Policy Specific Section: May 16, 1984 April 9, 2014
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1 Medical Policy Heart Transplant Type: Medical Necessity and Investigational / Experimental Policy Specific Section: Transplant Original Policy Date: Effective Date: May 16, 1984 April 9, 2014 Definitions of Decision Determinations Medically Necessary: A treatment, procedure or drug is medically necessary only when it has been established as safe and effective for the particular symptoms or diagnosis, is not investigational or experimental, is not being provided primarily for the convenience of the patient or the provider, and is provided at the most appropriate level to treat the condition. Investigational/Experimental: A treatment, procedure or drug is investigational when it has not been recognized as safe and effective for use in treating the particular condition in accordance with generally accepted professional medical standards. This includes services where approval by the federal or state governmental is required prior to use, but has not yet been granted. Split Evaluation: Blue Shield of California / Blue Shield of California Life & Health Insurance Company (Blue Shield) policy review can result in a Split Evaluation, where a treatment, procedure or drug will be considered to be investigational for certain indications or conditions, but will be deemed safe and effective for other indications or conditions, and therefore potentially medically necessary in those instances. Description A heart transplant or cardiac transplantation is a surgical replacement of a diseased or damaged heart with a healthy donor heart. Transplantation is used for patients with refractory end-stage cardiac disease that is not responsive to conventional medical or surgical treatment.
2 Policy Human heart transplantation may be considered medically necessary for selected adults and children with end-stage heart failure when patient selection criteria are met. Adult Patients Accepted Indications for Transplantation (one of the following): Hemodynamic compromise due to heart failure demonstrated by any of the following: Maximal V0 2 (oxygen consumption) <10 ml/kg/min with achievement of anaerobic metabolism Refractory cardiogenic shock Documented dependence on intravenous inotropic support to maintain adequate organ perfusion Severe ischemia consistently limiting routine activity not amenable to bypass surgery or angioplasty Recurrent symptomatic ventricular arrhythmias refractory to ALL accepted therapeutic modalities. Probable Indications for Cardiac Transplantation (any of the following): Maximal V0 2 <14 ml/kg/min and major limitation of the patient's activities, or Recurrent unstable ischemia not amenable to bypass surgery or angioplasty, or Instability of fluid balance/renal function not due to patient noncompliance with regimen of weight monitoring, flexible use of diuretic drugs, and salt restriction Inadequate indications for heart transplantation (unless other factors as listed above are present): Ejection fraction <20% History of functional class III or IV symptoms of heart failure Previous ventricular arrhythmias Maximal V0 2 >15 ml/kg/min Pediatric Patients Pediatric patients with heart failure with persistent symptoms at rest who require one or more of the following: Continuous infusion of intravenous inotropic agents Mechanical ventilatory support Mechanical circulatory support Pediatric patients with pediatric heart disease with symptoms of heart failure who do not meet the above criteria but who have any of the following: Severe limitation of exercise and activity (if measurable, such patients would have a peak maximum oxygen consumption < 50% predicted for age and sex) 2 of 6
3 Cardiomyopathies or previously repaired or palliated congenital heart disease and significant growth failure attributable to the heart disease Near sudden death and/or life-threatening arrhythmias untreatable with medications or an implantable defibrillator Restrictive cardiomyopathy with reactive pulmonary hypertension Reactive pulmonary hypertension and potential risk of developing fixed, irreversible elevation of pulmonary vascular resistance that could preclude orthotopic heart transplantation in the future Anatomical and physiological conditions likely to worsen the natural history of congenital heart disease in infants with a functional single ventricle Anatomical and physiological conditions that may lead to consideration for heart transplantation without systemic ventricular dysfunction Heart retransplantation after a failed primary heart transplant may be considered medically necessary in patients who meet criteria for heart transplantation. Heart transplantation is considered investigational in all other situations. Policy Guideline Potential contraindications subject to the judgment of the transplant center: Known current malignancy, including metastatic cancer Recent malignancy with high risk of recurrence Untreated systemic infection making immunosuppression unsafe, including chronic infection Other irreversible end-stage disease not attributed to heart or lung disease History of cancer with a moderate risk of recurrence Systemic disease that could be exacerbated by immunosuppression Psychosocial conditions or chemical dependency affecting ability to adhere to therapy Policy-specific potential contraindications Pulmonary hypertension that is fixed as evidenced by pulmonary vascular resistance (PVR) greater than 5 Wood units, or transpulmonary gradient (TPG) greater than or equal to 16 mm/hg despite treatment* Severe pulmonary disease despite optimal medical therapy, not expected to improve with heart transplantation* *Some patients may be candidates for combined heart-lung transplantation (see policy Heart/Lung Transplantation). Patients must meet the United Network for Organ Sharing (UNOS) guidelines for 1A, 1B, or 2 Status and not currently be Status 7. 3 of 6
4 Cardiac-Specific The UNOS prioritizes donor thoracic organs according to the severity of illness, with those patients who are most severely ill (Status 1A) given highest priority in allocation of the available organ as follows (UNOS, 2009): Adult patients (18 years of age or older) Status 1A A patient is admitted to the listing transplant center hospital and has at least one of the following devices or therapies in place: a. Mechanical circulatory support for acute hemodynamic decompensation that includes at least one of the following: Left and/or right ventricular assist device implanted Total artificial heart Intra-aortic balloon pump: or Extracorporeal membrane oxygenator (ECMO) b. Mechanical circulatory support c. Continuous mechanical ventilation d. Continuous infusion of inotropes and continuous monitoring of left ventricular filling pressures e. If criteria (a), (b), (c), and (d) are not met, such status can be obtained by application to the applicable Regional Review Board Status 1B A patient has at least one of the following devices or therapies in place: Left and/or right ventricular device implanted, or Continuous infusion of intravenous inotropes A patient who does not meet Status 1A or 1B is listed as Status 2. Pediatric patients A candidate listed as Status 1A meets at least one of the following criteria: a. Requires assistance with a ventilator; b. Requires assistance with a mechanical assist device (e.g., ECMO); c. Requires assistance with a balloon pump; d. A candidate younger than 6 months old with congenital or acquired heart disease exhibiting reactive pulmonary hypertension at greater than 50% of systemic level. Such a candidate may be treated with prostaglandin E (PGE) to maintain patency of the ductus arteriosus; 4 of 6
5 e. Requires infusion of high dose (e.g., dobutamine 7.5 mg/kg/min or milrinone 0.5 mg /kg/min) or multiple inotropes (e.g., addition of dopamine at 5.0 mg/kg/min); or A candidate who does not meet the criteria specified in (a), (b), (c), (d), or (e) may be listed as Status 1A if the candidate has a life expectancy without a heart transplant of less than 14 days, such as due to refractory arrhythmia. A candidate listed as Status 1B meets at least one of the following criteria: Requires infusion of low-dose single inotropes (e.g., dobutamine or dopamine 7.5 mg /kg/min); Younger than 6 months old and does not meet the criteria for Status 1A; or Growth failure, i.e., greater than 5th percentile for weight and/or height, or loss of 1.5 standard deviations of expected growth (height or weight) based on the National Center for Health Statistics for pediatric growth curves. A candidate who does not meet the criteria for Status 1A or 1B is listed as Status 2. Note: Pediatric heart transplant candidates who remain on the waiting list at the time of their 18th birthday without receiving a transplant continue to qualify for medical urgency status based upon the pediatric criteria. Status 7 patients are considered temporarily unsuitable to receive a thoracic organ transplant. Documentation Required for Clinical Review Referring physician history and physical Cardiology consultation report and/or progress notes documenting: o Diagnosis (including disease staging) and prognosis o Synopsis of alternative treatments performed and results o Specific transplant type being requested Surgical consultation report and/or progress notes Results of completed transplant evaluation including: o Clinical history o Specific issues identified during the transplant evaluation o Consultation reports/letters (when applicable) o Correspondence from referring physicians (when applicable) Medical social service/social worker and/or psychiatric (if issues are noted) evaluations including psychosocial assessment or impression of patient s ability to be an adequate candidate for transplant Chest x-ray (CXR) and other radiology reports (when applicable) Colonoscopy report if > 50 years of age Cardiology procedures and respiratory function reports: o EKG o Cardiac echocardiogram o Cardiac stress test o Cardiac catheterization 5 of 6
6 o Pulmonary function tests (PFTs) Laboratory reports The materials provided to you are guidelines used by this plan to authorize, modify, or deny care for persons with similar illness or conditions. Specific care and treatment may vary depending on individual need and the benefits covered under your contract. These Policies are subject to change as new information becomes available. 6 of 6
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