Vd. Sushant Sud M.D (Ayu); DHM; CHSE Asst. Prof Dpt of Agad Tantra Shri Gulabkunverba Ayurved Mahavidyalaya Dhanwantari Mandir Gujarat Ayurved

Transcription

1 Vd. Sushant Sud M.D (Ayu); DHM; CHSE Asst. Prof Dpt of Agad Tantra Shri Gulabkunverba Ayurved Mahavidyalaya Dhanwantari Mandir Gujarat Ayurved University, Jamnagar

2 1. The term Rasashastra literally means the divine science of mercury aimed to abolish the curse of poverty and suffering, it also helps to attain immortality. 2. Un processed parada is not used for administration as a medicine so to bring it in to medicinal form it needs to undergo many procedures including Moorchana, Moorchita Parada yoga have high therapeutic values. There are various methods to obtain Moorchita Parada based on specific mode of heat application. 3. One of the preparations of Moorchita parada is Rasakarpura. Rasakarpura is nirganda saagni Moorchana type of preparation, but according to Rasagranthas the nirganda murchita Parada yogas are more toxic in nature than the saganda Moorchita Parada yogas and opine it should not be used for long time.

3 Preparation of Rasakarpura as per Rasa Tarangini (6/65-70). The chemical formula mentioned for Rasa karpura is Hg2Cl2, it is considered as violent poison in modern science, but it has been advised to use in the form of medicine in Rasagranths, hence proper evaluation of drug will serve as an important tool for better understanding them, so as to provide scientific data and statistical validation for safety. An attempt is made to assess the quality control on Pharmaceutico-Analytical study of Rasakarpura.

4 Source of Data: A] Literary source: Literary source is collected from Ayurvedic classical textbooks, relevant modern text and published articles in repeated journals. [B] Pharmaceutical source: Raw drug for the preparation of Rasakarpura was collected from S.D.M Pharmacy Udupi. Preparation of Rasakarpura was done in the department of Rasashastra S.D.M.C.A, Udupi, Karnataka. [C] Analytical source: 1. Organoleptic characters. 2. Physico chemical constants. 3. Qualitative and Quantitative analysis. 4. Particle size assessment.

5 There are 38 methods found in various texts of Rasashastra for the preparation of Rasakarpura by using different mineral, metal and herbal drugs, though the ingredients are different along with Parada the final outcome is almost similar in nature. Pharmaceutical study: The pharmaceutical study was carried out in the following unit processes: Poorva karma Pradana karma Paschat karma

6 Preparation Method ऩऱस ममत प रयत नद व मऱ क र त रस शम सऩऱ द दक ऩऱ क व मऱ च गन दक म ऱम चषक ऩम व श द द ननदधधत क चऩ त र व ननध य क चऩ त र त यसस त रत रऩ ददक य म ज मऱत स र प रद ऩ स श षय ज जऱ षम अथ श वषत त च र त तय प रद ऩ त समभ धगक च दध ल ऱ र त स न द क यम ऩररम ल य च र म तस त न नदधधत क चक प यम य गस यक रत य म मसकत क य य न त रस रथम व ऩच दनतप रयत नत रसतन त रकम व ग न आ ब ध य क चक ऩ ए श तऱस त न म नस रन मध य रसमहर द रसझ: र.त ६/६५-७०

7 In the study 400 gm of mixture was taken in order to facilitate proper sublimation. The drug Parada was selected by considering Grahya- Agrahya lakshana, Shodana of Parada was performed to avoid the complications such as murcha, hikka, jwara, shwasa, kasa, brama etc. Preparation of the mixture was carried out in two steps: Parada was heated in Con. H 2 SO 4 Addition of saindava lavana to mixture of Parada and Con. H 2 SO 4

8 Kupi Sthapana Kupi Bhedan Kupi Poorana Pradhan Karma Initially mridu agni was started later madhyam agni was maintained till the corking (280 c -370 c), this was where actual formation of compound Hgcl 2 takes place, duration taken was 7 hours. After the mukha mudhrana the intensity of agni was increased for 5 hours the temperature maintained during this period was 428 c-610 c. After complete 12 hours of heating kupi was allowed to swangasheetata, here to make compound stable.

9 After kupi udharana wrapping around the kupi was scratched and removed carefully. By this the compound inside the bottle was clearly visible. This also facilitates the demarcation point between the Sublimation portion of the Rasa Karpura, also particles in the bottom of the bottle. Siddhi pramana: Needle like crystalline white structure was observed at the neck part of the kupi. Dull white smooth powder was observed at the base of the bottle. Totally there was 42.5% of the Rasa karpura attained by this procedure at the neck part of the kupi.

10 Analytical Study 1.Organoleptic characters. a) Colour b) Taste c) Odour d) Appearance 2.Physico chemical constants. a) Determination of ph. b) Total ash value. c) Acid insoluble ash. d) water soluble ash. e) Loss of drying. 3.Qualitative and Quantitative analysis. a) Atomic absorption spectroscopy(a.a.s). b) X R D 4. Particle size assessment.

11 Organo-leptic Characters: Colour: White. Odour: Characteristic. Taste: Palatable. Appearance: Crystalline. The ph of the sample of Rasakarpura is The ash value was found to be very less that is 32.84%. The percentage of acid insoluble ash value was 18.13%. The percentage of water soluble ash value was 2.44%. The Particle size vary from 18 microns to 31microns. Loss on Drying (moisture content) 3.25%.

12 Elemental analysis indicates presence of Mercury with some trace elements. Mercury: 32.1%. Arsenic: 1.70%. Lead: 0.02%. X-ray diffraction study indicated the presence, HgCl 2, Ca, Na, traces of Pb, Ar, Zn, Mg, Fe and almost absence of free Hg.

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15 Mercurous chloride(calomel)hgcl2 Mercurous chloride if fibrous, heavy dirty, white masses often mixed with mercuric chloride, it is heavy amorphous white and tasteless powder, insoluble in water, alchohal, ether,cold dilute acids. It is formed by the alteration of other mercury minerals, such as cinnabar or amalgams. The dose is mg.whwn heated it sublimates without fusing. it is converted into mercuric chloride by chlorine water, alkaline chlorides and common salts hence it should never be prescribed with any of these substance. exposure to sunlight decomposes into mercuric and mercuric chloride. Mercurous chloride has been most often used as a treatment for intestinal worms. In the past, large doses were often used to stimulate the intestines and remove blockages, although it is rarely used in medicine today. When it is used as a laxative, if the treatment fails to work, large doses of other laxatives and water must be used to insure that no mercury is allowed to accumulate in the body.

16 List OF REFERENCES Sharma Sadanand, Rasa Tarangini: with Prasadini Samskrta Commentary by Ayurvedacarya Shastri Haridatta, Rasa Vijnana Hindi Commentary by Shastri Dharmananda, 11th Ed. Delhi: Motilal Banarsidasa; 1979 (6thChapter/65-70) Pp-772. P- 115/116. Gosh MN, Fundamental of Experimental Pharmacology, 2nd Edition, Kolkatta by Scientific Book Agency Pp 230, P-155. Modi Jaising P. Subrahmanyam BV editor. Modi s Medical Jurisprudence & Toxicology.22nd Edition. New Delhi: Lexis Nexis Group of Companies; Pp- 1336, Section 2-Chapter 4/Inorganic Irritant Poisons/Arsenic P-136. Baghel M.S, Researches in Ayurveda, 2nd Edition, Jamnagar, Mridu Ayurvedic Publication & Sales, 2005, Pp-381, P-30,31,71,99,123.

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