The Spectrum of Dedicated Stents for Bifurcation Lesions: Current Status and Future Projections. Martin B. Leon, MD
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1 The Spectrum of Dedicated Stents for Bifurcation Lesions: Current Status and Future Projections Martin B. Leon, MD Columbia University Medical Center Cardiovascular Research Foundation New York City Angioplasty Summit TCT Asia-Pacific 2007 April 25-27, 27, 2007; Seoul, Korea
2 Presenter Disclosure Information for Angioplasty Summit 2007 Martin B. Leon, M.D. Consultant or Advisory Board: BSC, Cordis-JNJ, Medtronic, Abbott, Cappella, Tryton,, TMI Stockholder or other Equity: Cappella, TMI
3 Dedicated Bifurcation Stents Classification and Clinical Trends
4 Medina Bifurcation Classification 0, 1 MB (Distal),, MB (Proximal) SB 0, 1 0, 1 1,1,1 1,1,0 1,0,1 0,1,1 1,0,0 0,1,0 0,0,1
5 Medina Bifurcation Classification 0, 1 MB (Distal),, MB (Proximal) SB 0, 1 0, 1 17% 9% 18% 13% 1,1,1 1,1,0 1,0,1 0,1,1 17% 14% 12% 1,0,0 0,1,0 0,0,1
6 Medina Bifurcation Classification MB (Distal),, MB (Proximal) SB 0, 1 0, 1 60% of bifurcation cases 0, 1 17% 18% 13% have disease involvement of the sidebranch! 1,1,1 1,1,0 1,0,1 0,1,1 12% 1,0,0 0,1,0 0,0,1
7 SIRIUS Bifurcation Study In-lesion Restenosis (treatment received); 78% FU Total Restenosis (MV and/or SB) 25.7% (17/66) Total MV 6.1% (4/66) /50 1/16 12/50 3/16 Main Vessel Total SB 22.7% (15/66) 24.0 P = Side Branch
8 SIRIUS Bifurcation Study Restenosis Site (17 cases) Stent + Stent Stent + PTCA *2 11 *1 3 1! 1
9 DES (Cypher( Cypher) ) drug effects in side branches 30 days after implant (porcine coronaries) Courtesy of: AR Groothuis, ER Edelman, P Seifert, J Dooley, and C Rogers CBSET and Cordis Corporation Main Branch at site of Side Branch origin Side Branch ~1 mm in
10 NORDIC Bifurcation Trial (SES) Study Design 413 patients with bifurcation lesions (LMCA, LAD. LCx, or RCA) Stenting of both the main vessel and side branch (MV+SB) n=206 pts (95.1% SB stent) Stenting of the main vessel and optional stenting of the side branch (MV only) n=207 pts (4.3% SB stent) Primary Endpoint: Major adverse cardiac event (MACE) at 6 months, defined as cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) or stent thrombosis of the index lesion Steigen T. et al; ACC 2006 Oral Presentation
11 Nordic Bifurcation RCT 413 pts at 28 centers in 5 countries with true bifurcation received Cypher in main vessels and randomized to PTCA vs. Cypher (crush, culotte, Y or other techniques) of side branch with final kiss. Clinical FU at 6 months. MV stented (%) SB stented (%) Tx successful (%)* N= N= NS <0.001 Kissing balloon (%) <0.001 NS Steigen TC et al. ACC 2006
12 Nordic Bifurcation Study (n=413) Major Endpoints (clinically driven) In-hospital MI (%) P= month MACE (%) Primary endpoint P= CKMB >3x nl Death MI Stent TLR TVR MACE thrombosis Steigen TC et al. ACC 2006
13 Dedicated Bifurcation Stents Classification and Clinical Trends There is marked variability in the morphology of coronary bifurcation lesions. The variability includes vessel size (MB and SB), lesion location, eccentricity, length, morphology, and SB takeoff angle. Therefore, multiple strategies may be required to optimally treat highly variable bifurcation lesions.
14 Dedicated Bifurcation Stents Classification and Clinical Trends Main branch DES do not elicit anti-restenosis responses in covered side branches (requires SB ostial DES coverage). Current clinical trends favor a minimalist single stent approach, but restenosis at the sidebranch ostium remains problematic.
15 Dedicated Bifurcation Stents Categories of Bifurcation Stents
16 Dedicated Bifurcation Stents General Categories Complete bifurcation Y stents Sidebranch access MB stents Sidebranch stents Specialty designs (e.g. for LM disease)
17 Dedicated Bifurcation Stents General Categories Complete bifurcation Y stents Sidebranch access MB stents Sidebranch stents Specialty designs (e.g. for LM disease)
18 Dedicated Bifurcation Stents Complete Bifurcation Y Stents (1997-present) BARD AVE Guidant Cordis MDT
19 Dedicated Bifurcation Stents Complete Bifurcation Y Stents The holy grail has been the development of a complete bifurcation Y stent. Thusfar,, many problems have limited clinical progress: system complexity and profile, stent design, wire handling (and wrapping), delivery systems, variable lesion morphologies, AND perceived need. Main use in the future may focus on large vessel bifurcations (LM disease).
20 Dedicated Bifurcation Stents General Categories Complete bifurcation Y stents Sidebranch access MB stents Sidebranch stents Specialty designs (e.g. for LM disease)
21 Dedicated Bifurcation Stents Sidebranch Access MB Stents ABT Frontier Invatec Twinrail Minvasys Nile BSC Petal Ymed Sidekick Trireme Medical (TMI) StentYs
22 ABT Frontier Design Characterisitics Main Branch (RX) Specially designed dual lumen tip Side Branch (OTW) Joining mandrel inserted through OTW inner member Single-Tip Delivery to avoid wire wrap Two Wires maintain access across both branches Kissing Balloon Deployment to minimize plaque shift Provisional T-StentT approach maintains options for additional treatment
23 ABT Frontier Next Generation DES Main Branch Balloon XIENCETM V Everolimus Coating Side Branch Balloon MULTI-LINK FRONTIERTM DES for Bifurcation MULTI-LINK VISION CoCr Design ML VISIONTM Catheter Side Branch Access CAUTION: XIENCETM V is an investigational device. Limited by Federal (U.S.) law to investigational use only.
24 Invatec Twin-Rail Design Summary Stent Platform ¾ Closed Cell design ¾ Variable Stent Geometry ¾ Adequate scaffolding of main vessel and side branch ostium Stent Delivery System ¾ Double balloon design SDS Main vessel balloon 3.0mm and 3.5mm Side branch balloon 1.5mm ¾ Double RX design ¾ 6 F Guiding catheter compatible
25 Minvasys Nile Design Summary One System Two independent catheters Side branch balloon Main branch Balloon + stent + tip
26 TAXUS Petal Bifurcation Stent Side Branch Lumen (SBL) SBL Marker Bands Side (Petal) Balloon Petal Main Branch Marker Bands Main Branch Stent Main Branch Balloon First Human Use Q2 2007
27 BSC TAXUS Petal Design Characteristics Delivery System Advantages Side Branch wire lumen aids in alignment at ostium Side branch pre-wired,, no need to re-access through stent Final Petal size determined by post dilatation balloon Stent Advantages Special stent feature to cover ostium of side branch (~2mm) Reduces / eliminates side branch gap and reduce need for 2nd stent Placing 2nd stent, when necessary, is technically straight forward
28 Y-Med Side-kick Design Charactieristics Low profile system (5 Fr guide compatible) Steerable fixed wire for main branch Rx movable wire for sidebranch access Easily torquable for accurate positioning
29 Y-Med Side-kick Design Characteristics Mid exit port Steerable fixed wire 5F GC RX side branch protection wire
30 TriReme Bifurcation Stent Stent Design Design Characteristics Central custom cell with crowns extending into sidebranch ostium upon balloon expansion (ostial( coverage and support) Low profile (6-7Fr guide compatible) Delivery System Rx main branch wire Custom nested side branch wire advanced thru central cell when proximal to side branch Crown markers to assist with axial and rotational alignment
31 StentYs Bifurcation Stent Design Characteristics 1. Optimal strut selection 2. Disconnection 3. Self-expansion 31
32 StentYs - Features Anatomical reconstruction of the bifurcation shape Drug-eluting Positioning tolerance (disconnectable struts on full length) Excellent ostium coverage with SB stent Excellent SB access Single wire 5F delivery system Distal MB stented 32
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