Insight from Nordic III
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1 Insight from Nordic III Fifth European Bifurcation Club Meeting Berlin October 2009 Jens Flensted Lassen, MD, PH.D., FESC. Department of Cardiology Skejby Hospital, University of Aarhus Denmark
2 Nordic-Baltic Bifurcation Study III Participating Centers Denmark Aarhus University Hospital Odense University Hospital Aalborg University Hospital Rigshospitalet Copenhagen Latvia Paul Stradins Hospital, Riga (81 pts) (17 pts) (7 pts) (2 pts) (71 pts) Finland Oulu University Hospital Tampere University Hospital Turku University Hospital Kajaani Central Hospital Rovaniemi Central Hospital Kemi Central Hospital (149 pts) (24 pts) (13 pts) (12 pts) (5 pts) (1 pt) Sweden Örebro Hospital Uppsala University Hospital Falun Hospital (10 pts) (1 pt) (1 pt) Kuopio University Hospital Norway Feiring Heart Clinic (1 pt) (33 pts) Tromsø University Hospital (32 pts) Rikshopsitalet (13 pts)
3 Eurointerv.2007;3:44-49
4 Background In coronary bifurcation lesions, stenting of the main vessel and optional stenting of the side branch is the preferred bifurcation stenting strategy In the simple one-stent technique, the indication for mandatory kissing balloon post dilatation is unsettled
5 Purpose In a randomized clinical trial, to compare outcome of two different side-branch strategies in coronary bifurcation lesions treated with main vessel stenting using sirolimus eluting stents No kissing balloon postdilatation Kissing balloon postdilatation
6 NORD-BIF III Nordic kiss main branch stenting only versus main branch stenting and final kissing balloon N = 450, MV > 2.5 mm, SB > 2.25 mm 1 and 6 month clinical- and 8 month angiographic follow up. 14, 24, 36 and 60 month safety follow up Inclusion from April 1, Inclusion finalized September 23, 2008
7 NORD-BIF III Nordic kiss
8 Exclusion criteria ST-elevation AMI within 24 hours Expected survival < 1 year S-creatinine > 200 µmol/l Allergy to aspirin, clopidogrel, or ticlopidine Allergy to sirolimus
9 Primary Endpoint At 6 months composite of: Cardiac death Index lesion myocardial infarction* Target lesion revascularisation (TLR) Stent thrombosis angiographic confirmation cardiac death * Non-procedure related
10 Secondary Endpoints Individual endpoints of: Non-cardiac death Cardiac death Myocardial infarction* Stent thrombosis TLR Cardiac biomarker release CCS-angina score * Non-procedure related
11 Randomization Bifurcation patients with successful MV stenting n: 477 No Kissing balloon n: 239 Kissing balloon n: 238 Clinical follow-up after 1 and 6 months n: 477 (100%)
12 Baseline demographics No kissing Kissing n=239 +kiss Kissing n=238 n=238 P value - Age, mean+sd ns Male,% ns Diabetes, % ns Smoking, % ns Hypertension, % ns Statin Tx, % ns Family history, % ns History of PCI, % ns History of CABG, % 2 3 ns p value
13 Indication No kissing Kissing 0.4% 0.4% 26% 25% 74% 74% ns
14 Treated vessels No kissing Kissing 5% 7% 4% 8% 21% 12% 67% 77% ns
15 Baseline characteristics No kissing n= 239 Kissing n= 238 P value EF (%), mean SD ns 1-VD, % ns 2-VD, % ns 3-VD, % ns
16 Coronary angiography Visual assessment No kissing Kissing p value n=239 Crush n=238 Culotte P-value (n=210) (n=215) MV les. length (mm) ns MV stent length (mm) ns SB les. length (mm) ns Prx. MV ref. diam. (mm) ns Dis. MV ref. diam. (mm) ns SB ref. diam. (mm) ns
17 Coronary angiography Visual assessment No Kissing Kissing n = 239 n = 238 p MV prox stenosis before (%) ns MV dist stenosis before (%) ns SB stenosis before (%) ns MV prox stenosis after (%) ns MV dist stenosis after (%) ns SB stenosis after (%) <0.000
18 Patients with true bifurcation lesions Medina classification 1,1,1-1,0,1-0,1,1 No kissing Kissing n=239 n=238 p value True bifurcation lesion, n (%) 124 (51.8 %) 130 (54.6%) ns
19 Patients without side branch stenosis Medina classification 1,1,0-1,0,0-0,1,0 No kissing Kissing p value (n=239) (n=238) No side branch stenosis, n (%) 115 (48.2) 105 (45.4) ns
20 Procedural data I No kissing n=239 n=210 Kissing Culotte n=238n=210 p-value P value Aspirin Tx (%) ns Clopidogrel Tx (%) ns GPIIb/IIIa Tx (%) ns Bivalirudin Tx (%) ns Procedure time (min) Fluorosc. time (min) Contrast (ml)
21 Procedure data II No kissing n=239 Kissing n=238 p-value MV stented, % ns SB stented, % ns SB dil. thr. MV stent, % Final kissing ball, % SB dil. thr. MV stent/kissing, % Tx successful*, % ns *residual stenosis <30% of MV+TIMI III flow in SB
22 Primary end point MACE (cardiac death, index lesion MI, TLR, stent thrombosis) after 6 months % ns NO KISSING KISSING
23 Primary end point event free survival MACE (cardiac death, index lesion MI, TLR, stent thrombosis ns
24 Secondary end points after 6 months No kissing Kissing p-value n=239 n=238 Cardiac death (%) ns Non-cardiac death (%) ns Index lesion MI* (%) ns TLR (%) ns Stent thrombosis (%) ns * Non-procedure related
25 Limitations Short observation period Visually assessed implanation angiograms only Long term follow up and 8-month QCA data expected to be available at ACC 2010
26 Conclusion In coronary bifurcation lesions, a strategy of routine kissing balloon dilatation of side branch through the MV stent did not improve the 6-month clinical outcome as compared to a strategy of no kissing balloon dilatation In the kissing balloon dilatation group, the procedure and fluoroscopy time and the use of contrast were significantly increased
27 Implications Life can only be understood backwards; but it must be lived forwards." Soren Kirkegaard
28 Implications Final Kissing is optional (left to the operators descreation) Side branch preparation (therapeutic dilatation, if needed) has to be done before implanting the main vessel stent Change the stepwise strategy of provisional stenting of the sidebranch
29 Bifurcation treatment principles Provisional stentning Use MEDINA classification for lesion description. Plan the intervention beforehand Always use DES Therapeutic dilatation in the side branch Use jailed wire (double wire technique) Optional kissing balloon if the sidebranch is fine. Stent main branch and use step-wise provisional sidebranch stenting (T- or culotte-stenting) if needed. Ensure full stent coverage and good wall apposition
30 Thank you for your attention
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