 2006 Tennessee Department of Health 2006 ACKNOWLEDGEMENTS CONTRIBUTING
More informationLow-Carbohydrate Diets and All-Cause and Cause-Specific Mortality: A Population-based Cohort Study and Pooling Prospective Studies
Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality: A Population-based Cohort Study and Pooling Prospective Studies Mohsen Mazidi 1, Niki Katsiki 2, Dimitri P. Mikhailidis 3, Maciej Banach
More informationDiet-Related Factors, Educational Levels and Blood Pressure in a Chinese Population Sample: Findings from the Japan-China Cooperative Research Project
559 Original Article Diet-Related Factors, Educational Levels and Blood Pressure in a Chinese Population Sample: Findings from the Japan-China Cooperative Research Project Yukio YAMORI 1, Longjian LIU
More information2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension.
2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension Writing Group: Background Hypertension worldwide causes 7.1 million premature
More informationGuidelines on cardiovascular risk assessment and management
European Heart Journal Supplements (2005) 7 (Supplement L), L5 L10 doi:10.1093/eurheartj/sui079 Guidelines on cardiovascular risk assessment and management David A. Wood 1,2 * 1 Cardiovascular Medicine
More informationClinical Studies 129
Clinical Studies 129 Syncope in migraine. The population-based CAMERA study Roland D. Thijs, 1* Mark C. Kruit, 2* Mark A. van Buchem, 2 Michel D. Ferrari, 1 Lenore J. Launer, 3,4 and J. Gert van Dijk
More informationPFIZER INC. THERAPEUTIC AREA AND FDA APPROVED INDICATIONS: See USPI.
PFIZER INC. These results are supplied for informational purposes only. Prescribing decisions should be made based on the approved package insert. For publications based on this study, see associated bibliography.
More informationCONTRIBUTING FACTORS FOR STROKE:
CONTRIBUTING FACTORS FOR STROKE: HYPERTENSION AND HYPERCHOLESTEROLEMIA Melissa R. Stephens, MD, FAAFP Associate Professor of Clinical Sciences William Carey University College of Osteopathic Medicine LEARNING
More informationNew Hypertension Guideline Recommendations for Adults July 7, :45-9:30am
Advances in Cardiovascular Disease 30 th Annual Convention and Reunion UERM-CMAA, Inc. Annual Convention and Scientific Meeting July 5-8, 2018 New Hypertension Guideline Recommendations for Adults July
More informationHypertension Guidelines 2017
Hypertension Guidelines 2017 (American College of Cardiology and the American Heart Association) In 1977, the 1st comprehensive guideline for detection, evaluation, and management of high BP was published,
More informationWhat is hypertension?
HYPERTENSION What is hypertension? Abnormally elevated arterial blood pressure that is usually indicated by an adult systolic blood pressure of 140 mm Hg or greater or a diastolic blood pressure of 90
More informationCardiovascular Disease Prevention: Current Knowledge, Future Directions
Cardiovascular Disease Prevention: Current Knowledge, Future Directions Daniel Levy, MD Director, Framingham Heart Study Professor of Medicine, Boston University School of Medicine Editor-in-Chief, Journal
More informationStudy on occurrence of metabolic syndrome among patients with stroke: a descriptive study
Original article Study on occurrence of metabolic syndrome among patients with stroke: a descriptive study Dr. Mahesh K Savadi*, Dr Manjunatha N** *Assistant Professor, **Post graduate Dept. of General
More informationThe Latest Generation of Clinical
The Latest Generation of Clinical Guidelines: HTN and HLD Dave Brackett Clinical Guideline Purpose Uniform approach Awareness of key details Diagnosis Treatment Monitoring Evidence based approach Inform
More informationPredicting failure to follow-up screened high blood pressure in Japan: a cohort study
Journal of Public Health Vol. 37, No. 3, pp. 498 505 doi:10.1093/pubmed/fdu056 Advance Access Publication August 7, 2014 Predicting failure to follow-up screened high blood pressure in Japan: a cohort
More informationPhysical Activity, Sedentary Behaviors and the Incidence of Type 2 Diabetes Mellitus: The Multi-
Physical Activity, Sedentary Behaviors and the Incidence of Type 2 Diabetes Mellitus: The Multi- Ethnic Study of Atherosclerosis (MESA) Running Title: Physical Activity, Sedentary Behavior and Incident
More informationBlood Pressure Management in Acute Ischemic Stroke
Blood Pressure Management in Acute Ischemic Stroke Kimberly Clark, PharmD, BCCCP Clinical Pharmacy Specialist Critical Care, Greenville Health System Adjunct Assistant Professor, South Carolina College
More informationThe Impact of Smoking on Acute Ischemic Stroke
Smoking The Impact of Smoking on Acute Ischemic Stroke Wei-Chieh Weng, M.D. Department of Neurology, Chang-Gung Memorial Hospital, Kee-Lung, Taiwan Smoking related mortality Atherosclerotic vascular disease
More informationClinical Features and Subtypes of Ischemic Stroke Associated with Peripheral Arterial Disease
Cronicon OPEN ACCESS EC NEUROLOGY Research Article Clinical Features and Subtypes of Ischemic Stroke Associated with Peripheral Arterial Disease Jin Ok Kim, Hyung-IL Kim, Jae Guk Kim, Hanna Choi, Sung-Yeon
More informationCardiovascular Risk Assessment and Management Making a Difference
Cardiovascular Risk Assessment and Management Making a Difference Norman Sharpe March 2014 Numbers and age-standardised mortality rates from all causes, by sex, 1950 2010 Death rates halved Life expectancy
More informationNomogram of the Relation of Brachial-Ankle Pulse Wave Velocity with Blood Pressure
801 Original Article Nomogram of the Relation of Brachial-Ankle Pulse Wave Velocity with Blood Pressure Akira YAMASHINA, Hirofumi TOMIYAMA, Tomio ARAI, Yutaka KOJI, Minoru YAMBE, Hiroaki MOTOBE, Zydem
More informationARIC Manuscript Proposal # PC Reviewed: 2/10/09 Status: A Priority: 2 SC Reviewed: Status: Priority:
ARIC Manuscript Proposal # 1475 PC Reviewed: 2/10/09 Status: A Priority: 2 SC Reviewed: Status: Priority: 1.a. Full Title: Hypertension, left ventricular hypertrophy, and risk of incident hospitalized
More informationIdentification of subjects at high risk for cardiovascular disease
Master Class in Preventive Cardiology Focus on Diabetes and Cardiovascular Disease Geneva April 14 2011 Identification of subjects at high risk for cardiovascular disease Lars Rydén Karolinska Institutet
More informationPathology of Hypertension
2016-03-07 Pathology of Hypertension Honghe Zhang honghezhang@zju.edu.cn Tel:88208199 Department of Pathology ❶ Genetic predisposition ❷ Dietary factors ❸ Environmental factors ❹ Others Definition and
More informationKnow Your Number Aggregate Report Single Analysis Compared to National Averages
Know Your Number Aggregate Report Single Analysis Compared to National s Client: Study Population: 2242 Population: 3,000 Date Range: 04/20/07-08/08/07 Version of Report: V6.2 Page 2 Study Population Demographics
More informationGender Differences in Physical Inactivity and Cardiac Events in Men and Women with Type 2 Diabetes
Gender Differences in Physical Inactivity and Cardiac Events in Men and Women with Type 2 Diabetes Margaret M. McCarthy 1 Lawrence Young 2 Silvio Inzucchi 2 Janice Davey 2 Frans J Th Wackers 2 Deborah
More informationdoi: /j.atherosclerosis
doi: 10.1016/j.atherosclerosis.2012.01.013 Page 1 High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: the JPHC study Renzhe Cui 1, Hiroyasu Iso 1, Kazumasa
More informationAppendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors.
Appendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors. Appendix to: Banks E, Crouch SR, Korda RJ, et al. Absolute risk of cardiovascular
More informationDivision of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai 982
Tohoku J. exp. Med., 1978, 126, 125-132 Distribution of Intracranial Aneurysm TAKASHI YOSHIMOTO, TAKAMASA KAYAMA, NAMIO KODAMA and JIRO SUZUKI Division of Neurosurgery, Institute of Brain Diseases, Tohoku
More informationObjectives. Describe results and implications of recent landmark hypertension trials
Hypertension Update Daniel Schwartz, MD Assistant Professor of Medicine Associate Medical Director of Heart Transplantation Temple University School of Medicine Disclosures I currently have no relationships
More informationOriginal Research Article
A STUDY TO ESTIMATE SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS BY MEASURING THE CAROTID INTIMAL MEDIAL THICKNESS Natarajan Kandasamy 1, Rajan Ganesan 2, Thilakavathi Rajendiran
More informationKEEP Summary Figures S32. Am J Kidney Dis. 2011;57(3)(suppl 2):S32-S56
21 Summary Figures S32 Definitions DATA ANALYSES DIABETES Self-reported diabetes, self reported diabetic retinopathy, receiving medication for diabetes, or elevated blood glucose (WHO); fasting blood sugar
More informationNon communicable Diseases
Non communicable Diseases Vision, Goals and Challenges Where we are in Palestine? Dr. Johny R. Khoury Consultant Cardiologist Medical Relief Prevention and Diagnostic Center of cardiovascular diseases
More informationBlood Pressure Treatment Goals
Blood Pressure Treatment Goals Kenneth Izuora, MD, MBA, FACE Associate Professor UNLV School of Medicine November 18, 2017 Learning Objectives Discuss the recent studies on treating hypertension Review
More informationCauses of Poor BP control Rates
Goals Of Hypertension Management in Clinical Practice World Hypertension League (WHL) Meeting Adel E. Berbari, MD, FAHA, FACP Professor of Medicine and Physiology Head, Division of Hypertension and Vascular
More informationJNC Evidence-Based Guidelines for the Management of High Blood Pressure in Adults
JNC 8 2014 Evidence-Based Guidelines for the Management of High Blood Pressure in Adults Table of Contents Why Do We Treat Hypertension? Blood Pressure Treatment Goals Initial Therapy Strength of Recommendation
More informationKEEP Summary Figures S40. Am J Kidney Dis. 2012;59(3)(suppl 2):S40-S64
211 Summary Figures S4 Am J Kidney Dis. 212;59(3)(suppl 2):S4-S64 Definitions DATA ANALYSES DIABETES Self-reported diabetes, self reported diabetic retinopathy, receiving medication for diabetes, or elevated
More informationSerum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic
Supplementary Information The title of the manuscript Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke Xin-Wei He 1, Wei-Ling Li 1, Cai Li
More informationSupplementary Online Content
Supplementary Online Content Åsvold BO, Vatten LJ, Bjøro T, et al; Thyroid Studies Collaboration. Thyroid function within the normal range and risk of coronary heart disease: an individual participant
More informationUpdate on Lipid Management in Cardiovascular Disease: How to Understand and Implement the New ACC/AHA Guidelines
Update on Lipid Management in Cardiovascular Disease: How to Understand and Implement the New ACC/AHA Guidelines Paul Mahoney, MD Sentara Cardiology Specialists Lipid Management in Cardiovascular Disease
More informationA factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes
A factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes Hypotheses: Among individuals with type 2 diabetes, the risks of major microvascular
More informationNIH Public Access Author Manuscript JAMA Intern Med. Author manuscript; available in PMC 2015 August 01.
NIH Public Access Author Manuscript Published in final edited form as: JAMA Intern Med. 2014 August ; 174(8): 1397 1400. doi:10.1001/jamainternmed.2014.2492. Prevalence and Characteristics of Systolic
More informationDISCLOSURES OUTLINE OUTLINE 9/29/2014 ANTI-HYPERTENSIVE MANAGEMENT OF CHRONIC KIDNEY DISEASE
ANTI-HYPERTENSIVE MANAGEMENT OF CHRONIC KIDNEY DISEASE DISCLOSURES Editor-in-Chief- Nephrology- UpToDate- (Wolters Klewer) Richard J. Glassock, MD, MACP Geffen School of Medicine at UCLA 1 st Annual Internal
More informationPrevalence of Cardiac Risk Factors among People Attending an Exhibition
IOSR Journal of Nursing and Health Science (IOSR-JNHS) e-issn: 2320 1959.p- ISSN: 2320 1940 Volume 3, Issue 6 Ver. IV (Nov.-Dec. 2014), PP 4-51 Prevalence of Cardiac Risk Factors among People Attending
More informationRisk Assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication
41 Research Article Risk Assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication Amarjeet Singh*, Sudeep bhardwaj, Ashutosh aggarwal Department of Pharmacology, Seth
More informationPopulation Attributable Fraction of Mortality Associated with Tobacco Smoking in Japan: A Pooled Analysis of Three Large-scale Cohort Studies
doi:10.2188/jea.je2007429 Original Article Population Attributable Fraction of Mortality Associated with Tobacco Smoking in Japan: A Pooled Analysis of Three Large-scale Cohort Studies Kota Katanoda, 1
More informationTable 1 Baseline characteristics of 60 hemodialysis patients with atrial fibrillation and warfarin use
Table 1 Baseline characteristics of 60 hemodialysis patients with atrial fibrillation and warfarin use Baseline characteristics Users (n = 28) Non-users (n = 32) P value Age (years) 67.8 (9.4) 68.4 (8.5)
More informationKeizo TAKEMI. Member, House of Councilors
* Keizo TAKEMI Member, House of Councilors Trends in Healthy Life Expectancy in Japan Life Expectancy Healthy Life Expectancy (Years) 90 Male (Years) 90 Female 85 80 75 78.07 78.64 79.19 79.55 85 80 75
More informationSex Differences in Stroke Risk and Quality of Life after Stroke
Sex Differences in Stroke Risk and Quality of Life after Stroke Cheryl Bushnell, MD, MHS Associate Professor of Neurology Director, WFB Stroke Center Disclosures Research funding from: World Federation
More informationTreatment of Cardiovascular Risk Factors. Kevin M Hayes D.O. F.A.C.C. First Coast Heart and Vascular Center
Treatment of Cardiovascular Risk Factors Kevin M Hayes D.O. F.A.C.C. First Coast Heart and Vascular Center Disclosures: None Objectives What do risk factors tell us What to check and when Does treatment
More informationStroke is the third leading cause of death in the
Probability of Stroke: A Risk Profile From the Framingham Study Philip A. Wolf, MD; Ralph B. D'Agostino, PhD; Albert J. Belanger, MA; and William B. Kannel, MD A health risk appraisal function has been
More informationManagement of Hypertension. M Misra MD MRCP (UK) Division of Nephrology University of Missouri School of Medicine
Management of Hypertension M Misra MD MRCP (UK) Division of Nephrology University of Missouri School of Medicine Disturbing Trends in Hypertension HTN awareness, treatment and control rates are decreasing
More informationAssociation between Raised Blood Pressure and Dysglycemia in Hong Kong Chinese
Diabetes Care Publish Ahead of Print, published online June 12, 2008 Raised Blood Pressure and Dysglycemia Association between Raised Blood Pressure and Dysglycemia in Hong Kong Chinese Bernard My Cheung,
More informationRelationship between body mass index, coronary disease extension and clinical outcomes in patients with acute coronary syndrome
Relationship between body mass index, coronary disease extension and clinical outcomes in patients with acute coronary syndrome Helder Dores, Luís Bronze Carvalho, Ingrid Rosário, Sílvio Leal, Maria João
More informationYuqing Zhang, M.D., FESC Department of Cardiology, Fu Wai Hospital. CAMS & PUMC, Beijing, China
What Can We Learn from the Observational Studies and Clinical Trials of Prehypertension? Yuqing Zhang, M.D., FESC Department of Cardiology, Fu Wai Hospital. CAMS & PUMC, Beijing, China At ARIC visit 4
More informationAppendix: Supplementary tables [posted as supplied by author]
Appendix: Supplementary tables [posted as supplied by author] Table A. Hazard ratios and 95% confidence intervals for the associations between subtypes of opium use in relation to overall mortality Opium
More informationEuroPrevent 2010 Fatal versus total events in risk assessment models
EuroPrevent 2010 Fatal versus total events in risk assessment models Pekka Jousilahti, MD, PhD,Research Professor National Institute for Health and Welfare, Finland Risk assessment models Estimates the
More informationLecture 8 Cardiovascular Health Lecture 8 1. Introduction 2. Cardiovascular Health 3. Stroke 4. Contributing Factors
Lecture 8 Cardiovascular Health 1 Lecture 8 1. Introduction 2. Cardiovascular Health 3. Stroke 4. Contributing Factors 1 Human Health: What s Killing Us? Health in America Health is the U.S Average life
More informationTreating Hypertension in 2018: What Makes the Most Sense Today?
Treating Hypertension in 2018: What Makes the Most Sense Today? Daniel Blanchard, MD Professor of Medicine UC San Diego Cardiovascular Center La Jolla, California 1 2 Speaker Disclosures Consultant and/or
More informationSeasonal variation in blood pressure and its relationship with outdoor air temperature in 10 diverse regions of China: the China Kadoorie Biobank
Seasonal variation in blood pressure and its relationship with outdoor air temperature in diverse regions of China: the China Kadoorie Biobank SUPPLEMENTAL MATERIAL 1 Tables etable 1: Seasonal mean outdoor
More informationPrognostic significance of blood pressure measured in the office, at home and during ambulatory monitoring in older patients in general practice
(2005) 19, 801 807 & 2005 Nature Publishing Group All rights reserved 0950-9240/05 $30.00 www.nature.com/jhh ORIGINAL ARTICLE Prognostic significance of blood pressure measured in the office, at home and
More informationBranko N Huisa M.D. Assistant Professor of Neurology UNM Stroke Center
Branko N Huisa M.D. Assistant Professor of Neurology UNM Stroke Center THE END! CHANGABLE Blood pressure Diabetes Mellitus Hyperlipidemia Atrial fibrillation Nicotine Drug abuse Life style NOT CHANGABLE
More informationMetabolic Syndrome: A Preventable & Treatable Cluster of Conditions
Metabolic Syndrome: A Preventable & Treatable Cluster of Conditions April D. McNeill MD Candidate 2016, Southern Illinois University, School of Medicine GE-NMF Primary Care Leadership Program, July 2013
More informationStopping oral contraceptives: an effective blood pressure-lowering intervention in women with hypertension
(2005) 19, 451 455 & 2005 Nature Publishing Group All rights reserved 0950-9240/05 $30.00 www.nature.com/jhh ORIGINAL ARTICLE Stopping oral contraceptives: an effective blood pressure-lowering intervention
More information2/7/
Disclosure Intracranial Atherosclerosis an update None Mai N. Nguyen-Huynh, MD, MAS Assistant Professor of Neurology UCSF Neurovascular Service February 7, 2009 Case #1 60 y.o. Chinese-speaking speaking
More informationYOUNG ADULT MEN AND MIDDLEaged
BRIEF REPORT Favorable Cardiovascular Profile in Young Women and Long-term of Cardiovascular and All-Cause Mortality Martha L. Daviglus, MD, PhD Jeremiah Stamler, MD Amber Pirzada, MD Lijing L. Yan, PhD,
More informationFasting insulin and risk of cerebral infarction in a Japanese general population: The Jichi Medical School Cohort Study
Neurology Asia 2013; 18(4) : 343 348 ORIGINAL ARTICLES Fasting insulin and risk of cerebral infarction in a Japanese general population: The Jichi Medical School Cohort Study 1 Yuji Kaneda MD, 2 Shizukiyo
More informationPredicting and changing the future for people with CKD
Predicting and changing the future for people with CKD I. David Weiner, M.D. Co-holder, C. Craig and Audrae Tisher Chair in Nephrology Professor of Medicine and Physiology and Functional Genomics University
More information